Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 16, 2010, Pages 7479-7484

  Wu, Raymond P ^a   Hayashi, Tomoko ^a   Cottam, Howard B ^a   Jin, Guangyi ^a   Yao, Shiyin ^a   Wu, Christina C N ^a   Rosenbach, Michael D ^a   Corr, Maripat ^b   Schwab, Richard B ^a   Carson, Dennis A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antioxidant response; Dietary component; Electrophilic stress response activators; Natural product

Indexed keywords

ANTIOXIDANT; APIGENIN; BETA NAPHTHOFLAVONE; CAPSAICIN; CARBONYL DERIVATIVE; CURCUMIN; ELECTROPHILE; ETACRYNIC ACID; FLAVONE DERIVATIVE; FUMARIC ACID DIMETHYL ESTER; GOSSYPOL; HEME OXYGENASE 1; HYDROQUINONE; HYPOESTOXIDE; ISOTHIOCYANIC ACID DERIVATIVE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUTEOLIN; MERSALYL; METAL DERIVATIVE; PARTHENOLIDE; PICEATANNOL; POLYPHENOL DERIVATIVE; QUERCETIN; RESVERATROL; ROQUINIMEX; SUDAN I; SULFORAPHANE; TANGERETIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; FLAVONOIDS; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, REPORTER; HEME OXYGENASE-1; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKOCYTES, MONONUCLEAR; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHENOLS; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77952163328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1002890107     Document Type: Article

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