Is 1-Aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?

Drug Metabolism and Disposition

Volumn 37, Issue 1, 2009, Pages 10-13

  Linder, Collette D ^a   Renaud, Nicole A ^a   Hutzler, J Matthew ^a,b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; ALPHA NAPHTHOFLAVONE; AMFEBUTAMONE; CARBON MONOXIDE; CHLORZOXAZONE; CLOTRIMAZOLE; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; ENZYME INHIBITOR; FURAFYLLINE; MEPHENYTOIN; MIDAZOLAM; MONTELUKAST; NORMEPHENYTOIN; PACLITAXEL; PHENACETIN; QUINIDINE; SULFAPHENAZOLE; TRANYLCYPROMINE; UNINDEXED DRUG;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; PHENOTYPE; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; SPECTROPHOTOMETRY, ULTRAVIOLET; TANDEM MASS SPECTROMETRY; TRIAZOLES;

EID: 58149460394     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.024075     Document Type: Article

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