Genetic chemistry: production of non-native compounds in yeast

Current Opinion in Chemical Biology

Volumn 14, Issue 3, 2010, Pages 390-395

  Goldman, Stanley ^a  

^a Genetic Chemistry Inc (Evolva Holding Company)   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISINIC ACID; BISBENZYLISOQUINOLINE ALKALOID; COENZYME A; DOPAMINE; DRUG METABOLITE; FARNESYL DIPHOSPHATE; FLAVONOL; METHYLMALONYLCOENZYME A; MEVINOLIN; PACLITAXEL; POLYKETIDE SYNTHASE; PROPIONYL COENZYME A; SIMVASTATIN; UNCLASSIFIED DRUG;

ASPERGILLUS NIDULANS; BIOCATALYSIS; DOWN REGULATION; DRUG DETERMINATION; DRUG SYNTHESIS; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HYDROXYLATION; METABOLIC ENGINEERING; METABOLITE; NONHUMAN; REGULATORY MECHANISM; REVIEW; STEROL SYNTHESIS; UPREGULATION; YEAST; YEAST ARTIFICIAL CHROMOSOME;

CHROMOSOMES, ARTIFICIAL; DRUG DISCOVERY; GENETIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; MOLECULAR BIOLOGY; YEASTS;

DIEDERICH;

EID: 77952546318     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2010.03.036     Document Type: Review

References (31)

1. Li J., and Veredas J. Drug discovery and natural products: end of an era or an endless frontier. Science 325 (2009) 161-165
2. Bergmann S., Schumann J., Scherlach K., Lange C., Brakhage A.A., and Hertwech C. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol 3 4 (2007) 213-217. This work describes the use of genome sequence information to identify products from pathways that are rich in producing druggable molecules (polyketide and nonribosomal peptide synthesis hybrids) with medically important activities.
3. Russell R.B., and Aloy P. Targeting and tinkering with interaction networks. Nat Chem Biol 4 11 (2008) 666-673
4. Zamir E., and Bastiaens P.I. Reverse engineering intracellular biochemical networks. Nat Chem Biol 4 11 (2008) 643-647
5. Cordier H., Mendes F., Vasconcelos I., and Francois J. A metabolic and genomic study of engineered Saccharomyces cerevisiae strains for high glycerol production. Metab Eng 9 (2007) 364-378. The authors describe using genomic information to tailor the metabolome of a yeast strain to increase the production of glycerol.
6. Bumpus B.B., Evens B.S., Thomas P.M., Ntai I., and Kelleher N.I. A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 27 (2009) 951-956. This reviews techniques that allow for the identification of biochemical pathways that produce molecules of interest under very specific situations.
7. Ro D., Ouellet M., Paradise E., Burd H., Eng D., Paddon C., Newman J., and Keasling J. Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor artemisinic acid. BMC Biotechnol 8 (2008) 83-97. A very interesting analysis of the change in yeast transcriptome indicating increased levels of stress because of the expression of heterologous genes required to synthesize artemisinic acid.
8. Pscheidt B., and Glieder A. Yeast cell factories for fine chemical and API production. Microb Cell Factories 7 (2008) 25. Good recent review of the use of yeast whole cell systems for the production of active pharmaceutical ingredients and fine chemicals.
9. Huang B., Guo J., Yi B., Yu X., Sun L., and Chen W. Heterologous production of secondary metabolites as pharmaceuticals in Saccharomyces cerevisiae. Biotechnol Lett 30 (2008) 1121-1137. Excellent review of yeast produced molecules with therapeutic applications.
10. Steen E., Chan R., Prasad N., Myers S., Petzold C., Fedding A., Ouellet M., and Keasling J. Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Factories 7 (2008) 36-43
11. Van Vleet J.H., and Jeffries T.W. Yeast metabolic engineering for hemicellulosic ethanol production. Curr Opin Biotechnol 20 3 (2009) 300-306
12. Hawkins K.M., and Smolke C.D. Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. Nat Chem Biol 4 9 (2008) 564-573. Heterologous expression of genes that are fundamental to the production of a large class of alkaloid molecules greatly increasing the diversity of heterologously produced small compounds.
13. Hansen E., Moller B., Kock G., Bunner C., Kristensen C., Jensen O., Okkels F., Olsen C., Motawia M., and Hansen J. De novo synthesis of vanillin in fission yeast (Schizosaccharomyces pombe) and baker's yeast (Saccharomyces cerevisiae). Appl Environ Microbiol 75 (2009) 2765-2774
14. Engels B., Dahm P., and Jennewein S. Metabolic engineering of taxadiene biosynthesis in yeast as the first step towards Taxol (paxlitaxel) production. Metab Eng 10 (2008) 201-206
15. Ro D., Paradise E., Ouellet M., Fisher K., Newman K., Ndungu J., Ho K., Eachus R., Ham T., Kirby J., et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440 (2006) 940-943. Excellent demonstration of the use of whole cell biocatalysis, metabolic engineering, and heterologous gene expression to produce a drug intermediate in sufficient quantity to include the process in a pharmaceutical product.
16. Naesby M., Nielson S., Nielson C., Green T., Tange T., Simon E., Knechtle P., Hansson A., Schwab M., Titiz O., et al. Yeast artificial chromosome employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae. Microb Cell Factories 8 (2009) 45-56
17. Newman D., and Cragg G. Natural products as sources of new drugs over the last 25 years. J Nat Prod 70 (2007) 461-477. Excellent review of classes of drugs and their sources.
18. Lam K.S. New aspects of natural products in drug discovery. Trends Microbiol 15 6 (2007) 279-289
19. Harvey A. Natural products as a screening resource. Curr Opin Chem Biol 11 (2007) 480-484
20. Heijden R., Jacobs D., Snoeijer W., Hallard D., and Verpoorte R. The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem 11 (2004) 607-628
21. Zhou H., Xie X., and Tang Y. Engineering natural products using combinatorial biosynthesis and biocatalysis. Curr Opin Biotechnol 19 (2008) 590-596. This paper describes the use of synthetic chemistry tools to modify natural compounds and expand the diversity of available compounds.
22. Ortholand J.Y., and Ganesan A. Natural products and combinatorial chemistry: back to the future. Curr Opin Chem Biol 8 (2004) 271-280
23. Boldi A.M. Libraries from natural product-like scaffolds. Curr Opin Chem Biol 8 (2004) 281-286
24. Xie X., Watanbe K., Wojcicki W., Wang C., and Tang T. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol 13 (2006) 1161-1169
25. Ma S., Li J., Choi J., Zhou H., Lee K., Moorthie V., Xie X., Kealey J., Da Silva N., Vederas J., et al. Complete reconstitution of a highly iterative polyketide synthase. Science 326 (2009) 589-592. Metabolic engineering and heterologous gene expression effort to understand the synthetic components of the megasynthase that makes the precursor to lovastatin in yeast.
26. Nevoigt E. Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol Mol Biol Rev 72 3 (2008) 379-412
27. Fowler Z.F., and Koffas M.A. Biosynthesis and biotechnological production of flavanones: current state and perspectives. Appl Microbiol Biotechnol 83 (2009) 799-808
28. Baltz R.H. Daptomycin: mechanisms of action and resistance, and biosynthetic engineering. Curr Opin Chem Biol 13 (2009) 144-151
29. Hamberger B., Hall D., Yuen M., Oddy C., Hamberger B., Keeling C.I., Rotland C., Fitland K., and Bohlmann J. Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into conifer genome. BMC Plant Biol 9 (2009) 106-119
30. Herrero O., Ramon D., and Orejas M. Engineering the Saccharomyces cerevisiae isoprenoid pathway for de novo production of aromatic monoterpenes in wine. Metab Eng 10 (2008) 78-86
31. Mutka S., Bondi S., Carney J., DaSilva N., and Kealy J. Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae. FEMS Yeast Res 6 (2006) 40-47