-
1
-
-
12344326514
-
Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs
-
Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 2005; 10: 79-104.
-
(2005)
Mol Psychiatry
, vol.10
, pp. 79-104
-
-
Miyamoto, S.1
Duncan, G.E.2
Marx, C.E.3
Lieberman, J.A.4
-
2
-
-
34948858402
-
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized Phase 2 clinical trial
-
Patil ST, Zhang L, Martenyi F, Lowe SL, Jackson KA, Andreev BV, Avedisova AS, Bardenstein LM, Gurovich IY, Morozova MA, Mosolov SN, Neznanov NG, Reznik AM, Smulevich AB, Tochilov VA, Johnson BG, Monn JA, Schoepp DD. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nature Med 2007; 13: 1102-7.
-
(2007)
Nature Med
, vol.13
, pp. 1102-1107
-
-
Patil, S.T.1
Zhang, L.2
Martenyi, F.3
Lowe, S.L.4
Jackson, K.A.5
Andreev, B.V.6
Avedisova, A.S.7
Bardenstein, L.M.8
Gurovich, I.Y.9
Morozova, M.A.10
Mosolov, S.N.11
Neznanov, N.G.12
Reznik, A.M.13
Smulevich, A.B.14
Tochilov, V.A.15
Johnson, B.G.16
Monn, J.A.17
Schoepp, D.D.18
-
3
-
-
33947415606
-
-
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3. 1.0]hexane-4,6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther 2007; 321: 308-17.
-
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3. 1.0]hexane-4,6-dicarboxylic acid (LY404039). J Pharmacol Exp Ther 2007; 321: 308-17.
-
-
-
-
4
-
-
34347241277
-
Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
-
Palucha A, Pilc A. Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharmacol Ther 2007; 115: 116-47.
-
(2007)
Pharmacol Ther
, vol.115
, pp. 116-147
-
-
Palucha, A.1
Pilc, A.2
-
5
-
-
0042868860
-
Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: Behavioural characterization and implications for the treatment of CNS disorders
-
Spooren W, Ballard T, Gasparini F, Amalric M, Mutel V, Schreiber R. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol 2003; 14: 257-77.
-
(2003)
Behav Pharmacol
, vol.14
, pp. 257-277
-
-
Spooren, W.1
Ballard, T.2
Gasparini, F.3
Amalric, M.4
Mutel, V.5
Schreiber, R.6
-
6
-
-
4344624909
-
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
-
Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Shannon-Weickert C, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. Proc Natl Acad Sci USA 2004; 101: 12604-9.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12604-12609
-
-
Egan, M.F.1
Straub, R.E.2
Goldberg, T.E.3
Yakub, I.4
Callicott, J.H.5
Hariri, A.R.6
Mattay, V.S.7
Bertolino, A.8
Hyde, T.M.9
Shannon-Weickert, C.10
Akil, M.11
Crook, J.12
Vakkalanka, R.K.13
Balkissoon, R.14
Gibbs, R.A.15
Kleinman, J.E.16
Weinberger, D.R.17
-
7
-
-
39449104625
-
The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): Expression, function, and involvement in schizophrenia
-
In press
-
Harrison PJ, Lyon L, Sartorius LJ, Burnet PWJ, Lane TA. The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function, and involvement in schizophrenia. J Psychopharmacol 2008. In press.
-
(2008)
J Psychopharmacol
-
-
Harrison, P.J.1
Lyon, L.2
Sartorius, L.J.3
Burnet, P.W.J.4
Lane, T.A.5
-
8
-
-
0037305349
-
Molecular aspects of glutamate dysregulation: Implications for schizophrenia and its treatment
-
Konradi C, Heckers S. Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther 2004; 97: 153-79.
-
(2004)
Pharmacol Ther
, vol.97
, pp. 153-179
-
-
Konradi, C.1
Heckers, S.2
-
9
-
-
12344327212
-
Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence
-
Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005; 10: 40-68.
-
(2005)
Mol Psychiatry
, vol.10
, pp. 40-68
-
-
Harrison, P.J.1
Weinberger, D.R.2
-
10
-
-
0034843738
-
The emerging role of glutamate in the pathophysiology of schizophrenia
-
Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology of schizophrenia. Am J Psychiatry 2001; 158: 1367-77.
-
(2001)
Am J Psychiatry
, vol.158
, pp. 1367-1377
-
-
Goff, D.C.1
Coyle, J.T.2
-
11
-
-
8744278883
-
Glutamate as a therapeutic target in psychiatric disorders
-
Javitt DC. Glutamate as a therapeutic target in psychiatric disorders. Mol Psychiatry 2004; 9: 984-97.
-
(2004)
Mol Psychiatry
, vol.9
, pp. 984-997
-
-
Javitt, D.C.1
-
12
-
-
9244243064
-
Glutamatergic drugs for schizophrenia: A systematic review and meta-analysis
-
Tuominen HJ, Tiihonen J, Wahlbeck K. Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophr Res 2005; 72: 225-34.
-
(2005)
Schizophr Res
, vol.72
, pp. 225-234
-
-
Tuominen, H.J.1
Tiihonen, J.2
Wahlbeck, K.3
-
13
-
-
34748864737
-
The pipeline and future of drug development in schizophrenia
-
Gray JA, Roth BL. The pipeline and future of drug development in schizophrenia. Mol Psychiatry 2007; 12: 904-22.
-
(2007)
Mol Psychiatry
, vol.12
, pp. 904-922
-
-
Gray, J.A.1
Roth, B.L.2
-
14
-
-
3142739322
-
Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia
-
Moghaddam B. Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia. Psychopharmacol 2004; 174: 39-44.
-
(2004)
Psychopharmacol
, vol.174
, pp. 39-44
-
-
Moghaddam, B.1
|