Ongoing DNA synthesis in the rat cerebral cortex is regulated by a proteolytic pathway independent of the proteasome and calpains

Investigational New Drugs

Volumn 28, Issue 3, 2010, Pages 242-250

  Yakisich, J Sebastián ^a   Sidén, Åke ^a   Cruz, Mabel ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Calpains; Cerebral cortex; DNA synthesis; Protease inhibitors; Proteasome

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALPAIN; CALPAIN INHIBITOR I; CALPAIN INHIBITOR II; CALPASTATIN; LACTACYSTIN; LACTACYSTIN BETA LACTONE; PROTEASOME; PROTEINASE INHIBITOR; TOSYLLYSYL CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DRUG SELECTIVITY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; CYSTEINE PROTEINASE INHIBITORS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 77952241314     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9238-4     Document Type: Article

References (54)

1. RJ Deshaies 1995 Make it or brake it: the role of ubiquitin-dependent proteolysis in cellular regulation Trends Cell Biol 5 428 434 10.1016/S0962-8924(00)89102-3 1:CAS:528:DyaK2MXpslSntro%3D 14732048
2. JD Etlinger AL Goldberg 1997 A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes Proc Natl Acad Sci U S A 74 54 58 10.1073/pnas.74.1.54
3. AL Goldberg 1992 The mechanism and functions of ATP-dependent proteases in bacterial and animal cells Eur J Biochem 203 9 23 10.1111/j.1432-1033.1992. tb19822.x 1:CAS:528:DyaK38XhtVWntbg%3D 1730246
4. A Hershko D Ganoth V Sudakin A Dahan LH Cohen FC Luca JV Ruderman E Eytan 1994 Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2 J Biol Chem 269 4940 4946 1:CAS:528:DyaK2cXitlynsrg%3D 8106468
5. EJHJ Wiertz TR Jones L Sun M Bogyo HJ Geuze HL Ploegh 1996 The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol Cell 84 769 779 10.1016/S0092-8674(00) 81054-5 1:CAS:528:DyaK28Xhs1Cns7g%3D 8625414 (Pubitemid 26094206)
6. KL Rock C Gramm L Rothstein K Clark L Dick D Hwang AL Goldberg 1994 Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class Mol Cell 78 761 771 1:CAS:528:DyaK2cXmtVarsb8%3D
7. Y Yang J Kitagaki H Wang DX Hou AO Perantoni 2008 Targeting the ubiquitin-proteasome system for cancer therapy Cancer Sci 100 24 28 10.1111/j.1349-7006.2008.01013.x 19037995
8. M Orlowsky 1990 The multicatalytic proteinase complex, a major extralysosomal proteolytic system Biochemistry 28 9270 9278 10.1021/bi00450a006
9. J Sterz I von Metzler JC Hahne B Lamottke J Rademacher U Heider E Terpos O Sezer 2008 The potential of proteasome inhibitors in cancer therapy Expert Opin Investig Drugs 17 879 895 10.1517/13543784.17.6.879 1:CAS:528: DC%2BD1cXmtV2ktrc%3D 18491989 (Pubitemid 351864325)
10. A Devoy T Soane R Welchman RJ Mayer 2005 The ubiquitin-proteasome system and cancer Essays Biochem 41 187 203 10.1042/EB0410187 1:CAS:528: DC%2BD2MXht1aitbzL 16250906
11. SJ Elledge 1996 Cell cycle checkpoints: preventing an identity crisis Science 274 1664 1672 10.1126/science.274.5293.1664 1:CAS:528:DyaK28XntlyktL0%3D 8939848 (Pubitemid 26414889)
12. JW Harper SJ Elledge 2007 The DNA damage response: ten years after Mol Cell 28 739 745 10.1016/j.molcel.2007.11.015 1:CAS:528:DC%2BD1cXktVWisQ%3D%3D 18082599 (Pubitemid 350217064)
13. RW King RJ Deshaies J-M Peters MW Kirschner 1996 How proteolysis drives the cell cycle Science 274 1652 1659 10.1126/science.274.5293.1652 1:CAS:528:DyaK28Xntlykt7s%3D 8939846 (Pubitemid 26414887)
14. MS Song SJ Song SJ Kim K Nakayama KI Nakayama DS Lim 2008 Skp2 regulates the antiproliferative function of the tumor suppressor RASSF1A via ubiquitin-mediated degradation at the G1-S transition Oncogene 27 3176 3185 10.1038/sj.onc.1210971 1:CAS:528:DC%2BD1cXlvFSis70%3D 18071316 (Pubitemid 351693166)
15. R van Leuken L Clijsters R Wolthuis 2008 To cell cycle, swing the APC/C Biochim Biophys Acta 1786 49 59 18544349
16. PR Yew MW Kirschner 1997 Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle Science 277 1672 1676 10.1126/science.277.5332.1672 1:CAS:528:DyaK2sXmtVSntrw%3D 9287222 (Pubitemid 27446231)
17. JS Yakisich Å Sidén V Idoyaga Vargas P Eneroth M Cruz 1999 Early effects of protein kinase modulator on DNA synthesis in rat cerebral cortex Exp Neurol 159 164 176 10.1006/exnr.1999.7121 1:CAS:528: DyaK1MXlvVWqsr8%3D 10486185 (Pubitemid 29444913)
18. Yakisich JS, Sidén Å, Idoyaga Vargas V, Eneroth P, Cruz M (1998) Fast and sensitive method for simultaneous measurement of cell proliferation rate and drug sensitivity in rat cerebral cortex.151:194-202
19. C Labarca K Paigen 1980 A simple, rapid, and sensitive DNA assay procedure Anal Biochem 102 344 352 10.1016/0003-2697(80)90165-7 1:CAS:528:DyaL3cXhsF2qurk%3D 6158890
20. E Jones 1991 Tackling the protease problem in Saccharomyces cerevisiae Methods Enzymol 194 428 453 10.1016/0076-6879(91)94034-A 1:CAS:528: DyaK3MXktVertb8%3D 2005802
21. J Altman GD Das 1966 Autoradiographic and histopathological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions J Comp Neurol 126 337 390 10.1002/cne.901260302 1:STN:280: DyaF287ktF2ktA%3D%3D 5937257
22. K Tanaka K Li A Ichihara L Waxman AL Goldberg 1986 A high molecular weight protease in the cytosol of rat liver. 1. Purification, enzymological properties and tissue distribution J Biol Chem 261 15197 15203 1:CAS:528:DyaL2sXivFWlsQ%3D%3D 3095325 (Pubitemid 17218097)
23. E Mengual P Aritzi J Rodrigo JM Gimenez-Amaya JG Castano 1996 Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS J Neurosci 16 6331 6341 1:CAS:528:DyaK28Xnt1Ortbw%3D 8815912
24. MM Vilenchik TM Tretjak 1977 Evidence for unscheduled DNA synthesis in rat brain J Neurochem 29 1159 1161 10.1111/j.1471-4159.1977.tb06526.x 1:CAS:528:DyaE1cXhtFygsLk%3D 599347
25. I Merits J Cain 1969 Rapid loss of labeled DNA from rat brain due to radiation damage Biochim Biophys Acta 174 315 321 1:CAS:528:DyaF1MXmsV2jsg%3D%3D 5766299
26. LR Dick AA Cruikshank AT Destree L Grenier TA McCormack FD Melandri SL Nunes VJ Palombella LA Parent L Plamondon RL Stein 1997 Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells J Biol Chem 272 182 188 10.1074/jbc.272.20.13372 1:CAS:528:DyaK2sXjsVKhug%3D%3D 8995245 (Pubitemid 27216770)
27. LR Dick AA Cruiskshank L Grenier FD Melandri SL Nunes RL Stein 1996 Mechanistic studies on the inactivation of the proteasome by lactacystin. A central role for clasto-lactacystin-B-lactone J Biol Chem 271 7273 7276 10.1074/jbc.271.13.7273 1:CAS:528:DyaK28XhvFyltbY%3D 8631740 (Pubitemid 26111059)
28. G Fenteany SL Schreiber 1998 Lactacystin, proteasome function, and cell fate J Biol Chem 273 8545 8548 10.1074/jbc.273.15.8545 1:CAS:528: DyaK1cXis1els7c%3D 9535824 (Pubitemid 28176125)
29. G Fenteany RF Standaert WS Lane S Choi EJ Corey SL Schreiber 1995 Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin Science 268 726 731 10.1126/science. 7732382 1:CAS:528:DyaK2MXlsVGitrg%3D 7732382
30. A Craiu M Gaczynska T Akopian C Gramm G Fenteany AL Goldberg K Rock 1997 Lactacyctin and clasto-lactacystin B-lactone modify multiple proteasome B-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation J Biol Chem 272 23437 23445 10.1074/jbc.272.20.13437 (Pubitemid 27216779)
31. TJ Jensen MA Loo S Pind DB Williams AL Goldberg JR Riordan 1995 Multiple proteolytic systems, including the proteasome, contribute to CFTR processing Cell 83 129 135 10.1016/0092-8674(95)90241-4 1:CAS:528:DyaK2MXosF2rsr8%3D 7553864
32. S Mori K Tanaka S Omura Y Saito 1995 Degradation process of ligand-stimulated platelet-derived growth factor B-receptor involves ubiquitin-proteasome proteolytic pathway J Biol Chem 270 29447 29452 10.1074/jbc.270.52.30862 1:CAS:528:DyaK2MXpvVOgsLc%3D 7493983 (Pubitemid 26012167)
33. T Honda K Yasutake N Nihonmatsu M Mercken H Takahashi O Murayama M Murayama K Sato A Omori S Tsubuki 1999 Dual role of proteasome in the metabolism of presenilin 1 J Neurochem 72 255 261 10.1046/j.1471-4159.1999.0720255.x 1:CAS:528:DyaK1MXjtF2k 9886077 (Pubitemid 29013900)
34. SR Schow A Joly 1997 N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced BF-kB activation and prevents TNF and IL-6 synthesis in vivo Cell Immunol 175 199 202 10.1006/cimm.1996.1061 1:CAS:528: DyaK2sXpvV2gtw%3D%3D 9023426 (Pubitemid 27072910)
35. W Dubiel G Pratt K Ferrell M Rechsteiner 1992 Purification of an 11 S regulator of the multicatalytic protease J Biol Chem 267 22369 22377 1:CAS:528:DyaK38XlvVOitrc%3D 1429590
36. DH Lee AF Goldberg 1996 Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae J Biol Chem 271 27280 27284 10.1074/jbc.271.44.27280 1:CAS:528:DyaK28XmvVWms78%3D 8910302 (Pubitemid 26367280)
37. DH Lee AL Goldberg 1998 Proteasome inhibitors: valuable new tools for cell biologists Trends Cell Biol 8 397 403 10.1016/S0962-8924(98)01346-4 1:CAS:528:DyaK1cXmvFWjtbc%3D 9789328 (Pubitemid 28458705)
38. LM Grimm AL Goldberg GJ Poirier LM Schwartz BA Osborne 1996 Proteasomes play an essential role in thymocyte apoptosis EMBO J 15 3835 3844 1:CAS:528:DyaK28XltFertrs%3D 8670888
39. Q Lu RL Mellgren 1996 Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells Arch Biochem Biophys 334 175 181 10.1006/abbi.1996.0443 1:CAS:528:DyaK28XmtVyjt7w%3D 8837753 (Pubitemid 26329815)
40. SH Choi SJ Lee P Nguyen JS Jang J Lee M-L Wu E Takano M Maki PA Henkart JB Trepel 1997 Regulation of cyclin D1 by calpain protease J Biol Chem 272 28479 28484 10.1074/jbc.272.45.28479 1:CAS:528:DyaK2sXntlCkur4%3D 9353308 (Pubitemid 27517796)
41. A Sarin DH Adams PA Henkart 1993 Protease inhibitors selectively block T cell-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells J Exp Med 178 1693 1700 10.1084/jem.178.5.1693 1:CAS:528:DyaK3sXmtVWksLg%3D 8228816 (Pubitemid 23318448)
42. EG Minnaugh HY Chen JR Davie JE Celis K Neckers 1997 Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response Biochemistry 36 14418 14429 10.1021/bi970998j (Pubitemid 27509934)
43. 1 transit following brief starvation for serum factors Exp Cell Res 152 459 466 10.1016/0014-4827(84)90647-5 1:CAS:528:DyaL2cXkt1WhtLY%3D 6373328
44. 1 leading to proliferation or quiescence of Swiss 3T3 cells Proc Natl Acad Sci U S A 82 5365 5369 10.1073/pnas.82.16.5365 1:CAS:528: DyaL2MXlt1SrtLk%3D 3860868 (Pubitemid 15012107)
45. 1 events and regulation of cell proliferation Science 246 603 608 10.1126/science.2683075 1:CAS:528:DyaK3cXis12n 2683075
46. JA Diehl M Cheng MF Roussel CJ Sherr 1998 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization Genes Dev 12 3499 3511 10.1101/gad.12.22.3499 1:CAS:528:DyaK1cXnvVOgs7s%3D 9832503
47. M Sanchez A Calzada A Bueno 1999 The cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae J Biol Chem 26 9092 9097 10.1074/jbc.274.13.9092 (Pubitemid 29164716)
48. B Baum H Nishitani S Yanow P Nurse 1998 Cdc18 transcription and proteolysis couple S phase to passage through mitosis EMBO J 17 5689 5698 10.1093/emboj/17.19.5689 1:CAS:528:DyaK1cXmvVyjsLw%3D 9755169 (Pubitemid 28445980)
49. V Costanzo EV Avvedimento ME Gottesman J Gautier D Grieco 1999 Protein kinase A is required for chromosomal DNA replication Curr Biol 9 903 906 10.1016/S0960-9822(99)80395-9 1:CAS:528:DyaK1MXlslSntrk%3D 10469595 (Pubitemid 29456008)
50. HM Mahbudani JPJ Chong S Chevalier P Thommes JJ Blow 1997 Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor J Cell Biol 136 125 135 10.1083/jcb.136.1.125 (Pubitemid 27044809)
51. D Coverley HR Wilkinson MA Madine AD Mills RA Laskey 1998 Protein kinase inhibition in G2 causes mammalian mcm proteins to reassociates with chromatin and restores ability to replicate Exp Cell Res 238 63 69 10.1006/excr.1997.3829 1:CAS:528:DyaK1cXmt1SisQ%3D%3D 9457057 (Pubitemid 28366127)
52. KRFA Byrnes 2007 Role of cell cycle proteins in CNS injury Neurochem Res 32 1799 1807 10.1007/s11064-007-9312-2 1:CAS:528:DC%2BD2sXhtVGmsLzI 17404835 (Pubitemid 47428847)
53. B Dahlmann 2007 Role of proteasomes in disease BMC Biochem 8 S3 10.1186/1471-2091-8-S1-S3 18047740 (Pubitemid 351814004)
54. EH Yew NS Cheung MS Choy RZ Qi AY Lee ZF Peng AJ Melendez J Manikandan ES Koay LL Chiu 2005 Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis J Neurochem 4 943 956 10.1111/j.1471-4159. 2005.03220.x (Pubitemid 41170583)