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Volumn 14, Issue 5, 2010, Pages 467-478

The lysosome among targets of metformin: New anti-inflammatory uses for an old drug?

Author keywords

Cathepsin B; Chloroquine; Diabetes; Inflammation; Lysosome; Metformin; Nano pharmacology; Zinc

Indexed keywords

BIGUANIDE; CATHEPSIN B; CHLOROQUINE; CYSTEINE PROTEINASE; METFORMIN; ZINC ION;

EID: 77951140654     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728221003774135     Document Type: Article
Times cited : (21)

References (75)
  • 1
    • 57549097072 scopus 로고    scopus 로고
    • Autophagy: A target for therapeutic interventions in myocardial pathophysiology
    • Halapas A, Armakolas A, Koutsilieris M. Autophagy: a target for therapeutic interventions in myocardial pathophysiology. Expert Opin Ther Targets 2008;12:1509-1522
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 1509-1522
    • Halapas, A.1    Armakolas, A.2    Koutsilieris, M.3
  • 2
    • 48149111341 scopus 로고    scopus 로고
    • Gamma-IFN-induciblelysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma
    • Goldstein OG, Hajiaghamohseni LM, Amria S, et al. Gamma-IFN- induciblelysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma. Cancer Immunol Immunother 2008;57:1461-1470
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1461-1470
    • Goldstein, O.G.1    Hajiaghamohseni, L.M.2    Amria, S.3
  • 3
    • 52949091163 scopus 로고    scopus 로고
    • Zinc signalling and subcellular distribution: Emerging targets in type 2 diabetes
    • Mocchegiani E, Giacconi R, Malavolta M. Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes. Trends Mol Med 2008;14:419-428
    • (2008) Trends Mol Med , vol.14 , pp. 419-428
    • Mocchegiani, E.1    Giacconi, R.2    Malavolta, M.3
  • 4
    • 35648950010 scopus 로고    scopus 로고
    • New concepts in antimalarial use and mode of action in dermatology
    • Kalia S, Dutz JP. New concepts in antimalarial use and mode of action in dermatology. Dermatol Ther 2007;20:160-174
    • (2007) Dermatol Ther , vol.20 , pp. 160-174
    • Kalia, S.1    Dutz, J.P.2
  • 5
    • 73449120372 scopus 로고    scopus 로고
    • Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: A systematic review
    • Ruiz-Irastorza G, Ramos-Casals M, Brito-Zeron P, Khamashta MA. Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review. Ann Rheum Dis 2010;69:20-28
    • (2010) Ann Rheum Dis , vol.69 , pp. 20-28
    • Ruiz-Irastorza, G.1    Ramos-Casals, M.2    Brito-Zeron, P.3    Khamashta, M.A.4
  • 6
    • 0016255812 scopus 로고
    • Protein degradation in cultured cells.II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1
    • Wibo M, Poole B. Protein degradation in cultured cells.II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1. J Cell Biol 1974;63:430-440
    • (1974) J Cell Biol , vol.63 , pp. 430-440
    • Wibo, M.1    Poole, B.2
  • 7
    • 4243052029 scopus 로고    scopus 로고
    • Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana
    • Ehrhardt S, Mockenhaupt FP, Eggelte TA, et al. Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana. Trans R Soc Trop Med Hyg 2003;97:697-701
    • (2003) Trans R Soc Trop Med Hyg , vol.97 , pp. 697-701
    • Ehrhardt, S.1    Mockenhaupt, F.P.2    Eggelte, T.A.3
  • 8
    • 9144224186 scopus 로고    scopus 로고
    • Hydroxychloroquine for the prevention of acute graft-versus-host disease after unrelated donor transplantation
    • Khoury H, Trinkaus K, Zhang MJ, et al. Hydroxychloroquine for the prevention of acute graft-versus-host disease after unrelated donor transplantation. Biol Blood Marrow Transplant 2003;9:714-721
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 714-721
    • Khoury, H.1    Trinkaus, K.2    Zhang, M.J.3
  • 9
    • 48749092592 scopus 로고    scopus 로고
    • The known unknowns of antigen processing and presentation
    • Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol 2008;8:607-618
    • (2008) Nat Rev Immunol , vol.8 , pp. 607-618
    • Vyas, J.M.1    Van Der Veen, A.G.2    Ploegh, H.L.3
  • 10
    • 39449101201 scopus 로고    scopus 로고
    • Hypoglycaemia induced by hydroxychloroquine in a non-diabetic patient treated for RA
    • Cansu DU, Korkmaz C. Hypoglycaemia induced by hydroxychloroquine in a non-diabetic patient treated for RA. Rheumatology 2008;47:378-379
    • (2008) Rheumatology , vol.47 , pp. 378-379
    • Cansu, D.U.1    Korkmaz, C.2
  • 11
    • 0036175209 scopus 로고    scopus 로고
    • The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas-a randomized trial
    • Gerstein HC, Thorpe KE, Taylor DW, Haynes RB. The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas-a randomized trial. Diabetes Res Clin Pract 2002;55:209-219
    • (2002) Diabetes Res Clin Pract , vol.55 , pp. 209-219
    • Gerstein, H.C.1    Thorpe, K.E.2    Taylor, D.W.3    Haynes, R.B.4
  • 12
    • 0033224414 scopus 로고    scopus 로고
    • Effects of chloroquine on insulin sensitivity in insulin-resistant rats
    • Li C, Zhang S, Shu C. Effects of chloroquine on insulin sensitivity in insulin-resistant rats. Zhonghua Yi Xue Za Zhi Natl Med J China 1999;79:867-869
    • (1999) Zhonghua Yi Xue Za Zhi Natl Med J China , vol.79 , pp. 867-869
    • Li, C.1    Zhang, S.2    Shu, C.3
  • 13
    • 0029990745 scopus 로고    scopus 로고
    • Hydroxychloroquine use in the Baltimore Lupus Cohort: Effects on lipids, glucose and thrombosis
    • Petri M. Hydroxychloroquine use in the Baltimore Lupus Cohort: effects on lipids, glucose and thrombosis. Lupus Suppl 1996;1:S16-22
    • (1996) Lupus Suppl , vol.1
    • Petri, M.1
  • 14
    • 0027481309 scopus 로고
    • Effects of chloroquine on the dyslipidemia of non-insulin dependent diabetes mellitus
    • Powrie JK, Shojaee-Moradic F, Watts GF, et al. Effects of chloroquine on the dyslipidemia of non-insulin dependent diabetes mellitus. Metabolism 1993;42:415-419
    • (1993) Metabolism , vol.42 , pp. 415-419
    • Powrie, J.K.1    Shojaee-Moradic, F.2    Watts, G.F.3
  • 15
    • 0032892589 scopus 로고    scopus 로고
    • Hypoglycemia induced by hydroxychloroquine in a type 2 diabetic treated for polyarthritis
    • Shojana K, Koehler BF, Elliot T. Hypoglycemia induced by hydroxychloroquine in a type 2 diabetic treated for polyarthritis. J Rheumatol 1999;1:195-196
    • (1999) J Rheumatol , vol.1 , pp. 195-196
    • Shojana, K.1    Koehler, B.F.2    Elliot, T.3
  • 16
    • 0030011150 scopus 로고    scopus 로고
    • The use of chloroquine and hydroxychloroquine for non-infectious diseases other than rheumatoid arthritis or lupus: A critical review
    • Wallace DJ. The use of chloroquine and hydroxychloroquine for non-infectious diseases other than rheumatoid arthritis or lupus: a critical review. Lupus Suppl 1996;1:S59-64
    • (1996) Lupus Suppl , vol.1
    • Wallace, D.J.1
  • 18
    • 43049156331 scopus 로고    scopus 로고
    • Cardiovascular risk in rheumatoid arthritis: Effects of anti-TNF drugs
    • Avouac J, Allanore Y. Cardiovascular risk in rheumatoid arthritis: effects of anti-TNF drugs. Expert Opin Pharmacother 2008;9:1121-1128
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1121-1128
    • Avouac, J.1    Allanore, Y.2
  • 19
    • 42649134835 scopus 로고    scopus 로고
    • The implication of proinflammatory cytokines in type 2 diabetes
    • Guest CB, Park MJ, Johnson DR, Freund GG. The implication of proinflammatory cytokines in type 2 diabetes. Front Biosci 2008;13:5187-5194
    • (2008) Front Biosci , vol.13 , pp. 5187-5194
    • Guest, C.B.1    Park, M.J.2    Johnson, D.R.3    Freund, G.G.4
  • 20
    • 47149096915 scopus 로고    scopus 로고
    • Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity
    • Heilbronn LK, Campbell LV. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 2008;14:1225-1230
    • (2008) Curr Pharm des , vol.14 , pp. 1225-1230
    • Heilbronn, L.K.1    Campbell, L.V.2
  • 21
    • 58149092981 scopus 로고    scopus 로고
    • Autophagy and acute pancreatitis: A novel autophagy theory for trypsinogen activation
    • Ohmuraya M, Yamamura K. Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation. Autophagy 2008;4:1060-1062
    • (2008) Autophagy , vol.4 , pp. 1060-1062
    • Ohmuraya, M.1    Yamamura, K.2
  • 22
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997;389:610-614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 23
    • 34447257725 scopus 로고    scopus 로고
    • Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis
    • Wasko MC, Hubert HB, Lingala VB, et al. Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis. JAMA 298:187-193
    • JAMA , vol.298 , pp. 187-193
    • Wasko, M.C.1    Hubert, H.B.2    Lingala, V.B.3
  • 24
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type-2 diabetes
    • Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type-2 diabetes. Trends Endocrinol Metab 2000;11:212-217
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 25
    • 34147126829 scopus 로고    scopus 로고
    • The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk
    • Popa C, Netea MG, van Riel PL, et al. The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 2007;48:751-762
    • (2007) J Lipid Res , vol.48 , pp. 751-762
    • Popa, C.1    Netea, M.G.2    Van Riel, P.L.3
  • 26
    • 0035180207 scopus 로고    scopus 로고
    • Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha mediated hepatocyte apoptosis and liver injury: Implications for therapeutic applications
    • Guicciardi ME, Miyoshi H, Bronk SF, Gores GJ. Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications. Am J Pathol 2001;159:2045-2054
    • (2001) Am J Pathol , vol.159 , pp. 2045-2054
    • Guicciardi, M.E.1    Miyoshi, H.2    Bronk, S.F.3    Gores, G.J.4
  • 28
    • 70449455395 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Anti-atherosclerotic properties beyond glucose lowering?
    • Papanas N, Maltezos E. Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering? Curr Pharm Des 2009;15:3179-3192
    • (2009) Curr Pharm des , vol.15 , pp. 3179-3192
    • Papanas, N.1    Maltezos, E.2
  • 29
    • 29244469922 scopus 로고    scopus 로고
    • A practical guide to arylbiguanides: Synthesis and structural characterization
    • LeBel O, Maris T, Duval H, Wuest JD. A practical guide to arylbiguanides: synthesis and structural characterization Can J Chem 2005;83:615-625
    • (2005) Can J Chem , vol.83 , pp. 615-625
    • Lebel, O.1    Maris, T.2    Duval, H.3    Wuest, J.D.4
  • 30
    • 0142065613 scopus 로고
    • Chemistry and structure--activity relationships of biguanides
    • Prugnard E, Noel M. Chemistry and structure--activity relationships of biguanides. Handb Exp Pharmacol 1995;119:263-282
    • (1995) Handb Exp Pharmacol , vol.119 , pp. 263-282
    • Prugnard, E.1    Noel, M.2
  • 32
    • 50649103962 scopus 로고    scopus 로고
    • Metal compounds for the treatment of parasitic diseases
    • Fricker SP, Mosi RM, Cameron BR, et al. Metal compounds for the treatment of parasitic diseases. J Inorg Biochem 2008;102:1839-1845
    • (2008) J Inorg Biochem , vol.102 , pp. 1839-1845
    • Fricker, S.P.1    Mosi, R.M.2    Cameron, B.R.3
  • 34
    • 0142039130 scopus 로고    scopus 로고
    • Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents
    • Sweeney D, Raymer ML, Lockwood TD. Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents. Biochem Pharmacol 2003;66:663-677
    • (2003) Biochem Pharmacol , vol.66 , pp. 663-677
    • Sweeney, D.1    Raymer, M.L.2    Lockwood, T.D.3
  • 35
    • 7044230857 scopus 로고    scopus 로고
    • Cys--His proteases are among the wired proteins of the cell
    • Lockwood TD. Cys--His proteases are among the wired proteins of the cell. Arch Biochem Biophys 2004;432:12-24
    • (2004) Arch Biochem Biophys , vol.432 , pp. 12-24
    • Lockwood, T.D.1
  • 36
    • 70449698491 scopus 로고    scopus 로고
    • Acute metformin overdose: Examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: A systematic review of the literature
    • Dell'Aglio DM, Perino LJ, Kazzi Z, et al. Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. Ann Emerg Med 2009;54:818-823
    • (2009) Ann Emerg Med , vol.54 , pp. 818-823
    • Dell'Aglio, D.M.1    Perino, L.J.2    Kazzi, Z.3
  • 37
    • 0033007118 scopus 로고    scopus 로고
    • Redox-dependent and redox-independent subcomponents of protein degradation in perfused myocardium
    • Lockwood TD. Redox-dependent and redox-independent subcomponents of protein degradation in perfused myocardium. Am J Physiol 1999;276:E945-954
    • (1999) Am J Physiol , vol.276
    • Lockwood, T.D.1
  • 38
    • 0027266012 scopus 로고
    • Four proteolytic processes of myocardium, one insensitive to thiol reactive agents and thiol protease inhibitor
    • Thorne DP, Lockwood TD. Four proteolytic processes of myocardium, one insensitive to thiol reactive agents and thiol protease inhibitor. Am J Physiol 1993;265:E10-19
    • (1993) Am J Physiol , vol.265
    • Thorne, D.P.1    Lockwood, T.D.2
  • 39
    • 0023901026 scopus 로고
    • Determination of zinc in biological samples by atomic absorption spectrometry
    • Falchuk KH, Hilt KL, Vallee BL. Determination of zinc in biological samples by atomic absorption spectrometry. Methods Enzymol 1988;158:422-434
    • (1988) Methods Enzymol , vol.158 , pp. 422-434
    • Falchuk, K.H.1    Hilt, K.L.2    Vallee, B.L.3
  • 40
    • 44949264223 scopus 로고    scopus 로고
    • Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients
    • Kazi TG, Afridi HI, Kazi N, et al. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res 2008;122:1-18
    • (2008) Biol Trace Elem Res , vol.122 , pp. 1-18
    • Kazi, T.G.1    Afridi, H.I.2    Kazi, N.3
  • 41
    • 0020536226 scopus 로고
    • Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice
    • Levine AS, McClain CJ, Handwerger BS, et al. Tissue zinc status of genetically diabetic and streptozotocin-induced diabetic mice. Am J Clin Nutr 1983;37:382-386
    • (1983) Am J Clin Nutr , vol.37 , pp. 382-386
    • Levine, A.S.1    McClain, C.J.2    Handwerger, B.S.3
  • 42
    • 59149099932 scopus 로고    scopus 로고
    • Albumin as a zinc carrier: Properties of its high-affinity zinc-binding site
    • Lu J, Stewart AJ, Sadler PJ, et al. Albumin as a zinc carrier: properties of its high-affinity zinc-binding site. Biochem Soc Trans 2008;36(Pt 6):1317-1321
    • (2008) Biochem Soc Trans , vol.36 , Issue.PART 6 , pp. 1317-1321
    • Lu, J.1    Stewart, A.J.2    Sadler, P.J.3
  • 43
    • 33746888208 scopus 로고    scopus 로고
    • Inhibitors of cathepsin B
    • Frlan R, Gobec S. Inhibitors of cathepsin B. Curr Med Chem 2006;13:2309-2327
    • (2006) Curr Med Chem , vol.13 , pp. 2309-2327
    • Frlan, R.1    Gobec, S.2
  • 44
    • 21344456357 scopus 로고    scopus 로고
    • Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: Inhibitory effect of metformin
    • Li L, Mamputu JC, Wiernsperger N, Renier G. Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin. Diabetes 2005;54:2227-2234
    • (2005) Diabetes , vol.54 , pp. 2227-2234
    • Li, L.1    Mamputu, J.C.2    Wiernsperger, N.3    Renier, G.4
  • 45
    • 47949098831 scopus 로고    scopus 로고
    • Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
    • Ha SD, Martins A, Khazaie K, et al. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol 2008;181:690-697
    • (2008) J Immunol , vol.181 , pp. 690-697
    • Ha, S.D.1    Martins, A.2    Khazaie, K.3
  • 46
    • 0033795691 scopus 로고    scopus 로고
    • Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
    • Halangk W, Lerch MM, Brandt-Nedelev B, et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000;106:773-781
    • (2000) J Clin Invest , vol.106 , pp. 773-781
    • Halangk, W.1    Lerch, M.M.2    Brandt-Nedelev, B.3
  • 47
    • 26444591985 scopus 로고    scopus 로고
    • Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
    • Maehr R, Mintern JD, Herman AE, et al. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. Clin Invest 2005;115:2934-2943
    • (2005) Clin Invest , vol.115 , pp. 2934-2943
    • Maehr, R.1    Mintern, J.D.2    Herman, A.E.3
  • 48
    • 0036720909 scopus 로고    scopus 로고
    • Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity
    • Van Acker GJ, Saluja AK, Bhagat L, et al. Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. Am J Physiol Gastrointest Liver Physiol 2002;283:G794-800
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283
    • Van Acker, G.J.1    Saluja, A.K.2    Bhagat, L.3
  • 49
    • 67349150186 scopus 로고    scopus 로고
    • Autophagy in human type 2 diabetes pancreatic beta cells
    • Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 2009;52:1083-1086
    • (2009) Diabetologia , vol.52 , pp. 1083-1086
    • Masini, M.1    Bugliani, M.2    Lupi, R.3
  • 50
    • 33751210335 scopus 로고    scopus 로고
    • Responsiveness of parasite Cys His proteases to iron redox
    • Lockwood TD. Responsiveness of parasite Cys His proteases to iron redox. Parasitol Res 2006;100:175-181
    • (2006) Parasitol Res , vol.100 , pp. 175-181
    • Lockwood, T.D.1
  • 51
    • 66149094205 scopus 로고    scopus 로고
    • Death receptor 5. internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines
    • Akazawa Y, Mott JL, Bronk SF, et al. Death receptor 5. internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines. Gastroenterology 2009;136:2365-2376
    • (2009) Gastroenterology , vol.136 , pp. 2365-2376
    • Akazawa, Y.1    Mott, J.L.2    Bronk, S.F.3
  • 52
    • 22544442744 scopus 로고    scopus 로고
    • The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury
    • Li JH, Pober JS. The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury. J Immunol 2005;175:1858-1866
    • (2005) J Immunol , vol.175 , pp. 1858-1866
    • Li, J.H.1    Pober, J.S.2
  • 53
    • 70349263383 scopus 로고    scopus 로고
    • Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells
    • Li JH, D'Alessio A, Pober JS. Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells. Am J Pathol 2009;175:1124-1135
    • (2009) Am J Pathol , vol.175 , pp. 1124-1135
    • Li, J.H.1    D'Alessio, A.2    Pober, J.S.3
  • 54
    • 70349163894 scopus 로고    scopus 로고
    • Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe
    • Pratt MR, Sekedat MD, Chiang KP, Muir TW. Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe. Chem Biol 2009;16:1001-1012
    • (2009) Chem Biol , vol.16 , pp. 1001-1012
    • Pratt, M.R.1    Sekedat, M.D.2    Chiang, K.P.3    Muir, T.W.4
  • 55
    • 20444506408 scopus 로고    scopus 로고
    • Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism
    • Taha TA, Kitatani K, Bielawski J, et al. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem 2005;280:17196-17202
    • (2005) J Biol Chem , vol.280 , pp. 17196-17202
    • Taha, T.A.1    Kitatani, K.2    Bielawski, J.3
  • 56
    • 65649145033 scopus 로고    scopus 로고
    • Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice
    • Yan BZ, Wang W, Chen LY, et al. Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice. World J Gastroenterol 2009;15:1231-1236
    • (2009) World J Gastroenterol , vol.15 , pp. 1231-1236
    • Yan, B.Z.1    Wang, W.2    Chen, L.Y.3
  • 57
    • 52049096824 scopus 로고    scopus 로고
    • Cystatins: Biochemical and structural properties, and medical relevance
    • Turk V, Stoka V, Turk D. Cystatins: biochemical and structural properties, and medical relevance. Front Biosci 2008;13:5406-5420
    • (2008) Front Biosci , vol.13 , pp. 5406-5420
    • Turk, V.1    Stoka, V.2    Turk, D.3
  • 58
    • 43349093939 scopus 로고    scopus 로고
    • Molecular background of EPM1-Unverricht-Lundborg disease
    • Joensuu T, Lehesjoki AE, Kopra O. Molecular background of EPM1-Unverricht-Lundborg disease. Epilepsia 2008;49:557-563
    • (2008) Epilepsia , vol.49 , pp. 557-563
    • Joensuu, T.1    Lehesjoki, A.E.2    Kopra, O.3
  • 59
    • 34247139737 scopus 로고    scopus 로고
    • Seizures, ataxia, and neuronal loss in cystatin B heterozygous mice
    • Kaasik A, Kuum M, Aonurm A, et al. Seizures, ataxia, and neuronal loss in cystatin B heterozygous mice. Epilepsia 2007;48:752-757
    • (2007) Epilepsia , vol.48 , pp. 752-757
    • Kaasik, A.1    Kuum, M.2    Aonurm, A.3
  • 60
    • 50349097188 scopus 로고    scopus 로고
    • Analysis of metal-binding proteins separated by non-denaturating gel electrophoresis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
    • Becker JS, Mounicou S, Zoriy MV, et al. Analysis of metal-binding proteins separated by non-denaturating gel electrophoresis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Talanta 2008;76:1183-1188
    • (2008) Talanta , vol.76 , pp. 1183-1188
    • Becker, J.S.1    Mounicou, S.2    Zoriy, M.V.3
  • 61
    • 58449134643 scopus 로고    scopus 로고
    • Autocatalytic processing of procathepsin B is triggered by proenzyme activity
    • Pungercar JR, Caglic D, Sajid M, et al. Autocatalytic processing of procathepsin B is triggered by proenzyme activity. FEBS J 2009;276:660-668
    • (2009) FEBS J , vol.276 , pp. 660-668
    • Pungercar, J.R.1    Caglic, D.2    Sajid, M.3
  • 62
    • 53049095258 scopus 로고    scopus 로고
    • Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
    • Redzynia I, Ljunggren A, Abrahamson M, et al. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. J Biol Chem 2008;283:22815-22825
    • (2008) J Biol Chem , vol.283 , pp. 22815-22825
    • Redzynia, I.1    Ljunggren, A.2    Abrahamson, M.3
  • 63
    • 33747723380 scopus 로고    scopus 로고
    • Mammalian zinc transport, trafficking, and signals
    • Cousins RJ, Liuzzi JP, Lichten LA. Mammalian zinc transport, trafficking, and signals. J Biol Chem 2008;281:24085-24089
    • (2008) J Biol Chem , vol.281 , pp. 24085-24089
    • Cousins, R.J.1    Liuzzi, J.P.2    Lichten, L.A.3
  • 64
  • 65
    • 49749124150 scopus 로고    scopus 로고
    • Intracellular zinc homeostasis and zinc signaling
    • Murakami M, Hirano T. Intracellular zinc homeostasis and zinc signaling. Cancer Sci 2008;99:1515-1522
    • (2008) Cancer Sci , vol.99 , pp. 1515-1522
    • Murakami, M.1    Hirano, T.2
  • 67
    • 54049156405 scopus 로고    scopus 로고
    • The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel
    • Dong XP, Cheng X, Mills E, et al. The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature 2008;455:992-996
    • (2008) Nature , vol.455 , pp. 992-996
    • Dong, X.P.1    Cheng, X.2    Mills, E.3
  • 68
    • 0030763630 scopus 로고    scopus 로고
    • Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes
    • Bevan AP, Krook A, Tikerpae J, et al. Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes. J Biol Chem 1997;272:833-840
    • (1997) J Biol Chem , vol.272 , pp. 833-840
    • Bevan, A.P.1    Krook, A.2    Tikerpae, J.3
  • 69
    • 0021687736 scopus 로고
    • In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance
    • Blazar BR, Whitly CB, Kitabchi AE, et al. In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance. Diabetes 1984;33:1133-1137
    • (1984) Diabetes , vol.33 , pp. 1133-1137
    • Blazar, B.R.1    Whitly, C.B.2    Kitabchi, A.E.3
  • 70
    • 24744459211 scopus 로고    scopus 로고
    • The pharmacology of the insulinomimetic effect of zinc complexes
    • Sakurai H, Adachi Y. The pharmacology of the insulinomimetic effect of zinc complexes. Biometals. 2005;8:319-323
    • (2005) Biometals , vol.8 , pp. 319-323
    • Sakurai, H.1    Adachi, Y.2
  • 71
    • 0032803011 scopus 로고    scopus 로고
    • Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent
    • Emani J, Gerstein HC, Pasutto FM, Janmali F. Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent. Can J Physiol Pharmacol 1999;77:118-123
    • (1999) Can J Physiol Pharmacol , vol.77 , pp. 118-123
    • Emani, J.1    Gerstein, H.C.2    Pasutto, F.M.3    Janmali, F.4
  • 72
    • 0036234949 scopus 로고    scopus 로고
    • In-vivo kinetics of 123 iodine-labelled insulin in skeletal muscle of patients with type-2 diabetes: Effects of metformin
    • Valensi P, Behar A, Cohen-Boulakia F, et al. In-vivo kinetics of 123 iodine-labelled insulin in skeletal muscle of patients with type-2 diabetes: effects of metformin. Diabet Metab 2002;28:95-103
    • (2002) Diabet Metab , vol.28 , pp. 95-103
    • Valensi, P.1    Behar, A.2    Cohen-Boulakia, F.3
  • 74
    • 33645516747 scopus 로고    scopus 로고
    • Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
    • Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;1:CD002967
    • (2006) Cochrane Database Syst Rev , vol.1
    • Salpeter, S.1    Greyber, E.2    Pasternak, G.3    Salpeter, E.4
  • 75
    • 4944243985 scopus 로고    scopus 로고
    • An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase
    • Mayer S, Daigle DM, Brown ED, et al. An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase. J Comb Chem 2004;6:776-782
    • (2004) J Comb Chem , vol.6 , pp. 776-782
    • Mayer, S.1    Daigle, D.M.2    Brown, E.D.3


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