메뉴 건너뛰기




Volumn 37, Issue 1, 2010, Pages 22-28

A new family of regulators of calcineurin (RCANs)

Author keywords

Alzheimer's disease; Calcineurin; Rcan gene; Rcans; Tau

Indexed keywords


EID: 77952079890     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2009.00287     Document Type: Review
Times cited : (5)

References (65)
  • 1
    • 35248837988 scopus 로고    scopus 로고
    • Renaming the DSCR1/A dapt78 gene family as RCAN: Regulators of calcineurin
    • Davies K J A, Ermak G, Rothermal B A, et al. Renaming the DSCR1/A dapt78 gene family as RCAN: regulators of calcineurin. FASEB J, 2007, 21(12): 3023-3028
    • (2007) FASEB J , vol.21 , Issue.12 , pp. 3023-3028
    • Davies, K.J.A.1    Ermak, G.2    Rothermal, B.A.3
  • 2
    • 38549174065 scopus 로고    scopus 로고
    • The mouse genome database (MGD): Mouse biology and model systems
    • Bult C J, Eppig J T, Kadin J A, et al. The mouse genome database (MGD): mouse biology and model systems. Nucleic Acids Res, 2008, 36(Supplement 1): D724-D728
    • (2008) Nucleic Acids Res , vol.36 , Issue.SUPPL. 1
    • Bult, C.J.1    Eppig, J.T.2    Kadin, J.A.3
  • 4
    • 48249094953 scopus 로고    scopus 로고
    • Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes
    • Canellada A, Ramirez B G, Minami T, et al. Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes. Glia, 2008, 56(7): 709-722
    • (2008) Glia , vol.56 , Issue.7 , pp. 709-722
    • Canellada, A.1    Ramirez, B.G.2    Minami, T.3
  • 5
    • 23844525083 scopus 로고    scopus 로고
    • Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway
    • DOI 10.1074/jbc.M506205200
    • Cano E, Canellada A, Minami T, et al. Depolarization of neural cells induces transcription of the down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway. J Biol Chem, 2005, 280 (33): 29435-29443 (Pubitemid 41177016)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.33 , pp. 29435-29443
    • Cano, E.1    Canellada, A.2    Minami, T.3    Iglesias, T.4    Redondo, J.M.5
  • 6
    • 0028856422 scopus 로고
    • A new human gene from the down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart
    • Fuentes J J, Pritchard M A, Planas A M, et al. A new human gene from the down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. Hum Mol Genet, 1995, 4(10): 1935-1944
    • (1995) Hum Mol Genet , vol.4 , Issue.10 , pp. 1935-1944
    • Fuentes, J.J.1    Pritchard, M.A.2    Planas, A.M.3
  • 7
    • 33947193463 scopus 로고    scopus 로고
    • RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients
    • DOI 10.1111/j.1742-4658.2007.05717.x
    • Harris C D, Ermak G, Davies K J. RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. FEBS J, 2007, 274(7): 1715-1724 (Pubitemid 46426906)
    • (2007) FEBS Journal , vol.274 , Issue.7 , pp. 1715-1724
    • Harris, C.D.1    Ermak, G.2    Davies, K.J.A.3
  • 8
    • 0031172775 scopus 로고    scopus 로고
    • Hamster adapt78 mRNA is a down syndrome critical region homologue that is inducible by oxidative stress
    • Crawford D R, Leahy K P, Abramova N, et al. Hamster adapt78 mRNA is a down syndrome critical region homologue that is inducible by oxidative stress. Arch Biochem Biophys, 1997, 342(1): 6-12
    • (1997) Arch Biochem Biophys , vol.342 , Issue.1 , pp. 6-12
    • Crawford, D.R.1    Leahy, K.P.2    Abramova, N.3
  • 10
    • 0347915659 scopus 로고    scopus 로고
    • DSCR1(Adapt78) modulates expression of SOD1
    • Ermak G, Cheadle C, Becker K G, et al. DSCR1(Adapt78) modulates expression of SOD1. FASEB J, 2004, 18(1): 62-69
    • (2004) FASEB J , vol.18 , Issue.1 , pp. 62-69
    • Ermak, G.1    Cheadle, C.2    Becker, K.G.3
  • 11
    • 0036277167 scopus 로고    scopus 로고
    • The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress
    • Ermak G, Harris C D, Davies K J A. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J, 2002, 16(8): 814-824
    • (2002) FASEB J , vol.16 , Issue.8 , pp. 814-824
    • Ermak, G.1    Harris, C.D.2    Davies, K.J.A.3
  • 12
    • 0034661467 scopus 로고    scopus 로고
    • Adapt78 protects cells against stress damage and suppresses cell growth
    • Leahy K P, Crawford D R. Adapt78 protects cells against stress damage and suppresses cell growth. Arch Biochem Biophys, 2000, 379(2): 221-228
    • (2000) Arch Biochem Biophys , vol.379 , Issue.2 , pp. 221-228
    • Leahy, K.P.1    Crawford, D.R.2
  • 13
    • 3142646774 scopus 로고    scopus 로고
    • Multiple oxidative stress-response members of the Adapt78 family
    • Michtalik H J, Narayan A V, Bhatt N, et al. Multiple oxidative stress-response members of the Adapt78 family. Free Radic. Biol. Med, 2004, 37(4): 454-462
    • (2004) Free Radic. Biol. Med , vol.37 , Issue.4 , pp. 454-462
    • Michtalik, H.J.1    Narayan, A.V.2    Bhatt, N.3
  • 15
    • 0034234963 scopus 로고    scopus 로고
    • A conserved family of calcineurin regulators
    • Kingsbury T J, Cunningham K W. A conserved family of calcineurin regulators. Genes & Dev, 2000, 14(13): 1595-1604
    • (2000) Genes & Dev , vol.14 , Issue.13 , pp. 1595-1604
    • Kingsbury, T.J.1    Cunningham, K.W.2
  • 16
    • 0034708825 scopus 로고    scopus 로고
    • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
    • DOI 10.1074/jbc.275.12.8719
    • Rothermel B, Vega R B, Yang J, et al. A protein encoded within the down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem, 2000, 275(12): 8719-8725 (Pubitemid 30180224)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8719-8725
    • Rothermel, B.1    Vega, R.B.2    Yang, J.3    Wu, H.4    Bassel-Duby, R.5    Williams, R.S.6
  • 17
    • 0342314483 scopus 로고    scopus 로고
    • A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: Characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)
    • DOI 10.1006/geno.2000.6127
    • Strippoli P, Lenzi L, Petrini M, et al. A new gene family including DSCR1 (down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics, 2000, 64(3): 252-263 (Pubitemid 30212626)
    • (2000) Genomics , vol.64 , Issue.3 , pp. 252-263
    • Strippoli, P.1    Lenzi, L.2    Petrini, M.3    Carinci, P.4    Zannotti, M.5
  • 18
    • 0034624137 scopus 로고    scopus 로고
    • Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles
    • Yang J, Rothermel B, Vega R B. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res, 2000, 87(12): E61-E68
    • (2000) Circ Res , vol.87 , Issue.12
    • Yang, J.1    Rothermel, B.2    Vega, R.B.3
  • 19
    • 0141483523 scopus 로고    scopus 로고
    • Transcriptional regulation by calcium, calcineurin, and NFAT
    • DOI 10.1101/gad.1102703
    • Hogan P G, Chen L, Nardone J, et al. Transcriptional regulation by calcium, calcineurin, and NFAT. Gene Dev, 2003, 17(18): 2205-2232 (Pubitemid 37128637)
    • (2003) Genes and Development , vol.17 , Issue.18 , pp. 2205-2232
    • Hogan, P.G.1    Chen, L.2    Nardone, J.3    Rao, A.4
  • 20
    • 57849107130 scopus 로고    scopus 로고
    • Signaling to gene expression: Calcium, calcineurin and NFAT
    • Rao A. Signaling to gene expression: calcium, calcineurin and NFAT. Nat Immunol, 2009, 10(1): 3-5
    • (2009) Nat Immunol , vol.10 , Issue.1 , pp. 3-5
    • Rao, A.1
  • 21
    • 61649121557 scopus 로고    scopus 로고
    • A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants
    • Rodriguez A, Martinez-Martinez S, Lopez-Maderuelo M D, et al. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Mol Cell, 2009, 33(5): 616-626
    • (2009) Mol Cell , vol.33 , Issue.5 , pp. 616-626
    • Rodriguez, A.1    Martinez-Martinez, S.2    Lopez-Maderuelo, M.D.3
  • 22
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Rusnak F, Mertz P. Calcineurin: form and function. Physiol Rev, 2000, 80(4): 1483-1521
    • (2000) Physiol Rev , vol.80 , Issue.4 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 23
    • 33744832043 scopus 로고    scopus 로고
    • Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells
    • DOI 10.1016/j.cellsig.2005.11.006, PII S0898656805003074
    • Aubareda A, Mulero M C, Perez-Riba M. Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells. Cell Signal, 2006, 18(9): 1430-1438 (Pubitemid 43832079)
    • (2006) Cellular Signalling , vol.18 , Issue.9 , pp. 1430-1438
    • Aubareda, A.1    Mulero, M.C.2    Perez-Riba, M.3
  • 25
    • 0041761256 scopus 로고    scopus 로고
    • Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life
    • DOI 10.1042/BJ20030267
    • Genesca L, Aubareda A, Fuentes J J, et al. Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. Biochem J, 2003, 374 (pt 2): 567-575 (Pubitemid 37094118)
    • (2003) Biochemical Journal , vol.374 , Issue.2 , pp. 567-575
    • Genesca, L.1    Aubareda, A.2    Fuentes, J.J.3    Estivill, X.4    De La Luna, S.5    Perez-Riba, M.6
  • 26
    • 0037119382 scopus 로고    scopus 로고
    • Multiple domains of MCIP1 contribute to inhibition of calcineurin activity
    • Vega R B, Yang J, Rothermel B A, et al. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J Biol Chem, 2002, 277(33): 30401-30407
    • (2002) J Biol Chem , vol.277 , Issue.33 , pp. 30401-30407
    • Vega, R.B.1    Yang, J.2    Rothermel, B.A.3
  • 27
    • 64749114315 scopus 로고    scopus 로고
    • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis
    • Pinchai N, Zachary Perfect B, Juwadi P R, et al. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell, 2009, 8(4): 511-519
    • (2009) Eukaryot Cell , vol.8 , Issue.4 , pp. 511-519
    • Pinchai, N.1    Zachary Perfect, B.2    Juwadi, P.R.3
  • 28
    • 65549150814 scopus 로고    scopus 로고
    • The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators
    • Martínez-Martínez S, Genescà L, Rodríguez A, et al. The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators. Proc Natl Acad Sci USA, 2009, 106(15): 6117-6122
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.15 , pp. 6117-6122
    • Martínez-Martínez, S.1    Genescà, L.2    Rodríguez, A.3
  • 30
    • 66149096223 scopus 로고    scopus 로고
    • Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity
    • Carme Mulero M, Aubareda A, Orzáez M, et al. Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J Biol Chem, 2009, 284(14): 9394-9401
    • (2009) J Biol Chem , vol.284 , Issue.14 , pp. 9394-9401
    • Carme Mulero, M.1    Aubareda, A.2    Orzáez, M.3
  • 31
    • 0037457958 scopus 로고    scopus 로고
    • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy
    • Vega R B, Rothermel B A, Weinheimer C J, et al. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci USA, 2003, 100(2): 669-674
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.2 , pp. 669-674
    • Vega, R.B.1    Rothermel, B.A.2    Weinheimer, C.J.3
  • 33
    • 25144520524 scopus 로고    scopus 로고
    • Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans
    • DOI 10.1128/EC.4.9.1526-1538.2005
    • Fox D S, Heitman J. Calcineurin-binding protein Cbpl directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. Eukaryot Cell, 2005, 4(9): 1526-1538 (Pubitemid 41339108)
    • (2005) Eukaryotic Cell , vol.4 , Issue.9 , pp. 1526-1538
    • Fox, D.S.1    Heitman, J.2
  • 34
    • 33646357770 scopus 로고    scopus 로고
    • Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1
    • DOI 10.1074/jbc.M510775200
    • Abbasi S, Lee J D, Su B, et al. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin- interacting protein 1. J Biol Chem, 2006, 281(12): 7717-7726 (Pubitemid 43847385)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.12 , pp. 7717-7726
    • Abbasi, S.1    Lee, J.D.2    Su, B.3    Chen, X.4    Alcon, J.L.5    Yang, J.6    Kellems, R.E.7    Xia, Y.8
  • 36
    • 58749117045 scopus 로고    scopus 로고
    • Bursting into the nucleus
    • Graef I A, Crabtree G R. Bursting into the nucleus. Sci Signal, 2008, 1(51): pe54
    • (2008) Sci Signal , vol.1 , Issue.51
    • Graef, I.A.1    Crabtree, G.R.2
  • 37
    • 34250705186 scopus 로고    scopus 로고
    • The mitochondrial permeability transition in neurologic disease
    • DOI 10.1016/j.neuint.2007.02.008, PII S0197018607000472
    • Norenberg M D, Rao K V. The mitochondrial permeability transition in neurologic disease. Neurochem Int, 2007, 50(7-8): 983-997 (Pubitemid 46962816)
    • (2007) Neurochemistry International , vol.50 , Issue.7-8 , pp. 983-997
    • Norenberg, M.D.1    Rao, K.V.R.2
  • 38
    • 33646258512 scopus 로고    scopus 로고
    • RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta
    • Ermak G, Harris C D, Battocchio D, et al. RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. FEBS J, 2006, 273(10): 2100-2109
    • (2006) FEBS J , vol.273 , Issue.10 , pp. 2100-2109
    • Ermak, G.1    Harris, C.D.2    Battocchio, D.3
  • 40
    • 59649116320 scopus 로고    scopus 로고
    • Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point
    • Liu Q, Busby J C, Molkentin J D. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol, 2009, 11(2): 154-161
    • (2009) Nat Cell Biol , vol.11 , Issue.2 , pp. 154-161
    • Liu, Q.1    Busby, J.C.2    Molkentin, J.D.3
  • 41
    • 70349666552 scopus 로고    scopus 로고
    • Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways
    • Liu H, Wang P, Song W H, et al. Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J, 2009, 23(10): 3383-3392
    • (2009) FASEB J , vol.23 , Issue.10 , pp. 3383-3392
    • Liu, H.1    Wang, P.2    Song, W.H.3
  • 42
    • 66349086505 scopus 로고    scopus 로고
    • Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in Yeast
    • Mehta S, Li H M, Hogan P G, et al. Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in Yeast. Mol Cell Biol, 2009, 29(10): 2777-2793
    • (2009) Mol Cell Biol , vol.29 , Issue.10 , pp. 2777-2793
    • Mehta, S.1    Li, H.M.2    Hogan, P.G.3
  • 43
    • 0030945154 scopus 로고    scopus 로고
    • Cytoskeletal change in the brains of mice lacking calcineurin
    • Kayyali U S, Zhang W, Yee A G, et al. Cytoskeletal change in the brains of mice lacking calcineurin Act. J Neurochem, 1997, 68(4): 1668-1678
    • (1997) Act. J Neurochem , vol.68 , Issue.4 , pp. 1668-1678
    • Kayyali, U.S.1    Zhang, W.2    Yee, A.G.3
  • 44
    • 33746216555 scopus 로고    scopus 로고
    • Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau, accompanied by abnormal behavior in mice
    • Yu D Y, Luo J, Bu F, et al. Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau, accompanied by abnormal behavior in mice. Biological Chemistry, 2006, 387(7): 977-983
    • (2006) Biological Chemistry , vol.387 , Issue.7 , pp. 977-983
    • Yu, D.Y.1    Luo, J.2    Bu, F.3
  • 45
    • 33745684082 scopus 로고    scopus 로고
    • Effects of CsA, FK506 and rapamycin on calcineurin activity in mouse brain
    • Yu D Y, Luo J, Bu F, et al. Effects of CsA, FK506 and rapamycin on calcineurin activity in mouse brain. IUBMB life, 2006, 58(7): 429-433
    • (2006) IUBMB Life , vol.58 , Issue.7 , pp. 429-433
    • Yu, D.Y.1    Luo, J.2    Bu, F.3
  • 46
    • 0036015018 scopus 로고    scopus 로고
    • Dephosphorylation of tau protein by calcineurin triturated into neural living cells
    • DOI 10.1023/A:1015385527187
    • Wei Q, Holzer M, Brueckner M K, et al. Dephosphorylation of tau protein by calcineurin (PP2B) led to neural living cells. Cell Mol Neurobiol, 2002, 22(1): 13-24 (Pubitemid 34579405)
    • (2002) Cellular and Molecular Neurobiology , vol.22 , Issue.1 , pp. 13-24
    • Wei, Q.1    Holzer, M.2    Brueckner, M.K.3    Liu, Y.4    Arendt, T.5
  • 47
    • 0035914413 scopus 로고    scopus 로고
    • Chronic Overexpression of the Calcineurin Inhibitory Gene DSCR1 (Adapt78) Is Associated with Alzheimer's Disease
    • DOI 10.1074/jbc.M102829200
    • Ermak G, Morgan T E, Davies K J. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J Biol Chem, 2001, 276(42): 38787-38794 (Pubitemid 37371240)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.42 , pp. 38787-38794
    • Ermak, G.1    Morgan, T.E.2    Davies, K.J.A.3
  • 48
    • 29144484163 scopus 로고    scopus 로고
    • Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease
    • Harris C D, Ermak G, Davies K J A. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci, 2005, 62(21): 2477-2486
    • (2005) Cell Mol Life Sci , vol.62 , Issue.21 , pp. 2477-2486
    • Harris, C.D.1    Ermak, G.2    Davies, K.J.A.3
  • 49
    • 24644499539 scopus 로고    scopus 로고
    • Expression of calcipressin 1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease
    • Cook C N, Hejna M J, Magnuson D J, et al. Expression of calcipressin 1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease. J Alzheimers Dis, 2005, 8(1): 63-73
    • (2005) J Alzheimers Dis , vol.8 , Issue.1 , pp. 63-73
    • Cook, C.N.1    Hejna, M.J.2    Magnuson, D.J.3
  • 50
    • 36849005006 scopus 로고    scopus 로고
    • The down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling
    • Hoeffer C A, Dey A, Sachan N, et al. The down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling. J Neurosci, 2007, 27(48): 13161-13172
    • (2007) J Neurosci , vol.27 , Issue.48 , pp. 13161-13172
    • Hoeffer, C.A.1    Dey, A.2    Sachan, N.3
  • 51
    • 0347994896 scopus 로고    scopus 로고
    • The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: Implications for mental retardation
    • Chang K T, Shi Y J, Min K T. The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci USA, 2003, 100 (26): 15794-15799
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.26 , pp. 15794-15799
    • Chang, K.T.1    Shi, Y.J.2    Min, K.T.3
  • 53
    • 41149154002 scopus 로고    scopus 로고
    • DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: Implications for down syndrome and Alzheimer's disease
    • Keating D J, Dubach D, Zanin M P, et al. DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for down syndrome and Alzheimer's disease. Hum Mol Genet, 2008, 17(7): 1020-1030
    • (2008) Hum Mol Genet , vol.17 , Issue.7 , pp. 1020-1030
    • Keating, D.J.1    Dubach, D.2    Zanin, M.P.3
  • 55
    • 41449086815 scopus 로고    scopus 로고
    • Calcineurin regulation in Fungi and beyond
    • Stie J, Fox D. Calcineurin regulation in Fungi and beyond. Eukaryot Cell, 2008, 7(2): 177-186
    • (2008) Eukaryot Cell , vol.7 , Issue.2 , pp. 177-186
    • Stie, J.1    Fox, D.2
  • 56
    • 42049121101 scopus 로고    scopus 로고
    • 2+-operated transcriptional networks: Molecular mechanisms and in vivo models
    • 2+-operated transcriptional networks: molecular mechanisms and in vivo models. Physiol Rev, 2008, 88(2): 421-449
    • (2008) Physiol Rev , vol.88 , Issue.2 , pp. 421-449
    • Mellström, B.1    Gomez-Villafuertes, R.2    Naranjo, J.R.3
  • 57
    • 66449104770 scopus 로고    scopus 로고
    • Regulator of calcineurin (RCAN1-1L) is deficient in huntington disease and protective against mutant huntingtin toxicity in vitro
    • Ermak G, Hench K J, Chang K T, et al. Regulator of calcineurin (RCAN1-1L) is deficient in huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem, 2009, 284 (18): 11845-11853
    • (2009) J Biol Chem , vol.284 , Issue.18 , pp. 11845-11853
    • Ermak, G.1    Hench, K.J.2    Chang, K.T.3
  • 58
    • 60549103275 scopus 로고    scopus 로고
    • εRI-mediated signaling and mast cell function
    • εRI-mediated signaling and mast cell function. J Exp Med, 2009, 206(1): 195-207
    • (2009) J Exp Med , vol.206 , Issue.1 , pp. 195-207
    • Yang, Y.J.1    Chen, W.2    Edgar, A.3
  • 62
    • 44549086153 scopus 로고    scopus 로고
    • Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain
    • Luo J, Ma J, Yu D Y, et al. Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain. Brain Res Bull, 2008, 76(5): 464-468
    • (2008) Brain Res Bull , vol.76 , Issue.5 , pp. 464-468
    • Luo, J.1    Ma, J.2    Yu, D.Y.3
  • 63
    • 0142106493 scopus 로고    scopus 로고
    • The effect of calcineurin activator, extracted from Chinese herbal medicine, on memory and immunity in mice
    • DOI 10.1016/S0091-3057(03)00148-5
    • Luo J, Yin J H, Wei Q. The effect of a calcineurin activator, extracted from Chinese herbal medicine on memory and immunity in mice. Pharmacol Biochem Behav, 2003, 75(4): 749-754 (Pubitemid 37289459)
    • (2003) Pharmacology Biochemistry and Behavior , vol.75 , Issue.4 , pp. 749-754
    • Luo, J.1    Yin, J.H.2    Wei, Q.3
  • 64
    • 34347375484 scopus 로고    scopus 로고
    • Calmodulin-dependent activation of calcineurin by chlorogenic Acid
    • Tong L, Song Y, Zhang S D, et al. Calmodulin-dependent activation of calcineurin by chlorogenic Acid. IUBMB Life, 2007, 59(6): 402-407
    • (2007) IUBMB Life , vol.59 , Issue.6 , pp. 402-407
    • Tong, L.1    Song, Y.2    Zhang, S.D.3
  • 65
    • 10344266477 scopus 로고    scopus 로고
    • Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos lonicerae on macrophage
    • Wu H Z, Luo J, Yin Y X, et al. Effects of chlorogenic acid, an active compound activating calcineurin, purified from Flos lonicerae on macrophage. Acta Pharmacol Sin, 2004, 25 (12): 1685-1689
    • (2004) Acta Pharmacol Sin , vol.25 , Issue.12 , pp. 1685-1689
    • Wu, H.Z.1    Luo, J.2    Yin, Y.X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.