Erythropoietin prevents PC12 cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis via the Akt/GSK-3β/caspase-3 mediated signaling pathway

Apoptosis

Volumn 12, Issue 8, 2007, Pages 1365-1375

  Wu, Yan ^a   Shang, You ^a   Sun, Shenggang ^a   Liang, Huifang ^b   Liu, Rengang ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Akt; Caspase 3; EPO; GSK 3 ; MPP+; PC12 cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; THERAPY EFFECT; TREATMENT RESPONSE;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN; GLYCOGEN SYNTHASE KINASE 3; NEURONS; NEUROPROTECTIVE AGENTS; ONCOGENE PROTEIN V-AKT; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 34250866187     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0065-9     Document Type: Article

References (62)

1. Marti HH, Wenger RH, Rivas LA et al (1996) Erythropoietin gene expression in human monkey and murine brain. Eur J Neurosci 8:666-676
2. Morishita E, Masuda S, Nagao M, Tasuda Y, Sasaki R (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate induced neuronal death. Neuroscience 76:105-116
3. Chong ZZ, Lin SH, Kang JQ, Maiese K (2003) Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res 71:659-669
4. Villa P, Bigini P, Mennini T et al (2003) Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis. J Exp Med 198:971-975
5. Csete M, Rodriguez L, Wilcox M, Chadalavada S (2004) Erythropoietin receptor is expressed on adult rat dopaminergic neurons and erythropoietin is neurotrophic in cultured dopaminergic neuroblasts. Neurosci Lett 359:124-126
6. Genc S, Kuralay F, Genc K et al (2001) Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production. Neurosci Lett 298:139-141
7. Signore AP, Weng Z, Hastings T et al (2006) Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death. J Neurochem 96:428-443
8. Heikkila RE, Hess A, Duvoisin RC (1984) Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine in mice. Science 224:1451-1453
9. Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980
10. +)-induced cell death in PC12 cells. Neurochem Int 25:419-424
11. Rebois RV, Reynolds EE, Toll L, Howard BD (1980) Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line. Biochemistry 19:1240-1248
12. Hatanaka H (1981) Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line. Brain Res 222:225-233
13. Tuler SM, Hazen AA, Bowen JM (1989) Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. Fund Appl Toxicol 13:484-492
14. Mutoh T, Tokuda A, Marini AM, Fujiki N (1994) 1-Methyl-4-phenylpyridinum kills differentiated PC12 cells with a concomitant change in protein phosphorylation. Brain Res 661:51-55
15. + on the state of tubulin polymerisation in NGF-differentiated PC12 cells. J Neurosci Res 56:28-35
16. +-induced cytotoxicity in neuronal PC12 cells. J Neurosci Res 70:90-96
17. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA (2002) Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 22:10690-10698
18. Viswanath V, Wu Y, Boonplueang R et al (2001) Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease. J Neurosci 21:9519-9528
19. Yamamoto T, Yuyama K, Nakamura K, Kato T, Yamamoto H (2000) Kinetic characterization of the nitric oxide toxicity for PC12 cells: effect of half-life time of NO release. Eur J Pharmacol 397:25-33
20. Ohgoh M, Kimura M, Ogura H, Katayama K, Nishizawa Y (1998) Apoptotic cell death of cultured cerebral cortical neurons induced by withdrawal of astroglial trophic support. Exp Neurol 149:51-63
21. Hartley A, Stone JM, Heron C, Cooper JM, Schapira AH (1994) Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J Neurochem 63:1987-1990
22. Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22:8983-8998
23. Amaravadi R, Thompson CB (2005) The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 115:2618-2624
24. Li M, Wang X, Meintzer MK, Laessig T, Birnbaum MJ, Heidereich KA (2000) Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol 20:9356-9363
25. Kaytor MD, Orr HT (2002) The GSK3 beta signaling cascade and neurodegenerative disease. Curr Opin Neurobiol 12:275-278
26. Alvarez G, Munoz-Montano JR, Satrustegui J, Avila J, Bogonez E, Diaz-Nido J (1999) Lithium protects cultured neurons against betaamyloid-induced neurodegeneration. FEBS Lett 453:260-264
27. Liou AK, Clark RS, Henshall DC, Yin XM, Chen J (2003) To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 69:103-142
28. Han BS, Hong HS, Choi WS, Markelonis GJ, Oh TH, Oh YJ (2003) Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment. J Neurosci 23:5069-5078
29. Seaton TA, Cooper JM, Schapira AH (1997) Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors. Brain Res 777:110-118
30. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316
31. Blum D, Torch S, Lambeng N et al (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65:135-172
32. Di Monte D, Sandy MS, Ekstrom G, Smith MT (1986) Comparative studies on the mechanisms of paraquat and 1-methyl-4-phenylpyridine (MPP+) cytotoxicity. Biochem Biophys Res Commun 137:303-309
33. Cassarino DS, Parks JK, Parker WD Jr, Bennett JP Jr (1999) The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochem Biophys Acta 1453:49-62
34. Siren AL, Fratelli M, Brines M et al (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci USA 98:4044-4049
35. Chong ZZ, Lin SH, Kang JQ, Maiese K (2003) Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res 71:659-669
36. Sakanaka M, Wen TC, Matsuda S et al (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 95:4635-4640
37. Weishaupt JH, Rohde G, Polking E, Siren AL, Ehrenreich H, Bahr M (2004) Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells. Invest Ophthalmol Vis Sci 45(5):1514-1522
38. Ehrenreich H, Hasselblatt M, Dembowski C et al (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol Med 8:495-505
39. Masuda S, Nagao M, Takahata K et al (1993) Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells. J Biol Chem 268:11208-11216
40. Hong F, Kwon SJ, Jhun BS et al (2001) Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Life Sci 68:1095-1105
41. Di Segni A, Farin K, Pinkas Kramarski R (2006) ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling. J Mol Neurosci 29:257-268
42. Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF (1997) Interleukin-3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci USA 94:11345-11350
43. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789
44. Hajduch E, Alessi DR, Hemmings BA, Hundal HS (1998) Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes 47:1006-1013
45. Shaw M, Cohen P, Alessi DR (1997) Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKBinduced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 416:307-311
46. Bhat RV, Shanley J, Correll MP et al (2000) Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3-beta in cellular and animal models of neuronal degeneration. Proc Natl Acad Sci 97:11074-11079
47. Pap M, Cooper GM (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J Biol Chem 273:19929-19932
48. Somervaille TC, Linch DC, Khwaja A (2001) Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax. Blood 98:1374-1381
49. Bijur GN, Jope RS (2001) Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta. J Biol Chem 276:37436-37442
50. King TD, Bijur GN, Jope RS (2001) Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res 919:106-114
51. Yamaguchi H, Wang HG (2001) The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 20:7779-7786
52. +-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. Neurosci Res 53:183-188
53. Lee CS, Han ES, Kim YK (2006) Piperine inhibition of 1-methyl-4- phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells. Eur J Pharmacol 537:37-44
54. Guan S, Jiang B, Bao YM, An LJ (2006) Protocatechuic acid suppresses MPP (+)-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food Chem Toxicol 44:1659-1666
55. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of Erk and Jnk-P38 Map kinases on apoptosis. Science 270:1326-1331
56. Virdee K, Tolkovsky AM (1996) Inhibition of p42 and p44 mitogenactivated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neurons. J Neurochem 67:1801-1805
57. Yan CYI, Greene LA (1998) Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci 18:4042-4049
58. Ruscher K, Freyer D, Karsch M et al (2002) Erythropoietin is a paracrine mediator of is ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci 22:10291-10301
59. Hanlon PR, Fu P, Wright GL, Steenbergen C, Arcasoy MO, Murphy E (2005) Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling. FASEB J 19:1323-1325
60. Siren AL, Fratelli M, Brines M et al (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc Natl Acad Sci 98:4044-4049
61. Lee SM, Nguyen TH, Park MH et al (2004) EPO receptor-mediated ERK kinase and NF-kappaB activation in erythropoietin-promoted differentiation of astrocytes. Biochem Biophys Res Commun 320:1087-1095
62. Kilic E, Kilic U, Soliz J, Bassetti CL, Gassmann M, Hermann DM (2005) Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways. FASEB J 19:2026-2028