FTY720 inhibits S1P-mediated endothelial healing: Relationship to S1P1-receptor surface expression

Biochemical and Biophysical Research Communications

Volumn 370, Issue 4, 2008, Pages 603-608

  Krump Konvalinkova, Vera ^a   Chwalla, Ilona ^a   Siess, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Actin; Endothelial function; FTY720; Migration; S1P receptors

Indexed keywords

5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; ACTIN; CELL ADHESION MOLECULE; FINGOLIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

ANGIOGENESIS; ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; WOUND HEALING;

ACTINS; CELL ADHESION MOLECULES; CELL MEMBRANE; CELL MOVEMENT; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYSOPHOSPHOLIPIDS; NEOVASCULARIZATION, PHYSIOLOGIC; OXADIAZOLES; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; THIOPHENES; WOUND HEALING;

EID: 43049151117     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.144     Document Type: Article

References (21)

1. Chiba K., Yanagawa Y., Masubuchi Y., Kataoka H., Kawaguchi T., Ohtsuki M., and Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. 160 (1998) 5037-5044
2. Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol. Ther. 115 (2007) 84-105
3. Tedesco-Silva H., Mourad G., Kahan B.D., Boira J.G., Weimar W., Mulgaonkar S., Nashan B., Madsen S., Charpentier B., Pellet P., and Vanrenterghem Y. FTY720, a novel immunomodulator: efficacy and safety results from the first phase 2A study in de novo renal transplantation. Transplantation 79 (2005) 1553-1560
4. Sanchez T., Estrada-Hernandez T., Paik J.H., Wu M.T., Venkataraman K., Brinkmann V., Claffey K., and Hla T. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem. 278 (2003) 47281-47290
5. Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., Bruns C., Prieschl E., Baumruker T., Hiestand P., Foster C.A., Zollinger M., and Lynch K.R. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277 (2002) 21453-21457
6. Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., Rosenbach M., Hale J., Lynch C.L., Rupprecht K., Parsons W., and Rosen H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
7. Payne S.G., Oskeritzian C.A., Griffiths R., Subramanian P., Barbour S.E., Chalfant C.E., Milstien S., and Spiegel S. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109 (2007) 1077-1085
8. Xin C., Ren S., Eberhardt W., Pfeilschifter J., and Huwiler A. FTY720 suppresses interleukin-1beta-induced secretory phospholipase A(2) expression in renal mesangial cells by a transcriptional mechanism. Br. J. Pharmacol. 150 (2007) 943-950
9. Paugh S.W., Cassidy M.P., He H., Milstien S., Sim-Selley L.J., Spiegel S., and Selley D.E. Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor. Mol. Pharmacol. 70 (2006) 41-50
10. Dudek S.M., Camp S.M., Chiang E.T., Singleton P.A., Usatyuk P.V., Zhao Y., Natarajan V., and Garcia J.G. Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P(1) receptor. Cell Signal. 19 (2007) 1754-1764
11. Sanchez T., and Hla T. Structural and functional characteristics of S1P receptors. J. Cell Biochem. 92 (2004) 913-922
12. Kluk M.J., and Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim. Biophys. Acta 1582 (2002) 72-80
13. Windh R.T., Lee M.J., Hla T., An S., Barr A.J., and Manning D.R. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J. Biol. Chem. 274 (1999) 27351-27358
14. Paik J.H., Chae S., Lee M.J., Thangada S., and Hla T. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J. Biol. Chem. 276 (2001) 11830-11837
15. Butler J., Lana D., Round O., and LaMontagne K. Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. Prostaglandins Other Lipid Mediat. 73 (2004) 29-45
16. Oo M.L., Thangada S., Wu M.T., Liu C.H., Macdonald T.L., Lynch K.R., Lin C.Y., and Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem. 282 (2007) 9082-9089
17. Krump-Konvalinkova V., Yasuda S., Rubic T., Makarova N., Mages J., Erl W., Vosseler C., Kirkpatrick C.J., Tigyi G., and Siess W. Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 546-552
18. Kovarik J.M., Schmouder R., Barilla D., Riviere G.J., Wang Y., and Hunt T. Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J. Clin. Pharmacol. 44 (2004) 532-537
19. Tolle M., Levkau B., Keul P., Brinkmann V., Giebing G., Schonfelder G., Schafers M., von Wnuck Lipinski K., Jankowski J., Jankowski V., Chun J., Zidek W., and Van der Giet M. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ. Res. 96 (2005) 913-920
20. Li X.K., Enosawa S., Kakefuda T., Amemiya H., and Suzuki S. FTY720, a novel immunosuppressive agent, enhances upregulation of the cell adhesion molecular ICAM-1 in TNF-alpha treated human umbilical vein endothelial cells. Transplant. Proc. 29 (1997) 1265-1266
21. Ancellin N., Colmont C., Su J., Li Q., Mittereder N., Chae S.S., Stefansson S., Liau G., and Hla T. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J. Biol. Chem. 277 (2002) 6667-6675