Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B

Journal of Biological Chemistry

Volumn 283, Issue 33, 2008, Pages 22815-22825

  Redzynia, Izabela ^a   Ljunggren, Anna ^b   Abrahamson, Magnus ^b,f   Mort, John S ^c   Krupa, Joanne C ^c   Jaskolski, Mariusz ^d,e   Bujacz, Grzegorz ^a,e  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b LUND UNIVERSITY   (Sweden)

^c SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^d ADAM MICKIEWICZ UNIVERSITY   (Poland)

^e INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^f LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE;

ACTIVE SITES; ASSOCIATION RATES; CATHEPSIN B; CHAGAS DISEASES; CRYSTAL FORMS; CYSTEINE PROTEASES; EXOPEPTIDASE ACTIVITIES; HIGH AFFINITIES; HUMAN CATHEPSINS; KINETIC ANALYSES; LARGE RANGES; NATURAL PROTEINS; OUTER LOOPS; STRUCTURAL FRAMEWORKS; TRYPANOSOMA CRUZI; VIRULENCE FACTORS;

BINDING SITES;

CATHEPSIN B; CHAGASIN; PROTEIN; UNCLASSIFIED DRUG; CHAGASIN, TRYPANOSOMA; CYSTATIN; ENZYME INHIBITOR; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; KINETICS; SOLUTION AND SOLUBILITY;

TRYPANOSOMA CRUZI;

ANIMALS; CATHEPSIN B; CYSTATINS; ENZYME INHIBITORS; HUMANS; KINETICS; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SOLUTIONS; TRYPANOSOMA CRUZI;

EID: 53049095258     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802064200     Document Type: Article

References (43)

1. Rawlings, N. D., Morton, F. R., Kok, C. Y., Kong, J., and Barrett, A. J. (2008) Nucleic Acids Res. 36, 320-325
2. Yasuda, Y., Kaleta, J., and Brömme, D. (2005) Adv. Drug Delivery Rev. 57, 973-993
3. Nomura, T., and Katunuma, N. (2005) J. Med. Investig. 52, 1-9
4. Guncar, G., Podobnik, M., Pungercar, J., Strukelj, B., Turk, V., and Turk, D. (1998) Structure 6, 51-61
5. Molgaard, A., Arnau, J., Lauritzen, C., Larsen, S., Petersen, G., and Pedersen, J. (2007) Biochem. J. 401, 645-650
6. Sivaraman, J., Nägler, D. K., Zhang, R., Ménard, R., and Cygler, M. (2000) J. Mol. Biol. 295, 939-951
7. Musil, D., Zucic, D., Engh, R. A., Mayr, I., Huber, R., Popovic, T., Turk, V., Towatari, T., Katunuma, N., and Bode, W. (1991) EMBO J. 10, 2321-2330
8. Illy, C., Quraishi, O., Wang, J., Purisima, E., Vernet, T., and Mort, J. S. (1997) J. Biol. Chem. 272, 1197-1202
9. Murata, M., Miyashita, S., Yokoo, C., Tamai, M., Hanada, K., Hatayama, K., Towatari, T., Nikawa, T., and Katunuma, N. (1991) FEBS Lett. 280, 307-310
10. Hanada, K., Tamai, M., Yamagishi, M., Ohmura, S., Sawada, J., and Tanaka, I. (1978) Agric. Biol. Chem. 42, 523-528
11. Nägler, D. K., Storer, A. C., Portaro, F. C. V., Carmona, E., Juliano, L., and Ménard, R. (1997) Biochemistry 36, 12608-12615
12. Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A. C., and Mort, J. S. (1996) Structure 4, 405-416
13. Abrahamson, M., Alvarez-Fernandez, M., and Nathanson, C. M. (2003) Biochem. Soc. Symp. 70, 179-199
14. Pavlova, A., Krupa, J. C., Mort, J. S., Abrahamson, M., and Björk, I. (2000) FEBS Lett. 487, 156-160
15. Monteiro, A. C. S., Abrahamson, M., Lima, A. P. C. A., Vannier-Santos, M. A., and Scharfstein, J. (2001) J. Cell Sci. 114, 3933-3942
16. Ljunggren, A., Redzynia, I., Alvarez-Fernandez, M., Abrahamson, M., Mort, J. S., Krupa, J. C., Jaskolski, M., and Bujacz, G. (2007) J. Mol. Biol. 371, 137-153
17. Salmon, D., do Aido-Machado, R., Diehl, A., Leidert, M., Schmetzer, O., de Lima, A. A. P., Scharfstein, J., Oschkinat, H., and Pires, J. R. (2006) J. Mol. Biol. 357, 1511-1521
18. Wang, S. X., Pandey, K. C., Scharfstein, J., Whisstock, J., Huang, R. K., Jacobelli, J., Flatterick, R. J., Rosenthal, P. J., Abrahamson, M., Brinen, L. S., Rossi, A., Sali, A., and McKerrow, J. H. (2007) Structure 15, 535-543
19. Dos Reis, F. C., Smith, B. O., Santos, C. C., Costa, T. F., Scharfstein, J., Coombs, G. H., Mottram, J. C., and Lima, A. P. (2008) FEBS Lett. 582, 485-490
20. Benson, D. A., Karsch-Mizrachi, I., Lipman, D. J., Ostell, J., and Wheeler, D. L. (2007) Nucleic Acids Res. 35, 21-25
21. Mach, L., Mort, J. S., and Glössl, J. (1994) J. Biol. Chem. 269, 13030-13035
22. Krupa, J. C., Hasnain, S., Nägler, D. K., Ménard, R., and Mort, J. S. (2002) Biochem. J. 361, 613-619
23. Hasnain, S., Hirama, T., Tam, A., and Mort, J. S. (1992) J. Biol. Chem. 267, 4713-4721
24. Blumberg, S., Schechter, I., and Berger, A. (1970) Eur. J. Biochem. 15, 97-102
25. Hall, A., Håkansson, K., Mason, R. W., Grubb, A., and Abrahamson, M. (1995) J. Biol. Chem. 270, 5115-5121
26. Abrahamson, M. (1994) Methods Enzymol. 244, 685-700
27. Henderson, P. J. (1972) Biochem. J. 127, 321-333
28. Gasteiger, E., Hoogland, C., Gattiker, A., Duvaud, S., Wilkins, M. R., Appel, R. D., and Bairoch, A. (2005) ProtParam, Humana Press, Inc. Totowa, NJ
29. Jeppsson, J. O., Laurell, C. B., and Franzén, B. (1979) Clin. Chem. 25, 629-638
30. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
31. Vagin, A. A., and Teplyakov, A. (1997) J. Appl. Crystallogr. 30, 1022-1025
32. Murshudov, G. N., Vagin, A., and Dodson, E. (1997) Acta Crystallogr. Sect. D 53, 240-255
33. Potterton, E., Briggs, P., Turkenburg, M., and Dodson, E. (2003) Acta Crystallogr. Sect. D 59, 1131-1137
34. Winn, M. D., Isupov, M. N., and Murshudov, G. N. (2001) Acta Crystallogr. Sect. D 57, 122-133
35. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. Sect. D 60, 2126-2132
36. Brünger, A. T. (1992) Nature 355, 472-474
37. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
38. Saff, E. B., and Kuijlaars, A. B. J. (1997) The Mathematical Intelligencer 19, 5-11
39. Turk, D., Podobnik, M., Kuhelj, R., Dolinar, M., and Turk, V. (1996) FEBS Lett. 384, 211-214
40. DeLano, W. L. (2002) PyMol, Delano Scientific, San Carlos, CA
41. Weiss, M. (2001) J. Appl. Crystallogr. 34, 130-135
42. Evans, P. (2006) Acta Crystallogr. Sect. D 62, 72-82
43. Davis, I. W. (2007) Nucleic Acids Res. 35, 375-383