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Volumn 1, Issue 3, 2009, Pages 541-559

Tuning heavy metal compounds for anti-tumor activity: Is diversity the key to rutheniums success?

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; INDAZOLIUM TETRACHLOROBIS(INDAZOLE)RUTHENATE; NONSTEROID ANTIINFLAMMATORY AGENT; OXALIPLATIN; PLATINUM COMPLEX; POLYCYCLIC AROMATIC HYDROCARBON; RUTHENIUM; UNCLASSIFIED DRUG;

EID: 77951519609     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.25     Document Type: Review
Times cited : (19)

References (110)
  • 1
    • 0035301778 scopus 로고    scopus 로고
    • Ruthenium in medicine: Current clinical use and future prospects
    • Allardyce CS, Dyson PJ. Ruthenium in medicine: current clinical use and future prospects. Platinum Metal Rev. 45, 62-69 (2001).
    • (2001) Platinum Metal Rev. , vol.45 , pp. 62-69
    • Allardyce, C.S.1    Dyson, P.J.2
  • 2
    • 43049147578 scopus 로고    scopus 로고
    • New trends for metal complexes with anticancer activity
    • Bruijnincx PCA, Sadler PJ. New trends for metal complexes with anticancer activity. Curr. Opin. Chem. Biol. 12, 197-206 (2008).
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 197-206
    • Bruijnincx, P.C.A.1    Sadler, P.J.2
  • 4
    • 37049053957 scopus 로고
    • Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode
    • Rosenberg B, VanCamp L, Krigas T. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205, 698-699 (1965).
    • (1965) Nature , vol.205 , pp. 698-699
    • Rosenberg, B.1    Vancamp, L.2    Krigas, T.3
  • 5
    • 24644486532 scopus 로고    scopus 로고
    • Current status of platinum-based antitumor drugs
    • Wong E, Giandomenico CM. Current status of platinum-based antitumor drugs. Chem. Rev. 99, 2451-2466 (1999).
    • (1999) Chem. Rev. , vol.99 , pp. 2451-2466
    • Wong, E.1    Giandomenico, C.M.2
  • 6
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat. Rev. Drug Discov. 4, 307-320 (2005).
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 7
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: Mode of cytotoxic action and molecular basis of resistance
    • Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 22, 7265-7779 (2003).
    • (2003) Oncogene , vol.22 , pp. 7265-7779
    • Siddik, Z.H.1
  • 8
    • 0043073120 scopus 로고    scopus 로고
    • New metal complexes as potential therapeutics
    • Zhang CX, Lippard SJ. New metal complexes as potential therapeutics. Curr. Opin. Chem. Biol. 7, 481-489 (2003).
    • (2003) Curr. Opin. Chem. Biol. , vol.7 , pp. 481-489
    • Zhang, C.X.1    Lippard, S.J.2
  • 9
    • 13444306285 scopus 로고    scopus 로고
    • Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance
    • Ang WH, Khalaila I, Allardyce CS, Juillerat-Jeanneret L, Dyson PJ. Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance. J. Am. Chem. Soc. 127, 1382-1383 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 1382-1383
    • Ang, W.H.1    Khalaila, I.2    Allardyce, C.S.3    Juillerat-Jeanneret, L.4    Dyson, P.J.5
  • 10
    • 33645277617 scopus 로고    scopus 로고
    • Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP
    • Schluga P, Hartinger CG, Egger A et al. Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP. Dalton Trans. 1796 - 1802 (2006).
    • (2006) Dalton Trans. , pp. 1796-1802
    • Schluga, P.1    Hartinger, C.G.2    Egger, A.3
  • 11
    • 52449102438 scopus 로고    scopus 로고
    • Oxidation induced by the antioxidant glutathione (GSH)
    • Petzold H, Sadler PJ. Oxidation induced by the antioxidant glutathione (GSH). Chem. Commun. (Camb.) 4413-4415 (2008).
    • (2008) Chem. Commun. (Camb. , pp. 4413-4415
    • Petzold, H.1    Sadler, P.J.2
  • 12
    • 1942522066 scopus 로고    scopus 로고
    • Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes
    • Barnes KR, Kutikov A, Lippard SJ. Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes. Chem. Biol. 11, 557-564 (2004).
    • (2004) Chem. Biol. , vol.11 , pp. 557-564
    • Barnes, K.R.1    Kutikov, A.2    Lippard, S.J.3
  • 14
    • 33645698442 scopus 로고    scopus 로고
    • A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin
    • Mackay FS, Woods JA, Moseley H et al. A photoactivated trans-diammine platinum complex as cytotoxic as cisplatin. Chemistry Eur. J. 12, 3155-3161 (2006).
    • (2006) Chemistry Eur. J. , vol.12 , pp. 3155-3161
    • MacKay, F.S.1    Woods, J.A.2    Moseley, H.3
  • 15
    • 35548953077 scopus 로고    scopus 로고
    • Some uses of transition metal complexes as anti-cancer and anti-HIV agents
    • Sun RWY, Ma DL, Wong ELM, Che CM. Some uses of transition metal complexes as anti-cancer and anti-HIV agents. Dalton Trans. 4884-4892 (2007).
    • (2007) Dalton Trans. , pp. 4884-4892
    • Sun, R.W.Y.1    Ma, D.L.2    Wong, E.L.M.3    Che, C.M.4
  • 19
    • 0016794443 scopus 로고
    • In vivo inhibition of tumorgrowth by ruthenium red - Its relationship with metabolism of calcium in tumor
    • Anghileri LJ. In vivo inhibition of tumorgrowth by ruthenium red - its relationship with metabolism of calcium in tumor. Z. Krebsforsch. Klin. Onkol. Cancer Res. Clin. Oncol. 83, 213-217 (1975).
    • (1975) Z. Krebsforsch. Klin. Onkol. Cancer Res. Clin. Oncol. , vol.83 , pp. 213-217
    • Anghileri, L.J.1
  • 20
    • 0034939348 scopus 로고    scopus 로고
    • Blockade by ruthenium red of tissue factor-initiated coagulation
    • Chu AJ, Wang ZG, Nwobi OI, Beydoun S. Blockade by ruthenium red of tissue factor-initiated coagulation. Br. J. Pharmacol. 133, 659-664 (2001).
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 659-664
    • Chu, A.J.1    Wang, Z.G.2    Nwobi, O.I.3    Beydoun, S.4
  • 22
    • 33646956829 scopus 로고    scopus 로고
    • Non-platinum chemotherapeutic metallopharmaceuticals
    • Clarke MJ, Zhu FC, Frasca DR. Non-platinum chemotherapeutic metallopharmaceuticals. Chem. Rev. 99, 2511-2533 (1999).
    • (1999) Chem. Rev. , vol.99 , pp. 2511-2533
    • Clarke, M.J.1    Zhu, F.C.2    Frasca, D.R.3
  • 23
    • 0018882887 scopus 로고
    • Reduction and subsequent binding of ruthenium ions catalyzed by subcellular components
    • Clarke MJ, Bitler S, Rennert D, Buchbinder M, Kelman AD. Reduction and subsequent binding of ruthenium ions catalyzed by subcellular components. J. Inorg. Biochem. 12, 79-87 (1980).
    • (1980) J. Inorg. Biochem. , vol.12 , pp. 79-87
    • Clarke, M.J.1    Bitler, S.2    Rennert, D.3    Buchbinder, M.4    Kelman, A.D.5
  • 25
    • 0042948708 scopus 로고    scopus 로고
    • Ruthenium metallopharmaceuticals
    • Clarke MJ. Ruthenium metallopharmaceuticals. Coord. Chem. Rev. 236, 209-233 (2003).
    • (2003) Coord. Chem. Rev. , vol.236 , pp. 209-233
    • Clarke, M.J.1
  • 26
    • 37149048416 scopus 로고    scopus 로고
    • Metal-based anticancer drugs: From a past anchored in platinum postgenomic future and biology
    • Hannon MJ. Metal-based anticancer drugs: from a past anchored in platinum postgenomic future and biology. Pure Appl. Chem. 79, 2243-2261 (2007).
    • (2007) Pure Appl. Chem. , vol.79 , pp. 2243-2261
    • Hannon, M.J.1
  • 27
    • 0024442416 scopus 로고
    • Antitumour properties of dimethylsulfoxide ruthenium(II) complexes in the Lewis lung-carcinoma system
    • Sava G, Pacor S, Zorzet S, Alessio E, Mestroni G. Antitumour properties of dimethylsulfoxide ruthenium(II) complexes in the Lewis lung-carcinoma system. Pharmacol. Res. 21, 617-628 (1989).
    • (1989) Pharmacol. Res. , vol.21 , pp. 617-628
    • Sava, G.1    Pacor, S.2    Zorzet, S.3    Alessio, E.4    Mestroni, G.5
  • 28
    • 0024393226 scopus 로고
    • Trans-Ru(II) dimethylsulphoxides - Antineoplastic action on mouse-tumors
    • Sava G, Pacor S, Ceschia V, Alessio E, Mestroni G. Trans-Ru(II) dimethylsulphoxides - antineoplastic action on mouse-tumors. Pharmacol. Res. 21, 453-454 (1989).
    • (1989) Pharmacol. Res. , vol.21 , pp. 453-454
    • Sava, G.1    Pacor, S.2    Ceschia, V.3    Alessio, E.4    Mestroni, G.5
  • 29
    • 0034672614 scopus 로고    scopus 로고
    • Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media
    • Novakova O, Hofr C, Brabec V. Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media. Biochem. Pharmacol. 60, 1761-1771 (2000).
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1761-1771
    • Novakova, O.1    Hofr, C.2    Brabec, V.3
  • 30
    • 42649125564 scopus 로고    scopus 로고
    • New Ru(II)-dmso complexes with heterocyclic hydrazone ligands towards cancer chemotherapy
    • Mahalingam V, Chitrapriya N, Fronczek FR, Natarajan K. New Ru(II)-dmso complexes with heterocyclic hydrazone ligands towards cancer chemotherapy. Polyhedron 27, 1917-1924 (2008).
    • (2008) Polyhedron , vol.27 , pp. 1917-1924
    • Mahalingam, V.1    Chitrapriya, N.2    Fronczek, F.R.3    Natarajan, K.4
  • 31
    • 0033694303 scopus 로고    scopus 로고
    • Lack of in vitro cytotoxicity, associated to increased G2-M cell fraction and inhibition of Matrigel invasion, may predict in vivoselective antimetastasis activity of ruthenium complexes
    • Zorzet S, Bergamo A, Cocchietto M et al. Lack of in vitro cytotoxicity, associated to increased G2-M cell fraction and inhibition of Matrigel invasion, may predict in vivoselective antimetastasis activity of ruthenium complexes. J. Pharmacol. Exp. Ther. 295, 927-933 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 927-933
    • Zorzet, S.1    Bergamo, A.2    Cocchietto, M.3
  • 33
    • 0033033221 scopus 로고    scopus 로고
    • Reduction of lung metastasis by ImH[trans- RuCl4(DMSO)Im]: Mechanism of the selective action investigated on mouse tumors
    • Sava G, Clerici K, Capozzi I et al. Reduction of lung metastasis by ImH[trans- RuCl4(DMSO)Im]: mechanism of the selective action investigated on mouse tumors. Anticancer Drugs 10, 129-138 (1999).
    • (1999) Anticancer Drugs , vol.10 , pp. 129-138
    • Sava, G.1    Clerici, K.2    Capozzi, I.3
  • 34
    • 2542625358 scopus 로고    scopus 로고
    • A Phase i and pharmacological study with imidazolium-trans-DMSO- imidazoletetrachlororuthenate, a novel ruthenium anticancer agent
    • Rademaker-Lakhai JM, van den Bongard D, Pluim D, Beijnen JH, Schellens JHM. A Phase I and pharmacological study with imidazolium-trans-DMSO- imidazoletetrachlororuthenate, a novel ruthenium anticancer agent. Clin. Cancer Res. 10, 3717-3727 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3717-3727
    • Rademaker-Lakhai, J.M.1    Van Den Bongard, D.2    Pluim, D.3    Beijnen, J.H.4    Schellens, J.H.M.5
  • 35
    • 0031805229 scopus 로고    scopus 로고
    • Comparison of the effects of the antimetastatic compound ImH[trans- RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice
    • Sava G, Gagliardi R, Cocchietto M et al. Comparison of the effects of the antimetastatic compound ImH[trans- RuCl4(DMSO)Im] (NAMI-A) on the arthritic rat and on MCa mammary carcinoma in mice. Pathol. Oncol. Res. 4, 30-36 (1998).
    • (1998) Pathol. Oncol. Res. , vol.4 , pp. 30-36
    • Sava, G.1    Gagliardi, R.2    Cocchietto, M.3
  • 36
    • 58149339989 scopus 로고    scopus 로고
    • A new redox-active anticancer agent - Preclinical development and results of a clinical Phase i Study in tumor patients
    • Hartinger CG, Jakupec MA, Zorbas S-Seifried et al. KP1019, A new redox-active anticancer agent - preclinical development and results of a clinical Phase I Study in tumor patients. Chem. Biodivers. 5, 2140-2155 (2008).
    • (2008) Chem. Biodivers. , vol.5 , pp. 2140-2155
    • Hartinger, C.G.1    Jakupec, M.A.2    S-Seifried, Z.3
  • 37
    • 22844452813 scopus 로고    scopus 로고
    • The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells
    • Kapitza S, Jakupec MA, Uhl M, Keppler BK, Marian B. The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells. Cancer Lett. 226, 115-121 (2005).
    • (2005) Cancer Lett. , vol.226 , pp. 115-121
    • Kapitza, S.1    Jakupec, M.A.2    Uhl, M.3    Keppler, B.K.4    Marian, B.5
  • 38
    • 1342282311 scopus 로고    scopus 로고
    • Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy
    • Pongratz M, Schluga P, Jakupec MA et al. Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy. J. Anal. At. Spectrom. 19, 46-51 (2004).
    • (2004) J. Anal. At. Spectrom. , vol.19 , pp. 46-51
    • Pongratz, M.1    Schluga, P.2    Jakupec, M.A.3
  • 39
    • 77953420261 scopus 로고    scopus 로고
    • New insights into mechanisms underlying resistance against the anticancer Ru(III) compound KP1019 (FFC14a)
    • Heffeter P, Jakupec MA, Pongratz M et al. New insights into mechanisms underlying resistance against the anticancer Ru(III) compound KP1019 (FFC14a). Pharmacology 72, 154-154 (2004).
    • (2004) Pharmacology , vol.72 , pp. 154-154
    • Heffeter, P.1    Jakupec, M.A.2    Pongratz, M.3
  • 40
    • 33845378863 scopus 로고
    • Chiral discrimination in the covalent binding of bis(phenanthroline) dichlororuthenium(II) to B-DNA
    • Barton JK, Lolis E. Chiral discrimination in the covalent binding of bis(phenanthroline) dichlororuthenium(II) to B-DNA. J. Am. Chem. Soc. 107, 708-709 (1985).
    • (1985) J. Am. Chem. Soc. , vol.107 , pp. 708-709
    • Barton, J.K.1    Lolis, E.2
  • 41
    • 0022456486 scopus 로고
    • Metals and DNA - Molecular left-handed complements
    • Barton JK. Metals and DNA - molecular left-handed complements. Science 233, 727-734 (1986).
    • (1986) Science , vol.233 , pp. 727-734
    • Barton, J.K.1
  • 43
    • 22144475785 scopus 로고    scopus 로고
    • Characterization by NMR spectroscopy, x-ray analysis and cytotoxic activity of the ruthenium(II)compounds RuL3 (PF6)2 (L=2-phenylazopyridine or o-tolylazopyridine) and RuĹ L-2́́ (PF6) 2 (Ĺ, Ĺ́=2-phenylazopyridine, 2,2́-bipyridine)
    • Hotze ACG, EPL Van Der Geer, Kooijman H, Spek AL, Haasnoot JG, Reedijk J. Characterization by NMR spectroscopy, x-ray analysis and cytotoxic activity of the ruthenium(II) compounds RuL3 (PF6)2 (L=2-phenylazopyridine or o-tolylazopyridine) and RuĹ L-2́́ (PF6)2 (Ĺ, Ĺ́=2-phenylazopyridine, 2,2́-bipyridine). Eur. J. Inorg. Chem. 2648-2657 (2005).
    • (2005) Eur. J. Inorg. Chem. , pp. 2648-2657
    • Hotze, A.C.G.1    Van Der Geer, E.2    Kooijman, H.3    Spek, A.L.4    Haasnoot, J.G.5    Reedijk, J.6
  • 44
    • 0034631675 scopus 로고    scopus 로고
    • Strong differences in the in vitro cytotoxicity of three isomeric dichlorobis(2-phenylazopyridine) ruthenium(II) complexes
    • Velders AH, Kooijman H, Spek AL, Haasnoot JG, De Vos D, Reedijk J. Strong differences in the in vitro cytotoxicity of three isomeric dichlorobis(2- phenylazopyridine) ruthenium(II) complexes. Inorg. Chem. 39, 2966-2967 (2000).
    • (2000) Inorg. Chem. , vol.39 , pp. 2966-2967
    • Velders, A.H.1    Kooijman, H.2    Spek, A.L.3    Haasnoot, J.G.4    De Vos, D.5    Reedijk, J.6
  • 45
    • 0026513746 scopus 로고
    • Studies on DNA damage and induction of sos repair by novel multifunctional bioreducible compounds .2. A metronidazole adduct of a ruthenium-arene compound
    • Dale LD, Tocher JH, Dyson TM, Edwards DI, Tocher DA. Studies on DNA damage and induction of sos repair by novel multifunctional bioreducible compounds .2. A metronidazole adduct of a ruthenium-arene compound. Anticancer Drug Des. 7, 3-14 (1992).
    • (1992) Anticancer Drug Des. , vol.7 , pp. 3-14
    • Dale, L.D.1    Tocher, J.H.2    Dyson, T.M.3    Edwards, D.I.4    Tocher, D.A.5
  • 46
    • 30444446383 scopus 로고    scopus 로고
    • Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds
    • Guichard SM, Else R, Reid E et al. Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds. Biochem. Pharmacol. 71, 408-415 (2006).
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 408-415
    • Guichard, S.M.1    Else, R.2    Reid, E.3
  • 47
    • 0347624091 scopus 로고    scopus 로고
    • Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and x-ray structures of aqua adducts
    • Wang F, Chen H, Parsons S, Oswald ID, Davidson JE, Sadler PJ. Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and x-ray structures of aqua adducts. Chemistry 9, 5810-5820 (2003).
    • (2003) Chemistry , vol.9 , pp. 5810-5820
    • Wang, F.1    Chen, H.2    Parsons, S.3    Oswald, I.D.4    Davidson, J.E.5    Sadler, P.J.6
  • 48
    • 0037425530 scopus 로고    scopus 로고
    • Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: Novel recognition mechanisms
    • Chen H, Parkinson JA, Morris RE, Sadler PJ. Highly selective binding of organometallic ruthenium ethylenediamine complexes to nucleic acids: novel recognition mechanisms. J. Am. Chem. Soc. 125, 173-186 (2003).
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 173-186
    • Chen, H.1    Parkinson, J.A.2    Morris, R.E.3    Sadler, P.J.4
  • 49
    • 0035822755 scopus 로고    scopus 로고
    • [ Ru(eta6-p-cymene)Cl-2(pta)] (pta=1 3,5- triaza-7-phosphatricyclo[3.3.1. 1]decane): A water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells
    • Allardyce CS, Dyson PJ, Ellis DJ, Heath SL. [Ru(eta6-p-cymene)Cl-2(pta)] (pta=1,3,5- triaza-7-phosphatricyclo[3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells. Chem. Commun. (Camb.) 1396-1397 (2001).
    • (2001) Chem. Commun. (Camb. , pp. 1396-1397
    • Allardyce, C.S.1    Dyson, P.J.2    Ellis, D.J.3    Heath, S.L.4
  • 50
    • 20444400159 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of ruthenium(II)- arene PTA complexes
    • Scolaro C, Bergamo A, Brescacin L et al. In vitro and in vivo evaluation of ruthenium(II)- arene PTA complexes. J. Med. Chem. 48, 4161-4171 (2005).
    • (2005) J. Med. Chem. , vol.48 , pp. 4161-4171
    • Scolaro, C.1    Bergamo, A.2    Brescacin, L.3
  • 51
    • 0033528670 scopus 로고    scopus 로고
    • Inhibition of topoisomerase ii catalytic activity by two ruthenium compounds: A liganddependent mode of action
    • Gopal YNV, Jayaraju D, Kondapi AK. Inhibition of topoisomerase ii catalytic activity by two ruthenium compounds: a liganddependent mode of action. Biochemistry 38, 4382-4388 (1999).
    • (1999) Biochemistry , vol.38 , pp. 4382-4388
    • Gopal, Y.N.V.1    Jayaraju, D.2    Kondapi, A.K.3
  • 53
    • 55049083403 scopus 로고    scopus 로고
    • In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands
    • Berger I, Hanif M, Nazarov AA et al. In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chemistry 14, 9046-9057 (2008).
    • (2008) Chemistry , vol.14 , pp. 9046-9057
    • Berger, I.1    Hanif, M.2    Nazarov, A.A.3
  • 54
    • 41149179666 scopus 로고    scopus 로고
    • Ruthenium porphyrin compounds for photodynamic therapy of cancer
    • Schmitt F, Govindaswamy P, Suss G-Fink et al. Ruthenium porphyrin compounds for photodynamic therapy of cancer. J. Med. Chem. 51, 1811-1816 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 1811-1816
    • Schmitt, F.1    Govindaswamy, P.2    G-Fink, S.3
  • 55
    • 37249007346 scopus 로고    scopus 로고
    • Mixed ligand ruthenium(II) complexes of bis(pyrid- 2-yl)-/ bis(benzimidazol-2-yl)-dithioether and diimines: Study of non-covalent DNA binding and cytotoxicity
    • Rajendiran V, Murali M, Suresh E, Sinha S, Somasundaram K, Palaniandavar M. Mixed ligand ruthenium(II) complexes of bis(pyrid- 2-yl)-/bis(benzimidazol-2- yl)-dithioether and diimines: study of non-covalent DNA binding and cytotoxicity. Dalton Trans. 148-163 (2008).
    • (2008) Dalton Trans. , pp. 148-163
    • Rajendiran, V.1    Murali, M.2    Suresh, E.3    Sinha, S.4    Somasundaram, K.5    Palaniandavar, M.6
  • 56
    • 38149017955 scopus 로고    scopus 로고
    • Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes
    • Tan CP, Liu J, Li H et al. Differences in structure, physiological stability, electrochemistry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes. J. Inorg. Biochem. 102, 347-358 (2008).
    • (2008) J. Inorg. Biochem. , vol.102 , pp. 347-358
    • Tan, C.P.1    Liu, J.2    Li, H.3
  • 57
    • 33751403575 scopus 로고    scopus 로고
    • Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis
    • Ang WH, Daldini E, Scolaro C, Scopelliti R, Juillerat L-Jeannerat, Dyson PJ. Development of organometallic ruthenium-arene anticancer drugs that resist hydrolysis. Inorg. Chem. 45, 9006-9013 (2006).
    • (2006) Inorg. Chem. , vol.45 , pp. 9006-9013
    • Ang, W.H.1    Daldini, E.2    Scolaro, C.3    Scopelliti, R.4    L-Jeannerat, J.5    Dyson, P.J.6
  • 58
    • 46749108378 scopus 로고    scopus 로고
    • Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes
    • Tan CP, Liu J, Chen LM, Shi S, Ji LN. Synthesis, structural characteristics, DNA binding properties and cytotoxicity studies of a series of Ru(III) complexes. J. Inorg. Biochem. 102, 1644-1653 (2008).
    • (2008) J. Inorg. Biochem. , vol.102 , pp. 1644-1653
    • Tan, C.P.1    Liu, J.2    Chen, L.M.3    Shi, S.4    Ji, L.N.5
  • 59
    • 29444455073 scopus 로고    scopus 로고
    • Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity
    • Wang FY, Habtemariam A, van EPL der Geer et al. Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity. Proc. Natl Acad. Sci. USAa 102, 18269-18274 (2005).
    • (2005) Proc. Natl Acad. Sci. USAa , vol.102 , pp. 18269-18274
    • Wang, F.Y.1    Habtemariam, A.2    Van Epl Der Geer3
  • 60
    • 33750969384 scopus 로고    scopus 로고
    • Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N- N,O-, and O,O-chelating ligands
    • Habtemariam A, Melchart M, Fernandez R et al. Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands. J. Med. Chem. 49, 6858-6868 (2006).
    • (2006) J. Med. Chem. , vol.49 , pp. 6858-6868
    • Habtemariam, A.1    Melchart, M.2    Fernandez, R.3
  • 62
    • 51849098200 scopus 로고    scopus 로고
    • Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes
    • Bugarcic T, Novakova O, Halamikova A et al. Cytotoxicity, cellular uptake, and DNA interactions of new monodentate ruthenium(II) complexes containing terphenyl arenes. J. Med. Chem. 51, 5310-5319 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 5310-5319
    • Bugarcic, T.1    Novakova, O.2    Halamikova, A.3
  • 63
    • 60849131776 scopus 로고    scopus 로고
    • The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes
    • Bugarcic T, Habtemariam A, Stepankova J et al. The contrasting chemistry and cancer cell cytotoxicity of bipyridine and bipyridinediol ruthenium(II) arene complexes. Inorg. Chem. 47, 11470-11486 (2008).
    • (2008) Inorg. Chem. , vol.47 , pp. 11470-11486
    • Bugarcic, T.1    Habtemariam, A.2    Stepankova, J.3
  • 64
    • 24744453056 scopus 로고    scopus 로고
    • Is the aromatic fragment of piano-stool ruthenium compounds an essential feature for anticancer activity? the development of new Ru-II-[9]aneS3 analogues
    • Serli B, Zangrando E, Gianferrara T et al. Is the aromatic fragment of piano-stool ruthenium compounds an essential feature for anticancer activity? The development of new Ru-II-[9]aneS3 analogues. Eur. J. Inorg. Chem. 3423-3434 (2005).
    • (2005) Eur. J. Inorg. Chem. , pp. 3423-3434
    • Serli, B.1    Zangrando, E.2    Gianferrara, T.3
  • 65
    • 42449153275 scopus 로고    scopus 로고
    • Importance of the pi-ligand: Remarkable effect of the cyclopentadienyl ring on the cytotoxicity of ruthenium PTA compounds
    • Dutta B, Scolaro C, Scopelliti R, Dyson PJ, Severin K. Importance of the pi-ligand: Remarkable effect of the cyclopentadienyl ring on the cytotoxicity of ruthenium PTA compounds. Organometallics 27, 1355-1357 (2008).
    • (2008) Organometallics , vol.27 , pp. 1355-1357
    • Dutta, B.1    Scolaro, C.2    Scopelliti, R.3    Dyson, P.J.4    Severin, K.5
  • 66
    • 33644547393 scopus 로고    scopus 로고
    • Influence of hydrogen-bonding substituents on the cytotoxicity of RAPTA compounds
    • Scolaro C, Geldbach TJ, Rochat S et al. Influence of hydrogen-bonding substituents on the cytotoxicity of RAPTA compounds. Organometallics 25, 756-765 (2006).
    • (2006) Organometallics , vol.25 , pp. 756-765
    • Scolaro, C.1    Geldbach, T.J.2    Rochat, S.3
  • 67
    • 15444367843 scopus 로고    scopus 로고
    • Heteroaryl substituted ansa-titanocene anti-cancer drugs derived from fulvenes and titanium dichloride
    • Rehmann FJK, Cuffe LP, Mendoza O et al. Heteroaryl substituted ansa-titanocene anti-cancer drugs derived from fulvenes and titanium dichloride. App. Organomet. Chem. 19, 293-300 (2005).
    • (2005) App. Organomet. Chem. , vol.19 , pp. 293-300
    • Rehmann, F.J.K.1    Cuffe, L.P.2    Mendoza, O.3
  • 68
    • 33744486894 scopus 로고    scopus 로고
    • Metal-based antitumour drugs in the post genomic era
    • Dyson PJ, Sava G. Metal-based antitumour drugs in the post genomic era. Dalton Trans. 1929-1933 (2006).
    • (2006) Dalton Trans. , pp. 1929-1933
    • Dyson, P.J.1    Sava, G.2
  • 69
    • 4544263271 scopus 로고
    • A P-31 NMR-study of the water-soluble derivatives of 1,3,5-triaza-7- phosphaadamantane (Pta)
    • Fisher KJ, Alyea EC, Shahnazarian N. A P-31 NMR-study of the water-soluble derivatives of 1,3,5-triaza-7-phosphaadamantane (Pta). Phosphorus Sulfur Silicon Relat. Elem. 48, 37-40 (1990).
    • (1990) Phosphorus Sulfur Silicon Relat. Elem. , vol.48 , pp. 37-40
    • Fisher, K.J.1    Alyea, E.C.2    Shahnazarian, N.3
  • 70
    • 0000766060 scopus 로고    scopus 로고
    • Water-soluble organometallic compounds. 7. Further studies of 1, 3,5-triaza- 7-phosphaadamantane derivatives of group 10 metals, including metal carbonyls and hydrides
    • Darensbourg DJ, Robertson JB, Larkins DL, Reibenspies JH. Water-soluble organometallic compounds. 7. Further studies of 1,3,5-triaza- 7-phosphaadamantane derivatives of group 10 metals, including metal carbonyls and hydrides. Inorg. Chem. 38, 2473-2481 (1999).
    • (1999) Inorg. Chem. , vol.38 , pp. 2473-2481
    • Darensbourg, D.J.1    Robertson, J.B.2    Larkins, D.L.3    Reibenspies, J.H.4
  • 72
    • 53349169299 scopus 로고    scopus 로고
    • Influence of the diketonato ligand on the cytotoxicities of [Ru(eta6-p-cymene)-(R2acac)(PTA)]+ complexes (PTA=1, 3,5-triaza-7- phosphaadamantane)
    • Vock CA, Renfrew AK, Scopelliti R, Juillerat-Jeanneret L, Dyson PJ. Influence of the diketonato ligand on the cytotoxicities of [Ru(eta6-p-cymene)- (R2acac)(PTA)]+ complexes (PTA=1,3,5-triaza-7- phosphaadamantane). Eur. J. Inorg. Chem. 1661-1671 (2008).
    • (2008) Eur. J. Inorg. Chem. , pp. 1661-1671
    • Vock, C.A.1    Renfrew, A.K.2    Scopelliti, R.3    Juillerat-Jeanneret, L.4    Dyson, P.J.5
  • 73
    • 54149119337 scopus 로고    scopus 로고
    • Selective cytotoxic Ru(II) arene Cp* complex salts R-PhRuCp* X-+(-) for X = BF4- PF6-, and BPh4
    • Loughrey BT, Healy PC, Parsons PG, Williams ML. Selective cytotoxic Ru(II) arene Cp* complex salts R-PhRuCp* X-+(-) for X = BF4-, PF6-, and BPh4. Inorg. Chem. 47, 8589-8591 (2008).
    • (2008) Inorg. Chem. , vol.47 , pp. 8589-8591
    • Loughrey, B.T.1    Healy, P.C.2    Parsons, P.G.3    Williams, M.L.4
  • 74
    • 0037405663 scopus 로고    scopus 로고
    • Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines
    • Bergamo A, Stocco G, Gava B et al. Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines. J. Pharmacol. Exp. Ther. 305, 725-732 (2003).
    • (2003) J. Pharmacol. Exp. Ther. , vol.305 , pp. 725-732
    • Bergamo, A.1    Stocco, G.2    Gava, B.3
  • 75
    • 10744222449 scopus 로고    scopus 로고
    • Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers
    • Chen H, Parkinson JA, Novakova O et al. Induced-fit recognition of DNA by organometallic complexes with dynamic stereogenic centers. Proc. Natl Acad. Sci. USA 100, 14623-14628 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 14623-14628
    • Chen, H.1    Parkinson, J.A.2    Novakova, O.3
  • 76
    • 33746854277 scopus 로고    scopus 로고
    • Dinuclear double-stranded metallosupramolecular ruthenium complexes: Potential anticancer drugs
    • Hotze ACG, Kariuki BM, Hannon MJ. Dinuclear double-stranded metallosupramolecular ruthenium complexes: potential anticancer drugs. Angew. Chem. Int. Ed. Engl. 45, 4839-4842 (2006).
    • (2006) Angew. Chem. Int. Ed. Engl. , vol.45 , pp. 4839-4842
    • Hotze, A.C.G.1    Kariuki, B.M.2    Hannon, M.J.3
  • 77
    • 38749118595 scopus 로고    scopus 로고
    • Diruthenium(II, III) complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal antiinflammatory drugs: Synthesis, characterization and their effects on tumor-cell proliferation
    • Ribeiro G, Benadiba M, Colquhoun A, Silva DD. Diruthenium(II, III) complexes of ibuprofen, aspirin, naproxen and indomethacin non-steroidal antiinflammatory drugs: synthesis, characterization and their effects on tumor-cell proliferation. Polyhedron 27, 1131-1137 (2008).
    • (2008) Polyhedron , vol.27 , pp. 1131-1137
    • Ribeiro, G.1    Benadiba, M.2    Colquhoun, A.3    Silva, D.D.4
  • 78
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
    • Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J. Natl. Cancer Inst. 94, 252-266 (2002).
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patrono, C.3
  • 79
    • 0000463565 scopus 로고    scopus 로고
    • Mixed-metal polymetallic platinum complexes designed to interact with DNA
    • Milkevitch M, Shirley BW, Brewer KJ. Mixed-metal polymetallic platinum complexes designed to interact with DNA. Inorganica Chimica Acta 264, 249-256 (1997).
    • (1997) Inorganica Chimica Acta , vol.264 , pp. 249-256
    • Milkevitch, M.1    Shirley, B.W.2    Brewer, K.J.3
  • 80
    • 0027482289 scopus 로고
    • Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal-compounds as DNA-protein cross-linking agents - Potential suicide DNA lesions
    • van Houten B, Illenye S, Qu Y, Farrell N. Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal-compounds as DNA-protein cross-linking agents - potential suicide DNA lesions. Biochemistry 32, 11794-11801 (1993).
    • (1993) Biochemistry , vol.32 , pp. 11794-11801
    • Van Houten, B.1    Illenye, S.2    Qu, Y.3    Farrell, N.4
  • 81
    • 38749097073 scopus 로고    scopus 로고
    • Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex
    • Herman A, Tanski JM, Tibbetts MF, Anderson CM. Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex. Inorg. Chem. 47, 274-280 (2008).
    • (2008) Inorg. Chem. , vol.47 , pp. 274-280
    • Herman, A.1    Tanski, J.M.2    Tibbetts, M.F.3    Anderson, C.M.4
  • 82
    • 0035744296 scopus 로고    scopus 로고
    • The interactions of low oxidation state transition metal clusters with DNA: Potential applications in cancer therapy
    • Allardyce CS, Dyson PJ. The interactions of low oxidation state transition metal clusters with DNA: potential applications in cancer therapy. J. Clus. Sci. 12, 563-569 (2001).
    • (2001) J. Clus. Sci. , vol.12 , pp. 563-569
    • Allardyce, C.S.1    Dyson, P.J.2
  • 83
    • 34548496041 scopus 로고    scopus 로고
    • Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters
    • Therrien B, Ang WH, Cherioux F et al. Remarkable anticancer activity of triruthenium-arene clusters compared to tetraruthenium-arene clusters. J. Clus. Sci. 18, 741-752 (2007).
    • (2007) J. Clus. Sci. , vol.18 , pp. 741-752
    • Therrien, B.1    Ang, W.H.2    Cherioux, F.3
  • 84
    • 41049083879 scopus 로고    scopus 로고
    • Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with O-18-Labeling
    • Wang FY, Weidt S, Xu JJ, Mackay CL, Langridge PRR-Smith, Sadler PJ. Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with O-18-Labeling. J. Am. Soc. Mass Spectrom. 19, 544-549 (2008).
    • (2008) J. Am. Soc. Mass Spectrom. , vol.19 , pp. 544-549
    • Wang, F.Y.1    Weidt, S.2    Xu, J.J.3    MacKay, C.L.4    Prr-Smith, L.5    Sadler, P.J.6
  • 85
    • 45549104620 scopus 로고    scopus 로고
    • The "complex-in-acomplex"cations [(acac)2M subset of RU6(p-iPrC6H4Me) 6(tpt) 2(dhbq)3]6+: A Trojan horse for cancer cells
    • Therrien B, G Suss-Fink, Govindaswamy P, Renfrew AK, Dyson PJ. The "complex-in-acomplex" cations [(acac)2M subset of RU6(p-iPrC6H4Me) 6(tpt)2(dhbq)3]6+: a Trojan horse for cancer cells. Angew. Chem. Int. Ed. Engl. 47, 3773-3776 (2008).
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , pp. 3773-3776
    • Therrien, B.1    Suss-Fink, G.2    Govindaswamy, P.3    Renfrew, A.K.4    Dyson, P.J.5
  • 86
    • 31444446334 scopus 로고    scopus 로고
    • Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: Discovery of potent and selective protein kinase inhibitors
    • Bregman H, Carroll PJ, Meggers E. Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors. J. Am. Chem. Soc. 128, 877-884 (2006).
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 877-884
    • Bregman, H.1    Carroll, P.J.2    Meggers, E.3
  • 87
    • 34250728162 scopus 로고    scopus 로고
    • Exploring biologically relevant chemical space with metal complexes
    • Meggers E. Exploring biologically relevant chemical space with metal complexes. Curr. Opin. Chem. Biol. 11, 287-292 (2007).
    • (2007) Curr. Opin. Chem. Biol. , vol.11 , pp. 287-292
    • Meggers, E.1
  • 88
    • 44649150564 scopus 로고    scopus 로고
    • Structure-based design of an organoruthenium phosphatidyl-inositol-3- kinase inhibitor reveals a switch governing lipid kinase potency and selectivity
    • Xie P, Williams DS, Atilta GE-Gokcumen et al. Structure-based design of an organoruthenium phosphatidyl-inositol-3- kinase inhibitor reveals a switch governing lipid kinase potency and selectivity. ACS Chem. Biol. 3, 305-316 (2008).
    • (2008) ACS Chem. Biol. , vol.3 , pp. 305-316
    • Xie, P.1    Williams, D.S.2    Ge-Gokcumen, A.3
  • 89
    • 59649119743 scopus 로고    scopus 로고
    • Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3
    • Atilla-Gokcumen GE, Pagano N, Streu C et al. Extremely tight binding of a ruthenium complex to glycogen synthase kinase 3. Chembiochem. 9, 2933-2936 (2008).
    • (2008) Chembiochem. , vol.9 , pp. 2933-2936
    • Atilla-Gokcumen, G.E.1    Pagano, N.2    Streu, C.3
  • 90
    • 34447291388 scopus 로고    scopus 로고
    • Dinuclear ruthenium(II) triple-stranded helicates: Luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines
    • Pascu GI, Hotze ACG, Sanchez-Cano C, Kariuki BM, Hannon MJ. Dinuclear ruthenium(II) triple-stranded helicates: Luminescent supramolecular cylinders that bind and coil DNA and exhibit activity against cancer cell lines. Angew. Chem. Int. Ed. Engl. 46, 4374-4378 (2007).
    • (2007) Angew. Chem. Int. Ed. Engl. , vol.46 , pp. 4374-4378
    • Pascu, G.I.1    Hotze, A.C.G.2    Sanchez-Cano, C.3    Kariuki, B.M.4    Hannon, M.J.5
  • 91
    • 33745763300 scopus 로고    scopus 로고
    • Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
    • Timerbaev AR, Hartinger CG, Aleksenko SS, Keppler BK. Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology. Chem. Rev. 106, 2224-2248 (2006).
    • (2006) Chem. Rev. , vol.106 , pp. 2224-2248
    • Timerbaev, A.R.1    Hartinger, C.G.2    Aleksenko, S.S.3    Keppler, B.K.4
  • 92
    • 33745384809 scopus 로고    scopus 로고
    • From bench to bedside - Preclinical and early clinical development of the anticancer agent indazolium trans- tetrachlorobis(1Hindazole) ruthenate(III) (KP1019 or FFC14A)
    • Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK. From bench to bedside - preclinical and early clinical development of the anticancer agent indazolium trans- tetrachlorobis(1Hindazole) ruthenate(III) (KP1019 or FFC14A). J. Inorg. Biochem. 100, 891-904 (2006).
    • (2006) J. Inorg. Biochem. , vol.100 , pp. 891-904
    • Hartinger, C.G.1    Zorbas-Seifried, S.2    Jakupec, M.A.3    Kynast, B.4    Zorbas, H.5    Keppler, B.K.6
  • 93
    • 0001752711 scopus 로고    scopus 로고
    • Binding of ruthenium(III) anti-tumor drugs to human lactoferrin probed by high resolution x-ray crystallographic structure analyses
    • Smith CA, SutherlandSmith AJ, Keppler BK, Kratz F, Baker EN. Binding of ruthenium(III) anti-tumor drugs to human lactoferrin probed by high resolution x-ray crystallographic structure analyses. J. Biol. Inorg. Chem. 1, 424-431 (1996).
    • (1996) J. Biol. Inorg. Chem. , vol.1 , pp. 424-431
    • Smith, C.A.1    Sutherlandsmith, A.J.2    Keppler, B.K.3    Kratz, F.4    Baker, E.N.5
  • 94
    • 43049083298 scopus 로고    scopus 로고
    • Application of capillary electrophoresisinductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins
    • Polec-Pawlak K, Abramski JK, Ferenc J et al. Application of capillary electrophoresisinductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins. J. Chromatogr. A 1192, 323-326 (2008).
    • (2008) J. Chromatogr. A. , vol.1192 , pp. 323-326
    • Polec-Pawlak, K.1    Abramski, J.K.2    Ferenc, J.3
  • 95
    • 47149102244 scopus 로고    scopus 로고
    • Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma
    • Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK. Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma. Electrophoresis 29, 2224-2232 (2008).
    • (2008) Electrophoresis , vol.29 , pp. 2224-2232
    • Groessl, M.1    Hartinger, C.G.2    Polec-Pawlak, K.3    Jarosz, M.4    Keppler, B.K.5
  • 98
    • 0035930663 scopus 로고    scopus 로고
    • Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems
    • Allardyce CS, Dyson PJ, Abou FR-Shakra, Birtwistle H, Coffey J. Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems. Chem. Commun. (Camb.) 2708-2709 (2001).
    • (2001) Chem. Commun. (Camb. , pp. 2708-2709
    • Allardyce, C.S.1    Dyson, P.J.2    Fr-Shakra, A.3    Birtwistle, H.4    Coffey, J.5
  • 99
    • 48749108102 scopus 로고    scopus 로고
    • Proteomic approaches in understanding action mechanisms of metal-based anticancer drugs
    • Wang Y, Chiu J-F. Proteomic approaches in understanding action mechanisms of metal-based anticancer drugs. Met. Based Drugs 2008, 716329 (2008).
    • (2008) Met. Based Drugs , vol.2008 , pp. 716329
    • Wang, Y.1    Chiu, J.-F.2
  • 100
    • 55949110295 scopus 로고    scopus 로고
    • Characterisation of cisplatin binding sites in human serum proteins using hyphenated multidimensional liquid chromatography and ESI tandem mass spectrometry
    • Will J, Wolters DA, Sheldrick WS. Characterisation of cisplatin binding sites in human serum proteins using hyphenated multidimensional liquid chromatography and ESI tandem mass spectrometry. Chemmedchem. 3, 1696-1707 (2008).
    • (2008) Chemmedchem. , vol.3 , pp. 1696-1707
    • Will, J.1    Wolters, D.A.2    Sheldrick, W.S.3
  • 101
    • 34547468216 scopus 로고    scopus 로고
    • Identification of (eta(6)-arene) ruthenium(II) protein binding sites in E-coli cells by combined multidimensional liquid chromatography and ESI tandem mass spectrometry: Specific binding of (eta(6)-pcymene) RuCl2(DMSO) to stress-regulated proteins and to helicases
    • Will J, Kyas A, Sheldrick WS, Wolters D. Identification of (eta(6)-arene) ruthenium(II) protein binding sites in E-coli cells by combined multidimensional liquid chromatography and ESI tandem mass spectrometry: specific binding of (eta(6)-pcymene) RuCl2(DMSO) to stress-regulated proteins and to helicases. J. Biol. Inorg. Chem. 12, 883-894 (2007).
    • (2007) J. Biol. Inorg. Chem. , vol.12 , pp. 883-894
    • Will, J.1    Kyas, A.2    Sheldrick, W.S.3    Wolters, D.4
  • 102
    • 39849093202 scopus 로고    scopus 로고
    • X-ray structure and designed evolution of an artificial transfer hydrogenase
    • Creus M, Pordea A, Rossel T et al. X-ray structure and designed evolution of an artificial transfer hydrogenase. Angew. Chem. Int. Ed. Engl. 47, 1400-1404 (2008).
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , pp. 1400-1404
    • Creus, M.1    Pordea, A.2    Rossel, T.3
  • 109
    • 32844455577 scopus 로고    scopus 로고
    • Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB
    • Yu B, Edstrom WC, Benach J et al. Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 439, 879-884 (2006).
    • (2006) Nature , vol.439 , pp. 879-884
    • Yu, B.1    Edstrom, W.C.2    Benach, J.3
  • 110
    • 59449109182 scopus 로고    scopus 로고
    • Iron homeostasis: Recently identified proteins provide insight into novel control mechanisms
    • Zhang AS, Enns CA. Iron homeostasis: recently identified proteins provide insight into novel control mechanisms. J. Biol. Chem. 284, 711-715 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 711-715
    • Zhang, A.S.1    Enns, C.A.2


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