Acceleration of wound healing by combined gene transfer of hepatocyte growth factor and prostacyclin synthase with Shima Jet

Gene Therapy

Volumn 13, Issue 15, 2006, Pages 1143-1152

  Kunugiza, Y ^a   Tomita, N ^a   Taniyama, Y ^a   Tomita, T ^a   Osako, M K ^a   Tamai, K ^a   Tanabe, T ^b   Kaneda, Y ^a   Yoshikawa, H ^a   Morishita, R ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AnGes MG Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; INSULIN; LUCIFERASE; PROSTACYCLIN SYNTHASE; SCATTER FACTOR;

ACCELERATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GRANULATION TISSUE; INTERMETHOD COMPARISON; JET INJECTOR; MALE; MICROVASCULATURE; NEEDLE; NONHUMAN; PLASMID; PRIORITY JOURNAL; RAT; SKIN DISEASE; WOUND ASSESSMENT; WOUND HEALING;

ANIMALS; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; DNA; EPIDERMIS; FEMALE; GENE THERAPY; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS, JET; INTRAMOLECULAR OXIDOREDUCTASES; LASER-DOPPLER FLOWMETRY; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; TRANSFECTION; WOUND HEALING;

EID: 33746169418     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302767     Document Type: Article

References (40)

1. Deodato B, Arsic N, Zentilin L, Geleano M, Santoro D, Torre V et al. Recombinant AAV vector encoding human VEGF165 enhances wound healing. Gene Therapy 2002; 9: 777-785.
2. Kuhn U, Terunuma A, Pfutzner W, Foster RA, Vogel JC. In vivo assessment of gene delivery to keratinocytes by lentiviral vectors. J Virol 2002; 76: 1496-1504.
3. Nakanishi K, Uenoyama M, Tomita N, Morishita R, Kaneda Y, Ogihara T et al. Gene transfer of hepatocyte growth factor into rat skin wounds mediated by liposomes coated with the Sendai virus (Hemagglutinating Virus of Japan). Am J Pathol 2002; 161: 1761-1772.
4. Nanney LB, Paulsen S, Davidson MK, Cardwell NL, Whitsitt JS, Davidson JM. Boosting epidermal growth factor receptor expression by gene gun tranfection stimulates epidermal growth in vivo. Wound Rep Reg 2000; 8: 117-127.
5. Zhang L, Nolan E, Kreitschitz S, Rabussay DP. Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biol Biophys Acta 2002; 1572: 1-9.
6. Marti G, Ferguson M, Wang J, Byrnes C, Dieb R, Qaiser R et al. Electroporative transfection with KGF-1 DNA improves wound healing in a diabetic mouse model. Gene Therapy 2004; 11: 1780-1785.
7. Andre F, Mir LM. DNA electrotransfer: Its principles and an updated review of its therapeutic applications. Gene Therapy 2004; 11: S33-S42.
8. Raghavachari N, Fahl W. Targeted gene delivery to skin cells in vivo: comparative study of liposomes and polymers as delivery vehicles. J Pharm Sci 2002; 91: 615-622.
9. Hengge U, Dexling B, Mirmohammadsadegh A. Safety and pharmacokinetics of naked plasmid DNA in the skin: Studies on dissemination and ectopic expression. J Invest Dermatol 2001; 116: 979-982.
10. Sawamura D, Yasukawa K, Kodama K, Yokota K, Sato-Matsumura KC, Tanaka T et al. The majority of keratinocytes incorporate intradermally injected plasmid DNA regardless of size but only a small proportion of cells can express the gene product. J Invest Dermatol 2002; 118: 967-971.
11. Sawamura D, Ina S, Itai K, Meng X, Kon A, Tamai K et al. In vivo gene introduction into keratinocytes using jet injection. Gene Therapy 1999; 6: 1785-1787.
12. Pierce GF, Mustoe TA. Pharmacologic enhancement of wound healing. Annu Rev Med 1995; 46: 467-481.
13. Slavin J. The role of cytokines in wound healing. J Pathol 1996; 178: 5-10.
14. Yoshida S, Yamaguchi Y, Itami S, Yoshikawa K, Tabata Y, Matsumoto K et al. Neutralization of hepatocyte growth factors leads to retarded cutaneous wound healing associated with decreased neovascularization and granulation tissue formation. J Invest Dermatol 2003; 120: 335-343.
15. Cowin AJ, Kallincos N, Hatzirodos N, Robertson JG, Pickering KJ, Couper J et al. Hepatocyte growth factor and macrophage stimulating protein are upregulated during excisional wound repair in rats. Cell Tissue Res 2001; 306: 239-250.
16. Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984; 122: 1450-1459.
17. Nakamura T, Nishizawa T, Hagiya M, Seki T, Shimonishi M, Sugimura A et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 1989; 342: 440-443.
18. Matsumoto K, Hashimoto K, Yoshikawa K, Nakamura T. Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factor. Exp Cell Res 1991; 196: 114-120.
19. Sato C, Tsuboi R, Shi CM, Rubin JS, Ogawa H. Comparative study of hepatocyte growth factor/scatter factor and keratinocyte growth factor effects on human keratinocytes. J Invest Deramtol 1995; 104: 958-963.
20. Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL et al. Scatter factor induces blood vessel foramation in vivo. Proc Natl Acad Sci USA 1993; 90: 1937-1941.
21. Morishita R, Nakamura S, Hayashi S, Taniyama Y, Moriguchi A, Nagano T et al. Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy. Hypertension 1999; 33: 1379-1384.
22. Miyata A, Hara S, Yokoyama C, Inoue H, Ullrich V, Tanabe T. Molecular cloning and expression of human prostacyclin synthase. Biochem Biophys Res Commun 1994; 200: 1728-1734.
23. Hara S, Morishita R, Tone Y, Yokoyama C, Inoue H, Kaneda Y et al. Overexpression of prostacyclin synthase inhibits growth of vascular smooth muscle cell. Biochem Biophys Res Commun 1995; 216: 862-867.
24. Todaka T, Yokoyama C, Yamamoto H, Hashimoto S, Nagata I, Tsukahara T et al. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Stroke 1999; 30: 419-426.
25. Nagaya N, Yokoyama C, Kyotani S, Shimonishi M, Morishita R, Uematsu M et al. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Circulation 2000; 102: 2005-2010.
26. Koike H, Morishita R, Iguchi S, Aoki M, Matsumoto K, Nakamura T et al. Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. FASEB J 2003; 17: 779-781.
27. Hiraoka K, Koike H, Yamamoto S, Tomita N, Yokoyama C, Tanabe T et al. Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of intramuscular injecton on naked plasmid DNA. Circulation 2003; 108: 2689-2696.
28. Schacke H, Docke W, Asadullah K. Mechanism involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96: 23-43.
29. Gupta A, Jain K, Raghubir R. A time course study for the development of an immunocompromised wound model, using hydrocortisone. J Pharmacol Toxicol 1999; 41: 183-187.
30. Babiuk S, Baca-Estrada ME, Foldvari M, Baizer L, Stout R, Storms M et al. Needle-free topical electroporation improves gene expression from plasmids administered in porcrine skin. Mol Ther 2003; 8: 992-998.
31. Toyoda M, Takayama H, Horiguchi N, Otsuka T, Fukusato T, Merlino G et al. Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo. FEBS Lett 2001; 509: 95-100.
32. Yoshida S, Matsumoto K, Tomioka D, Bessho K, Itami S, Yoshikawa K et al. Recombinant hepatocyte growth factor accelerates cutaneous wound healing in a diabetic mouse model. Growth Factors 2004; 22: 111-119.
33. Tomita N, Morishita R, Taniyama Y, Koike H, Aoki M, Shimizu H et al. Angiogenic property of hepatocyte growth factor is dependent on upregulation of essential transcription factor for angiogenesis, Ets-1. Circulation 2003; 107: 1411-1417.
34. Aso Y, Inukai T, Takemura Y. Evaluation of microangiography of the skin in patients with non-insulin-dependent diabetes mellitus by laser Doppler flowmetry: Microvasodilatory responses to beraprost sodium. Diabetes Res Clin Pract 1997; 36: 19-26.
35. 2 analogue. J Endocrinol 2002; 175: 217-223.
36. 2 analogue, for intermittent claudication a double-blinded, randomized, multicenter controlled trial. Circulation 2000; 102: 426-431.
37. Kushiro M, Shikata K, Sugimoto H, Shikata Y, Miyatake N, Wada J et al. Therapeutic effects of prostacyclin analog on crescentic glomerulonephritis of rat. Kidney Int 1998; 53: 1314-1320.
38. Yamada M, Sasaki R, Sato N, Suzuki M, Tamura M, Matsushita T et al. Amelioration by beraprost sodium, prostayclin analogue, of established renal dysfunction in rat glomerulonephritis model. Eur J Pharmacol 2002; 449: 167-176.
39. Endoh M, Koibuchi N, Sato M, Morishita R, Kanzaki T, Murata Y et al. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Mol Ther 2002; 5: 501-508.
40. Niwano Y, Koga H, Sakai A, Kanai K, Hamaguchi H, Uchida M et al. Wound healing effect of Malotilate in rats. Drug Res 1996; 46: 450-455.