An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase

Journal of Combinatorial Chemistry

Volumn 6, Issue 5, 2004, Pages 776-782

  Mayer, Stanislas ^a   Daigle, Denis M ^b   Brown, Eric D ^b   Khatri, Jayantilal ^a   Organ, Michael G ^a  

^a YORK UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHALENEMETHYLBIGUANIDE; 1,2,3,4 TETRAHYDRO 1 NAPHTHYLBIGUANIDE; 2 [(3,4 DIMETHOXY)PHENYL]ETHYLBIGUANIDE; 2 BROMOPHENYLBIGUANIDE; 2 FLUOROPHENYLBIGUANIDE; 2,3 DICHLOROPHENYLBIGUANIDE; 2,3 DIMETHYLPHENYLBIGUANIDE; 2,4 DIMETHYLPHENYLBIGUANIDE; 3 FLUOROPHENYLBIGUANIDE; 3 TRIFLUOROMETHYLPHENYLBIGUANIDE; 3,4 DICHLOROBENZYLBIGUANIDE; 3,4 DICHLOROPHENYLBIGUANIDE; 4 (PHENYLAZA)PHENYLBIGUANIDE; 4 ACETYLPHENYLBIGUANIDE; 4 BROMOPHENYLBIGUANIDE; 4 CHLOROPHENYLBIGUANIDE; 4 FLUOROPHENYLBIGUANIDE; 4 IODOPHENYLBIGUANIDE; 4 METHOXYBENZYLBIGUANIDE; 4 METHOXYPHENYLBIGUANIDE; 4 TRIFLUOROMETHYLPHENYLBIGUANIDE; BENZYLBIGUANIDE; BIGUANIDE DERIVATIVE; CHLORIDE; DIHYDROFOLATE REDUCTASE INHIBITOR; ETHYL 4 BIGUANIDEBENZOATE; N METHYLBENZYLBIGUANIDE; NAPHTHYLBIGUANIDE; PHENYLBIGUANIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; COMBINATORIAL LIBRARY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; FILTRATION; METHODOLOGY; MICROWAVE IRRADIATION;

BIGUANIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; ESCHERICHIA COLI; FILTRATION; FOLIC ACID ANTAGONISTS; MICROWAVES; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 4944243985     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc049953+     Document Type: Article

References (13)

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