Ras isoform abundance and signalling in human cancer cell lines

Oncogene

Volumn 27, Issue 19, 2008, Pages 2754-2762

  Omerovic, J ^a   Hammond, D E ^a   Clague, M J ^a   Prior, I A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Akt; EGF; HGF; Ras; siRNA

Indexed keywords

EPIDERMAL GROWTH FACTOR; ISOPROTEIN; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAF PROTEIN; RAS PROTEIN; SCATTER FACTOR; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; EPIDERMIS CELL; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; HELA CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; NEOPLASM PROTEINS; PROTEIN ISOFORMS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 42549117665     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210925     Document Type: Article

References (34)

1. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. (2003). Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4: 915-925.
2. Bos JL. (1989). Ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689.
3. Chen G, Oh S, Monia BP, Stacey DW. (1996). Antisense oligonucleotides demonstrate a dominant role of c-Ki-RAS proteins in regulating the proliferation of diploid human fibroblasts. J Biol Chem 271: 28259-28265.
4. Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H et al. (2002). Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 4: 343-350.
5. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
6. Fridman M, Muruta H, Gonez J, Walker F, Treutlein H, Zeng J et al. (2000). Point mutations of c-Raf-1 RBD with elevated binding to v-Ha-Ras. J Biol Chem 275: 30363-30371.
7. Giehl K, Skripczynski B, Mansard A, Menke A, Gierschik P. (2000). Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration. Oncogene 19: 2930-2942.
8. Haigler H, Ash JF, Singer SJ, Cohen S. (1978). Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci USA 75: 3317-3321.
9. Hammond DE, Carter S, McCullough J, Urbe S, Vande Woude G, Clague MJ. (2003). Endosomal dynamics of met determine signaling output. Mol Biol Cell 14: 1346-1354.
10. Hammond DE, Urbe S, Vande Woude GF, Clague MJ. (2001). Downregulation of MET, the receptor for hepatocyte growth factor. Oncogene 20: 2761-2770.
11. Hancock JF. (2003). Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol 4: 373-384.
12. Iida M, Towatari M, Nakao A, Iida H, Kiyoi H, Nakano Y et al. (1999). Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation. Leukemia 13: 585-589.
13. Lim KH, O'Hayer K, Adam SJ, Kendall SD, Campbell PM, Der CJ et al. (2006). Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol 16: 2385-2394.
14. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konleczny SF, Taparowsky EJ. (2004). Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem 279: 22353-22361.
15. Prior IA, Harding A, Yan J, Sluimer J, Parton RG, Hancock JF. (2001). GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol 3: 368-375.
16. Prior IA, Muncke C, Parton RG, Hancock JF. (2003). Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol 160: 165-170.
17. Roy S, Luetterforst R, Harding A, Apolloni A, Etheridge M, Stang E et al. (1999). Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol 1: 98-105.
18. Roy S, Wyse B, Hancock JF. (2002). H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol Cell Biol 22: 5128-5140.
19. Sanger. The data was obtained from the Wellcome Trust Sanger Institute Cancer Genome Project web site,http://www.sanger.ac.uk/genetics/CGP.
20. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
21. Seufferlein T, Van Lint J, Liptay S, Adler G, Schmid RM. (1999). Transforming growth factor alpha activates Ha-Ras in human pancreatic cancer cells with Ki-ras mutations. Gastroenterology 116: 1441-1452.
22. Sharpe CC, Dockrell ME, Noor MI, Monia BP, Hendry BM. (2000). Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture. J Am Soc Nephrol 11: 1600-1606.
23. Trusolino L, Bertotti A, Comoglio PM. (2001). A signaling adapter function for a6b4 integrin in the control of HGF-dependent invasive growth. Cell 107: 643-654.
24. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S et al. (2004). Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5: 375-387.
25. van der Bliek A, Redelmeier T, Damke H, Tisdale E, Meyerowitz E, Schmid S. (1993). Mutations in human dynamin block an intermediate in clathrin coated vesicle formation. J Cell Biol 122: 553-563.
26. Vieria AV, Lamaze C, Schmid SL. (1996). Control of EGF receptor signaling by clathrin-mediated endocytosis. Science 274: 2086-2089.
27. Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J et al. (2001). Calmodulin binds to K-Ras, but not to H- or N- Ras, and modulates its downstream signaling. Mol Cell Biol 21: 7345-7354.
28. Vos MD, Ellis CA, Elam C, Ülku AS, Taylor BJ, Clark GJ. (2003). RASSF2 is a novel K-Ras-specific effector and potential tumour suppressor. J Biol Chem 278: 28045-28051.
29. Walsh AB, Bar-Sagi D. (2001). Differential activation of the Rac pathway by Ha-Ras and K-Ras. J Biol Chem 276: 15609-15615.
30. Wittinghofer A, Herrmann C. (1995). Ras-effector interactions, the problem of specificity. FEBS Lett 369: 52-56.
31. Wolfman JC, Wolfman A. (2000). Endogenous c-N-Ras provides a steady-state anti-apoptotic signal. J Biol Chem 275: 19315-19323.
32. Yan J, Roy S, Apolloni A, Lane A, Hancock JF. (1998). Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase. J Biol Chem 273: 24052-24056.
33. Yip-Schneider MT, Lin A, Barnard D, Sweeney CJ, Marshall MS. (1999). Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression. Int J Oncol 15: 271-279.
34. Yip-Schneider MT, Lin A, Marshall MS. (2001). Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Biochem Biophys Res Commun 280: 992-997.