The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 12028-12036

  De La Vega, Michelle ^a   Burrows, James F ^a   McFarlane, Cheryl ^a   Govender, Ureshnie ^a   Scott, Christopher J ^a   Johnston, James A ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CAAX MOTIFS; DEUBIQUITINATING ENZYMES; ISOFORMS; MEMBRANE LOCALIZATION; MEMBRANE TRAFFICKING; OVER-EXPRESSION; PLASMA MEMBRANES; POST-TRANSLATIONAL PROCESSING;

CELL MEMBRANES; ENZYMES;

MEMBRANES;

EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN N RAS; PROTEINASE; STRESS ACTIVATED PROTEIN KINASE; UBIQUITIN SPECIFIC PROTEINASE 17; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

BIOLOGICAL TRANSPORT, ACTIVE; BREFELDIN A; CELL MEMBRANE; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS P21(RAS); RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 77951242559     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.081448     Document Type: Article

References (38)

1. Malumbres, M., and Barbacid, M. (2001) Nat. Rev. Cancer. 1, 222-231
2. nd, Cox, A. D., and Philips, M. R. (2002) Nat. Cell Biol. 4, 343-350
3. Caloca, M. J., Zugaza, J. L., and Bustelo, X. R. (2003) J. Biol. Chem. 278, 33465-33473
4. Perez de Castro, I., Bivona, T. G., Philips, M. R., and Pellicer, A. (2004) Mol. Cell. Biol. 24, 3485-3496
5. Matallanas, D., Sanz-Moreno, V., Arozarena, I., Calvo, F., Agudo-Ibáñez, L., Santos, E., Berciano, M. T., and Crespo, P. (2006) Mol. Cell. Biol. 26, 100-116
6. Inder, K., Harding, A., Plowman, S. J., Philips, M. R., Parton, R. G., and Hancock, J. F. (2008) Mol. Biol. Cell 19, 4776-4784
7. Casar, B., Arozarena, I., Sanz-Moreno, V., Pinto, A., Agudo-Ibáñez, L., Marais, R., Lewis, R. E., Berciano, M. T., and Crespo, P. (2009) Mol. Cell. Biol. 29, 1338-1353
8. Torii, S., Kusakabe, M., Yamamoto, T., Maekawa, M., and Nishida, E. (2004) Dev. Cell. 7, 33-44
9. Jura, N., Scotto-Lavino, E., Sobczyk, A., and Bar-Sagi, D. (2006) Mol. Cell 21, 679-687
10. Wright, L. P., and Philips, M. R. (2006) J. Lipid Res. 47, 883-891
11. Bergo, M. O., Ambroziak, P., Gregory, C., George, A., Otto, J. C., Kim, E., Nagase, H., Casey, P. J., Balmain, A., and Young, S. G. (2002) Mol. Cell. Biol. 22, 171-181
12. Bergo, M. O., Gavino, B. J., Hong, C., Beigneux, A. P., McMahon, M., Casey, P. J., and Young, S. G. (2004) J. Clin. Invest. 113, 539-550
13. Rocks, O., Peyker, A., Kahms, M., Verveer, P. J., Koerner, C., Lumbierres, M., Kuhlmann, J., Waldmann, H., Wittinghofer, A., and Bastiaens, P. I. (2005) Science 307, 1746-1752
14. Komander, D., Clague, M. J., and Urbé, S. (2009) Nat. Rev. Mol. Cell Biol. 10, 550-563
15. Nijman, S. M., Luna-Vargas, M. P., Velds, A., Brummelkamp, T. R., Dirac, A. M., Sixma, T. K., and Bernards, R. (2005) Cell 123, 773-786
16. Burrows, J. F., McGrattan, M. J., and Johnston, J. A. (2005) Genomics 85, 524-529
17. Burrows, J. F., McGrattan, M. J., Rascle, A., Humbert, M., Baek, K. H., and Johnston, J. A. (2004) J. Biol. Chem. 279, 13993-14000
18. Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., de la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J., and Johnston, J. A. (2009) J. Biol. Chem. 284, 9587-9595
19. Schubbert, S., Shannon, K., and Bollag, G. (2007) Nat. Rev. Cancer. 7, 295-308
20. Ren, J. G., Li, Z., and Sacks, D. B. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 10465-10469
21. Omerovic, J., Hammond, D. E., Clague, M. J., and Prior, I. A. (2008) Oncogene 27, 2754-2762
22. Ibiza, S., Pérez-Rodriguez, A., Ortega, A., Martínez-Ruiz, A, Barreiro, O., García-Domínguez, C. A., Víctor, V. M., Esplugues, J. V., Rojas, J. M., Sánchez-Madrid, F., and Serrador, J. M. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 10507-10512
23. Apolloni, A., Prior, I. A., Lindsay, M., Parton, R. G., and Hancock, J. F. (2000) Mol. Cell. Biol. 20, 2475-2487
24. Ballard-Croft, C., Locklar, A. C., Kristo, G., and Lasley, R. D. (2006) Am. J. Physiol. Heart Circ. Physiol. 291, H658-H667
25. Zheng, H., McKay, J., and Buss, J. E. (2007) J. Biol. Chem. 282, 25760-25768
26. Bannykh, S. I., Plutner, H., Matteson, J., and Balch, W. E. (2005) Traffic 6, 803-819
27. Rotblat, B., Yizhar, O., Haklai, R., Ashery, U., and Kloog, Y. (2006) Cancer Res. 66, 1974-1981
28. Choy, E., Chiu, V. K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I. E., and Philips, M. R. (1999) Cell 98, 69-80
29. Blum, R., Cox, A. D., and Kloog, Y. (2008) Recent. Pat. Anticancer Drug Discov. 3, 31-47
30. Sousa, S. F., Fernandes, P. A., and Ramos, M. J. (2008) Curr. Med. Chem. 15, 1478-1492
31. Saxena, N., Lahiri, S. S., Hambarde, S., and Tripathi, R. P. (2008) Cancer Invest. 26, 948-955
32. Konstantinopoulos, P. A., Karamouzis, M. V., and Papavassiliou, A. G. (2007) Nat. Rev. Drug Discov. 6, 541-555
33. Wong, K. K. (2009) Recent. Pat. Anticancer Drug Discov. 4, 28-35
34. Roberts, P. J., Mitin, N., Keller, P. J., Chenette, E. J., Madigan, J. P., Currin, R. O., Cox, A. D., Wilson, O., Kirschmeier, P., and Der, C. J. (2008) J. Biol. Chem. 283, 25150-25163
35. Michaelson, D., Ali, W., Chiu, V. K., Bergo, M., Silletti, J., Wright, L., Young, S. G., and Philips, M. (2005) Mol. Biol. Cell 16, 1606-1616
36. Nakamura, K., Ichise, H., Nakao, K., Hatta, T., Otani, H., Sakagami, H., Kondo, H., and Katsuki, M. (2008) Oncogene 27, 2961-2968
37. Liu, L., Channavajhala, P. L., Rao, V. R., Moutsatsos, I., Wu, L., Zhang, Y., Lin, L. L., and Qiu, Y. (2009) Biochim. Biophys. Acta 1794, 1485-1495
38. Bivona, T. G., Pérez De Castro, I., Ahearn, I. M., Grana, T. M., Chiu, V. K., Lockyer, P. J., Cullen, P. J., Pellicer, A., Cox, A. D., and Philips, M. R. (2003) Nature 424, 694-698