Depletion of Securin Induces Senescence After Irradiation and Enhances Radiosensitivity in Human Cancer Cells Regardless of Functional p53 Expression

International Journal of Radiation Oncology Biology Physics

Volumn 77, Issue 2, 2010, Pages 566-574

  Chen, Wen Shu ^a   Yu, Yi Chu ^a   Lee, Yi Jang ^b   Chen, Ji Hshiung ^a   Hsu, Hsue Yin ^a   Chiu, Shu Jun ^a,c  

^a TZU CHI UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; p53; Radiosensitivity; Securin; Senescence

Indexed keywords

APOPTOSIS; BEST CHOICE; CANCER CELLS; CANCER TREATMENT; CASPASE-3; CELL SURVIVAL; CLONOGENIC ASSAYS; DNA DAMAGES; DNA REPAIR; GALACTOSIDASES; GENE KNOCK DOWN; HAIRPIN RNA; HUMAN CANCER CELLS; INDUCED APOPTOSIS; NEW STRATEGY; RADIATION-INDUCED; RADIATION-INDUCED APOPTOSIS; SECURIN; SMALL INTERFERING RNA; STAINING ASSAYS; SUSTAINED ACTIVATION; TUMOR CELLS; WESTERN-BLOT ANALYSIS; WILD TYPES; WILD-TYPE CELLS;

ASSAYS; CELL DEATH; DNA; GENES; IRRADIATION; NETWORK SECURITY; PHOSPHORYLATION; RADIATION; RADIOTHERAPY; RNA; RUBIDIUM; SOFTWARE ARCHITECTURE; STRATEGIC PLANNING;

NETWORK PROTOCOLS;

BETA GALACTOSIDASE; CASPASE 3; CHECKPOINT KINASE 2; COMPLEMENTARY DNA; HISTONE H2AX; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PLASMID DNA; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SECURIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CELL ACTIVATION; CELL FATE; CELL STRAIN HCT116; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IRRADIATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; WILD TYPE;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL AGING; CELL LINE, TUMOR; COLONY-FORMING UNITS ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA REPAIR; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HISTONES; HUMANS; NEOPLASM PROTEINS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77951788934     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.12.013     Document Type: Article

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