Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice

European Journal of Pharmacology

Volumn 634, Issue 1-3, 2010, Pages 121-131

  Qi, Xun ^a,b   Okamoto, Yasuo ^a   Murakawa, Tomomi ^c   Wang, Fei ^a   Oyama, Osamu ^a   Ohkawa, Ryunosuke ^d   Yoshioka, Kazuaki ^a   Du, Wa ^a   Sugimoto, Naotoshi ^a   Yatomi, Yutaka ^d   Takuwa, Noriko ^a,e   Takuwa, Yoh ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e ISHIKAWA PREFECTURAL NURSING UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Ischemia; Poly(lactic co glycolic acid); Sphingosine 1 phosphate; Sustained release

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; N(G) NITROARGININE METHYL ESTER; POLYGLACTIN; PROTEIN KINASE B; SPHINGOSINE 1 PHOSPHATE; VASCULOTROPIN; DELAYED RELEASE FORMULATION; LACTIC ACID; LYSOPHOSPHOLIPID; MICROSPHERE; NOS3 PROTEIN, MOUSE; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; BIODEGRADABILITY; BLOOD FLOW; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIMB ISCHEMIA; MALE; MATURATION; MEMBRANE MICROPARTICLE; MICROVASCULATURE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUSTAINED RELEASE FORMULATION; VASCULAR MATURATION; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; HINDLIMB; ISCHEMIA; NEOVASCULARIZATION, PATHOLOGIC; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TRANSGENIC MOUSE; VASCULARIZATION;

ANIMALS; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HINDLIMB; ISCHEMIA; LACTIC ACID; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSPHERES; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; POLYGLYCOLIC ACID; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; REGIONAL BLOOD FLOW; SPHINGOSINE;

EID: 77951204014     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.02.038     Document Type: Article

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