Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease

Circulation

Volumn 108, Issue 15, 2003, Pages 1804-1808

  Novaro, Gian M ^a   Sachar, Ravish ^b   Pearce, Gregory L ^b   Sprecher, Dennis L ^b   Griffin, Brian P ^b  

^a DEPARTMENT OF COLORECTAL SURGERY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Apolipoproteins; Calcification; Genomics; Stenosis

Indexed keywords

APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; ATHEROSCLEROSIS; CALCIFICATION; CORONARY ARTERY DISEASE; FEMALE; GENETIC ANALYSIS; GENETIC RISK; GENOMICS; GENOTYPE; HISTOPATHOLOGY; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; TRANSTHORACIC ECHOCARDIOGRAPHY; VALVULAR HEART DISEASE;

AGED; ALLELES; AORTIC VALVE STENOSIS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; CALCINOSIS; COHORT STUDIES; COMORBIDITY; DIABETES MELLITUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERLIPIDEMIAS; HYPERTENSION; MALE; MIDDLE AGED; MITRAL VALVE STENOSIS; PREVALENCE; RISK FACTORS; SMOKING;

EID: 0142053965     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000097560.96431.3E     Document Type: Article

References (27)

1. Benjamin EJ, Plehn JF, D'Agostino RB, et al. Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med. 1992;327:374-379.
2. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol. 1997;29:630-634.
3. Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999;341:142-147.
4. Tolstrup K, Roldan CA, Qualls CR, et al. Aortic valve sclerosis, mitral annular calcium, and aortic root sclerosis as markers of atherosclerosis in men. Am J Cardiol. 2002;89:1030-1034.
5. Aronow WS, Schwartz KS, Koenigsberg M. Correlation of serum lipids, calcium, and phosphorus, diabetes mellitus and history of systemic hypertension with presence or absence of calcified or thickened aortic cusps or root in elderly patients. Am J Cardiol. 1987;59:998-999.
6. Boon A, Cheriex E, Lodder J, et al. Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve. Heart. 1997;78:472-474.
7. Otto CM, Kuusisto J, Reichenbach DD, et al. Characterization of the early lesion of 'degenerative' valvular aortic stenosis: histological and immunohistochemical studies. Circulation. 1994;90:844-853.
8. Roberts WC. The senile cardiac calcification syndrome. Am J Cardiol. 1986;58:572-574.
9. Ortlepp JR, Hoffmann R, Ohme F, et al. The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis. Heart. 2001;85:635-638.
10. Siest G, Pillot T, Regis-Bailly A, et al. Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem. 1995;41:1068-1086.
11. Smit M, de Knijff P, Rosseneu M, et al. Apolipoprotein E polymorphism in the Netherlands and its effect on plasma lipid and apolipoprotein levels. Hum Genet. 1988;80:287-292.
12. Braeckman L, De Bacquer D, Rosseneu M, et al. Apolipoprotein E polymorphism in middle-aged Belgian men: phenotype distribution and relation to serum lipids and lipoproteins. Atherosclerosis. 1996;120:67-73.
13. Wilson PW, Schaefer EJ, Larson MG, et al. Apolipoprotein E alleles and risk of coronary disease: a meta-analysis. Arterioscler Thromb Vasc Biol. 1996;16:1250-1255.
14. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1-21.
15. Miyata M, Smith JD. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet. 1996;14:55-61.
16. Skjaerpe T, Hegrenaes L, Hatle L. Noninvasive estimation of valve area in patients with aortic stenosis by Doppler ultrasound and twodimensional echocardiography. Circulation. 1985;72:810-818.
17. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res. 1990;31:545-548.
18. O'Brien KD, Reichenbach DD, Marcovina SM, et al. Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of 'degenerative' valvular aortic stenosis. Arterioscler Thromb Vasc Biol. 1996;16:523-532.
19. Lindroos M, Kupari M, Valvanne J, et al. Factors associated with calcific aortic valve degeneration in the elderly. Eur Heart J. 1994;15:865-870.
20. Mohler ER III, Gannon F, Reynolds C, et al. Bone formation and inflammation in cardiac valves. Circulation. 2001;103:1522-1528.
21. Rajamannan NM, Subramaniam M, Rickard D, et al. Human aortic valve calcification is associated with an osteoblast phenotype. Circulation. 2003;107:2181-2184.
22. Drolet MC, Arsenault M, Couet J, Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol. 2003;41:1211-1217.
23. Slooter AJ, Bots ML, Havekes LM, et al. Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam study. Stroke. 2001;32:1947-1952.
24. Hanon O, Girerd X, Luong V, et al. Association between the apolipoprotein E polymorphism and arterial wall thickness in asymptomatic adults. J Hypertens. 2000;18:431-436.
25. Avakian SD, Annicchino-Bizzacchi JM, Grinberg M, et al. Apolipoproteins AI, B, and E polymorphisms in severe aortic valve stenosis. Clin Genet. 2001;60:381-384.
26. Olsson M, Thyberg J, Nilsson J. Presence of oxidized low-density lipoprotein in nonrheumatic stenotic aortic valves. Arterioscler Thromb Vasc Biol. 1999;19:1218-1222.
27. Mazzone T. Apolipoprotein E secretion by macrophages: its potential physiological functions. Curr Opin Lipidol. 1996;7:303-307.