Single exposure gamma-irradiation amplifies xanthine oxidase activity and induces endothelial dysfunction in rat aorta

Radiation and Environmental Biophysics

Volumn 46, Issue 2, 2007, Pages 179-186

  Soucy, Kevin G ^a   Lim, Hyun Kyo ^a,b   Benjo, Alexandre ^a   Santhanam, Lakshmi ^a   Ryoo, Sungwoo ^a   Shoukas, Artin A ^a   Vazquez, Marcelo E ^c   Berkowitz, Dan E ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC INFLAMMATION; ENDOTHELIAL DYSFUNCTIONS; MOLECULAR MECHANISMS; XANTHINE OXIDASE ACTIVITY;

BIOLOGICAL ORGANS; CARDIOLOGY; DISEASES; OXIDATIVE STRESS; RISK ANALYSIS; SPECTRUM ANALYSIS;

GAMMA RAYS;

ACETYLCHOLINE; OXIPURINOL; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; AORTA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYMPTOM; CARDIOVASCULAR SYSTEM; CHRONIC INFLAMMATION; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; GAMMA IRRADIATION; HEART INFARCTION; IN VIVO STUDY; ISCHEMIC HEART DISEASE; MALE; NONHUMAN; OXIDATIVE STRESS; PULSE WAVE; RADIATION INJURY; RAT; UPREGULATION;

ANIMALS; AORTA; ELASTICITY; ENDOTHELIUM, VASCULAR; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; GAMMA RAYS; RADIATION DOSAGE; RATS; RATS, SPRAGUE-DAWLEY; WHOLE-BODY IRRADIATION; XANTHINE OXIDASE;

RATTUS;

EID: 34248185485     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-006-0090-z     Document Type: Conference Paper

References (27)

1. Hancock SL, Tucker MA, Hoppe RT (1993) Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA 270:1949-1955
2. Stewart JR, Fajardo LF (1971) Radiation-induced heart disease. Clinical and experimental aspects. Radiol Clin North Am 9:511-531
3. Hauptmann M, Mohan AK, Doody MM, Linet MS, Mabuchi K (2003) Mortality from diseases of the circulatory system in radiologic technologists in the United States. Am J Epidemiol 157:239-248
4. Ivanov VK, Gorski AI, Maksioutov MA, Tsyb AF, Souchkevitch GN (2001) Mortality among the Chernobyl emergency workers: estimation of radiation risks (preliminary analysis). Health Phys 81:514-521
5. McGale P, Darby SC (2005) Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res 163:247-257
6. Denham JW, Hauer-Jensen M (2002) The radiotherapeutic injury: a complex "wound". Radiother Oncol 63:129-145
7. Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408:239-247
8. Stamler JS, Singel DJ, Loscalzo J (1992) Biochemistry of nitric oxide and its redox-activated forms. Science 258:1898-1902
9. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84:9265-9269
10. Vallance P, Chan N (2001) Endothelial function and nitric oxide: clinical relevance. Heart 85:342-350
11. 2+-sensitizing property of xanthine oxidase inhibitors. Circ Res 83:423-430
12. Wilkinson IB, Franklin SS, Cockcroft JR (2004) Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension 44:112-116
13. Benderitter M, Maingon P, Abadie C, Assem M, Maupoil V, Briot F, Horiot JC, Rochette L (1995) Effect of in vivo heart irradiation on the development of antioxidant defenses and cardiac functions in the rat. Radiat Res 144:64-72
14. Lauk S, Kiszel Z, Buschmann J, Trott KR (1985) Radiation-induced heart disease in rats. Int J Radiat Oncol Biol Phys 11:801-808
15. Soloviev AI, Tishkin SM, Zelensky SN, Ivanova IV, Kizub IV, Pavlova AA, Moreland RS (2005) Ionizing radiation alters myofilament calcium sensitivity in vascular smooth muscle: potential role of protein kinase C. Am J Physiol Regul Integr Comp Physiol 289:R755-R762
16. Levesque L, Lam MH, Allaire P, Mondat M, Houle S, Beaudoin G, Donath D, Leclerc G (2001) Effects of radiation therapy on vascular responsiveness. J Cardiovasc Pharmacol 37:381-393
17. Mitsuoka W, Egashira S, Tagawa H, Kuga T, Hayashi Y, Yamada A, Tomoike H, Nakamura M, Takeshita A (1995) Augmentation of coronary responsiveness to serotonin at the site of X-ray-induced intimal thickening in miniature pigs. Cardiovasc Res 30:246-254
18. Najjar SS, Scuteri A, Lakatta EG (2005) Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 46:454-462
19. van Popele NM, Grobbee DE, Bots ML, Asmar R, Topouchian J, Reneman RS, Hoeks AP, van der Kuip DA, Hofman A, Witteman JC (2001) Association between arterial stiffness and atherosclerosis: the Rotterdam study. Stroke 32:454-460
20. Jadhav UM, Kadam NN (2005) Non-invasive assessment of arterial stiffness by pulse-wave velocity correlates with endothelial dysfunction. Ind Heart J 57:226-232
21. Kameyama H, Takeda K, Kusaba T, Narumiya H, Tanda S, Kuwahara N, Yamada K, Tamagaki K, Okigaki M, Hatta T, Sasaki S (2005) Augmentation of pulse wave velocity precedes vascular structural changes of the aorta in rats treated with N(omega)-nitro-L-arginine methyl ester. Hypertens Res 28:439-445
22. McNally JS, Davis ME, Giddens DP, Saha A, Hwang J, Dikalov S, Jo H, Harrison DG (2003) Vascular signaling by free radicals: role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol 285:H2290-H2297
23. Srivastava M, Kale RK (2000) Radiomodification of xanthine oxidoreductase system in the liver of mice by phenylmethylsulfonyl fluoride and dithiothreitol. Radiat Res 154:94-103
24. Srivastava M, Chandra D, Kale RK (2002) Modulation of radiation-induced changes in the xanthine oxidoreductase system in the livers of mice by its inhibitors. Radiat Res 157:290-297
25. Munzel T, Daiber A, Ullrich V, Mulsch A (2005) Vascular consequences of endothelial nitric oxide synthase uncoupling for the activity and expression of the soluble guanylyl cyclase and the cGMP-dependent protein kinase. Arterioscler Thromb Vasc Biol 25:1551-1557
26. Qiu W, Kass DA, Hu Q, Ziegelstein RC (2001) Determinants of shear stress-stimulated endothelial nitric oxide production assessed in real-time by 4,5-diaminofluorescein fluorescence. Biochem Biophys Res Commun 286:328-335
27. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, Mitch WE, Harrison DG (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111:1201-1209