Autocatalytic processing of procathepsin B is triggered by proenzyme activity

FEBS Journal

Volumn 276, Issue 3, 2009, Pages 660-668

  Pungerčar, Jerica Rozman ^a   Caglič, Dejan ^a   Sajid, Mohammed ^c   Dolinar, Marko ^b   Vasiljeva, Olga ^a   Požgan, Urška ^a   Turk, Dušan ^a   Bogyo, Matthew ^d   Turk, Vito ^a   Turk, Boris ^a  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoactivation; DCG 04; Lysosomal cysteine protease; Procathepsin B; Processing

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 7 N BENZYLOXYCARBONYLARGINYLARGINYLAMIDE 4 METHYLCOUMARIN; CATHEPSIN B; COUMARIN DERIVATIVE; CYSTEINE PROTEINASE; ENZYME PRECURSOR; GLYCOSAMINOGLYCAN; PEPTIDE DERIVATIVE; PROCATHEPSIN B; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; ZYMOGRAPHY;

AMINO ACID SEQUENCE; BIOCATALYSIS; CATHEPSIN B; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME PRECURSORS; MOLECULAR SEQUENCE DATA; SUBSTRATE SPECIFICITY;

EID: 58449134643     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06815.x     Document Type: Article

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