Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice

Chemical Research in Toxicology

Volumn 23, Issue 5, 2010, Pages 967-976

  Kale, Vijay M ^a   Hsiao, Chin Ju J ^a   Boelsterli, Urs A ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; NIMESULIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BINDING; ELECTROPHILIC STRESS; HISTOPATHOLOGY; LIVER CELL; LIVER MICROSOME; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOCHROME P-450 ENZYME SYSTEM; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONAMIDES;

MUS;

EID: 77952360237     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx100063z     Document Type: Article

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