Angiotensin II AT1 receptor constitutive activation: From molecular mechanisms to pathophysiology

Molecular and Cellular Endocrinology

Volumn 302, Issue 2, 2009, Pages 176-184

  Petrel, Christophe ^a   Clauser, Eric ^a  

^a INSTITUT COCHIN   (France)

Author keywords

Angiotensin; Constitutive activation; G protein coupled receptor; Hypertension; Signaling

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ASPARAGINE; CANDESARTAN; GUANINE NUCLEOTIDE BINDING PROTEIN; IRBESARTAN; LOSARTAN; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; PEPTIDE DERIVATIVE; PHOSPHOLIPASE C; SARTAN DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

ADENOVIRUS; CARDIOVASCULAR DISEASE; CRYSTAL STRUCTURE; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; REVIEW; SIGNAL TRANSDUCTION; VASOCONSTRICTION; ANIMAL; ARTICLE; GENETICS; HUMAN; METABOLISM; MUTATION;

ANIMALS; CARDIOVASCULAR DISEASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; MUTATION; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION;

EID: 62949111054     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.10.049     Document Type: Review

References (47)

1. Allen A.M., Dosanjh J.K., Erac M., Dassanayake S., Hannan R.D., and Thomas W.G. Expression of constitutively active angiotensin receptors in the rostral ventrolateral medulla increases blood pressure. Hypertension 47 (2006) 1054-1061
2. 1 receptor for angiotensin II maintains a high affinity conformation despite being uncoupled from its cognate G protein Gq/11alpha. Endocrinology 144 (2003) 5277-5284
3. Auger-Messier M., Arguin G., Chaloux B., Leduc R., Escher E., and Guillemette G. Down-regulation of inositol 1,4,5-trisphosphate receptor in cells stably expressing the constitutively active angiotensin II N111G-AT(1) receptor. Mol. Endocrinol. 18 (2004) 2967-2980
4. 1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII. J. Biol. Chem. 272 (1997) 4245-4251
5. 1A receptor "gain-of-function" mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin II. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E840-E848
6. Billet S., Bardin S., Verp S., Baudrie V., Michaud A., Conchon S., Muffat-Joly M., Escoubet B., Souil E., Hamard G., Bernstein K.E., Gasc J.M., Elghozi J.L., Corvol P., and Clauser E. Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J. Clin. Invest. 117 (2007) 1914-1925
7. Boucard A.A., Roy M., Beaulieu M.E., Lavigne P., Escher E., Guillemette G., and Leduc R. Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket. J. Biol. Chem. 278 (2003) 36628-36636
8. 1b receptors: pharmacological and functional requirements. FEBS Lett. 349 (1994) 365-370
9. 1A angiotensin II receptor plays a key role in G protein coupling specificity and transduction of the mitogenic signal. J. Biol. Chem. 272 (1997) 25566-25572
10. 1A receptor transduces an amplified ANG II signal. Am. J. Physiol. 274 (1998) E336-E345
11. Correa S.A., Pignatari G.C., Ferro E.S., Pacheco N.A., Costa-Neto C.M., Pesquero J.B., Oliveira L., Paiva A.C., and Shimuta S.I. Role of the Cys18-Cys274 disulfide bond and of the third extracellular loop in the constitutive activation and internalization of angiotensin II type 1 receptor. Regul. Pept. 134 (2006) 132-140
12. Cotecchia S., Exum S., Caron M.G., and Lefkowitz R.J. Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 2896-2900
13. Dale L.B., Seachrist J.L., Babwah A.V., and Ferguson S.S. Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases. J. Biol. Chem. 279 (2004) 13110-13118
14. 1) receptor gene are not present in aldosterone-producing adenoma. J. Clin. Endocrinol. Metab. 82 (1997) 611-615
15. de Gasparo M., Catt K.J., Inagami T., Wright J.W., and Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 52 (2000) 415-472
16. 1 receptor: influence of the size of the agonist switch binding residue Asn(111). Biochemistry 37 (1998) 15791-15798
17. 1 receptor induce promiscuous agonist specificity for angiotensin II fragments: a pseudo-constitutive activity. Mol. Pharmacol. 68 (2005) 347-355
18. 1 angiotensin receptor activation and signaling. Endocrinology 144 (2003) 2220-2228
19. Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr. Rev. 21 (2000) 90-113
20. 1A angiotensin II receptor induces its constitutive activation. J. Biol. Chem. 272 (1997) 1822-1826
21. 1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II. Mol. Endocrinol. 20 (2006) 953-970
22. Hunyady L., Baukal A.J., Balla T., and Catt K.J. Independence of type 1 angiotensin II receptor endocytosis from G protein coupling and signal transduction. J. Biol. Chem. 269 (1994) 24798-24804
23. Hunyady L., Vauquelin G., and Vanderheyden P. Agonist induction and conformational selection during activation of a G-protein-coupled receptor. Trends Pharmacol. Sci. 24 (2003) 81-86
24. Joseph M.P., Maigret B., Bonnafous J.C., Marie J., and Scheraga H.A. A computer modeling postulated mechanism for angiotensin II receptor activation. J. Protein Chem. 14 (1995) 381-398
25. 1 receptor activation. J. Biol. Chem. 277 (2002) 23107-23110
26. 1 receptors. Biochem. Pharmacol. 65 (2003) 1329-1338
27. 1A angiotensin II receptor is essential for its coupling to phospholipase C. J. Biol. Chem. 269 (1994) 20815-20818
28. Martin S.S., Boucard A.A., Clement M., Escher E., Leduc R., and Guillemette G. Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis. J. Biol. Chem. 279 (2004) 51415-51423
29. Martin S.S., Holleran B.J., Escher E., Guillemette G., and Leduc R. Activation of the angiotensin II type 1 receptor leads to movement of the sixth transmembrane domain: analysis by the substituted cysteine accessibility method. Mol. Pharmacol. 72 (2007) 182-190
30. Miserey-Lenkei S., Lenkei Z., Parnot C., Corvol P., and Clauser E. A functional enhanced green fluorescent protein (EGFP)-tagged angiotensin II at(1a) receptor recruits the endogenous Galphaq/11 protein to the membrane and induces its specific internalization independently of receptor-g protein coupling in HEK-293 cells. Mol. Endocrinol. 15 (2001) 294-307
31. Miserey-Lenkei S., Parnot C., Bardin S., Corvol P., and Clauser E. Constitutive internalization of constitutively active angiotensin II AT(1A) receptor mutants is blocked by inverse agonists. J. Biol. Chem. 277 (2002) 5891-5901
32. Miura S., and Karnik S.S. Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2. J. Biol. Chem. 277 (2002) 24299-24305
33. Miura S., Zhang J., Boros J., and Karnik S.S. TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor. J. Biol. Chem. 278 (2003) 3720-3725
34. Miura S., Kiya Y., Kanazawa T., Imaizumi S., Fujino M., Matsuo Y., Karnik S.S., and Saku K. Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state. Mol. Endocrinol. 22 (2008) 139-146
35. 1 receptor. J. Pept. Res. 66 (2005) 236-248
36. 1 angiotensin receptor is generated by angiotensin II induction. Biochemistry 35 (1996) 16435-16442
37. 1 receptor structure-activity correlations in the light of rhodopsin structure. Physiol. Rev. 87 (2007) 565-592
38. Palczewski K., Kumasaka T., Hori T., Behnke C.A., Motoshima H., Fox B.A., Le Trong I., Teller D.C., Okada T., Stenkamp R.E., Yamamoto M., and Miyano M. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
39. Parnot C., Bardin S., Miserey-Lenkei S., Guedin D., Corvol P., and Clauser E. Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 7615-7620
40. Parnot C., Miserey-Lenkei S., Bardin S., Corvol P., and Clauser E. Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol. Metabol. 13 (2002) 336-343
41. Ramchandran R., Takezako T., Saad Y., Stull L., Fink B., Yamada H., Dikalov S., Harrison D.G., Moravec C., and Karnik S.S. Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 19087-19092
42. Sachse R., Shao X.J., Rico A., Finckh U., Rolfs A., Reincke M., and Hensen J. Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors. Eur. J. Endocrinol. 137 (1997) 262-266
43. 1A) receptor carboxyl terminus: a role in receptor endocytosis. Mol. Endocrinol. 12 (1998) 1513-1524
44. Thomas W.G., Qian H., Chang C.S., and Karnik S. Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. J. Biol. Chem. 275 (2000) 2893-2900
45. Timmermans P.B.M.W.M., Wong P.C., Chiu A.T., Herblin W.F., Benfield P., Carini D.J., Lee R.J., Wexler R.R., Saye J.A.M., and Smith R.D. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol. Rev. 45 (1993) 205-251
46. Whitebread S., Mele M., Kamber B., and De Gasparo M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem. Biophys. Res. Commun. 163 (1989) 284-291
47. Wilbanks A.M., Laporte S.A., Bohn L.M., Barak L.S., and Caron M.G. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry 41 (2002) 11981-11989