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Volumn 3, Issue 6, 2009, Pages 705-716

Advances in molecular imaging for the diagnosis of dementia

Author keywords

Acetylcholine; Alzheimer's disease; Amyloid protein; Dementia; Imaging; Molecular imaging; Near infrared; Positron emission tomography; Prion; Single photon emission computed tomography; Tau

Indexed keywords

2 [1 [6 (2 FLUOROETHYLMETHYLAMINO) 2 NAPHTHYL]ETHYLIDENE]MALONONITRILE F 18; 2 [2 (2 DIMETHYLAMINOTHIAZOL 5 YL)ETHENYL] 6 [2 (FLUORO)ETHOXY]BENZOXAZOLE C 11; 4 (N METHYLAMINO) 4' [2 [2 (2 FLUOROETHOXY)ETHOXY]ETHOXY]STILBENE F 18; 4 N METHYLAMINO 4' HYDROXYSTILBENE C 11; ALPHA SYNUCLEIN; AMYLOID; BAY 94 9172; BF 227; CARBON 11; FLUORINE 18; N METHYL 2 (4' METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE C 11; PRION PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 77951810268     PISSN: 17530059     EISSN: 17530067     Source Type: Journal    
DOI: 10.1517/17530050903133790     Document Type: Review
Times cited : (18)

References (100)
  • 1
    • 0030874251 scopus 로고    scopus 로고
    • Metabolic reduction in the posterior cingulate cortex in very early AD
    • Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early AD. Ann Neurol 1997;42:85-94
    • (1997) Ann Neurol , vol.42 , pp. 85-94
    • Minoshima, S.1    Giordani, B.2    Berent, S.3
  • 2
    • 34547727201 scopus 로고    scopus 로고
    • Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT
    • Matsuda H. Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT. J Nucl Med 2007;48:1289-1300
    • (2007) J Nucl Med , vol.48 , pp. 1289-1300
    • Matsuda, H.1
  • 3
    • 0036152419 scopus 로고    scopus 로고
    • Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease
    • Herholz K, Schopphoff H, Schmidt M, et al. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J Nucl Med 2002;43:21-26
    • (2002) J Nucl Med , vol.43 , pp. 21-26
    • Herholz, K.1    Schopphoff, H.2    Schmidt, M.3
  • 4
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein e
    • Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996;334:752-758
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3
  • 5
    • 0035824167 scopus 로고    scopus 로고
    • Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
    • Silverman DH, Small GW, Chang CY, et al. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA 2001;286:2120-2127
    • (2001) JAMA , vol.286 , pp. 2120-2127
    • Silverman, D.H.1    Small, G.W.2    Chang, C.Y.3
  • 6
    • 0006164301 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
    • McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124
    • (1996) Neurology , vol.47 , pp. 1113-1124
    • McKeith, I.G.1    Galasko, D.2    Kosaka, K.3
  • 7
    • 9144224226 scopus 로고    scopus 로고
    • International psychogeriatric association expert meeting on DLB: Dementia with Lewy bodies
    • McKeith I, Mintzer J, Aarsland D, et al. International psychogeriatric association expert meeting on DLB: Dementia with Lewy bodies. Lancet Neurol 2004;3:19-28
    • (2004) Lancet Neurol , vol.3 , pp. 19-28
    • McKeith, I.1    Mintzer, J.2    Aarsland, D.3
  • 8
    • 0030970869 scopus 로고    scopus 로고
    • Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease
    • Donnemiller E, Heilmann J, Wenning GK, et al. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. Eur J Nucl Med 1997;24:320-325
    • (1997) Eur J Nucl Med , vol.24 , pp. 320-325
    • Donnemiller, E.1    Heilmann, J.2    Wenning, G.K.3
  • 9
    • 33750510034 scopus 로고    scopus 로고
    • Differentiation of dementia with Lewy bodies from Alzheimer's disease using mini-mental state examination and brain perfusion SPECT
    • Hanyu H, Shimizu S, Hirao K, et al. Differentiation of dementia with Lewy bodies from Alzheimer's disease using mini-mental state examination and brain perfusion SPECT. J Neurol Sci 2006;250:97-102
    • (2006) J Neurol Sci , vol.250 , pp. 97-102
    • Hanyu, H.1    Shimizu, S.2    Hirao, K.3
  • 10
    • 40449083016 scopus 로고    scopus 로고
    • Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    • Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med 2008;49:390-398
    • (2008) J Nucl Med , vol.49 , pp. 390-398
    • Mosconi, L.1    Tsui, W.H.2    Herholz, K.3
  • 11
    • 34848814460 scopus 로고    scopus 로고
    • FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
    • Foster NL, Heidebrink JL, Clark CM, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain 2007;130:2616-2635
    • (2007) Brain , vol.130 , pp. 2616-2635
    • Foster, N.L.1    Heidebrink, J.L.2    Clark, C.M.3
  • 12
    • 33744494881 scopus 로고    scopus 로고
    • Brain receptor imaging
    • Heiss WD, Herholz K. Brain receptor imaging. J Nucl Med 2006;47:302-312
    • (2006) J Nucl Med , vol.47 , pp. 302-312
    • Heiss, W.D.1    Herholz, K.2
  • 13
    • 38149071577 scopus 로고    scopus 로고
    • Current and future uses of neuroimaging for cognitively impaired patients
    • Small GW, Bookheimer SY, Thompson PM, et al. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol 2008;7:161-172
    • (2008) Lancet Neurol , vol.7 , pp. 161-172
    • Small, G.W.1    Bookheimer, S.Y.2    Thompson, P.M.3
  • 14
    • 34447102399 scopus 로고    scopus 로고
    • Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders
    • Bohnen NI, Frey KA. Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders. Mol Imaging Biol 2007;9:243-257
    • (2007) Mol Imaging Biol , vol.9 , pp. 243-257
    • Bohnen, N.I.1    Frey, K.A.2
  • 15
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • Whitehouse PJ, Price DL, Clark AW, et al. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981;10:122-126
    • (1981) Ann Neurol , vol.10 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3
  • 16
    • 0022616905 scopus 로고
    • Distribution of the molecular forms of acetylcholinesterase in human brain: Alterations in dementia of the Alzheimer type
    • Fishman EB, Siek GC, MacCallum RD, et al. Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type. Ann Neurol 1986;19:246-252
    • (1986) Ann Neurol , vol.19 , pp. 246-252
    • Fishman, E.B.1    Siek, G.C.2    MacCallum, R.D.3
  • 17
    • 0018078940 scopus 로고
    • Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile. dementia
    • Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile. dementia BMJ 1978;25:1457-1459
    • (1978) BMJ , vol.25 , pp. 1457-1459
    • Perry, E.K.1    Tomlinson, B.E.2    Blessed, G.3
  • 18
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;30:408-414
    • (1982) Science , vol.30 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3
  • 20
    • 0030061557 scopus 로고    scopus 로고
    • In vivo studies of acetylcholinesterase activity using a labeled substrate, n-[C-11]methylpiperdin-4-yl propionate ([C-11]PMP)
    • Kilbourn MR, Snyder SE, Sherman PS, et al. In vivo studies of acetylcholinesterase activity using a labeled substrate, n-[C-11]methylpiperdin- 4-yl propionate ([C-11]PMP). Synapse 1996;22:123-131
    • (1996) Synapse , vol.22 , pp. 123-131
    • Kilbourn, M.R.1    Snyder, S.E.2    Sherman, P.S.3
  • 21
    • 0030910311 scopus 로고    scopus 로고
    • Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease
    • Iyo M, Namba H, Fukushi K, et al. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet 1997;349:1805-1809
    • (1997) Lancet , vol.349 , pp. 1805-1809
    • Iyo, M.1    Namba, H.2    Fukushi, K.3
  • 22
    • 0033541026 scopus 로고    scopus 로고
    • In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease
    • Kuhl DE, Koeppe RA, Minoshima S, et al. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology 1999;52:691-699
    • (1999) Neurology , vol.52 , pp. 691-699
    • Kuhl, D.E.1    Koeppe, R.A.2    Minoshima, S.3
  • 23
    • 68249119247 scopus 로고    scopus 로고
    • Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
    • doi:10.1212/WNL.0b013e3181ab2b58
    • Shimada H, Hirano S, Shinotoh H, et al. Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Neurology 2009:doi:10.1212/WNL.0b013e3181ab2b58
    • (2009) Neurology
    • Shimada, H.1    Hirano, S.2    Shinotoh, H.3
  • 24
    • 0036016027 scopus 로고    scopus 로고
    • Research and development of donepezil hydrochloride,a new type of acetylcholinesterase inhibitor
    • Sugimoto H, Ogura H, Arai Y, et al. Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor.Jpn J Pharmacol 2002;89:7-20
    • (2002) Jpn J Pharmacol , vol.89 , pp. 7-20
    • Sugimoto, H.1    Ogura, H.2    Arai, Y.3
  • 25
    • 40549089277 scopus 로고    scopus 로고
    • In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease
    • Okamura N, Funaki Y, Tashiro M, et al. In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease. Br J Clin Pharmacol 2008;65:472-479
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 472-479
    • Okamura, N.1    Funaki, Y.2    Tashiro, M.3
  • 26
    • 0035852825 scopus 로고    scopus 로고
    • Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET
    • Shinotoh H, Aotsuka A, Fukushi K, et al. Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Neurology 2001;56:408-410
    • (2001) Neurology , vol.56 , pp. 408-410
    • Shinotoh, H.1    Aotsuka, A.2    Fukushi, K.3
  • 28
    • 20244389167 scopus 로고
    • Nicotine receptors in the brain of patients with Alzheimer's disease
    • Studies with 11C-nicotine and positron emission tomography
    • Nordberg A, Hartvig P, Lilja A, et al. Nicotine receptors in the brain of patients with Alzheimer's disease. Studies with 11C-nicotine and positron emission tomography. Acta Radiol Suppl 1991;376:165-166
    • (1991) Acta Radiol Suppl , vol.376 , pp. 165-166
    • Nordberg, A.1    Hartvig, P.2    Lilja, A.3
  • 29
    • 33749863936 scopus 로고    scopus 로고
    • The quest for Eldorado: Development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain
    • Horti AG, Villemagne VL. The quest for Eldorado: development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain. Curr Pharm Des 2006;12:3877-3900
    • (2006) Curr Pharm des , vol.12 , pp. 3877-3900
    • Horti, A.G.1    Villemagne, V.L.2
  • 30
    • 48549104780 scopus 로고    scopus 로고
    • Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: A 2-[18F]fluoro-A-85380 PET study
    • Ellis JR, Villemagne VL, Nathan PJ, et al. Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study. Neurobiol Learn Mem 2008;90:404-412
    • (2008) Neurobiol Learn Mem , vol.90 , pp. 404-412
    • Ellis, J.R.1    Villemagne, V.L.2    Nathan, P.J.3
  • 31
    • 27744583479 scopus 로고    scopus 로고
    • On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease
    • Koch HJ, Haas S, Jurgens T. On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease. Curr Med Chem 2005;12:2915-2921
    • (2005) Curr Med Chem , vol.12 , pp. 2915-2921
    • Koch, H.J.1    Haas, S.2    Jurgens, T.3
  • 32
    • 34548362105 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
    • Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 2007;6:721-733
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 721-733
    • Wess, J.1    Eglen, R.M.2    Gautam, D.3
  • 33
    • 33749858854 scopus 로고    scopus 로고
    • Imaging of muscarinic receptors in the central nervous system
    • Eckelman WC. Imaging of muscarinic receptors in the central nervous system. Curr Pharm Des 2006;12:3901-3913
    • (2006) Curr Pharm des , vol.12 , pp. 3901-3913
    • Eckelman, W.C.1
  • 34
    • 0030970869 scopus 로고    scopus 로고
    • Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer type and diffuse Lewy body disease
    • Donnemiller E, Heilmann J, Wenning GK, et al. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer type and diffuse Lewy body disease. Eur J Nucl Med 1997;24:320-325
    • (1997) Eur J Nucl Med , vol.24 , pp. 320-325
    • Donnemiller, E.1    Heilmann, J.2    Wenning, G.K.3
  • 35
    • 2942538455 scopus 로고    scopus 로고
    • Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
    • O'Brien JT, Colloby S, Fenwick J, et al. Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. Arch Neurol 2004;61:919-925
    • (2004) Arch Neurol , vol.61 , pp. 919-925
    • O'Brien, J.T.1    Colloby, S.2    Fenwick, J.3
  • 36
    • 0034727533 scopus 로고    scopus 로고
    • 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies
    • Hu XS, Okamura N, Arai H, et al. 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology 2000;55:1575-1577
    • (2000) Neurology , vol.55 , pp. 1575-1577
    • Hu, X.S.1    Okamura, N.2    Arai, H.3
  • 37
    • 41149120583 scopus 로고    scopus 로고
    • Imaging of the dopaminergic system in differential diagnosis of dementia
    • Tatsch K. Imaging of the dopaminergic system in differential diagnosis of dementia. Eur J Nucl Med Mol Imaging 2008;35(Suppl 1):S51-7
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , Issue.SUPPL. 1
    • Tatsch, K.1
  • 38
    • 0034987727 scopus 로고    scopus 로고
    • Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: Comparison with Alzheimer's disease
    • Watanabe H, Ieda T, Katayama T, et al. Cardiac 123I-meta- iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease. J Neurol Neurosurg Psychiatry 2001;70:781-783
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 781-783
    • Watanabe, H.1    Ieda, T.2    Katayama, T.3
  • 39
    • 33745918625 scopus 로고    scopus 로고
    • Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD
    • Yoshita M, Taki J, Yokoyama K, et al. Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology 2006;66:1850-1854
    • (2006) Neurology , vol.66 , pp. 1850-1854
    • Yoshita, M.1    Taki, J.2    Yokoyama, K.3
  • 40
    • 33846205518 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: From pathology to imaging
    • Venneti S, Lopresti BJ, Wiley CA. The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol 2006;80:308-322
    • (2006) Prog Neurobiol , vol.80 , pp. 308-322
    • Venneti, S.1    Lopresti, B.J.2    Wiley, C.A.3
  • 41
    • 0035845283 scopus 로고    scopus 로고
    • In-vivo measurement of activated microglia in dementia
    • Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet 2001;358:461-467
    • (2001) Lancet , vol.358 , pp. 461-467
    • Cagnin, A.1    Brooks, D.J.2    Kennedy, A.M.3
  • 42
    • 56349144614 scopus 로고    scopus 로고
    • Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
    • Edison P, Archer HA, Gerhard A, et al. Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis 2008;32:412-419
    • (2008) Neurobiol Dis , vol.32 , pp. 412-419
    • Edison, P.1    Archer, H.A.2    Gerhard, A.3
  • 43
    • 63849193695 scopus 로고    scopus 로고
    • Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
    • Okello A, Edison P, Archer HA, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009;72:56-62
    • (2009) Neurology , vol.72 , pp. 56-62
    • Okello, A.1    Edison, P.2    Archer, H.A.3
  • 44
    • 58449115240 scopus 로고    scopus 로고
    • Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    • Wiley CA, Lopresti BJ, Venneti S, et al. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 2009;66:60-67
    • (2009) Arch Neurol , vol.66 , pp. 60-67
    • Wiley, C.A.1    Lopresti, B.J.2    Venneti, S.3
  • 45
    • 59649098348 scopus 로고    scopus 로고
    • PET imaging of the peripheral benzodiazepine receptor: Monitoring disease progression and therapy response in neurodegenerative disorders
    • Doorduin J, de Vries EF, Dierckx RA, et al. PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des 2008;14:3297-3315
    • (2008) Curr Pharm des , vol.14 , pp. 3297-3315
    • Doorduin, J.1    De Vries, E.F.2    Dierckx, R.A.3
  • 46
    • 0033991035 scopus 로고    scopus 로고
    • The cause of neuronal degeneration in Alzheimer's disease
    • Vickers JC, Dickson TC, Adlard PA, et al. The cause of neuronal degeneration in Alzheimer's disease. Prog Neurobiol 2000;60:139-165
    • (2000) Prog Neurobiol , vol.60 , pp. 139-165
    • Vickers, J.C.1    Dickson, T.C.2    Adlard, P.A.3
  • 47
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 48
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease
    • Price JL, Morris JC. Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease. Ann Neurol 1999;45:358-368
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 49
    • 33750603844 scopus 로고    scopus 로고
    • Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
    • Masters CL, Beyreuther K. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. Brain 2006;129:2823-2839
    • (2006) Brain , vol.129 , pp. 2823-2839
    • Masters, C.L.1    Beyreuther, K.2
  • 50
    • 33750920107 scopus 로고    scopus 로고
    • La Lunga Attesa: Towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease
    • Villemagne VL, Ng S, Cappai R, et al. La Lunga Attesa: towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease. Neuroradiol J 2006;19:51-75
    • (2006) Neuroradiol J , vol.19 , pp. 51-75
    • Villemagne, V.L.1    Ng, S.2    Cappai, R.3
  • 51
    • 0029083059 scopus 로고
    • Chrysamine-G binding to Alzheimer and control brain: Autopsy study of a new amyloid probe
    • Klunk WE, Debnath ML, Pettegrew JW. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging 1995;16:541-548
    • (1995) Neurobiol Aging , vol.16 , pp. 541-548
    • Klunk, W.E.1    Debnath, M.L.2    Pettegrew, J.W.3
  • 52
    • 0034691124 scopus 로고    scopus 로고
    • In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
    • Skovronsky DM, Zhang B, Kung MP, et al. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.Proc Natl Acad Sci USA 2000;97:7609-7614
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7609-7614
    • Skovronsky, D.M.1    Zhang, B.2    Kung, M.P.3
  • 53
    • 0035821603 scopus 로고    scopus 로고
    • Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates
    • Zhuang ZP, Kung MP, Hou C, et al. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 2001;44:1905-1914
    • (2001) J Med Chem , vol.44 , pp. 1905-1914
    • Zhuang, Z.P.1    Kung, M.P.2    Hou, C.3
  • 54
    • 0035109444 scopus 로고    scopus 로고
    • Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
    • Link CD, Johnson CJ, Fonte V, et al. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 2001;22:217-226
    • (2001) Neurobiol Aging , vol.22 , pp. 217-226
    • Link, C.D.1    Johnson, C.J.2    Fonte, V.3
  • 55
    • 0036707494 scopus 로고    scopus 로고
    • Imaging Aß plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    • Klunk WE, Bacskai BJ, Mathis CA, et al. Imaging Aß plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropath Exp Neurol 2002;61:797-805
    • (2002) J Neuropath Exp Neurol , vol.61 , pp. 797-805
    • Klunk, W.E.1    Bacskai, B.J.2    Mathis, C.A.3
  • 56
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2- naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
    • Agdeppa ED, Kepe V, Liu J, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 2001;21:RC189
    • (2001) J Neurosci , vol.21
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3
  • 57
    • 38549142362 scopus 로고    scopus 로고
    • Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment
    • Barrio JR, Kepe V, Satyamurthy N, et al. Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment. J Nutr Health Aging 2008;12:61S-5S
    • (2008) J Nutr Health Aging , vol.12
    • Barrio, J.R.1    Kepe, V.2    Satyamurthy, N.3
  • 58
    • 33845707784 scopus 로고    scopus 로고
    • PET of brain amyloid and tau in mild cognitive impairment
    • Small GW, Kepe V, Ercoli LM, et al. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med 2006;355:2652-6359.
    • (2006) N Engl J Med , vol.355 , pp. 2652-6359
    • Small, G.W.1    Kepe, V.2    Ercoli, L.M.3
  • 59
    • 59249092659 scopus 로고    scopus 로고
    • Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    • Tolboom N, Yaqub M, van der Flier WM, et al. Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET. J Nucl Med 2009;50:191-197
    • (2009) J Nucl Med , vol.50 , pp. 191-197
    • Tolboom, N.1    Yaqub, M.2    Van Der Flier, W.M.3
  • 60
    • 53049093702 scopus 로고    scopus 로고
    • Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease
    • Shin J, Lee SY, Kim SH, et al. Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease. Neuroimage 2008;43:236-244
    • (2008) Neuroimage , vol.43 , pp. 236-244
    • Shin, J.1    Lee, S.Y.2    Kim, S.H.3
  • 61
    • 0037444535 scopus 로고    scopus 로고
    • The binding of 2-(4?-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    • Klunk WE, Wang Y, Huang GF, et al. The binding of 2-(4?- methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 2003;23:2086-2092
    • (2003) J Neurosci , vol.23 , pp. 2086-2092
    • Klunk, W.E.1    Wang, Y.2    Huang, G.F.3
  • 62
    • 0038792263 scopus 로고    scopus 로고
    • Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    • Mathis CA, Wang Y, Holt DP, et al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003;46:2740-2754
    • (2003) J Med Chem , vol.46 , pp. 2740-2754
    • Mathis, C.A.1    Wang, Y.2    Holt, D.P.3
  • 63
    • 34848885454 scopus 로고    scopus 로고
    • PIB is a non-specific imaging marker of amyloid-beta (A?) peptide-related cerebral amyloidosis
    • Lockhart A, Lamb JR, Osredkar T, et al. PIB is a non-specific imaging marker of amyloid-beta (A?) peptide-related cerebral amyloidosis. Brain 2007;130:2607-2615
    • (2007) Brain , vol.130 , pp. 2607-2615
    • Lockhart, A.1    Lamb, J.R.2    Osredkar, T.3
  • 64
    • 35348821915 scopus 로고    scopus 로고
    • Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    • Maeda J, Ji B, Irie T, et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci 2007;27:10957-10968
    • (2007) J Neurosci , vol.27 , pp. 10957-10968
    • Maeda, J.1    Ji, B.2    Irie, T.3
  • 65
    • 0034710784 scopus 로고    scopus 로고
    • Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain
    • Harigaya Y, Saido TC, Eckman CB, et al. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochem Biophys Res Commun 2000;276:422-427
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 422-427
    • Harigaya, Y.1    Saido, T.C.2    Eckman, C.B.3
  • 66
    • 34848864297 scopus 로고    scopus 로고
    • In vitro characterization of Pittsburgh compound-B binding to Lewy bodies
    • Fodero-Tavoletti MT, Smith DP, et al. In vitro characterization of Pittsburgh compound-B binding to Lewy bodies. J Neurosci 2007;27:10365-10371
    • (2007) J Neurosci , vol.27 , pp. 10365-10371
    • Fodero-Tavoletti, M.T.1    Smith, D.P.2
  • 67
    • 27544513056 scopus 로고    scopus 로고
    • Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    • Price JC, Klunk WE, Lopresti BJ, et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005;25:1528-1547
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1528-1547
    • Price, J.C.1    Klunk, W.E.2    Lopresti, B.J.3
  • 68
    • 33644876596 scopus 로고    scopus 로고
    • Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: A comparative analysis
    • Lopresti BJ, Klunk WE, Mathis CA, et al. Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med 2005;46:1959-1972
    • (2005) J Nucl Med , vol.46 , pp. 1959-1972
    • Lopresti, B.J.1    Klunk, W.E.2    Mathis, C.A.3
  • 69
    • 62449341361 scopus 로고    scopus 로고
    • Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements
    • McNamee RL, Yee SH, Price JC, et al. Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements. J Nucl Med 2009;50:348-355
    • (2009) J Nucl Med , vol.50 , pp. 348-355
    • McNamee, R.L.1    Yee, S.H.2    Price, J.C.3
  • 70
    • 0033757865 scopus 로고    scopus 로고
    • Importance of partial-volume correction in brain PET studies
    • Fazio F, Perani D. Importance of partial-volume correction in brain PET studies. J Nucl Med 2000;41:1849-1850
    • (2000) J Nucl Med , vol.41 , pp. 1849-1850
    • Fazio, F.1    Perani, D.2
  • 71
    • 66649137729 scopus 로고    scopus 로고
    • Comparison of 18F-FDG and PiB PET in cognitive impairment
    • Lowe J, Kemp BJ, Jack CR Jr, et al. Comparison of 18F-FDG and PiB PET in cognitive impairment. J Nucl Med 2009;50:878-886
    • (2009) J Nucl Med , vol.50 , pp. 878-886
    • Lowe, J.1    Kemp, B.J.2    Jr J.Cr3
  • 72
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004;55:306-319
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 73
    • 34248579291 scopus 로고    scopus 로고
    • Imaging beta-amyloid burden in aging and dementia
    • Rowe CC, Ng S, Ackermann U, et al. Imaging beta-amyloid burden in aging and dementia. Neurology 2007;68:1718-1725
    • (2007) Neurology , vol.68 , pp. 1718-1725
    • Rowe, C.C.1    Ng, S.2    Ackermann, U.3
  • 74
    • 33947198109 scopus 로고    scopus 로고
    • Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report
    • Bacskai BJ, Frosch MP, Freeman SH, et al. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007;64:431-434
    • (2007) Arch Neurol , vol.64 , pp. 431-434
    • Bacskai, B.J.1    Frosch, M.P.2    Freeman, S.H.3
  • 75
    • 43849083580 scopus 로고    scopus 로고
    • Post-mortem correlates of in vivo PIB-PET amyloid imaging in a typical case of Alzheimer's disease
    • Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PIB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008;131:1630-1645
    • (2008) Brain , vol.131 , pp. 1630-1645
    • Ikonomovic, M.D.1    Klunk, W.E.2    Abrahamson, E.E.3
  • 76
    • 54049120245 scopus 로고    scopus 로고
    • Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B
    • Leinonen V, Alafuzoff I, Aalto S, et al. Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol 2008;65:1304-1309
    • (2008) Arch Neurol , vol.65 , pp. 1304-1309
    • Leinonen, V.1    Alafuzoff, I.2    Aalto, S.3
  • 77
    • 54049100454 scopus 로고    scopus 로고
    • Imaging amyloid deposition in Lewy body diseases
    • Gomperts SN, Rentz DM, Moran E, et al. Imaging amyloid deposition in Lewy body diseases. Neurology 2008;71:903-910
    • (2008) Neurology , vol.71 , pp. 903-910
    • Gomperts, S.N.1    Rentz, D.M.2    Moran, E.3
  • 78
    • 34948819200 scopus 로고    scopus 로고
    • Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    • Johnson KA, Gregas M, Becker JA, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007;62:229-234
    • (2007) Ann Neurol , vol.62 , pp. 229-234
    • Johnson, K.A.1    Gregas, M.2    Becker, J.A.3
  • 79
    • 33745700402 scopus 로고    scopus 로고
    • Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study
    • Archer HA, Edison P, Brooks DJ, et al. Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol 2006;60:145-147
    • (2006) Ann Neurol , vol.60 , pp. 145-147
    • Archer, H.A.1    Edison, P.2    Brooks, D.J.3
  • 80
    • 33644832047 scopus 로고    scopus 로고
    • Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans
    • Fagan AM, Mintun MA, Mach RH, et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans. Ann Neurol 2006;59:512-519
    • (2006) Ann Neurol , vol.59 , pp. 512-519
    • Fagan, A.M.1    Mintun, M.A.2    MacH, R.H.3
  • 81
    • 23944444806 scopus 로고    scopus 로고
    • Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
    • Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005;25:7709-7717
    • (2005) J Neurosci , vol.25 , pp. 7709-7717
    • Buckner, R.L.1    Snyder, A.Z.2    Shannon, B.J.3
  • 82
    • 34547780019 scopus 로고    scopus 로고
    • Abeta amyloid deposition in the language system and how the brain responds
    • Nelissen N, Vandenbulcke M, Fannes K, et al. Abeta amyloid deposition in the language system and how the brain responds. Brain 2007;130:2055-2069
    • (2007) Brain , vol.130 , pp. 2055-2069
    • Nelissen, N.1    Vandenbulcke, M.2    Fannes, K.3
  • 83
    • 33747048954 scopus 로고    scopus 로고
    • [11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
    • Mintun MA, Larossa GN, Sheline YI, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006;67:446-452
    • (2006) Neurology , vol.67 , pp. 446-452
    • Mintun, M.A.1    Larossa, G.N.2    Sheline, Y.I.3
  • 84
    • 43849084404 scopus 로고    scopus 로고
    • Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease
    • Villemagne VL, Pike KE, Darby D, et al. Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia 2008;46:1688-1697
    • (2008) Neuropsychologia , vol.46 , pp. 1688-1697
    • Villemagne, V.L.1    Pike, K.E.2    Darby, D.3
  • 85
    • 54249117138 scopus 로고    scopus 로고
    • Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
    • Fripp J, Bourgeat P, Acosta O, et al. Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging. Neuroimage 2008;43:430-439
    • (2008) Neuroimage , vol.43 , pp. 430-439
    • Fripp, J.1    Bourgeat, P.2    Acosta, O.3
  • 86
    • 49349092320 scopus 로고    scopus 로고
    • PET imaging of amyloid deposition in patients with mild cognitive impairment
    • Forsberg A, Engler H, Almkvist O, et al. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging 2008;29:1456-1465
    • (2008) Neurobiol Aging , vol.29 , pp. 1456-1465
    • Forsberg, A.1    Engler, H.2    Almkvist, O.3
  • 87
    • 39749108812 scopus 로고    scopus 로고
    • 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
    • Jack CR Jr, Lowe VJ, Senjem ML, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008;131:665-680
    • (2008) Brain , vol.131 , pp. 665-680
    • Jack Jr, C.R.1    Lowe, V.J.2    Senjem, M.L.3
  • 88
    • 33749506795 scopus 로고    scopus 로고
    • Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    • Engler H, Forsberg A, Almkvist O, et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 2006;129:2856-2866
    • (2006) Brain , vol.129 , pp. 2856-2866
    • Engler, H.1    Forsberg, A.2    Almkvist, O.3
  • 89
    • 33847062118 scopus 로고    scopus 로고
    • Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study
    • Edison P, Archer HA, Hinz R, et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 2007;68:501-508
    • (2007) Neurology , vol.68 , pp. 501-508
    • Edison, P.1    Archer, H.A.2    Hinz, R.3
  • 90
    • 66549106850 scopus 로고    scopus 로고
    • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease
    • Jack CR Jr, Lowe VJ, Weigand SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009;132:1355-1365
    • (2009) Brain , vol.132 , pp. 1355-1365
    • Jack Jr, C.R.1    Lowe, V.J.2    Weigand, S.D.3
  • 91
    • 0037448350 scopus 로고    scopus 로고
    • Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting ?-amyloid plaques in the brain
    • Zhuang ZP, Kung MP, Wilson A, et al. Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting ?-amyloid plaques in the brain. J Med Chem 2003;46:237-243
    • (2003) J Med Chem , Issue.46 , pp. 237-243
    • Zhuang, Z.P.1    Kung, M.P.2    Wilson, A.3
  • 92
    • 0142075238 scopus 로고    scopus 로고
    • 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease
    • Ono M, Wilson A, Nobrega J, et al. 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease. Nucl Med Biol 2003;30:565-571
    • (2003) Nucl Med Biol , vol.30 , pp. 565-571
    • Ono, M.1    Wilson, A.2    Nobrega, J.3
  • 93
    • 15944366880 scopus 로고    scopus 로고
    • In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
    • Verhoeff NP, Wilson AA, Takeshita S, et al. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am J Geriatr Psychiatry 2004;12:584-595
    • (2004) Am J Geriatr Psychiatry , vol.12 , pp. 584-595
    • Verhoeff, N.P.1    Wilson, A.A.2    Takeshita, S.3
  • 95
    • 34248579112 scopus 로고    scopus 로고
    • 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
    • Kudo Y, Okamura N, Furumoto S, et al. 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients. J Nucl Med 2007;48:553-561
    • (2007) J Nucl Med , vol.48 , pp. 553-561
    • Kudo, Y.1    Okamura, N.2    Furumoto, S.3
  • 96
    • 38149081191 scopus 로고    scopus 로고
    • Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
    • Rowe CC, Ackerman U, Browne W, et al. Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008;7:129-135
    • (2008) Lancet Neurol , vol.7 , pp. 129-135
    • Rowe, C.C.1    Ackerman, U.2    Browne, W.3
  • 97
    • 28044460038 scopus 로고    scopus 로고
    • Quinoline and benzimidazole derivatives: Candidate probes for in vivo imaging of tau pathology in Alzheimer's disease
    • Okamura N, Suemoto T, Furumoto S, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci 2005;25:10857-10862
    • (2005) J Neurosci , vol.25 , pp. 10857-10862
    • Okamura, N.1    Suemoto, T.2    Furumoto, S.3
  • 98
    • 34547590133 scopus 로고    scopus 로고
    • Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease
    • Boxer AL, Rabinovici GD, Kepe V, et al. Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease. Neurology 2007;69:283-290
    • (2007) Neurology , vol.69 , pp. 283-290
    • Boxer, A.L.1    Rabinovici, G.D.2    Kepe, V.3
  • 99
    • 69449086022 scopus 로고    scopus 로고
    • 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease
    • doi:10.1136/jnnp.2008.171496
    • Villemagne VL, McLean CA, Reardon K, et al. 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 2009: doi:10.1136/jnnp.2008.171496
    • (2009) J Neurol Neurosurg Psychiatry
    • Villemagne, V.L.1    McLean, C.A.2    Reardon, K.3
  • 100
    • 22144433066 scopus 로고    scopus 로고
    • In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe
    • Hintersteiner M, Enz A, Frey P, et al. In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nat Biotechnol 2005;23:577-583
    • (2005) Nat Biotechnol , vol.23 , pp. 577-583
    • Hintersteiner, M.1    Enz, A.2    Frey, P.3


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