-
2
-
-
16244393685
-
Signalling by PI3K isoforms: Insights from gene-targeted mice
-
Vanhaesebroeck B, Ali K, Bilancio A, Geering B, Foukas LC (2005) Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 30:194-204.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 194-204
-
-
Vanhaesebroeck, B.1
Ali, K.2
Bilancio, A.3
Geering, B.4
Foukas, L.C.5
-
3
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, Nussbaum RL (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem 274:10963-10968.
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
4
-
-
0036185944
-
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
-
Bi L, Okabe I, Bernard DJ, Nussbaum RL (2002) Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome 13:169-172.
-
(2002)
Mamm Genome
, vol.13
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
5
-
-
33744990592
-
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
-
Foukas LC, et al. (2006) Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 441:366-370.
-
(2006)
Nature
, vol.441
, pp. 366-370
-
-
Foukas, L.C.1
-
6
-
-
42149140646
-
Phosphoinositide 3-kinases p110alpha and beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase
-
Marqués M, et al. (2008) Phosphoinositide 3-kinases p110alpha and beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase. Mol Cell Biol 28: 2803-2814.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2803-2814
-
-
Marqués, M.1
-
7
-
-
66149112970
-
Specific function of phosphoinositide 3-kinase beta in the control of DNA replication
-
Marqués M, et al. (2009) Specific function of phosphoinositide 3-kinase beta in the control of DNA replication. Proc Natl Acad Sci USA 106:7525-7530.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7525-7530
-
-
Marqués, M.1
-
8
-
-
49649087385
-
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
-
Jia S, et al. (2008) Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 454:776-779.
-
(2008)
Nature
, vol.454
, pp. 776-779
-
-
Jia, S.1
-
9
-
-
44349119736
-
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
-
Graupera M, et al. (2008) Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature 453:662-666.
-
(2008)
Nature
, vol.453
, pp. 662-666
-
-
Graupera, M.1
-
10
-
-
55649084906
-
Phosphoinositide 3-kinase p110beta activity: Key role in metabolism and mammary gland cancer but not development
-
Ciraolo E, et al. (2008) Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal 1:ra3.
-
(2008)
Sci Signal
, vol.1
-
-
Ciraolo, E.1
-
11
-
-
4344698901
-
Analysis of cell cycle progression and genomic integrity in early lethal knockouts
-
Brown EJ (2004) Analysis of cell cycle progression and genomic integrity in early lethal knockouts. Methods Mol Biol 280:201-212.
-
(2004)
Methods Mol Biol
, vol.280
, pp. 201-212
-
-
Brown, E.J.1
-
12
-
-
0942268167
-
Repair of DNA double strand breaks by nonhomologous end joining
-
Lees-Miller SP, Meek K (2003) Repair of DNA double strand breaks by nonhomologous end joining. Biochimie 85:1161-1173.
-
(2003)
Biochimie
, vol.85
, pp. 1161-1173
-
-
Lees-Miller, S.P.1
Meek, K.2
-
13
-
-
2342527027
-
DNA damage checkpoint and repair centers
-
Lisby M, Rothstein R (2004) DNA damage checkpoint and repair centers. Curr Opin Cell Biol 16:328-334.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 328-334
-
-
Lisby, M.1
Rothstein, R.2
-
16
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J (2003) Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol 5:255-260.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
17
-
-
0037178748
-
Interfaces between the detection, signaling, and repair of DNA damage
-
Rouse J, Jackson SP (2002) Interfaces between the detection, signaling, and repair of DNA damage. Science 297:547-551.
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
18
-
-
47949121598
-
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
-
Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V (2008) Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J 27:1953-1962.
-
(2008)
EMBO J
, vol.27
, pp. 1953-1962
-
-
Jazayeri, A.1
Balestrini, A.2
Garner, E.3
Haber, J.E.4
Costanzo, V.5
-
19
-
-
33745058037
-
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
-
Dupré A, Boyer-Chatenet L, Gautier J (2006) Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 13:451-457.
-
(2006)
Nat Struct Mol Biol
, vol.13
, pp. 451-457
-
-
Dupré, A.1
Boyer-Chatenet, L.2
Gautier, J.3
-
20
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177-2196.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
21
-
-
35548978945
-
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
-
Löbrich M, Jeggo PA (2007) The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 7:861-869.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 861-869
-
-
Löbrich, M.1
Jeggo, P.A.2
-
22
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
Kolas NK, et al. (2007) Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318:1637-1640.
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
-
23
-
-
21044454703
-
PI 3-kinase p110beta: A new target for antithrombotic therapy
-
Jackson SP, et al. (2005) PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med 11:507-514.
-
(2005)
Nat Med
, vol.11
, pp. 507-514
-
-
Jackson, S.P.1
-
24
-
-
34748902384
-
Global chromatin compaction limits the strength of the DNA damage response
-
Murga M, et al. (2007) Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol 178:1101-1108.
-
(2007)
J Cell Biol
, vol.178
, pp. 1101-1108
-
-
Murga, M.1
-
25
-
-
77952196492
-
Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy
-
Kruhlak MJ, Celeste A, Nussenzweig A (2009) Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy. Methods Mol Biol 523:125-140.
-
(2009)
Methods Mol Biol
, vol.523
, pp. 125-140
-
-
Kruhlak, M.J.1
Celeste, A.2
Nussenzweig, A.3
-
26
-
-
0035844208
-
Interaction between the Btk PH domain and phosphatidylinositol-3,4,5- trisphosphate directly regulates Btk
-
Saito K, Scharenberg AM, Kinet JP (2001) Interaction between the Btk PH domain and phosphatidylinositol-3,4,5-trisphosphate directly regulates Btk. J Biol Chem 276: 16201-16206.
-
(2001)
J Biol Chem
, vol.276
, pp. 16201-16206
-
-
Saito, K.1
Scharenberg, A.M.2
Kinet, J.P.3
-
27
-
-
0033594403
-
Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
-
Watton SJ, Downward J (1999) Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction. Curr Biol 9:433-436.
-
(1999)
Curr Biol
, vol.9
, pp. 433-436
-
-
Watton, S.J.1
Downward, J.2
-
28
-
-
3042685445
-
Phosphorylation of histone H2B at DNA double-strand breaks
-
Fernandez-Capetillo O, Allis CD, Nussenzweig A (2004) Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med 199:1671-1677.
-
(2004)
J Exp Med
, vol.199
, pp. 1671-1677
-
-
Fernandez-Capetillo, O.1
Allis, C.D.2
Nussenzweig, A.3
-
29
-
-
42449155412
-
Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif
-
Chen YC, et al. (2008) Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif. J Mol Med 86:401-412.
-
(2008)
J Mol Med
, vol.86
, pp. 401-412
-
-
Chen, Y.C.1
-
30
-
-
3342915628
-
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
-
Lukas C, et al. (2004) Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 23:2674-2683.
-
(2004)
EMBO J
, vol.23
, pp. 2674-2683
-
-
Lukas, C.1
-
31
-
-
38149057387
-
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
-
Haince JF, et al. (2008) PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem 283:1197-1208.
-
(2008)
J Biol Chem
, vol.283
, pp. 1197-1208
-
-
Haince, J.F.1
-
32
-
-
0034903925
-
Mre11 complex and DNA replication: Linkage to E2F and sites of DNA synthesis
-
Maser RS, et al. (2001) Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis. Mol Cell Biol 21:6006-6016.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6006-6016
-
-
Maser, R.S.1
-
33
-
-
21344438129
-
PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins
-
Sporbert A, Domaing P, Leonhardt H, Cardoso MC (2005) PCNA acts as a stationary loading platform for transiently interacting Okazaki fragment maturation proteins. Nucleic Acids Res 33:3521-3528.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3521-3528
-
-
Sporbert, A.1
Domaing, P.2
Leonhardt, H.3
Cardoso, M.C.4
-
34
-
-
0035869118
-
Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells
-
Balajee AS, Geard CR (2001) Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res 29:1341-1351.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 1341-1351
-
-
Balajee, A.S.1
Geard, C.R.2
-
35
-
-
57749169348
-
SUMOylation regulates Rad18-mediated template switch
-
Branzei D, Vanoli F, Foiani M (2008) SUMOylation regulates Rad18-mediated template switch. Nature 456:915-920.
-
(2008)
Nature
, vol.456
, pp. 915-920
-
-
Branzei, D.1
Vanoli, F.2
Foiani, M.3
-
36
-
-
0042847381
-
Use of the single cellgel electrophoresis/comet assay for detecting DNA damage in aquatic (marine and freshwater) animals
-
Lee RF, Steinert S (2003) Use of the single cellgel electrophoresis/comet assay for detecting DNA damage in aquatic (marine and freshwater) animals. Mutat Res 544:43-64.
-
(2003)
Mutat Res
, vol.544
, pp. 43-64
-
-
Lee, R.F.1
Steinert, S.2
-
37
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic L, Surucu B, Hynx D, Hemmings BA (2008) PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell 30: 203-213.
-
(2008)
Mol Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
38
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
Shen WH, et al. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-170.
-
(2007)
Cell
, vol.128
, pp. 157-170
-
-
Shen, W.H.1
|