Acyl-coenzyme A synthetases in metabolic control

Current Opinion in Lipidology

Volumn 21, Issue 3, 2010, Pages 212-217

  Ellis, Jessica M ^a   Frahm, Jennifer L ^a   Li, Lei O ^a   Coleman, Rosalind A ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

oxidation; Acyl CoA synthetase; AMP activated kinase; Fatty acid; Fatty acid transport protein; Glycerolipid synthesis

Indexed keywords

LONG CHAIN FATTY ACID COENZYME A LIGASE; TRIACYLGLYCEROL;

CELLULAR DISTRIBUTION; ENZYME REGULATION; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; LIPID METABOLISM; LIPOGENESIS; METABOLIC REGULATION; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOLOGICAL TRANSPORT; COENZYME A LIGASES; DISEASE; FATTY ACIDS; HUMANS;

MAMMALIA;

EID: 77952409179     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32833884bb     Document Type: Review

References (52)

1. Watkins PA, Maiguel D, Jia Z, Pevsner J. Evidence for 26 distinct acylcoenzyme A synthetase genes in the human genome. J Lipid Res 2007; 48:2736-2750.
2. Watkins PA. Very-long-chain acyl-CoA synthetases. J Biol Chem 2008; 283:1773-1777.
3. Gulick AM. Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of nonribosomal peptide synthetases, and firefly luciferase. ACS Chem Biol 2009; 4:811-827.
4. Oba Y, Iida K, Inouye S. Functional conversion of fatty acyl-CoA synthetase to firefly luciferase by site-directed mutagenesis: a key substitution responsible for luminescence activity. FEBS Lett 2009; 583:2004-2008.
5. Kochan G, Pilka ES, von Delft F, et al. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J Mol Biol 2009; 388:997-1008.
6. Doege H, Stahl A. Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda) 2006; 21:259-268.
7. Mashek DG, Coleman RA. Cellular fatty acid uptake: the contribution of metabolism. Curr Opin Lipidol 2006; 17:274-278.
8. Schaffer JE, Lodish HF. Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 1994; 79:427-436.
9. Gargiulo CE, Stuhlsatz-Krouper SM, Schaffer JE. Localization of adipocyte long-chain fatty acyl-CA synthetase at the plasma membrane. J Lipid Res 1999; 40:881-892.
10. Milger K, Herrmann T, Becker C, et al. Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4. J Cell Sci 2006; 119:4678-4688.
11. Li LO, Mashek DG, An J, et al. Overexpression of rat long chain acyl-CoA synthetase 1 alters fatty acid metabolism in rat primary hepatocytes. J Biol Chem 2006; 281:37246-37255.
12. Li LO, Ellis JM, Paich HA, et al. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem 2009; 284:27816-27826.
13. Lobo S, Wiczer BM, Bernlohr DA. Functional analysis of long-chain acyl-CoA synthetase 1 in 3T3-L1 adipocytes. J Biol Chem 2009; 284:18347-18356.
14. Bu SY, Mashek MT, Mashek DG. Suppression of long chain acyl-CoA synthetase 3 decreases hepatic de novo fatty acid synthesis through decreased transcriptional activity. J Biol Chem 2009; 284:30474-30483.
15. Yao H, Ye J. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. J Biol Chem 2008; 283:849-854.
16. Mashek DG, McKenzie MA, Van Horn CG, Coleman RA. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. J Biol Chem 2006; 281:945-950.
17. Zhou Y, Abidi P, Kim A, et al. Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin M reduces hypertriglyceridemia through enhanced beta-oxidation. Arterioscler Thromb Vasc Biol 2007; 27:2198-2205.
18. Souza SC, Muliro KV, Liscum L, et al. Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system. J Biol Chem 2002; 277:8267-8272.
19. Forner F, KumarC, LuberCA, et al. Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions. Cell Metab 2009; 10:324-335.
20. Wiczer BM, Bernlohr DA. A novel role for fatty acid transport protein 1 in the regulation of tricarboxylic acid cycle and mitochondrial function in 3T3-L1 adipocytes. J Lipid Res 2009; 50:2502-2513.
21. Sebastian D, Guitart M, Garcia-Martinez C, et al. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. J Lipid Res 2009; 50:1789-1799.
22. Richards MR, Harp JD,Ory DS,Schaffer JE. Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes. J Lipid Res 2006; 47:665-672.
23. Soupene E, Kuypers FA. Mammalian long-chain acyl-CoA synthetases. Exp Biol Med (Maywood) 2008; 233:507-521.
24. Jia Z, Pei Z, Maiguel D, et al. The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers? J Mol Neurosci 2007; 33:25-31. (Pubitemid 47574954)
25. Starai VJ, Celic I, Cole RN, et al. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science 2002; 298:2390-2392.
26. North BJ, Sinclair DA. Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci 2007; 32:1-4.
27. Schwer B, Eckersdorff M, Li Y, et al. Calorie restriction alters mitochondrial protein acetylation. Aging Cell 2009; 8:604-606.
28. Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 2002; 13:155-164.
29. Tomoda H, Igarashi K, Cyong JC, Omura S. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. J Biol Chem 1991; 266:4214-4219.
30. Mashima T, Sato S, Okabe S, et al. Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci 2009; 100:1556-1562.
31. MashimaT, Sato S,SugimotoY, et al. Promotion of glioma cell survival by acylCoA synthetase 5 under extracellular acidosis conditions. Oncogene 2009; 28:9-19.
32. Pei Z, Sun P, Huang P, et al. Acyl-CoA synthetase VL3 knockdown inhibits human glioma cell proliferation and tumorigenicity. Cancer Res 2009; 15:9175-9182.
33. Teng AC, Adamo K, Tesson F, Stewart AF. Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss. FASEB J 2009; 23:1705-1709.
34. Perera F, Tang WY, Herbstman J, et al. Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One 2009; 4:e4488.
35. Meloni I, Parri V, De Filippis R, et al. The XLMR gene ACSL4 plays a role in dendritic spine architecture. Neuroscience 2009; 159:657-669.
36. Zeman M, Vecka M, Jachymova M, et al. Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression. Tohoku J Exp Med 2009; 217:287-293.
37. Kotronen A, Yki-Jarvinen H, Aminoff A, et al. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. Eur J Endocrinol 2009; 160:593-602.
38. Klar J, Schweiger M, Zimmerman R, et al. Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. Am J Hum Genet 2009; 85:248-253.
39. Herrmann T, van der Hoeven F, Grone HJ, et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol 2003; 161:1105-1115.
40. Gonzalez AA, Kumar R, Mulligan JD, et al. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity. Am J Physiol Endocrinol Metab 2004; 287: E1032-E1037.
41. Mulligan JD, Gonzalez AA, Stewart AM, et al. Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse. J Physiol 2007; 580:677-684.
42. Gauthier MS, Miyoshi H, Souza SC, et al. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem 2008; 283:16514-16524.
43. Wiczer BM, Lobo S, Machen GL, et al. FATP1 mediates fatty acid-induced activation of AMPK in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2009; 387:234-238.
44. Clark H, Carling D, Saggerson D. Covalent activation of heart AMP-activated protein kinase in response to physiological concentrations of long-chain fatty acids. EurJ Biochem 2004; 271:2215-2224.
45. Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev 2009; 89:1025-1078.
46. Fediuc S, Gaidhu MP, Ceddia RB. Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells. J Lipid Res 2006; 47:412-420.
47. Maeda K, Cao H, Kono K, et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab 2005; 1:107-119.
48. Za'tara G, Bar-Tana J, Kalderon B, et al. AMPK activation by long chain fatty acyl analogs. Biochem Pharmacol 2008; 76:1263-1275.
49. Watt MJ, Steinberg GR, Chen ZP, et al. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol 2006; 574:139-147.
50. Taylor EB, Ellingson WJ, Lamb JD, et al. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. Am J Physiol Endocrinol Metab 2005; 288:E1055-E1061.
51. Djouder N, Tuerk RD, Suter M, et al. PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis. EMBO J 2009; 29:469-481.
52. Færgeman NJ, Knudsen J. Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling. Biochem J 1997; 323:1-12.