-
1
-
-
52949098296
-
Frequency-modulated nuclear localization bursts coordinate gene regulation
-
L. Cai, C. K. Dalal, M. B. Elowitz, Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 455, 485-490 (2008).
-
(2008)
Nature
, vol.455
, pp. 485-490
-
-
Cai, L.1
Dalal, C.K.2
Elowitz, M.B.3
-
2
-
-
1542750499
-
Oscillatory behavior of the nuclear localization of the transcription factors msn2 and msn4 in response to stress in yeast
-
M. Jacquet, G. Renault, S. Lallet, J. De Mey, A. Goldbeter, Oscillatory behavior of the nuclear localization of the transcription factors Msn2 and Msn4 in response to stress in yeast. Sci.World J. 3, 609-612 (2003).
-
(2003)
Sci.World J
, vol.3
, pp. 609-612
-
-
Jacquet, M.1
Renault, G.2
Lallet, S.3
De Mey, J.4
Goldbeter, A.5
-
3
-
-
0030883032
-
Regulated nuclear translocation of the mig1 glucose repressor
-
M. J. De Vit, J. A. Waddle, M. Johnston, Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8, 1603-1618 (1997).
-
(1997)
Mol. Biol. Cell
, vol.8
, pp. 1603-1618
-
-
De Vit, M.J.1
Waddle, J.A.2
Johnston, M.3
-
4
-
-
0034633702
-
Generation of oscillations by the p53-mdm2 feedback loop: A theoretical and experimental study
-
R. Lev Bar-Or, R. Maya, L. A. Segel, U. Alon, A. J. Levine, M. Oren, Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study. Proc. Natl. Acad. Sci. U.S.A. 97, 11250-11255 (2000).
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 11250-11255
-
-
Lev Bar-Or, R.1
Maya, R.2
Segel, L.A.3
Alon, U.4
Levine, A.J.5
Oren, M.6
-
5
-
-
0037044575
-
The ib-nf-b signaling module: Temporal control and selective gene activation
-
A. Hoffmann, A. Levchenko, M. L. Scott, D. Baltimore, The IB-NF-B signaling module: Temporal control and selective gene activation. Science 298, 1241-1245 (2002).
-
(2002)
Science
, vol.298
, pp. 1241-1245
-
-
Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
-
6
-
-
7444254365
-
Oscillations in nf-b signaling control the dynamics of gene expression
-
D. E. Nelson, A. E. C. Ihekwaba, M. Elliott, J. R. Johnson, C. A. Gibney, B. E. Foreman, G. Nelson, V. See, C. A. Horton, D. G. Spiller, S. W. Edwards, H. P. McDowell, J. F. Unitt, E. Sullivan, R. Grimley, N. Benson, D. Broomhead, D. B. Kell, M. R. H. White, Oscillations in NF-B signaling control the dynamics of gene expression. Science 306, 704-708 (2004).
-
(2004)
Science
, vol.306
, pp. 704-708
-
-
Nelson, D.E.1
Ihekwaba, A.E.C.2
Elliott, M.3
Johnson, J.R.4
Gibney, C.A.5
Foreman, B.E.6
Nelson, G.7
See, V.8
Horton, C.A.9
Spiller, D.G.10
Edwards, S.W.11
McDowell, H.P.12
Unitt, J.F.13
Sullivan, E.14
Grimley, R.15
Benson, N.16
Broomhead, D.17
Kell, D.B.18
White, M.R.H.19
-
7
-
-
0037174669
-
Oscillatory expression of the bhlh factor hes1 regulated by a negative feedback loop
-
H. Hirata, S. Yoshiura, T. Ohtsuka, Y. Bessho, T. Harada, K. Yoshikawa, R. Kageyama, Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298, 840-843 (2002).
-
(2002)
Science
, vol.298
, pp. 840-843
-
-
Hirata, H.1
Yoshiura, S.2
Ohtsuka, T.3
Bessho, Y.4
Harada, T.5
Yoshikawa, K.6
Kageyama, R.7
-
8
-
-
0043180477
-
Oscillatory expression of hes1, p53, and nf-b driven by transcriptional time delays
-
N. A. Monk, Oscillatory expression of Hes1, p53, and NF-B driven by transcriptional time delays. Curr. Biol. 13, 1409-1413 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 1409-1413
-
-
Monk, N.A.1
-
9
-
-
0025084605
-
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the tcell antigen receptor
-
S. Fiering, J. P. Northrop, G. P. Nolan, P. S. Mattila, G. R. Crabtree, L. A. Herzenberg, Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the Tcell antigen receptor. Genes Dev. 4, 1823-1834 (1990).
-
(1990)
Genes Dev
, vol.4
, pp. 1823-1834
-
-
Fiering, S.1
Northrop, J.P.2
Nolan, G.P.3
Mattila, P.S.4
Crabtree, G.R.5
Herzenberg, L.A.6
-
10
-
-
0025127307
-
The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates
-
M. S. Ko, H. Nakauchi, N. Takahashi, The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates. EMBO J. 9, 2835-2842 (1990).
-
(1990)
EMBO J
, vol.9
, pp. 2835-2842
-
-
Ko, M.S.1
Nakauchi, H.2
Takahashi, N.3
-
11
-
-
0023821516
-
Identification of a putative regulator of early t cell activation genes
-
J. P. Shaw, P. J. Utz, D. B. Durand, J. J. Toole, E. A. Emmel, G. R. Crabtree, Identification of a putative regulator of early T cell activation genes. Science 241, 202-205 (1988).
-
(1988)
Science
, vol.241
, pp. 202-205
-
-
Shaw, J.P.1
Utz, P.J.2
Dur, D.B.3
Toole, J.J.4
Emmel, E.A.5
Crabtree, G.R.6
-
12
-
-
0026643141
-
Identification of calcineurin as a key signalling enzyme in t cell activation
-
N. A. Clipstone, G. R. Crabtree, Identification of calcineurin as a key signalling enzyme in T cell activation. Nature 357, 695-697 (1992).
-
(1992)
Nature
, vol.357
, pp. 695-697
-
-
Clipstone, N.A.1
Crabtree, G.R.2
-
13
-
-
0028361589
-
Nf-At components define a family of transcription factors targeted in t-cell activation
-
J. P. Northrop, S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan, A. Admon, G. R. Crabtree, NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369, 497-502 (1994)
-
(1994)
Nature
, vol.369
, pp. 497-502
-
-
Northrop, J.P.1
Ho, S.N.2
Chen, L.3
Thomas, D.J.4
Timmerman, L.A.5
Nolan, G.P.6
Admon, A.7
Crabtree, G.R.8
-
14
-
-
0033525748
-
Generic signals and specific outcomes: Signaling through ca2, calcineurin, and nf-At
-
G. R. Crabtree, Generic signals and specific outcomes: Signaling through Ca2, calcineurin, and NF-AT. Cell 96, 611-614 (1999).
-
(1999)
Cell
, vol.96
, pp. 611-614
-
-
Crabtree, G.R.1
-
15
-
-
0030973579
-
Transcription factors of the nfat family: Regulation and function
-
A. Rao, C. Luo, P. G. Hogan, Transcription factors of the NFAT family: Regulation and function. Annu. Rev. Immunol. 15, 707-747 (1997).
-
(1997)
Annu. Rev. Immunol.
, vol.15
, pp. 707-747
-
-
Rao, A.1
Luo, C.2
Hogan, P.G.3
-
16
-
-
0025871394
-
Nuclear association of a t-cell transcription factor blocked by fk-506 and cyclosporin a
-
W. M. Flanagan, B. Corthésy, R. J. Bram, G. R. Crabtree, Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352, 803-807 (1991).
-
(1991)
Nature
, vol.352
, pp. 803-807
-
-
Flanagan, W.M.1
Corthésy, B.2
Bram, R.J.3
Crabtree, G.R.4
-
17
-
-
0029125831
-
Nfatc3, a lymphoid-specific nfatc family member that is calcium-regulated and exhibits distinct dna binding specificity
-
S. N. Ho, D. J. Thomas, L. A. Timmerman, X. Li, U. Francke, G. R. Crabtree, NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J. Biol. Chem. 270, 19898-19907 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19898-19907
-
-
Ho, S.N.1
Thomas, D.J.2
Timmerman, L.A.3
Li, X.4
Francke, U.5
Crabtree, G.R.6
-
18
-
-
0030899131
-
Nuclear localization of nf-Atc by a calcineurindependent, cyclosporin-sensitive intramolecular interaction
-
C. R. Beals, N. A. Clipstone, S. N. Ho, G. R. Crabtree, Nuclear localization of NF-ATc by a calcineurindependent, cyclosporin-sensitive intramolecular interaction. Genes Dev. 11, 824-834 (1997).
-
(1997)
Genes Dev
, vol.11
, pp. 824-834
-
-
Beals, C.R.1
Clipstone, N.A.2
Ho, S.N.3
Crabtree, G.R.4
-
19
-
-
0031438164
-
Calcineurin acts through the crz1/tcn1-encoded transcription factor to regulate gene expression in yeast
-
A. M. Stathopoulos, M. S. Cyert, Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev. 11, 3432-3444 (1997).
-
(1997)
Genes Dev
, vol.11
, pp. 3432-3444
-
-
Stathopoulos, A.M.1
Cyert, M.S.2
-
20
-
-
0030888186
-
Differential activation of transcription factors induced by ca2 response amplitude and duration
-
R. E. Dolmetsch, R. S. Lewis, C. C. Goodnow, J. I. Healy, Differential activation of transcription factors induced by Ca2 response amplitude and duration. Nature 386, 855-858 (1997).
-
(1997)
Nature
, vol.386
, pp. 855-858
-
-
Dolmetsch, R.E.1
Lewis, R.S.2
Goodnow, C.C.3
Healy, J.I.4
-
21
-
-
0032580202
-
Calcium oscillations increase the efficiency and specificity of gene expression
-
R. E. Dolmetsch, K. Xu, R. S. Lewis, Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933-936 (1998).
-
(1998)
Nature
, vol.392
, pp. 933-936
-
-
Dolmetsch, R.E.1
Xu, K.2
Lewis, R.S.3
-
22
-
-
0032580157
-
Cell-permeant caged insp3 ester shows that ca2 spike frequency can optimize gene expression
-
W.-H. Li, J. Llopis, M. Whitney, G. Zlokarnik, R. Y. Tsien, Cell-permeant caged InsP3 ester shows that Ca2 spike frequency can optimize gene expression. Nature 392, 936-941 (1998).
-
(1998)
Nature
, vol.392
, pp. 936-941
-
-
Li, W.-H.1
Llopis, J.2
Whitney, M.3
Zlokarnik, G.4
Tsien, R.Y.5
-
23
-
-
0033554699
-
L-Type calcium channels and gsk-3 regulate the activity of nf-Atc4 in hippocampal neurons
-
I. A. Graef, P. G. Mermelstein, K. Stankunas, J. R. Neilson, K. Deisseroth, R. W. Tsien, G. R. Crabtree, L-Type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature 401, 703-708 (1999).
-
(1999)
Nature
, vol.401
, pp. 703-708
-
-
Graef, I.A.1
Mermelstein, P.G.2
Stankunas, K.3
Neilson, J.R.4
Deisseroth, K.5
Tsien, R.W.6
Crabtree, G.R.7
-
24
-
-
3242727456
-
Nfat is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching
-
K. J. McCullagh, E. Calabria, G. Pallafacchina, S. Ciciliot, A. L. Serrano, C. Argentini, J. M. Kalhovde, T. Lømo, S. Schiaffino, NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching. Proc. Natl. Acad. Sci. U.S.A. 101, 10590-10595 (2004).
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 10590-10595
-
-
McCullagh, K.J.1
Calabria, E.2
Pallafacchina, G.3
Ciciliot, S.4
Serrano, A.L.5
Argentini, C.6
Kalhovde, J.M.7
Lømo, T.8
Schiaffino, S.9
-
25
-
-
0032529188
-
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
-
E. R. Chin, E. N. Olson, J. A. Richardson, Q. Yang, C. Humphries, J. M. Shelton, H. Wu, W. Zhu, R. Bassel-Duby, R. S. Williams, A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 12, 2499-2509 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 2499-2509
-
-
Chin, E.R.1
Olson, E.N.2
Richardson, J.A.3
Yang, Q.4
Humphries, C.5
Shelton, J.M.6
Wu, H.7
Zhu, W.R.8
Williams, R.S.9
-
26
-
-
0034681315
-
Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo
-
F. J. Naya, B. Mercer, J. Shelton, J. A. Richardson, R. S. Williams, E. N. Olson, Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. J. Biol. Chem. 275, 4545-4548 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 4545-4548
-
-
Naya, F.J.1
Mercer, B.2
Shelton, J.3
Richardson, J.A.4
Williams, R.S.5
Olson, E.N.6
-
27
-
-
0035818491
-
Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth
-
A. L. Serrano, M. Murgia, G. Pallafacchina, E. Calabria, P. Coniglio, T. Lømo, S. Schiaffino, Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. Proc. Natl. Acad. Sci. U.S.A. 98, 13108-13113 (2001).
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 13108-13113
-
-
Serrano, A.L.1
Murgia, M.2
Pallafacchina, G.3
Calabria, E.4
Coniglio, P.5
Lømo, T.6
Schiaffino, S.7
-
28
-
-
0034624137
-
Independent signals control expression of the calcineurin inhibitory proteins mcip1 and mcip2 in striated muscles
-
J. Yang, B. Rothermel, R. B. Vega, N. Frey, T. A. McKinsey, E. N. Olson, R. Bassel-Duby, R. S. Williams, Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ. Res. 87, E61-E68 (2000).
-
(2000)
Circ. Res.
, vol.87
-
-
Yang, J.1
Rothermel, B.2
Vega, R.B.3
Frey, N.4
McKinsey, T.A.5
Olson, E.N.R.6
Williams, R.S.7
-
29
-
-
0034234963
-
A conserved family of calcineurin regulators
-
T. J. Kingsbury, K. W. Cunningham, A conserved family of calcineurin regulators. Genes Dev. 14, 1595-1604 (2000).
-
(2000)
Genes Dev
, vol.14
, pp. 1595-1604
-
-
Kingsbury, T.J.1
Cunningham, K.W.2
-
30
-
-
0035853110
-
Myocyte-enriched calcineurin-interacting protein, mcip1, inhibits cardiac hypertrophy in vivo
-
B. A. Rothermel, T. A. McKinsey, R. B. Vega, R. L. Nicol, P. Mammen, J. Yang, C. L. Antos, J. M. Shelton, R. Bassel-Duby, E. N. Olson, R. S. Williams, Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci.U.S.A. 98, 3328-3333 (2001).
-
(2001)
Proc. Natl. Acad. Sci.U.S.A.
, vol.98
, pp. 3328-3333
-
-
Rothermel, B.A.1
McKinsey, T.A.2
Vega, R.B.3
Nicol, R.L.4
Mammen, P.5
Yang, J.6
Antos, C.L.7
Shelton, J.M.R.8
Olson, E.N.9
Williams, R.S.10
-
31
-
-
33646171446
-
Nfat dysregulation by increased dosage of dscr1 and dyrk1a on chromosome 21
-
J. R. Arron, M. M. Winslow, A. Polleri, C.-P. Chang, H. Wu, X. Gao, J. R. Neilson, L. Chen, J. J. Heit, S. K. Kim, N. Yamasaki, T. Miyakawa, U. Francke, I. A. Graef, G. R. Crabtree, NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006).
-
(2006)
Nature
, vol.441
, pp. 595-600
-
-
Arron, J.R.1
Winslow, M.M.2
Polleri, A.3
Chang, C.-P.4
Wu, H.5
Gao, X.6
Neilson, J.R.7
Chen, L.8
Heit, J.J.9
Kim, S.K.10
Yamasaki, N.11
Miyakawa, T.12
Francke, U.13
Graef, I.A.14
Crabtree, G.R.15
-
32
-
-
0029851762
-
Rapid shuttling of nf-At in discrimination of ca2 signals and immunosuppression
-
L. A. Timmerman, N. A. Clipstone, S. N. Ho, J. P. Northrop, G. R. Crabtree, Rapid shuttling of NF-AT in discrimination of Ca2 signals and immunosuppression. Nature 383, 837-840 (1996).
-
(1996)
Nature
, vol.383
, pp. 837-840
-
-
Timmerman, L.A.1
Clipstone, N.A.2
Ho, S.N.3
Northrop, J.P.4
Crabtree, G.R.5
-
33
-
-
0030890234
-
Nuclear export of nf-Atc enhanced by glycogen synthase kinase-3
-
C. R. Beals, C. M. Sheridan, C. W. Turck, P. Gardner, G. R. Crabtree, Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1934 (1997).
-
(1997)
Science
, vol.275
, pp. 1930-1934
-
-
Beals, C.R.1
Sheridan, C.M.2
Turck, C.W.3
Gardner, P.4
Crabtree, G.R.5
-
34
-
-
33646559053
-
A genome-wide drosophila rnai screen identifies dyrk-family kinases as regulators of nfat
-
Y. Gwack, S. Sharma, J. Nardone, B. Tanasa, A. Iuga, S. Srikanth, H. Okamura, D. Bolton, S. Feske, P. G. Hogan, A. Rao, A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441, 646-650 (2006).
-
(2006)
Nature
, vol.441
, pp. 646-650
-
-
Gwack, Y.1
Sharma, S.2
Nardone, J.3
Tanasa, B.4
Iuga, A.5
Srikanth, S.6
Okamura, H.7
Bolton, D.8
Feske, S.9
Hogan, P.G.10
Rao, A.11
|