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Volumn 35, Issue 6, 2010, Pages 284-306

Statins for calcific aortic valve stenosis: Into oblivion after SALTIRE and SEAS? An extensive review from bench to bedside

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ATORVASTATIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EZETIMIBE; EZETIMIBE PLUS SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; AZETIDINE DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT;

EID: 77952560272     PISSN: 01462806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cpcardiol.2010.02.002     Document Type: Article
Times cited : (17)

References (98)
  • 1
    • 0027477079 scopus 로고
    • Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample
    • Lindroos M., Kuppari M., Heikkilä J., et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol 1993, 21(5):1220-1225.
    • (1993) J Am Coll Cardiol , vol.21 , Issue.5 , pp. 1220-1225
    • Lindroos, M.1    Kuppari, M.2    Heikkilä, J.3
  • 2
    • 33847134400 scopus 로고    scopus 로고
    • Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology
    • Vahanian A., Baumgartner H., Bax J., et al. Guidelines on the management of valvular heart disease: the Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology. Eur Heart J 2007, 28(2):230-268.
    • (2007) Eur Heart J , vol.28 , Issue.2 , pp. 230-268
    • Vahanian, A.1    Baumgartner, H.2    Bax, J.3
  • 3
    • 0035885130 scopus 로고    scopus 로고
    • Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons
    • Aronow W.S., Ahn C., Kronzon I., et al. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol 2001, 88(6):693-695.
    • (2001) Am J Cardiol , vol.88 , Issue.6 , pp. 693-695
    • Aronow, W.S.1    Ahn, C.2    Kronzon, I.3
  • 4
    • 0035975938 scopus 로고    scopus 로고
    • Effect of hydroxymethylglutaryl coenzyme A reductase inhibitors on the progression of calcific aortic valve stenosis
    • Novaro G.M., Tiong I., Pearce G.L., et al. Effect of hydroxymethylglutaryl coenzyme A reductase inhibitors on the progression of calcific aortic valve stenosis. Circulation 2001, 104:2205-2209.
    • (2001) Circulation , vol.104 , pp. 2205-2209
    • Novaro, G.M.1    Tiong, I.2    Pearce, G.L.3
  • 5
    • 0037145893 scopus 로고    scopus 로고
    • Association of cholesterol levels, hydroxymethylglutaryl coenzyme A reductase inhibitor treatment, and progression of aortic stenosis in the community
    • Bellamy M.F., Pellikka P.A., Klarich K.W., et al. Association of cholesterol levels, hydroxymethylglutaryl coenzyme A reductase inhibitor treatment, and progression of aortic stenosis in the community. J Am Coll Cardiol 2002, 40:1723-1730.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1723-1730
    • Bellamy, M.F.1    Pellikka, P.A.2    Klarich, K.W.3
  • 6
    • 0037197017 scopus 로고    scopus 로고
    • HMG CoA reductase inhibitor (statin) and aortic valve calcium
    • Shavelle D.M., Takasu J., Budoff M.J., et al. HMG CoA reductase inhibitor (statin) and aortic valve calcium. Lancet 2002, 359(9312):1125-1126.
    • (2002) Lancet , vol.359 , Issue.9312 , pp. 1125-1126
    • Shavelle, D.M.1    Takasu, J.2    Budoff, M.J.3
  • 7
    • 4444332263 scopus 로고    scopus 로고
    • Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis
    • Rosenhek R., Rader F., Loho N., et al. Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis. Circulation 2004, 110:1291-1295.
    • (2004) Circulation , vol.110 , pp. 1291-1295
    • Rosenhek, R.1    Rader, F.2    Loho, N.3
  • 8
    • 33846593363 scopus 로고    scopus 로고
    • Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis
    • Moura L.M., Ramos S.F., Zamorano J.L., et al. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007, 49:554-561.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 554-561
    • Moura, L.M.1    Ramos, S.F.2    Zamorano, J.L.3
  • 9
    • 0035899912 scopus 로고    scopus 로고
    • Progression of aortic valve calcification. Association with coronary atherosclerosis and cardiovascular risk factors
    • Pohle K., Mäffert R., Ropers D., et al. Progression of aortic valve calcification. Association with coronary atherosclerosis and cardiovascular risk factors. Circulation 2001, 104:1927-1932.
    • (2001) Circulation , vol.104 , pp. 1927-1932
    • Pohle, K.1    Mäffert, R.2    Ropers, D.3
  • 10
    • 52649120889 scopus 로고    scopus 로고
    • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
    • Rossebø A.B., Pedersen T., Boman K., et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008, 359:1343-1356.
    • (2008) N Engl J Med , vol.359 , pp. 1343-1356
    • Rossebø, A.B.1    Pedersen, T.2    Boman, K.3
  • 11
    • 20344364674 scopus 로고    scopus 로고
    • A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    • Cowell S.J., Newby D.E., Prescott R.J., et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005, 352:2389-2397.
    • (2005) N Engl J Med , vol.352 , pp. 2389-2397
    • Cowell, S.J.1    Newby, D.E.2    Prescott, R.J.3
  • 12
    • 0028236385 scopus 로고
    • Factors associated with calcific aortic valve degeneration in the elderly
    • Lindroos M., Kupari M., Valvanne J., et al. Factors associated with calcific aortic valve degeneration in the elderly. Eur Heart J 1994, 15(7):865-870.
    • (1994) Eur Heart J , vol.15 , Issue.7 , pp. 865-870
    • Lindroos, M.1    Kupari, M.2    Valvanne, J.3
  • 13
    • 0031051128 scopus 로고    scopus 로고
    • Clinical factors associated with calcific aortic valve disease. Cardiovascular health study
    • Stewart B.F., Siscovick D., Lind B.K., et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular health study. J Am Coll Cardiol 1997, 29:630-634.
    • (1997) J Am Coll Cardiol , vol.29 , pp. 630-634
    • Stewart, B.F.1    Siscovick, D.2    Lind, B.K.3
  • 14
    • 0038267070 scopus 로고    scopus 로고
    • A prospective survey of patients with valvular heart disease in Europe: the Euro heart survey on valvular heart disease
    • Iung B., Baron G., Butchart E.G., et al. A prospective survey of patients with valvular heart disease in Europe: the Euro heart survey on valvular heart disease. Eur Heart J 2003, 24:1231-1243.
    • (2003) Eur Heart J , vol.24 , pp. 1231-1243
    • Iung, B.1    Baron, G.2    Butchart, E.G.3
  • 15
    • 0028329052 scopus 로고
    • Accumulation of T-lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves
    • Olsson M., Dalsgaard C.J., Haegerstrand A., et al. Accumulation of T-lymphocytes and expression of interleukin-2 receptors in nonrheumatic stenotic aortic valves. J Am Coll Cardiol 1994, 23(5):1162-1170.
    • (1994) J Am Coll Cardiol , vol.23 , Issue.5 , pp. 1162-1170
    • Olsson, M.1    Dalsgaard, C.J.2    Haegerstrand, A.3
  • 16
    • 0027991976 scopus 로고
    • Characterization of the early lesion of degenerative valvular aortic stenosis. Histological and immunohistochemical studies
    • Otto C.M., Kuusisto J., Reichenbach D.D., et al. Characterization of the early lesion of degenerative valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994, 90:844-853.
    • (1994) Circulation , vol.90 , pp. 844-853
    • Otto, C.M.1    Kuusisto, J.2    Reichenbach, D.D.3
  • 17
    • 0029872345 scopus 로고    scopus 로고
    • Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of degenerative valvular aortic stenosis
    • O'Brien K.D., Reichenbach D.D., Marcinova S.M., et al. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of degenerative valvular aortic stenosis. Arterioscler Thromb Vasc Biol 1996, 16:523-532.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 523-532
    • O'Brien, K.D.1    Reichenbach, D.D.2    Marcinova, S.M.3
  • 18
    • 0037024284 scopus 로고    scopus 로고
    • Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve
    • Rajamannan N.M., Subramaniam M., Springett M., et al. Atorvastatin inhibits hypercholesterolemia-induced cellular proliferation and bone matrix production in the rabbit aortic valve. Circulation 2002, 105:2660-2665.
    • (2002) Circulation , vol.105 , pp. 2660-2665
    • Rajamannan, N.M.1    Subramaniam, M.2    Springett, M.3
  • 19
    • 17644380642 scopus 로고    scopus 로고
    • Spatial heterogeneity of endothelial phenotypes correlates with site-specific vulnerability to calcification in normal porcine aortic valves
    • Simmons C.A., Grant G.R., Manduchi E., et al. Spatial heterogeneity of endothelial phenotypes correlates with site-specific vulnerability to calcification in normal porcine aortic valves. Circ Res 2005, 96:792-799.
    • (2005) Circ Res , vol.96 , pp. 792-799
    • Simmons, C.A.1    Grant, G.R.2    Manduchi, E.3
  • 20
    • 0026144908 scopus 로고
    • An ultrastructural study of beta very low density lipoprotein uptake and transport by valvular endothelium of hyperlipidemic rabbits
    • Vasile E., Antohe F. An ultrastructural study of beta very low density lipoprotein uptake and transport by valvular endothelium of hyperlipidemic rabbits. J Submicrosc Cytol Pathol 1991, 23:279-287.
    • (1991) J Submicrosc Cytol Pathol , vol.23 , pp. 279-287
    • Vasile, E.1    Antohe, F.2
  • 21
    • 0028222314 scopus 로고
    • An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit
    • Nievelstein-Post P., Mottino G., Fogelman A., et al. An ultrastructural study of lipoprotein accumulation in cardiac valves of the rabbit. Arterioscler Thromb 1994, 14:1151-1161.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1151-1161
    • Nievelstein-Post, P.1    Mottino, G.2    Fogelman, A.3
  • 22
    • 0035005753 scopus 로고    scopus 로고
    • Experimental hypercholesterolemia induces apoptosis in the aortic valve
    • Rajamannan N.M., Sangiorgi G., Springett M., et al. Experimental hypercholesterolemia induces apoptosis in the aortic valve. J Heart Valve Dis 2001, 10:371-374.
    • (2001) J Heart Valve Dis , vol.10 , pp. 371-374
    • Rajamannan, N.M.1    Sangiorgi, G.2    Springett, M.3
  • 23
    • 0037414072 scopus 로고    scopus 로고
    • Experimental aortic valve stenosis in rabbits
    • Drolet M.C., Arsenault M., Couet J. Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 2003, 41:1211-1217.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1211-1217
    • Drolet, M.C.1    Arsenault, M.2    Couet, J.3
  • 24
    • 24344434589 scopus 로고    scopus 로고
    • Development of aortic valve stenosis in a rabbit model of atherosclerosis: an immunohistochemical and histological study
    • Cimini M., Boughner D.R., Ronald J.A., et al. Development of aortic valve stenosis in a rabbit model of atherosclerosis: an immunohistochemical and histological study. J Heart Valve Dis 2005, 14:365-375.
    • (2005) J Heart Valve Dis , vol.14 , pp. 365-375
    • Cimini, M.1    Boughner, D.R.2    Ronald, J.A.3
  • 25
    • 34447498758 scopus 로고    scopus 로고
    • Macromolecular transport in heart valves III: experiment and theory for the size distribution of extracellular liposomes in hyperlipidemic rabbits
    • Zeng Z., Nievelstein-Post P., Yin Y., et al. Macromolecular transport in heart valves III: experiment and theory for the size distribution of extracellular liposomes in hyperlipidemic rabbits. Am J Physiol Heart Circ Physiol 2007, 292:H2687-H2697.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Zeng, Z.1    Nievelstein-Post, P.2    Yin, Y.3
  • 26
    • 0030947025 scopus 로고    scopus 로고
    • Spontaneous calcification of arteries and cartilage in mice lacking matrix gla protein
    • Luo G., Ducy P., McKee M.D., et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix gla protein. Nature 1997, 386:78-81.
    • (1997) Nature , vol.386 , pp. 78-81
    • Luo, G.1    Ducy, P.2    McKee, M.D.3
  • 27
    • 17444453852 scopus 로고    scopus 로고
    • A role for SmadVI in development and homeostasis of the cardiovascular system
    • Galvin K.M., Donovan M.J., Lynch C.A., et al. A role for SmadVI in development and homeostasis of the cardiovascular system. Nat Genet 2000, 24:171-174.
    • (2000) Nat Genet , vol.24 , pp. 171-174
    • Galvin, K.M.1    Donovan, M.J.2    Lynch, C.A.3
  • 28
    • 0034704998 scopus 로고    scopus 로고
    • Abnormal aortic development in mice lacking endothelial nitric oxide synthase
    • Lee T.C., Zhao Y.D., Courtman D.W., et al. Abnormal aortic development in mice lacking endothelial nitric oxide synthase. Circulation 2000, 101:2345-2348.
    • (2000) Circulation , vol.101 , pp. 2345-2348
    • Lee, T.C.1    Zhao, Y.D.2    Courtman, D.W.3
  • 29
    • 21344439830 scopus 로고    scopus 로고
    • Age-associated aortic stenosis in apolipoprotein E-deficient mice
    • Tanaka K., Sata M., Fukuda D., et al. Age-associated aortic stenosis in apolipoprotein E-deficient mice. J Am Coll Cardiol 2005, 46:134-141.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 134-141
    • Tanaka, K.1    Sata, M.2    Fukuda, D.3
  • 30
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in NOTCH 1 cause aortic valve disease
    • Garg V., Muth A.N., Ransom J.F., et al. Mutations in NOTCH 1 cause aortic valve disease. Nature 2005, 437:270-274.
    • (2005) Nature , vol.437 , pp. 270-274
    • Garg, V.1    Muth, A.N.2    Ransom, J.F.3
  • 31
    • 32644445773 scopus 로고    scopus 로고
    • A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice
    • Drolet M.C., Roussel E., Deshaies Y., et al. A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice. J Am Coll Cardiol 2006, 47:850-855.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 850-855
    • Drolet, M.C.1    Roussel, E.2    Deshaies, Y.3
  • 32
    • 33750703971 scopus 로고    scopus 로고
    • Dl. Calcific aortic valve stenosis in old hypercholesterolemic mice
    • Weiss R.M., Ohashi M., Miller J.D., et al. Dl. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 2006, 114:2065-2069.
    • (2006) Circulation , vol.114 , pp. 2065-2069
    • Weiss, R.M.1    Ohashi, M.2    Miller, J.D.3
  • 33
    • 33846429618 scopus 로고    scopus 로고
    • Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    • Aikawa E., Nahrendorf M., Sosnovik D., et al. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007, 115:377-386.
    • (2007) Circulation , vol.115 , pp. 377-386
    • Aikawa, E.1    Nahrendorf, M.2    Sosnovik, D.3
  • 34
    • 2942720515 scopus 로고    scopus 로고
    • Beneficial cardiovascular pleitropic effects of statins
    • Davignon J. Beneficial cardiovascular pleitropic effects of statins. Circulation 2004, 109(suppl III):III-39-III-43.
    • (2004) Circulation , vol.109 , Issue.SUPPL. III , pp. 39-43
    • Davignon, J.1
  • 35
    • 0041386133 scopus 로고    scopus 로고
    • Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis
    • Soini Y., Salo T., Satta J. Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis. Hum Pathol 2003, 34(8):756-763.
    • (2003) Hum Pathol , vol.34 , Issue.8 , pp. 756-763
    • Soini, Y.1    Salo, T.2    Satta, J.3
  • 36
    • 0038711036 scopus 로고    scopus 로고
    • Human aortic valve calcification is associated with an osteoblast phenotype
    • Rajamannan N.M., Subramaniam M., Rickard D., et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 2003, 107:2181-2184.
    • (2003) Circulation , vol.107 , pp. 2181-2184
    • Rajamannan, N.M.1    Subramaniam, M.2    Rickard, D.3
  • 37
    • 14044262240 scopus 로고    scopus 로고
    • Frequency by decades of unicuspid, bicuspid and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated regurgitation
    • Roberts W.C., Ko J.M. Frequency by decades of unicuspid, bicuspid and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated regurgitation. Circulation 2005, 111:920-925.
    • (2005) Circulation , vol.111 , pp. 920-925
    • Roberts, W.C.1    Ko, J.M.2
  • 38
    • 0022509636 scopus 로고
    • Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress
    • Thubrikar M.J., Aouad J., Nolan S.P. Patterns of calcific deposits in operatively excised stenotic or purely regurgitant aortic valves and their relation to mechanical stress. Am J Cardiol 1986, 58(3):304-308.
    • (1986) Am J Cardiol , vol.58 , Issue.3 , pp. 304-308
    • Thubrikar, M.J.1    Aouad, J.2    Nolan, S.P.3
  • 39
    • 0344897548 scopus 로고    scopus 로고
    • A coupled fluid-structure finite-element model of the aortic valve and root
    • Nicosia M.A., Cochran R.P., Reichenbach D.R., et al. A coupled fluid-structure finite-element model of the aortic valve and root. J Heart Valve Dis 2003, 12:781-789.
    • (2003) J Heart Valve Dis , vol.12 , pp. 781-789
    • Nicosia, M.A.1    Cochran, R.P.2    Reichenbach, D.R.3
  • 40
    • 2942733214 scopus 로고    scopus 로고
    • Role of endothelial dysfunction in atherosclerosis
    • Davignon J., Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004, 109(suppl lIII):III-27-III-32.
    • (2004) Circulation , vol.109 , Issue.SUPPL. III , pp. 27-32
    • Davignon, J.1    Ganz, P.2
  • 41
    • 44149084832 scopus 로고    scopus 로고
    • Macrophages: an elusive yet emerging therapeutic target of atherosclerosis
    • Tiwari R.L., Singh V., Barthwal M.K. Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. Med Res Rev 2008, 28(4):483-544.
    • (2008) Med Res Rev , vol.28 , Issue.4 , pp. 483-544
    • Tiwari, R.L.1    Singh, V.2    Barthwal, M.K.3
  • 42
    • 0036212190 scopus 로고    scopus 로고
    • Cause of degenerative disease of the trileaflet valve: review of the subject and presentation of a new theory
    • Robicsek F., Thubrikar M.J., Fokin A.A. Cause of degenerative disease of the trileaflet valve: review of the subject and presentation of a new theory. Ann Thorac Surg 2002, 73:1346-1354.
    • (2002) Ann Thorac Surg , vol.73 , pp. 1346-1354
    • Robicsek, F.1    Thubrikar, M.J.2    Fokin, A.A.3
  • 43
    • 53449096148 scopus 로고    scopus 로고
    • Age-related changes in the aortic valve affect leaflet stress distributions: implications for aortic valve degeneration
    • Singh R., Strom J.A., Ondrovic L., et al. Age-related changes in the aortic valve affect leaflet stress distributions: implications for aortic valve degeneration. J Heart Valve Dis 2008, 17(3):290-298.
    • (2008) J Heart Valve Dis , vol.17 , Issue.3 , pp. 290-298
    • Singh, R.1    Strom, J.A.2    Ondrovic, L.3
  • 44
    • 34547608816 scopus 로고    scopus 로고
    • Heart valve function: a biomechanical perspective
    • Sacks M.S., Yoganathan A.P. Heart valve function: a biomechanical perspective. Philos Trans R Soc Lond 2007, 362:1369-1391.
    • (2007) Philos Trans R Soc Lond , vol.362 , pp. 1369-1391
    • Sacks, M.S.1    Yoganathan, A.P.2
  • 45
    • 64049108554 scopus 로고    scopus 로고
    • Elevated cyclic stretch alters matrix remodelling in aortic valve cusps: implications for degenerative aortic valve disease
    • Balachandran K., Sucosky P., Jo H., et al. Elevated cyclic stretch alters matrix remodelling in aortic valve cusps: implications for degenerative aortic valve disease. Am J Physiol Heart Circ Physiol 2009, 296:H756-H764.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Balachandran, K.1    Sucosky, P.2    Jo, H.3
  • 46
    • 34548485827 scopus 로고    scopus 로고
    • Synergistic effects of cyclic tension and transforming growth factor -β1 on the aortic valve myofibroblast
    • Merryman W.D., Lukoff H.D., Long R.A., et al. Synergistic effects of cyclic tension and transforming growth factor -β1 on the aortic valve myofibroblast. Cardiovasc Pathol 2007, 16:268-276.
    • (2007) Cardiovasc Pathol , vol.16 , pp. 268-276
    • Merryman, W.D.1    Lukoff, H.D.2    Long, R.A.3
  • 47
    • 59449104824 scopus 로고    scopus 로고
    • Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGFβ1-dependent pathway
    • Sucosky P., Balachandran K., Elhammaly A., et al. Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGFβ1-dependent pathway. Arterioscler Thromb Vasc Biol 2009, 29:254-260.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 254-260
    • Sucosky, P.1    Balachandran, K.2    Elhammaly, A.3
  • 48
    • 63449120348 scopus 로고    scopus 로고
    • Endothelium-dependent regulation of the mechanical properties of aortic valve cusps
    • El-Hamamsy I., Balachandran K., Yacoub M.H., et al. Endothelium-dependent regulation of the mechanical properties of aortic valve cusps. J Am Coll Cardiol 2009, 53:1448-1455.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1448-1455
    • El-Hamamsy, I.1    Balachandran, K.2    Yacoub, M.H.3
  • 49
    • 3943101416 scopus 로고    scopus 로고
    • Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments
    • Butcher J.T., Penrod A.M., Garcia A.J., et al. Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. Arterioscler Thromb Vasc Biol 2004, 24:1429-1434.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1429-1434
    • Butcher, J.T.1    Penrod, A.M.2    Garcia, A.J.3
  • 50
    • 33644831129 scopus 로고    scopus 로고
    • Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences. Influence of shear stress
    • Butcher J.T., Tressel S., Johnson T., et al. Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences. Influence of shear stress. Arterioscler Thromb Vasc Biol 2006, 26:69-77.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 69-77
    • Butcher, J.T.1    Tressel, S.2    Johnson, T.3
  • 51
    • 36348976915 scopus 로고    scopus 로고
    • The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology
    • Liu A.C., Joag V.R., Gotlieb A.I. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. Am J Pathol 2007, 171:1407-1418.
    • (2007) Am J Pathol , vol.171 , pp. 1407-1418
    • Liu, A.C.1    Joag, V.R.2    Gotlieb, A.I.3
  • 52
    • 0034800126 scopus 로고    scopus 로고
    • Aortic valve endothelial cells undergo transforming-growth-factor-β-mediated and non-transforming-growth-factor-β-mediated transdifferentiation in vitro
    • Paranya G., Vineberg S., Dvorin E., et al. Aortic valve endothelial cells undergo transforming-growth-factor-β-mediated and non-transforming-growth-factor-β-mediated transdifferentiation in vitro. Am J Pathol 2001, 159:1335-1343.
    • (2001) Am J Pathol , vol.159 , pp. 1335-1343
    • Paranya, G.1    Vineberg, S.2    Dvorin, E.3
  • 53
    • 33749676226 scopus 로고    scopus 로고
    • Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming-growth-factor-β2
    • Paruchuri S., Yang J.H., Aikawa E., et al. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming-growth-factor-β2. Circ Res 2006, 99:861-869.
    • (2006) Circ Res , vol.99 , pp. 861-869
    • Paruchuri, S.1    Yang, J.H.2    Aikawa, E.3
  • 54
    • 64049113676 scopus 로고    scopus 로고
    • Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix
    • Yip C.Y.Y., Chen J.H., Zhao R., et al. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol 2009, 29:936.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 936
    • Yip, C.Y.Y.1    Chen, J.H.2    Zhao, R.3
  • 55
    • 59449090300 scopus 로고    scopus 로고
    • Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment
    • Monzack E.L., Gu X., Masters K.S. Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment. Arterioscler Thromb Vasc Biol 2009, 29:246-253.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 246-253
    • Monzack, E.L.1    Gu, X.2    Masters, K.S.3
  • 56
    • 14644435807 scopus 로고    scopus 로고
    • Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts. Implications for end-stage valvular heart disease
    • Wu B., Elmariah S., Kaplan F.S., et al. Paradoxical effects of statins on aortic valve myofibroblasts and osteoblasts. Implications for end-stage valvular heart disease. Arterioscler Thromb Vasc Biol 2005, 25:592-597.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 592-597
    • Wu, B.1    Elmariah, S.2    Kaplan, F.S.3
  • 57
    • 52149097331 scopus 로고    scopus 로고
    • Statins stimulate RGS-regulated ERK 1/2 activation in human calcified and stenotic aortic valves
    • Anger T., El-Chafchak J., Habib A., et al. Statins stimulate RGS-regulated ERK 1/2 activation in human calcified and stenotic aortic valves. Exp Mol Pathol 2008, 85:101-111.
    • (2008) Exp Mol Pathol , vol.85 , pp. 101-111
    • Anger, T.1    El-Chafchak, J.2    Habib, A.3
  • 58
    • 0033735304 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression in nonrheumatic aortic stenosis
    • Edep M.E., Shirani J., Wolf P., et al. Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol 2000, 9:281-286.
    • (2000) Cardiovasc Pathol , vol.9 , pp. 281-286
    • Edep, M.E.1    Shirani, J.2    Wolf, P.3
  • 59
    • 26444473660 scopus 로고    scopus 로고
    • Extracellular matrix remodeling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors
    • Fondard O., Detaint D., Iung B., et al. Extracellular matrix remodeling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J 2005, 26:1333-1341.
    • (2005) Eur Heart J , vol.26 , pp. 1333-1341
    • Fondard, O.1    Detaint, D.2    Iung, B.3
  • 60
    • 0041328399 scopus 로고    scopus 로고
    • Evidence for an altered balance between matrix-metalloproteinase-9 and its inhibitors in calcific aortic stenosis
    • Satta J., Oiva J., Salo T., et al. Evidence for an altered balance between matrix-metalloproteinase-9 and its inhibitors in calcific aortic stenosis. Ann Thorac Surg 2003, 76:681-688.
    • (2003) Ann Thorac Surg , vol.76 , pp. 681-688
    • Satta, J.1    Oiva, J.2    Salo, T.3
  • 61
    • 33746834187 scopus 로고    scopus 로고
    • Increased expression of elasolytic cathepsins S, K, V and their inhibitor cystatin C in stenotic aortic valves
    • Helske S., Syvaranta S., Lindstedt K.A., et al. Increased expression of elasolytic cathepsins S, K, V and their inhibitor cystatin C in stenotic aortic valves. Arterioscler Thromb Vasc Biol 2006, 26:1791-1798.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1791-1798
    • Helske, S.1    Syvaranta, S.2    Lindstedt, K.A.3
  • 62
    • 33745725939 scopus 로고    scopus 로고
    • Possible role for mast cell-derived cathepsin G in the adverse remodeling of aortic valves
    • Helske S., Syvaranta S., Kupari M., et al. Possible role for mast cell-derived cathepsin G in the adverse remodeling of aortic valves. Eur Heart J 2006, 27:1495-1504.
    • (2006) Eur Heart J , vol.27 , pp. 1495-1504
    • Helske, S.1    Syvaranta, S.2    Kupari, M.3
  • 63
    • 20144377112 scopus 로고    scopus 로고
    • Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis
    • Kaden J.J., Dempfle C.E., Grobholz R., et al. Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol 2005, 14:80-87.
    • (2005) Cardiovasc Pathol , vol.14 , pp. 80-87
    • Kaden, J.J.1    Dempfle, C.E.2    Grobholz, R.3
  • 64
    • 37549064021 scopus 로고    scopus 로고
    • Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis
    • Mohty D., Pibarot P., Després J.P., et al. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis. Arterioscler Thromb Vasc Biol 2008, 28:187-193.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 187-193
    • Mohty, D.1    Pibarot, P.2    Després, J.P.3
  • 65
    • 0030734713 scopus 로고    scopus 로고
    • Calcification of the aortic valve: its progression and grading
    • Warren B.A., Yong J.L. Calcification of the aortic valve: its progression and grading. Pathology 1997, 29(4):360-368.
    • (1997) Pathology , vol.29 , Issue.4 , pp. 360-368
    • Warren, B.A.1    Yong, J.L.2
  • 66
    • 0038160993 scopus 로고    scopus 로고
    • Oxidation: ROS in vascular signal transduction
    • Chen K., Thomas S.R., Keaney J.F., et al. Oxidation: ROS in vascular signal transduction. Free Radic Biol Med 2003, 35:117-132.
    • (2003) Free Radic Biol Med , vol.35 , pp. 117-132
    • Chen, K.1    Thomas, S.R.2    Keaney, J.F.3
  • 67
    • 49849089138 scopus 로고    scopus 로고
    • Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans
    • Miller J.D., Chu Y., Brooks R.M., et al. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008, 52:843-850.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 843-850
    • Miller, J.D.1    Chu, Y.2    Brooks, R.M.3
  • 68
    • 40749104256 scopus 로고    scopus 로고
    • Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification
    • Liberman M., Bassi E., Martinatti M.K., et al. Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vasc Biol 2008, 28:463-470.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 463-470
    • Liberman, M.1    Bassi, E.2    Martinatti, M.K.3
  • 69
    • 49849083168 scopus 로고    scopus 로고
    • Oxidation, inflammation, and aortic valve calcification
    • Towler D.A. Oxidation, inflammation, and aortic valve calcification. J Am Coll Cardiol 2008, 52:851-854.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 851-854
    • Towler, D.A.1
  • 70
    • 0023231642 scopus 로고
    • Aortic and mitral valve calcification in patients with end-stage renal disease
    • Maher E.R., Young G., Smyth-Walsh B., et al. Aortic and mitral valve calcification in patients with end-stage renal disease. Lancet 1987, 2(8564):875-877.
    • (1987) Lancet , vol.2 , Issue.8564 , pp. 875-877
    • Maher, E.R.1    Young, G.2    Smyth-Walsh, B.3
  • 71
    • 33746429527 scopus 로고    scopus 로고
    • Lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis
    • Ortlepp J.R., Pillich M., Schmitz F., et al. Lower serum calcium levels are associated with greater calcium hydroxyapatite deposition in native aortic valves of male patients with severe calcific aortic stenosis. J Heart Valve Dis 2006, 15(4):502-508.
    • (2006) J Heart Valve Dis , vol.15 , Issue.4 , pp. 502-508
    • Ortlepp, J.R.1    Pillich, M.2    Schmitz, F.3
  • 72
    • 40949148662 scopus 로고    scopus 로고
    • Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis
    • Linhartova K., Veselka J., Sterbakova G., et al. Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circ J 2008, 72:245-250.
    • (2008) Circ J , vol.72 , pp. 245-250
    • Linhartova, K.1    Veselka, J.2    Sterbakova, G.3
  • 73
    • 0028823030 scopus 로고
    • Osteopontin is expressed in human aortic valvular lesions
    • O'Brien K.D., Kuusisto J., Reichenbach D.D., et al. Osteopontin is expressed in human aortic valvular lesions. Circulation 1995, 92:2163-2168.
    • (1995) Circulation , vol.92 , pp. 2163-2168
    • O'Brien, K.D.1    Kuusisto, J.2    Reichenbach, D.D.3
  • 74
    • 0035916929 scopus 로고    scopus 로고
    • Bone formation and inflammation in cardiac valves
    • Mohler E.R., Gannon F., Reynolds C., et al. Bone formation and inflammation in cardiac valves. Circulation 2001, 103:1522-1528.
    • (2001) Circulation , vol.103 , pp. 1522-1528
    • Mohler, E.R.1    Gannon, F.2    Reynolds, C.3
  • 75
    • 33646466212 scopus 로고    scopus 로고
    • Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein-5 receptor-mediated bone formation
    • Caira F.C., Stock S.R., Gleason T.G., et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein-5 receptor-mediated bone formation. J Am Coll Cardiol 2006, 47:1707-1712.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1707-1712
    • Caira, F.C.1    Stock, S.R.2    Gleason, T.G.3
  • 76
    • 0347004546 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kB ligand and osteoprotegerin regulate aortic valve calcification
    • Kaden J.J., Bickelhaupt S., Grobholz R., et al. Receptor activator of nuclear factor kB ligand and osteoprotegerin regulate aortic valve calcification. J Mol Cell Cardiol 2004, 36:57-66.
    • (2004) J Mol Cell Cardiol , vol.36 , pp. 57-66
    • Kaden, J.J.1    Bickelhaupt, S.2    Grobholz, R.3
  • 77
    • 50549102361 scopus 로고    scopus 로고
    • Differential profile of the OPG/RANKL/RANK system in degenerative aortic native and bioprosthetic valves
    • Steinmetz M., Skowasch D., Wernert N., et al. Differential profile of the OPG/RANKL/RANK system in degenerative aortic native and bioprosthetic valves. J Heart Valve Dis 2008, 17(2):187-193.
    • (2008) J Heart Valve Dis , vol.17 , Issue.2 , pp. 187-193
    • Steinmetz, M.1    Skowasch, D.2    Wernert, N.3
  • 78
    • 0037005776 scopus 로고    scopus 로고
    • Progression of human aortic valve stenosis is associated with tenascin-C expression
    • Satta J., Melkko J., Pöllänen R., et al. Progression of human aortic valve stenosis is associated with tenascin-C expression. J Am Coll Cardiol 2002, 39:96-101.
    • (2002) J Am Coll Cardiol , vol.39 , pp. 96-101
    • Satta, J.1    Melkko, J.2    Pöllänen, R.3
  • 79
    • 38349118289 scopus 로고    scopus 로고
    • Expression of functional toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis
    • Meng X., Ao L., Song Y., et al. Expression of functional toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis. Am J Physiol Cell Physiol 2008, 294:C29-C35.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Meng, X.1    Ao, L.2    Song, Y.3
  • 80
    • 58949103283 scopus 로고    scopus 로고
    • Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of toll-like receptors 2 and 4 and enhanced expression of bone morphogenic protein 2
    • Yang X., Fullerton D.A., Su X., et al. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of toll-like receptors 2 and 4 and enhanced expression of bone morphogenic protein 2. J Am Coll Cardiol 2009, 53(6):491-500.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.6 , pp. 491-500
    • Yang, X.1    Fullerton, D.A.2    Su, X.3
  • 81
    • 7044237097 scopus 로고    scopus 로고
    • Induction of local angiotensin II producing systems in stenotic aortic valves
    • Helske S., Lindstedt K.A., Laine M., et al. Induction of local angiotensin II producing systems in stenotic aortic valves. J Am Coll Cardiol 2004, 44:1859-1866.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1859-1866
    • Helske, S.1    Lindstedt, K.A.2    Laine, M.3
  • 82
    • 0037159283 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma
    • O'Brien K.D., Shavelle D.M., Caulfield M.T., et al. Association of angiotensin-converting enzyme with low-density lipoprotein in aortic valvular lesions and in human plasma. Circulation 2002, 106:2224-2230.
    • (2002) Circulation , vol.106 , pp. 2224-2230
    • O'Brien, K.D.1    Shavelle, D.M.2    Caulfield, M.T.3
  • 84
    • 2342435070 scopus 로고    scopus 로고
    • Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein- 60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis
    • Mazzone A., Epistolato M.C., De Caterina R., et al. Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein- 60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis. J Am Coll Cardiol 2004, 43:1670-1676.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1670-1676
    • Mazzone, A.1    Epistolato, M.C.2    De Caterina, R.3
  • 85
    • 0034768262 scopus 로고    scopus 로고
    • The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis
    • Ortlepp J.R., Hoffmann R., Ohme F., et al. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart 2001, 85:635-638.
    • (2001) Heart , vol.85 , pp. 635-638
    • Ortlepp, J.R.1    Hoffmann, R.2    Ohme, F.3
  • 86
    • 24644467759 scopus 로고    scopus 로고
    • Mutations in Notch 1 cause aortic valve disease
    • Garg V., Muth A.N., Ransom J.F., et al. Mutations in Notch 1 cause aortic valve disease. Nature 2005, 437:270-274.
    • (2005) Nature , vol.437 , pp. 270-274
    • Garg, V.1    Muth, A.N.2    Ransom, J.F.3
  • 87
    • 0042343900 scopus 로고    scopus 로고
    • Oestrogen receptor alpha gene polymorphism is related to aortic valve sclerosis in postmenopausal women
    • Nordström P., Glader C.A., Dahlen G., et al. Oestrogen receptor alpha gene polymorphism is related to aortic valve sclerosis in postmenopausal women. J Intern Med 2003, 254:140-146.
    • (2003) J Intern Med , vol.254 , pp. 140-146
    • Nordström, P.1    Glader, C.A.2    Dahlen, G.3
  • 88
    • 0142053965 scopus 로고    scopus 로고
    • Association between apolipoprotein E alleles and calcific valvular heart disease
    • Novaro G.M., Sachar R., Pearce G.L., et al. Association between apolipoprotein E alleles and calcific valvular heart disease. Circulation 2003, 108:1804-1808.
    • (2003) Circulation , vol.108 , pp. 1804-1808
    • Novaro, G.M.1    Sachar, R.2    Pearce, G.L.3
  • 89
    • 0035184482 scopus 로고    scopus 로고
    • Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis
    • Avakian S.D., Annicchino-Bizzacchi J.M., Grinberg M., et al. Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis. Clin Genet 2001, 60:381-384.
    • (2001) Clin Genet , vol.60 , pp. 381-384
    • Avakian, S.D.1    Annicchino-Bizzacchi, J.M.2    Grinberg, M.3
  • 90
    • 33750091938 scopus 로고    scopus 로고
    • ApoE alleles are not associated with calcific aortic stenosis
    • Ortlepp J.R., Pillich M., Mevissen V., et al. ApoE alleles are not associated with calcific aortic stenosis. Heart 2006, 92:1463-1466.
    • (2006) Heart , vol.92 , pp. 1463-1466
    • Ortlepp, J.R.1    Pillich, M.2    Mevissen, V.3
  • 91
    • 11144353821 scopus 로고    scopus 로고
    • The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis
    • Ortlepp J.R., Schmitz F., Mevissen V., et al. The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis. Eur Heart J 2004, 25:514-522.
    • (2004) Eur Heart J , vol.25 , pp. 514-522
    • Ortlepp, J.R.1    Schmitz, F.2    Mevissen, V.3
  • 92
    • 33749549021 scopus 로고    scopus 로고
    • P21WAF1/CIP1 and 14-3-3 sigma gene expression in degenerated aortic valves: a link between cell cycle checkpoints and calcification
    • Golubnitschaja O., Yeghiazaryan K., Skowasch D., et al. P21WAF1/CIP1 and 14-3-3 sigma gene expression in degenerated aortic valves: a link between cell cycle checkpoints and calcification. Amino Acids 2006, 31:309-316.
    • (2006) Amino Acids , vol.31 , pp. 309-316
    • Golubnitschaja, O.1    Yeghiazaryan, K.2    Skowasch, D.3
  • 93
    • 17644401765 scopus 로고    scopus 로고
    • Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study
    • Kuusisto J., Räsänen K., Särkioja T., et al. Atherosclerosis-like lesions of the aortic valve are common in adults of all ages: a necropsy study. Heart 2005, 91:576-582.
    • (2005) Heart , vol.91 , pp. 576-582
    • Kuusisto, J.1    Räsänen, K.2    Särkioja, T.3
  • 94
    • 33644853792 scopus 로고    scopus 로고
    • Familial aggregation of calcific aortic valve stenosis in the western part of France
    • Probst V., Le Scouarnec S., Legendre A., et al. Familial aggregation of calcific aortic valve stenosis in the western part of France. Circulation 2006, 113:856-860.
    • (2006) Circulation , vol.113 , pp. 856-860
    • Probst, V.1    Le Scouarnec, S.2    Legendre, A.3
  • 95
    • 0025135439 scopus 로고
    • Progression of aortic stenosis in adults: new appraisal using Doppler echocardiography
    • Roger V.L., Tajik A.J., Bailey K.R., et al. Progression of aortic stenosis in adults: new appraisal using Doppler echocardiography. Am Heart J 1990, 119:331-338.
    • (1990) Am Heart J , vol.119 , pp. 331-338
    • Roger, V.L.1    Tajik, A.J.2    Bailey, K.R.3
  • 96
    • 1242272041 scopus 로고    scopus 로고
    • Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography
    • Rosenhek R., Klaar U., Schemper M., et al. Mild and moderate aortic stenosis. Natural history and risk stratification by echocardiography. Eur Heart J 2004, 25:199-205.
    • (2004) Eur Heart J , vol.25 , pp. 199-205
    • Rosenhek, R.1    Klaar, U.2    Schemper, M.3
  • 97
    • 33646926441 scopus 로고    scopus 로고
    • Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis
    • Briand M., Lemieux I., Dumesnil J.G., et al. Metabolic syndrome negatively influences disease progression and prognosis in aortic stenosis. J Am Coll Cardiol 2006, 47:2229-2236.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2229-2236
    • Briand, M.1    Lemieux, I.2    Dumesnil, J.G.3
  • 98
    • 50949107980 scopus 로고    scopus 로고
    • Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis
    • Antonini-Canterin F., Hirsu M., Popescu B.A., et al. Stage-related effect of statin treatment on the progression of aortic valve sclerosis and stenosis. Am J Cardiol 2008, 102:738-742.
    • (2008) Am J Cardiol , vol.102 , pp. 738-742
    • Antonini-Canterin, F.1    Hirsu, M.2    Popescu, B.A.3


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