Hydroxychloroquine for the prevention of acute graft-versus-host disease after unrelated donor transplantation

Biology of Blood and Marrow Transplantation

Volumn 9, Issue 11, 2003, Pages 714-721

  Khoury, H ^a   Trinkaus, K ^b   Zhang, M J ^c   Adkins, D ^a   Brown, R ^a   Vij, R ^a   Goodnough, L T ^a   Ma, M K ^b   McLeod, H L ^b   Shenoy, S ^a   Horowitz, M ^c   DiPersio, J F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Washington University in St Louis School of Medicine   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

GVHD prophylaxis; Hematopoietic stem cell transplantation; Hydroxychloroquine; Unrelated donor

Indexed keywords

ACICLOVIR; COTRIMOXAZOLE; CYCLOSPORIN A; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; ITRACONAZOLE; METHOTREXATE; METHYLPREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; BONE MARROW TRANSPLANTATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL TOXICITY; HEMATOLOGIC MALIGNANCY; HUMAN; INCIDENCE; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOSIS; MYOPATHY; NEUROPATHY; PHASE 2 CLINICAL TRIAL; PNEUMOCYSTOSIS; RECIPIENT; REGISTER; SURVIVAL RATE; VIRUS INFECTION;

ADOLESCENT; ADULT; ANTIGENS, CD; BONE MARROW TRANSPLANTATION; CAUSE OF DEATH; ENZYME INHIBITORS; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HUMANS; HYDROXYCHLOROQUINE; INCIDENCE; LIVING DONORS; LYMPHOCYTE SUBSETS; MIDDLE AGED; NEOPLASMS; RETROSPECTIVE STUDIES; TISSUE DONORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

EID: 9144224186     PISSN: 10838791     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbmt.2003.08.006     Document Type: Article

References (30)

1. Silberman G. Crosse M.G. Peterson E.A. et al. Availability and appropriateness of allogeneic bone marrow transplantation for chronic myeloid leukemia in 10 countries N Engl J Med 331 1994 1063-1067
2. McGlave P. Shu X. Wen W. et al. Unrelated donor marrow transplantation for chronic myelogenous leukemia: 9 years' experience of the national marrow donor program Blood 95 2000 2219-2225
3. Marks D. Cullis J. Ward K. et al. Allogeneic bone marrow transplantation for chronic myeloid leukemia using sibling and volunteer unrelated donors Ann Intern Med 119 1993 207-214
4. Hansen J. Gooley T. Martin P. et al. Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia N Engl J Med 338 1998 962-968
5. Fox R. Mechanism of action of hydroxychloroquine as an antirheumatic drug Semin Arthritis Rheum 23 1993 82-91
6. Gilman A. Beams F. Tefft M. et al. The effect of hydroxychloroquine on alloreactivity and its potential use for graft-versus-host disease Bone Marrow Transplant 17 1996 1069-1075
7. Schultz K. Gilman A. The lysosomotropic amines, chloroquine and hydroxychloroquine: a potentially novel therapy for graft-versus-host disease Leuk Lymphoma 24 1997 201-210
8. Schultz K. Nelson D. Bader S. et al. Synergy between lysosomotropic amines and cyclosporin A on human T cell responses to an exogenous protein antigen, tetanus toxoid Bone Marrow Transplant 18 1996 625-631
9. Schultz K. Bader S. Nelson D. Immune suppression by lysosomotropic amines and cyclosporine on T-cell responses to minor and major histocompatibility antigens Transplantation 64 1997 1055-1065
10. Schultz K. Bader S. Paquet J. et al. Chloroquine treatment affects T-cell priming to minor histocompatibility antigens and graft-versus-host disease Blood 86 1995 4344-4352
11. Gilman A. Chan K.W. Mogul M. et al. Hydroxychloroquine for the treatment of chronic graft-versus-host disease Biol Blood Marrow Transplant 6 2000 327-334
12. Khoury H. Adkins D. Brown R. et al. Low transplant-related complications in patients with chronic myeloid leukemia undergoing allogeneic stem cell transplantation with a low-dose (550 cGy) total body irradiation conditioning regimen Biol Blood Marrow Transplant 7 2001 352-358
13. Blum W. Brown R. Lin H.S. et al. Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity Biol Blood Marrow Transplant 8 2002 608-618
14. Reed K.C. Mann D.A. Rapid transfer of DNA from agarose gels to nylon membrane Nucleic Acids Res 13 1985 7207-7221
15. Przepiorka D. Weisdorf D. Martin P. et al. 1994 Consensus Conference on Acute GVHD Grading Bone Marrow Transplant 15 1995 825-828
16. Khoury H. Kashyap A. Adkins D. et al. Anti-thymocyte globulin for steroid-resistant acute graft-versus-host disease Bone Marrow Transplant 27 2001 1059-1064
17. Brocks D.R. Pasutto F.M. Jamali F. Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers J Chromatogr 581 1992 83-92
18. Brown R.R. Stroshane R.M. Benziger D.P. High-performance liquid chromatographic assay for hydroxychloroquine and three of its major metabolites, desethylhydroxychloroquine, desethylchloroquine and bidesethylchloroquine, in human plasma J Chromatogr 377 1986 454-459
19. Shenoy S. Mohanakumar T. Todd G. et al. Immune reconstitution following allogeneic peripheral blood stem cell transplants Bone Marrow Transplant 23 1999 335-346
20. Szydlo R. Goldman J. Klein J. et al. Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings J Clin Oncol 15 1997 1767-1777
21. Clark F.J. Chakraverty R. Role of dendritic cells in graft-versus-host disease J Hematother Stem Cell Res 11 2002 601-616
22. Zhang Y. Schlomchik W. Joe G. et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease J Immunol 169 2002 7111-7118
23. Tett S. Day R. Cutler D. et al. Hydroxychloroquine relative bioavailability: within subject reproducibility Br J Clin Pharmacol 41 1996 244-246
24. McLachlan A. Tett S. Cutler D. et al. Bioavailability of hydroxychloroquine tablets in patients with rheumatoid arthritis Br J Rheumatol 33 1994 235-239
25. Miller D. Fiechtner J. Carpenter S. Plasma hydroxychloroquine concentrations and efficacy in rheumatoid arthritis Arthritis Rheum 30 1987 567-571
26. Przepiorka D. Khouri I. Ippoliti C. et al. Tacrolimus and minidose methotrexate for prevention of acute graft-versus-host disease after HLA-mismatched or blood stem cell transplantation Bone Marrow Transplant 24 1999 763-768
27. Zander A. Zabelina T. Kroger N. et al. Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow Bone Marrow Transplant 23 1999 889-893
28. Nash R. Pineiro L. Storb R. et al. FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantations from matched unrelated donors Blood 88 1996 3634-3641
29. Sierra J. Storer B. Hansen J. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose Blood 89 1997 4226-4235
30. Weisdorf D. Anasetti C. Antin J. Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated versus matched sibling donor transplantation Blood 99 2002 1971-1977