The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen

Journal of Cell Science

Volumn 123, Issue 8, 2010, Pages 1253-1261

  Zwart, Wilbert ^a   De Leeuw, Renée ^a   Rondaij, Mariska ^a   Neefjes, Jacques ^a   Mancini, Michael A ^b   Michalides, Rob ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Activation domain 1; Activation domain 2; Estrogen receptor alpha; Estrogen receptor beta; Hinge region; SRC 1; Tamoxifen agonism; Transcriptional capacity

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; STEROID RECEPTOR COACTIVATOR 1; TAMOXIFEN;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HINGE REGION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RECEPTOR BINDING;

CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; MUTANT PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 1; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RNA POLYMERASE II; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN; TRANSCRIPTIONAL ACTIVATION;

EID: 77951157335     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.061135     Document Type: Article

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