Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of phosphatidylinositol-3-kinase/Akt and modulation of extracellular signal-regulated kinase 1/2 activation in PC12 cells and neurons

Neuroscience

Volumn 167, Issue 4, 2010, Pages 1115-1124

  Liu, L ^a   Cao, J X ^a   Sun, B ^b   Li, H L ^b,c   Xia, Y ^a   Wu, Z ^a   Tang, C L ^a   Hu, J ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment   (China)

Author keywords

Antioxidant action; Chronic ethanol; Mesenchymal stem cells conditioned medium; PC12 cells; Primary cortical neurons; Signal transduction pathways

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ALCOHOL; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; LONG TERM EXPOSURE; MESENCHYMAL STEM CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENZYME ACTIVATION; ETHANOL; MESENCHYMAL STEM CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77952546054     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.01.057     Document Type: Article

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