Oestrogen receptor α gene polymorphism is related to aortic valve sclerosis in postmenopausal women

Journal of Internal Medicine

Volumn 254, Issue 2, 2003, Pages 140-146

  Nordström, Peter ^a,b   Glader, C A ^a   Dahlen G ^a   Birgander, L Slunga ^a   Lorentzon, R ^a   Waldenstrom A ^a   Lorentzon, M ^a  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b Sports Medicine Unit   (Sweden)

Author keywords

Aortic valvular sclerosis; Genetic polymorphisms; Women

Indexed keywords

CHOLESTEROL; ESTROGEN RECEPTOR ALPHA; LIPID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RESTRICTION ENDONUCLEASE; TRANSFORMING GROWTH FACTOR BETA1;

ADOLESCENCE; ADULT; AGED; AGING; AORTA VALVE DISEASE; AORTA VALVE SCLEROSIS; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; INFLAMMATION; LIPID BLOOD LEVEL; POSTMENOPAUSE; PRIORITY JOURNAL; RESTRICTION SITE; RISK FACTOR; SMOKING;

ADOLESCENT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; AORTIC VALVE STENOSIS; CASE-CONTROL STUDIES; ESTROGEN RECEPTOR ALPHA; FEMALE; GENOTYPE; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC; POSTMENOPAUSE; RECEPTORS, ESTROGEN; RESTRICTION MAPPING; RISK FACTORS;

EID: 0042343900     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2003.01179.x     Document Type: Article

References (35)

1. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies. Circulation 1994; 90: 844-53.
2. Boon A, Cheriex E, Lodder J, Kessels F. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart 1997; 78: 472-4.
3. Palta S, Pai AM, Gill KS, Pai RG. New insights into the progression of aortic stenosis: implications for secondary prevention. Circulation 2000; 101: 2497-502.
4. Rosenhek R, Binder T, Porenta G et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 2000; 343: 611-7.
5. Wahl P, Walden C, Knopp R et al. Effect of estrogen/progestin potency on lipid/lipoprotein cholesterol. N Engl J Med 1983; 308: 862-7.
6. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999; 340: 1801-11.
7. Border WA, Noble NA. Transforming growth factor β in tissue fibrosis. N Engl J Med 1994; 331: 1286-92.
8. Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-β1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 1998; 66: 1014-20.
9. Nabel EG, Shum L, Pompili VJ et al. Direct transfer of transforming growth factor β1 gene into arteries stimulates fibrocellular hyperplasia. Proc Natl Acad Sci USA 1993; 90: 10759-63.
10. Schulick AH, Taylor AJ, Zuo W et al. Overexpression of transforming growth factor β1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia. Proc Natl Acad Sci USA 1998; 95: 6983-8.
11. Cambien F, Ricard S, Troesch A et al. Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure. The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study. Hypertension 1996; 28: 881-7.
12. Lorentzon M, Lorentzon R, Bäckström T, Nordström P. Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: a cross-sectional and longitudinal study. J Clin Endocrinol Metab 1999; 84: 4597-601.
13. Matsubara Y, Murata M, Kawano K et al. Genotype distribution of estrogen receptor polymorphisms in men and postmenopausal women from healthy and coronary populations and its relation to serum lipid levels. Arterioscler Thromb Vasc Biol 1997; 17: 3006-12.
14. Kunnas TA, Laippala P, Penttila A, Lehtimaki T, Karhunen PJ. Association of polymorphism of human alpha estrogen receptor gene with coronary artery disease in men: a necropsy study. BMJ 2000; 321: 273-4.
15. Lehtimaki T, Laaksonen R, Mattila KM et al. Oestrogen receptor gene variation is a determinant of coronary reactivity in healthy young men. Eur J Clin Invest 2002; 32: 400-4.
16. Lehtimaki T, Kunnas TA, Mattila KM et al. Coronary artery wall atherosclerosis in relation to the estrogen receptor 1 gene polymorphism: an autopsy study. J Mol Med 2002; 80: 176-80.
17. Mooser V, Mancini FP, Bopp S et al. Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma. Hum Mol Genet 1995; 4: 173-81.
18. Napoli C, Glass CK, Witztum JL, Deutsch R, D'Armiento FP, Palinski W. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 1999; 354: 1234-41.
19. Mendelsohn ME, Karas RH. Estrogen and the blood vessel wall. Curr Opin Cardiol 1994; 9: 619-26.
20. Stewart BF, Siscovick D, Lind BK et al. Clinical factors associated with calcific aortic valve disease. J Am Coll Cardiol 1997; 29: 630-4.
21. Novaro GM, Tiong IY, Pearce GL, Lauer MS, Sprecher DL, Griffin BP. Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis. Circulation 2001: 104: 2205-9
22. Koh KK, Mincemoyer R, Bui MN et al. Effects of hormone-replacement therapy on fibrinolysis in postmenopausal women. N Engl J Med 1997; 336: 683-90.
23. Wellman GC, Bonev AD, Nelson MT, Brayden JE. Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca(2+)-dependent K+ channels. Circ Res 1996; 79: 1024-30.
24. Sack MN, Rader DJ, Cannon RO 3rd. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 1994; 343: 269-70.
25. Grady D, Wenger NK, Herrington D et al. Postmenopausal hormone therapy increases the risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study. Ann Intern Med 2000; 132: 689-96.
26. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999; 341: 738-46.
27. Homma H, Kurachi H, Nishio Y et al. Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter. J Biol Chem 2000; 275: 11404-11.
28. Nicholson AC, Hajjar DP. Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells. J Biol Chem 1992; 267: 25982-7.
29. Zhu Y, Bian Z, Lu P et al. Abnormal vascular function and hypertension in mice deficient on estrogen receptor beta. Science 2002; 295: 505-8.
30. Yaich L, Dupont WD, Cavener DR, Parl FF. Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 1992; 52: 77-83.
31. Han KO, Moon IG, Kang YS, Chung HY, Min HK, Han IK. Nonassociation of estrogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean postmenopausal women. J Clin Endocrinol Metab 1997; 82: 991-5.
32. Aronow B, Lattier D, Silbiger R et al. Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene. Genes Dev 1989: 3: 1384-400.
33. Gasch A, Hinz U, Renkawitz-Pohl R. Intron and upstream sequences regulate expression of the Drosophila beta 3-tubulin gene in the visceral and somatic musculature, respectively. Proc Natl Acad Sci USA 1989; 86: 3215-8.
34. Carstens RP, McKeehan WL, Garcia-Blanco MA. An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol 1998; 18: 2205-17.
35. Laurie CC, Stam LF. The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster. Genetics 1994; 138: 379-85.