-
1
-
-
0030874251
-
Metabolic reduction in the posterior cingulate cortex in very early AD
-
Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early AD. Ann Neurol 1997;42:85-94
-
(1997)
Ann Neurol
, vol.42
, pp. 85-94
-
-
Minoshima, S.1
Giordani, B.2
Berent, S.3
-
2
-
-
34547727201
-
Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT
-
Matsuda H. Role of neuroimaging in Alzheimer's disease, with emphasis on brain perfusion SPECT. J Nucl Med 2007;48:1289-1300
-
(2007)
J Nucl Med
, vol.48
, pp. 1289-1300
-
-
Matsuda, H.1
-
3
-
-
0036152419
-
Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease
-
Herholz K, Schopphoff H, Schmidt M, et al. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J Nucl Med 2002;43:21-26
-
(2002)
J Nucl Med
, vol.43
, pp. 21-26
-
-
Herholz, K.1
Schopphoff, H.2
Schmidt, M.3
-
4
-
-
0029970342
-
Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein e
-
Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996;334:752-758
-
(1996)
N Engl J Med
, vol.334
, pp. 752-758
-
-
Reiman, E.M.1
Caselli, R.J.2
Yun, L.S.3
-
5
-
-
0035824167
-
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome
-
Silverman DH, Small GW, Chang CY, et al. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA 2001;286:2120-2127
-
(2001)
JAMA
, vol.286
, pp. 2120-2127
-
-
Silverman, D.H.1
Small, G.W.2
Chang, C.Y.3
-
6
-
-
0006164301
-
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
-
McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124
-
(1996)
Neurology
, vol.47
, pp. 1113-1124
-
-
McKeith, I.G.1
Galasko, D.2
Kosaka, K.3
-
7
-
-
9144224226
-
International psychogeriatric association expert meeting on DLB: Dementia with Lewy bodies
-
McKeith I, Mintzer J, Aarsland D, et al. International psychogeriatric association expert meeting on DLB: Dementia with Lewy bodies. Lancet Neurol 2004;3:19-28
-
(2004)
Lancet Neurol
, vol.3
, pp. 19-28
-
-
McKeith, I.1
Mintzer, J.2
Aarsland, D.3
-
8
-
-
0030970869
-
Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease
-
Donnemiller E, Heilmann J, Wenning GK, et al. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer-type and diffuse Lewy body disease. Eur J Nucl Med 1997;24:320-325
-
(1997)
Eur J Nucl Med
, vol.24
, pp. 320-325
-
-
Donnemiller, E.1
Heilmann, J.2
Wenning, G.K.3
-
9
-
-
33750510034
-
Differentiation of dementia with Lewy bodies from Alzheimer's disease using mini-mental state examination and brain perfusion SPECT
-
Hanyu H, Shimizu S, Hirao K, et al. Differentiation of dementia with Lewy bodies from Alzheimer's disease using mini-mental state examination and brain perfusion SPECT. J Neurol Sci 2006;250:97-102
-
(2006)
J Neurol Sci
, vol.250
, pp. 97-102
-
-
Hanyu, H.1
Shimizu, S.2
Hirao, K.3
-
10
-
-
40449083016
-
Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
-
Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med 2008;49:390-398
-
(2008)
J Nucl Med
, vol.49
, pp. 390-398
-
-
Mosconi, L.1
Tsui, W.H.2
Herholz, K.3
-
11
-
-
34848814460
-
FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease
-
Foster NL, Heidebrink JL, Clark CM, et al. FDG-PET improves accuracy in distinguishing frontotemporal dementia and Alzheimer's disease. Brain 2007;130:2616-2635
-
(2007)
Brain
, vol.130
, pp. 2616-2635
-
-
Foster, N.L.1
Heidebrink, J.L.2
Clark, C.M.3
-
12
-
-
33744494881
-
Brain receptor imaging
-
Heiss WD, Herholz K. Brain receptor imaging. J Nucl Med 2006;47:302-312
-
(2006)
J Nucl Med
, vol.47
, pp. 302-312
-
-
Heiss, W.D.1
Herholz, K.2
-
13
-
-
38149071577
-
Current and future uses of neuroimaging for cognitively impaired patients
-
Small GW, Bookheimer SY, Thompson PM, et al. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol 2008;7:161-172
-
(2008)
Lancet Neurol
, vol.7
, pp. 161-172
-
-
Small, G.W.1
Bookheimer, S.Y.2
Thompson, P.M.3
-
14
-
-
34447102399
-
Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders
-
Bohnen NI, Frey KA. Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders. Mol Imaging Biol 2007;9:243-257
-
(2007)
Mol Imaging Biol
, vol.9
, pp. 243-257
-
-
Bohnen, N.I.1
Frey, K.A.2
-
15
-
-
0019410162
-
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
-
Whitehouse PJ, Price DL, Clark AW, et al. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 1981;10:122-126
-
(1981)
Ann Neurol
, vol.10
, pp. 122-126
-
-
Whitehouse, P.J.1
Price, D.L.2
Clark, A.W.3
-
16
-
-
0022616905
-
Distribution of the molecular forms of acetylcholinesterase in human brain: Alterations in dementia of the Alzheimer type
-
Fishman EB, Siek GC, MacCallum RD, et al. Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type. Ann Neurol 1986;19:246-252
-
(1986)
Ann Neurol
, vol.19
, pp. 246-252
-
-
Fishman, E.B.1
Siek, G.C.2
MacCallum, R.D.3
-
17
-
-
0018078940
-
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile. dementia
-
Perry EK, Tomlinson BE, Blessed G, et al. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile. dementia BMJ 1978;25:1457-1459
-
(1978)
BMJ
, vol.25
, pp. 1457-1459
-
-
Perry, E.K.1
Tomlinson, B.E.2
Blessed, G.3
-
18
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Bartus RT, Dean RL, Beer B, et al. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982;30:408-414
-
(1982)
Science
, vol.30
, pp. 408-414
-
-
Bartus, R.T.1
Dean, R.L.2
Beer, B.3
-
20
-
-
0030061557
-
In vivo studies of acetylcholinesterase activity using a labeled substrate, n-[C-11]methylpiperdin-4-yl propionate ([C-11]PMP)
-
Kilbourn MR, Snyder SE, Sherman PS, et al. In vivo studies of acetylcholinesterase activity using a labeled substrate, n-[C-11]methylpiperdin- 4-yl propionate ([C-11]PMP). Synapse 1996;22:123-131
-
(1996)
Synapse
, vol.22
, pp. 123-131
-
-
Kilbourn, M.R.1
Snyder, S.E.2
Sherman, P.S.3
-
21
-
-
0030910311
-
Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease
-
Iyo M, Namba H, Fukushi K, et al. Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease. Lancet 1997;349:1805-1809
-
(1997)
Lancet
, vol.349
, pp. 1805-1809
-
-
Iyo, M.1
Namba, H.2
Fukushi, K.3
-
22
-
-
0033541026
-
In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease
-
Kuhl DE, Koeppe RA, Minoshima S, et al. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology 1999;52:691-699
-
(1999)
Neurology
, vol.52
, pp. 691-699
-
-
Kuhl, D.E.1
Koeppe, R.A.2
Minoshima, S.3
-
23
-
-
68249119247
-
Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET
-
doi:10.1212/WNL.0b013e3181ab2b58
-
Shimada H, Hirano S, Shinotoh H, et al. Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. Neurology 2009:doi:10.1212/WNL.0b013e3181ab2b58
-
(2009)
Neurology
-
-
Shimada, H.1
Hirano, S.2
Shinotoh, H.3
-
24
-
-
0036016027
-
Research and development of donepezil hydrochloride,a new type of acetylcholinesterase inhibitor
-
Sugimoto H, Ogura H, Arai Y, et al. Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor.Jpn J Pharmacol 2002;89:7-20
-
(2002)
Jpn J Pharmacol
, vol.89
, pp. 7-20
-
-
Sugimoto, H.1
Ogura, H.2
Arai, Y.3
-
25
-
-
40549089277
-
In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease
-
Okamura N, Funaki Y, Tashiro M, et al. In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease. Br J Clin Pharmacol 2008;65:472-479
-
(2008)
Br J Clin Pharmacol
, vol.65
, pp. 472-479
-
-
Okamura, N.1
Funaki, Y.2
Tashiro, M.3
-
26
-
-
0035852825
-
Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET
-
Shinotoh H, Aotsuka A, Fukushi K, et al. Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Neurology 2001;56:408-410
-
(2001)
Neurology
, vol.56
, pp. 408-410
-
-
Shinotoh, H.1
Aotsuka, A.2
Fukushi, K.3
-
28
-
-
20244389167
-
Nicotine receptors in the brain of patients with Alzheimer's disease
-
Studies with 11C-nicotine and positron emission tomography
-
Nordberg A, Hartvig P, Lilja A, et al. Nicotine receptors in the brain of patients with Alzheimer's disease. Studies with 11C-nicotine and positron emission tomography. Acta Radiol Suppl 1991;376:165-166
-
(1991)
Acta Radiol Suppl
, vol.376
, pp. 165-166
-
-
Nordberg, A.1
Hartvig, P.2
Lilja, A.3
-
29
-
-
33749863936
-
The quest for Eldorado: Development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain
-
Horti AG, Villemagne VL. The quest for Eldorado: development of radioligands for in vivo imaging of nicotinic acetylcholine receptors in human brain. Curr Pharm Des 2006;12:3877-3900
-
(2006)
Curr Pharm des
, vol.12
, pp. 3877-3900
-
-
Horti, A.G.1
Villemagne, V.L.2
-
30
-
-
48549104780
-
Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: A 2-[18F]fluoro-A-85380 PET study
-
Ellis JR, Villemagne VL, Nathan PJ, et al. Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: a 2-[18F]fluoro-A-85380 PET study. Neurobiol Learn Mem 2008;90:404-412
-
(2008)
Neurobiol Learn Mem
, vol.90
, pp. 404-412
-
-
Ellis, J.R.1
Villemagne, V.L.2
Nathan, P.J.3
-
31
-
-
27744583479
-
On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease
-
Koch HJ, Haas S, Jurgens T. On the physiological relevance of muscarinic acetylcholine receptors in Alzheimer's disease. Curr Med Chem 2005;12:2915-2921
-
(2005)
Curr Med Chem
, vol.12
, pp. 2915-2921
-
-
Koch, H.J.1
Haas, S.2
Jurgens, T.3
-
32
-
-
34548362105
-
Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development
-
Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov 2007;6:721-733
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 721-733
-
-
Wess, J.1
Eglen, R.M.2
Gautam, D.3
-
33
-
-
33749858854
-
Imaging of muscarinic receptors in the central nervous system
-
Eckelman WC. Imaging of muscarinic receptors in the central nervous system. Curr Pharm Des 2006;12:3901-3913
-
(2006)
Curr Pharm des
, vol.12
, pp. 3901-3913
-
-
Eckelman, W.C.1
-
34
-
-
0030970869
-
Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer type and diffuse Lewy body disease
-
Donnemiller E, Heilmann J, Wenning GK, et al. Brain perfusion scintigraphy with 99mTc-HMPAO or 99mTc-ECD and 123I-beta-CIT single-photon emission tomography in dementia of the Alzheimer type and diffuse Lewy body disease. Eur J Nucl Med 1997;24:320-325
-
(1997)
Eur J Nucl Med
, vol.24
, pp. 320-325
-
-
Donnemiller, E.1
Heilmann, J.2
Wenning, G.K.3
-
35
-
-
2942538455
-
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies
-
O'Brien JT, Colloby S, Fenwick J, et al. Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. Arch Neurol 2004;61:919-925
-
(2004)
Arch Neurol
, vol.61
, pp. 919-925
-
-
O'Brien, J.T.1
Colloby, S.2
Fenwick, J.3
-
36
-
-
0034727533
-
18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies
-
Hu XS, Okamura N, Arai H, et al. 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology 2000;55:1575-1577
-
(2000)
Neurology
, vol.55
, pp. 1575-1577
-
-
Hu, X.S.1
Okamura, N.2
Arai, H.3
-
37
-
-
41149120583
-
Imaging of the dopaminergic system in differential diagnosis of dementia
-
Tatsch K. Imaging of the dopaminergic system in differential diagnosis of dementia. Eur J Nucl Med Mol Imaging 2008;35(Suppl 1):S51-7
-
(2008)
Eur J Nucl Med Mol Imaging
, vol.35
, Issue.SUPPL. 1
-
-
Tatsch, K.1
-
38
-
-
0034987727
-
Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: Comparison with Alzheimer's disease
-
Watanabe H, Ieda T, Katayama T, et al. Cardiac 123I-meta- iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease. J Neurol Neurosurg Psychiatry 2001;70:781-783
-
(2001)
J Neurol Neurosurg Psychiatry
, vol.70
, pp. 781-783
-
-
Watanabe, H.1
Ieda, T.2
Katayama, T.3
-
39
-
-
33745918625
-
Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD
-
Yoshita M, Taki J, Yokoyama K, et al. Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Neurology 2006;66:1850-1854
-
(2006)
Neurology
, vol.66
, pp. 1850-1854
-
-
Yoshita, M.1
Taki, J.2
Yokoyama, K.3
-
40
-
-
33846205518
-
The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: From pathology to imaging
-
Venneti S, Lopresti BJ, Wiley CA. The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol 2006;80:308-322
-
(2006)
Prog Neurobiol
, vol.80
, pp. 308-322
-
-
Venneti, S.1
Lopresti, B.J.2
Wiley, C.A.3
-
41
-
-
0035845283
-
In-vivo measurement of activated microglia in dementia
-
Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet 2001;358:461-467
-
(2001)
Lancet
, vol.358
, pp. 461-467
-
-
Cagnin, A.1
Brooks, D.J.2
Kennedy, A.M.3
-
42
-
-
56349144614
-
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
-
Edison P, Archer HA, Gerhard A, et al. Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol Dis 2008;32:412-419
-
(2008)
Neurobiol Dis
, vol.32
, pp. 412-419
-
-
Edison, P.1
Archer, H.A.2
Gerhard, A.3
-
43
-
-
63849193695
-
Microglial activation and amyloid deposition in mild cognitive impairment: A PET study
-
Okello A, Edison P, Archer HA, et al. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009;72:56-62
-
(2009)
Neurology
, vol.72
, pp. 56-62
-
-
Okello, A.1
Edison, P.2
Archer, H.A.3
-
44
-
-
58449115240
-
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
-
Wiley CA, Lopresti BJ, Venneti S, et al. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 2009;66:60-67
-
(2009)
Arch Neurol
, vol.66
, pp. 60-67
-
-
Wiley, C.A.1
Lopresti, B.J.2
Venneti, S.3
-
45
-
-
59649098348
-
PET imaging of the peripheral benzodiazepine receptor: Monitoring disease progression and therapy response in neurodegenerative disorders
-
Doorduin J, de Vries EF, Dierckx RA, et al. PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des 2008;14:3297-3315
-
(2008)
Curr Pharm des
, vol.14
, pp. 3297-3315
-
-
Doorduin, J.1
De Vries, E.F.2
Dierckx, R.A.3
-
46
-
-
0033991035
-
The cause of neuronal degeneration in Alzheimer's disease
-
Vickers JC, Dickson TC, Adlard PA, et al. The cause of neuronal degeneration in Alzheimer's disease. Prog Neurobiol 2000;60:139-165
-
(2000)
Prog Neurobiol
, vol.60
, pp. 139-165
-
-
Vickers, J.C.1
Dickson, T.C.2
Adlard, P.A.3
-
47
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
48
-
-
0032989712
-
Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease
-
Price JL, Morris JC. Tangles and plaques in nondemented aging and 'preclinical' Alzheimer's disease. Ann Neurol 1999;45:358-368
-
(1999)
Ann Neurol
, vol.45
, pp. 358-368
-
-
Price, J.L.1
Morris, J.C.2
-
49
-
-
33750603844
-
Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
-
Masters CL, Beyreuther K. Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway. Brain 2006;129:2823-2839
-
(2006)
Brain
, vol.129
, pp. 2823-2839
-
-
Masters, C.L.1
Beyreuther, K.2
-
50
-
-
33750920107
-
La Lunga Attesa: Towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease
-
Villemagne VL, Ng S, Cappai R, et al. La Lunga Attesa: towards a molecular approach to neuroimaging and therapeutics in Alzheimer's disease. Neuroradiol J 2006;19:51-75
-
(2006)
Neuroradiol J
, vol.19
, pp. 51-75
-
-
Villemagne, V.L.1
Ng, S.2
Cappai, R.3
-
51
-
-
0029083059
-
Chrysamine-G binding to Alzheimer and control brain: Autopsy study of a new amyloid probe
-
Klunk WE, Debnath ML, Pettegrew JW. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging 1995;16:541-548
-
(1995)
Neurobiol Aging
, vol.16
, pp. 541-548
-
-
Klunk, W.E.1
Debnath, M.L.2
Pettegrew, J.W.3
-
52
-
-
0034691124
-
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
-
Skovronsky DM, Zhang B, Kung MP, et al. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.Proc Natl Acad Sci USA 2000;97:7609-7614
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7609-7614
-
-
Skovronsky, D.M.1
Zhang, B.2
Kung, M.P.3
-
53
-
-
0035821603
-
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates
-
Zhuang ZP, Kung MP, Hou C, et al. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 2001;44:1905-1914
-
(2001)
J Med Chem
, vol.44
, pp. 1905-1914
-
-
Zhuang, Z.P.1
Kung, M.P.2
Hou, C.3
-
54
-
-
0035109444
-
Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
-
Link CD, Johnson CJ, Fonte V, et al. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 2001;22:217-226
-
(2001)
Neurobiol Aging
, vol.22
, pp. 217-226
-
-
Link, C.D.1
Johnson, C.J.2
Fonte, V.3
-
55
-
-
0036707494
-
Imaging Aß plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
-
Klunk WE, Bacskai BJ, Mathis CA, et al. Imaging Aß plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropath Exp Neurol 2002;61:797-805
-
(2002)
J Neuropath Exp Neurol
, vol.61
, pp. 797-805
-
-
Klunk, W.E.1
Bacskai, B.J.2
Mathis, C.A.3
-
56
-
-
0035893245
-
Binding characteristics of radiofluorinated 6-dialkylamino-2- naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
-
Agdeppa ED, Kepe V, Liu J, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 2001;21:RC189
-
(2001)
J Neurosci
, vol.21
-
-
Agdeppa, E.D.1
Kepe, V.2
Liu, J.3
-
57
-
-
38549142362
-
Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment
-
Barrio JR, Kepe V, Satyamurthy N, et al. Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment. J Nutr Health Aging 2008;12:61S-5S
-
(2008)
J Nutr Health Aging
, vol.12
-
-
Barrio, J.R.1
Kepe, V.2
Satyamurthy, N.3
-
58
-
-
33845707784
-
PET of brain amyloid and tau in mild cognitive impairment
-
Small GW, Kepe V, Ercoli LM, et al. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med 2006;355:2652-6359.
-
(2006)
N Engl J Med
, vol.355
, pp. 2652-6359
-
-
Small, G.W.1
Kepe, V.2
Ercoli, L.M.3
-
59
-
-
59249092659
-
Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
-
Tolboom N, Yaqub M, van der Flier WM, et al. Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET. J Nucl Med 2009;50:191-197
-
(2009)
J Nucl Med
, vol.50
, pp. 191-197
-
-
Tolboom, N.1
Yaqub, M.2
Van Der Flier, W.M.3
-
60
-
-
53049093702
-
Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease
-
Shin J, Lee SY, Kim SH, et al. Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease. Neuroimage 2008;43:236-244
-
(2008)
Neuroimage
, vol.43
, pp. 236-244
-
-
Shin, J.1
Lee, S.Y.2
Kim, S.H.3
-
61
-
-
0037444535
-
The binding of 2-(4?-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
-
Klunk WE, Wang Y, Huang GF, et al. The binding of 2-(4?- methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 2003;23:2086-2092
-
(2003)
J Neurosci
, vol.23
, pp. 2086-2092
-
-
Klunk, W.E.1
Wang, Y.2
Huang, G.F.3
-
62
-
-
0038792263
-
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
-
Mathis CA, Wang Y, Holt DP, et al. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J Med Chem 2003;46:2740-2754
-
(2003)
J Med Chem
, vol.46
, pp. 2740-2754
-
-
Mathis, C.A.1
Wang, Y.2
Holt, D.P.3
-
63
-
-
34848885454
-
PIB is a non-specific imaging marker of amyloid-beta (A?) peptide-related cerebral amyloidosis
-
Lockhart A, Lamb JR, Osredkar T, et al. PIB is a non-specific imaging marker of amyloid-beta (A?) peptide-related cerebral amyloidosis. Brain 2007;130:2607-2615
-
(2007)
Brain
, vol.130
, pp. 2607-2615
-
-
Lockhart, A.1
Lamb, J.R.2
Osredkar, T.3
-
64
-
-
35348821915
-
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
-
Maeda J, Ji B, Irie T, et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci 2007;27:10957-10968
-
(2007)
J Neurosci
, vol.27
, pp. 10957-10968
-
-
Maeda, J.1
Ji, B.2
Irie, T.3
-
65
-
-
0034710784
-
Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain
-
Harigaya Y, Saido TC, Eckman CB, et al. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochem Biophys Res Commun 2000;276:422-427
-
(2000)
Biochem Biophys Res Commun
, vol.276
, pp. 422-427
-
-
Harigaya, Y.1
Saido, T.C.2
Eckman, C.B.3
-
66
-
-
34848864297
-
In vitro characterization of Pittsburgh compound-B binding to Lewy bodies
-
Fodero-Tavoletti MT, Smith DP, et al. In vitro characterization of Pittsburgh compound-B binding to Lewy bodies. J Neurosci 2007;27:10365-10371
-
(2007)
J Neurosci
, vol.27
, pp. 10365-10371
-
-
Fodero-Tavoletti, M.T.1
Smith, D.P.2
-
67
-
-
27544513056
-
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
-
Price JC, Klunk WE, Lopresti BJ, et al. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005;25:1528-1547
-
(2005)
J Cereb Blood Flow Metab
, vol.25
, pp. 1528-1547
-
-
Price, J.C.1
Klunk, W.E.2
Lopresti, B.J.3
-
68
-
-
33644876596
-
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: A comparative analysis
-
Lopresti BJ, Klunk WE, Mathis CA, et al. Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med 2005;46:1959-1972
-
(2005)
J Nucl Med
, vol.46
, pp. 1959-1972
-
-
Lopresti, B.J.1
Klunk, W.E.2
Mathis, C.A.3
-
69
-
-
62449341361
-
Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements
-
McNamee RL, Yee SH, Price JC, et al. Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements. J Nucl Med 2009;50:348-355
-
(2009)
J Nucl Med
, vol.50
, pp. 348-355
-
-
McNamee, R.L.1
Yee, S.H.2
Price, J.C.3
-
70
-
-
0033757865
-
Importance of partial-volume correction in brain PET studies
-
Fazio F, Perani D. Importance of partial-volume correction in brain PET studies. J Nucl Med 2000;41:1849-1850
-
(2000)
J Nucl Med
, vol.41
, pp. 1849-1850
-
-
Fazio, F.1
Perani, D.2
-
71
-
-
66649137729
-
Comparison of 18F-FDG and PiB PET in cognitive impairment
-
Lowe J, Kemp BJ, Jack CR Jr, et al. Comparison of 18F-FDG and PiB PET in cognitive impairment. J Nucl Med 2009;50:878-886
-
(2009)
J Nucl Med
, vol.50
, pp. 878-886
-
-
Lowe, J.1
Kemp, B.J.2
Jr J.Cr3
-
72
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
-
Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004;55:306-319
-
(2004)
Ann Neurol
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
-
73
-
-
34248579291
-
Imaging beta-amyloid burden in aging and dementia
-
Rowe CC, Ng S, Ackermann U, et al. Imaging beta-amyloid burden in aging and dementia. Neurology 2007;68:1718-1725
-
(2007)
Neurology
, vol.68
, pp. 1718-1725
-
-
Rowe, C.C.1
Ng, S.2
Ackermann, U.3
-
74
-
-
33947198109
-
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: A case report
-
Bacskai BJ, Frosch MP, Freeman SH, et al. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007;64:431-434
-
(2007)
Arch Neurol
, vol.64
, pp. 431-434
-
-
Bacskai, B.J.1
Frosch, M.P.2
Freeman, S.H.3
-
75
-
-
43849083580
-
Post-mortem correlates of in vivo PIB-PET amyloid imaging in a typical case of Alzheimer's disease
-
Ikonomovic MD, Klunk WE, Abrahamson EE, et al. Post-mortem correlates of in vivo PIB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008;131:1630-1645
-
(2008)
Brain
, vol.131
, pp. 1630-1645
-
-
Ikonomovic, M.D.1
Klunk, W.E.2
Abrahamson, E.E.3
-
76
-
-
54049120245
-
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B
-
Leinonen V, Alafuzoff I, Aalto S, et al. Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol 2008;65:1304-1309
-
(2008)
Arch Neurol
, vol.65
, pp. 1304-1309
-
-
Leinonen, V.1
Alafuzoff, I.2
Aalto, S.3
-
77
-
-
54049100454
-
Imaging amyloid deposition in Lewy body diseases
-
Gomperts SN, Rentz DM, Moran E, et al. Imaging amyloid deposition in Lewy body diseases. Neurology 2008;71:903-910
-
(2008)
Neurology
, vol.71
, pp. 903-910
-
-
Gomperts, S.N.1
Rentz, D.M.2
Moran, E.3
-
78
-
-
34948819200
-
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
-
Johnson KA, Gregas M, Becker JA, et al. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007;62:229-234
-
(2007)
Ann Neurol
, vol.62
, pp. 229-234
-
-
Johnson, K.A.1
Gregas, M.2
Becker, J.A.3
-
79
-
-
33745700402
-
Amyloid load and cerebral atrophy in Alzheimer's disease: An 11C-PIB positron emission tomography study
-
Archer HA, Edison P, Brooks DJ, et al. Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study. Ann Neurol 2006;60:145-147
-
(2006)
Ann Neurol
, vol.60
, pp. 145-147
-
-
Archer, H.A.1
Edison, P.2
Brooks, D.J.3
-
80
-
-
33644832047
-
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans
-
Fagan AM, Mintun MA, Mach RH, et al. Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta(42) in humans. Ann Neurol 2006;59:512-519
-
(2006)
Ann Neurol
, vol.59
, pp. 512-519
-
-
Fagan, A.M.1
Mintun, M.A.2
MacH, R.H.3
-
81
-
-
23944444806
-
Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
-
Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005;25:7709-7717
-
(2005)
J Neurosci
, vol.25
, pp. 7709-7717
-
-
Buckner, R.L.1
Snyder, A.Z.2
Shannon, B.J.3
-
82
-
-
34547780019
-
Abeta amyloid deposition in the language system and how the brain responds
-
Nelissen N, Vandenbulcke M, Fannes K, et al. Abeta amyloid deposition in the language system and how the brain responds. Brain 2007;130:2055-2069
-
(2007)
Brain
, vol.130
, pp. 2055-2069
-
-
Nelissen, N.1
Vandenbulcke, M.2
Fannes, K.3
-
83
-
-
33747048954
-
[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
-
Mintun MA, Larossa GN, Sheline YI, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006;67:446-452
-
(2006)
Neurology
, vol.67
, pp. 446-452
-
-
Mintun, M.A.1
Larossa, G.N.2
Sheline, Y.I.3
-
84
-
-
43849084404
-
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease
-
Villemagne VL, Pike KE, Darby D, et al. Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia 2008;46:1688-1697
-
(2008)
Neuropsychologia
, vol.46
, pp. 1688-1697
-
-
Villemagne, V.L.1
Pike, K.E.2
Darby, D.3
-
85
-
-
54249117138
-
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
-
Fripp J, Bourgeat P, Acosta O, et al. Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging. Neuroimage 2008;43:430-439
-
(2008)
Neuroimage
, vol.43
, pp. 430-439
-
-
Fripp, J.1
Bourgeat, P.2
Acosta, O.3
-
86
-
-
49349092320
-
PET imaging of amyloid deposition in patients with mild cognitive impairment
-
Forsberg A, Engler H, Almkvist O, et al. PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging 2008;29:1456-1465
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1456-1465
-
-
Forsberg, A.1
Engler, H.2
Almkvist, O.3
-
87
-
-
39749108812
-
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
-
Jack CR Jr, Lowe VJ, Senjem ML, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008;131:665-680
-
(2008)
Brain
, vol.131
, pp. 665-680
-
-
Jack Jr, C.R.1
Lowe, V.J.2
Senjem, M.L.3
-
88
-
-
33749506795
-
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
-
Engler H, Forsberg A, Almkvist O, et al. Two-year follow-up of amyloid deposition in patients with Alzheimer's disease. Brain 2006;129:2856-2866
-
(2006)
Brain
, vol.129
, pp. 2856-2866
-
-
Engler, H.1
Forsberg, A.2
Almkvist, O.3
-
89
-
-
33847062118
-
Amyloid, hypometabolism, and cognition in Alzheimer disease: An [11C]PIB and [18F]FDG PET study
-
Edison P, Archer HA, Hinz R, et al. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology 2007;68:501-508
-
(2007)
Neurology
, vol.68
, pp. 501-508
-
-
Edison, P.1
Archer, H.A.2
Hinz, R.3
-
90
-
-
66549106850
-
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: Implications for sequence of pathological events in Alzheimer's disease
-
Jack CR Jr, Lowe VJ, Weigand SD, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009;132:1355-1365
-
(2009)
Brain
, vol.132
, pp. 1355-1365
-
-
Jack Jr, C.R.1
Lowe, V.J.2
Weigand, S.D.3
-
91
-
-
0037448350
-
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting ?-amyloid plaques in the brain
-
Zhuang ZP, Kung MP, Wilson A, et al. Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting ?-amyloid plaques in the brain. J Med Chem 2003;46:237-243
-
(2003)
J Med Chem
, Issue.46
, pp. 237-243
-
-
Zhuang, Z.P.1
Kung, M.P.2
Wilson, A.3
-
92
-
-
0142075238
-
11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease
-
Ono M, Wilson A, Nobrega J, et al. 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease. Nucl Med Biol 2003;30:565-571
-
(2003)
Nucl Med Biol
, vol.30
, pp. 565-571
-
-
Ono, M.1
Wilson, A.2
Nobrega, J.3
-
93
-
-
15944366880
-
In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET
-
Verhoeff NP, Wilson AA, Takeshita S, et al. In-vivo imaging of Alzheimer disease beta-amyloid with [11C]SB-13 PET. Am J Geriatr Psychiatry 2004;12:584-595
-
(2004)
Am J Geriatr Psychiatry
, vol.12
, pp. 584-595
-
-
Verhoeff, N.P.1
Wilson, A.A.2
Takeshita, S.3
-
94
-
-
12144289490
-
Styrylbenzoxazole Derivatives for In Vivo Imaging Amyloid Plaques in the Brain
-
DOI 10.1523/JNEUROSCI.4456-03.2004
-
Okamura N, Suemoto T, Shimadzu H, et al. Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci 2004;24:2535-2541 (Pubitemid 38327966)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.10
, pp. 2535-2541
-
-
Okamura, N.1
Suemoto, T.2
Shimadzu, H.3
Suzuki, M.4
Shiomitsu, T.5
Akatsu, H.6
Yamamoto, T.7
Staufenbiel, M.8
Yanai, K.9
Arai, H.10
Sasaki, H.11
Kudo, Y.12
Sawada, T.13
-
95
-
-
34248579112
-
2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole: A novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients
-
Kudo Y, Okamura N, Furumoto S, et al. 2-(2-[2-Dimethylaminothiazol-5-yl] ethenyl)-6-(2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients. J Nucl Med 2007;48:553-561
-
(2007)
J Nucl Med
, vol.48
, pp. 553-561
-
-
Kudo, Y.1
Okamura, N.2
Furumoto, S.3
-
96
-
-
38149081191
-
Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: Proof of mechanism
-
Rowe CC, Ackerman U, Browne W, et al. Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol 2008;7:129-135
-
(2008)
Lancet Neurol
, vol.7
, pp. 129-135
-
-
Rowe, C.C.1
Ackerman, U.2
Browne, W.3
-
97
-
-
28044460038
-
Quinoline and benzimidazole derivatives: Candidate probes for in vivo imaging of tau pathology in Alzheimer's disease
-
Okamura N, Suemoto T, Furumoto S, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci 2005;25:10857-10862
-
(2005)
J Neurosci
, vol.25
, pp. 10857-10862
-
-
Okamura, N.1
Suemoto, T.2
Furumoto, S.3
-
98
-
-
34547590133
-
Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease
-
Boxer AL, Rabinovici GD, Kepe V, et al. Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease. Neurology 2007;69:283-290
-
(2007)
Neurology
, vol.69
, pp. 283-290
-
-
Boxer, A.L.1
Rabinovici, G.D.2
Kepe, V.3
-
99
-
-
69449086022
-
11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease
-
doi:10.1136/jnnp.2008.171496
-
Villemagne VL, McLean CA, Reardon K, et al. 11C-PiB PET studies in typical sporadic Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry 2009: doi:10.1136/jnnp.2008.171496
-
(2009)
J Neurol Neurosurg Psychiatry
-
-
Villemagne, V.L.1
McLean, C.A.2
Reardon, K.3
-
100
-
-
22144433066
-
In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe
-
Hintersteiner M, Enz A, Frey P, et al. In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nat Biotechnol 2005;23:577-583
-
(2005)
Nat Biotechnol
, vol.23
, pp. 577-583
-
-
Hintersteiner, M.1
Enz, A.2
Frey, P.3
|