Never take candy from a stranger: The role of the bacterial glycome in host-pathogen interactions

Future Microbiology

Volumn 5, Issue 2, 2010, Pages 267-288

  Reid, Christopher W ^a   Fulton, Kelly M ^a   Twine, Susan M ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

NMR

Indexed keywords

CARBOHYDRATE; GLYCOLIPID; GLYCOPROTEIN; LECTIN; PEPTIDOGLYCAN; VIRULENCE FACTOR;

BACTERIAL GENOME; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BIOENGINEERING; BIOINFORMATICS; CAMPYLOBACTER JEJUNI; CAPILLARY ELECTROPHORESIS; CHEMICAL LABELING; CHEMICAL STRUCTURE; GENOME ANALYSIS; GENOMICS; GLYCOBIOLOGY; HIGH ANGLE MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; MASS SPECTROMETRY; MICROARRAY ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN GLYCOSYLATION; PROTEOMICS; REVIEW; TRANSCRIPTOMICS;

BACTERIA; GLYCOCONJUGATES; HOST-PATHOGEN INTERACTIONS; POLYSACCHARIDES;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

EID: 77951138081     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/fmb.09.103     Document Type: Review

References (219)

1. Roseman S: Reflections on glycobiology. J. Biol. Chem. 276(45), 41527-41542 (2001).
2. German JB, Gillies LA, Smilowitz JT, Zivkovic AM, Watkins SM: Lipidomics and lipid profiling in metabolomics. Curr. Opin. Lipidol. 18(1), 66-71 (2007).
3. Dettmer K, Aronov PA, Hammock BD: Mass spectrometry-based metabolomics. Mass Spectrom. Rev. 26(1), 51-78 (2007).
4. Schmidt MA, Riley LW, Benz I: Sweet new world: glycoproteins in bacterial pathogens. Trends Microbiol. 11(12), 554-561 (2003).
5. Lerouge I, Vanderleyden J: O-antigen structural variation: mechanisms and possible roles in animal/plant-microbe interactions. FEMS Microbiol. Rev. 26(1), 17-47 (2002).
6. Weintraub A: Immunology of bacterial polysaccharide antigens. Carbohydr. Res. 338(23), 2539-2547 (2003).
7. Ryder C, Byrd M, Wozniak DJ: Role of polysaccharides in Pseudomonas aeruginosa biofilm development. Curr. Opin. Microbiol. 10(6), 644-648 (2007).
8. Messner P: Prokaryotic glycoproteins: unexplored but important. J. Bacteriol. 186(9), 2517-2519 (2004).
9. Logan SM: Flagellar glycosylation - a new component of the motility repertoire? Microbiology 152(Pt 5), 1249-1262 (2006).
10. Laine RA: A calculation of all possible oligosaccharide isomers both branched and linear yields 1.05 × 10(12) structures for a reducing hexasaccharide: the isomer barrier to development of single-method saccharide sequencing or synthesis systems. Glycobiology 4(6), 759-767 (1994).
11. Voisin S, Houliston RS, Kelly J et al.: Identification and characterization of the unique N-linked glycan common to the flagellins and S-layer glycoprotein of Methanococcus voltae. J. Biol. Chem. 280(17), 16586-16593 (2005).
12. Twine SM, Paul CJ, Vinogradov E et al.: Flagellar glycosylation in Clostridium botulinum. FEBS J. 275(17), 4428-4444 (2008).
13. Mescher MF, Strominger JL: Structural (shape-maintaining) role of the cell surface glycoprotein of Halobacterium salinarium. Proc. Natl Acad. Sci. USA 73(8), 2687-2691 (1976).
14. Mescher MF, Strominger JL: Purification and characterization of a prokaryotic glucoprotein from the cell envelope of Halobacterium salinarium. J. Biol. Chem. 251(7), 2005-2014 (1976).
15. Szymanski CM, Wren BW: Protein glycosylation in bacterial mucosal pathogens. Nat. Rev. Microbiol. 3(3), 225-237 (2005).
16. Szymanski CM, Yao R, Ewing CP, Trust TJ, Guerry P: Evidence for a system of general protein glycosylation in Campylobacter jejuni. Mol. Microbiol. 32(5), 1022-1030 (1999).
17. Schirm M, Soo EC, Aubry AJ, Austin J, Thibault P, Logan SM: Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori. Mol. Microbiol. 48(6), 1579-1592 (2003).
18. Castric P, Cassels FJ, Carlson RW: Structural characterization of the Pseudomonas aeruginosa 1244 pilin glycan. J. Biol. Chem. 276(28), 26479-26485 (2001).
19. Schirm M, Arora SK, Verma A et al.: Structural and genetic characterization of glycosylation of type A flagellin in Pseudomonas aeruginosa. J. Bacteriol. 186(9), 2523-2531 (2004).
20. Banerjee A, Ghosh SK: The role of pilin glycan in neisserial pathogenesis. Mol. Cell. Biochem. 253(1-2), 179-190 (2003).
21. Stimson E, Virji M, Makepeace K et al.: Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose. Mol. Microbiol. 17(6), 1201-1214 (1995).
22. Lindenthal C, Elsinghorst EA: Identification of a glycoprotein produced by enterotoxigenic Escherichia coli. Infect. Immun. 67(8), 4084-4091 (1999).
23. Benz I, Schmidt MA: Glycosylation with heptose residues mediated by the AAH gene product is essential for adherence of the AIDA-I adhesin. Mol. Microbiol. 40(6), 1403-1413 (2001).
24. Twine SM, Reid CW, Aubry A et al.: Motility and flagellar glycosylation in Clostridium difficile. J. Bacteriol. 191(22), 7050-7062 (2009).
25. Ghosh SK, Zhao J, Philogene MC, Alzaharani A, Rane S, Banerjee A: Pathogenic consequences of Neisseria gonorrhoeae pilin glycan variation. Microbes Infect. 6(7), 693-701 (2004).
26. Ng SY, Chaban B, Jarrell KF: Archaeal flagella, bacterial flagella and type IV pili: a comparison of genes and posttranslational modifications. J. Mol. Microbiol. Biotechnol. 11(3-5), 167-191 (2006).
27. Voisin S, Kus JV, Houliston S et al.: Glycosylation of Pseudomonas aeruginosa strain Pa5196 type IV pilins with mycobacterium-like a-1,5-linked d-Araf oligosaccharides. J. Bacteriol. 189(1), 151-159 (2007).
28. Wu H, Zeng M, Fives-Taylor P: The glycan moieties and the N-terminal polypeptide backbone of a fimbria-associated adhesin, Fap1, play distinct roles in the biofilm development of Streptococcus parasanguinis. Infect. Immun. 75(5), 2181-2188 (2007).
29. Zhou M, Wu H: Glycosylation and biogenesis of a family of serine-rich bacterial adhesins. Microbiology 155(Pt 2), 317-327 (2009).
30. Takahashi Y, Sandberg AL, Ruhl S, Muller J, Cisar JO: A specific cell surface antigen of Streptococcus gordonii is associated with bacterial hemagglutination and adhesion to a2-3-linked sialic acid-containing receptors. Infect. Immun. 65(12), 5042-5051 (1997).
31. Plummer C, Wu H, Kerrigan SW, Meade G, Cox D, Ian Douglas CW: A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb. Br. J. Haematol. 129(1), 101-109 (2005).
32. Schaffer C, Messner P: Surface-layer glycoproteins: an example for the diversity of bacterial glycosylation with promising impacts on nanobiotechnology. Glycobiology 14(8), 31R-42R (2004).
33. Guerry P, Ewing CP, Schirm M et al.: Changes in flagellin glycosylation affect Campylobacter autoagglutination and virulence. Mol. Microbiol. 60(2), 299-311 (2006).
34. Schirm M, Kalmokoff M, Aubry A, Thibault P, Sandoz M, Logan SM: Flagellin from Listeria monocytogenes is glycosylated with b-O-linked N-acetylglucosamine. J. Bacteriol. 186(20), 6721-6727 (2004).
35. Grass S, Buscher AZ, Swords WE et al.: The Haemophilus influenzae HMW1 adhesin is glycosylated in a process that requires HMW1C and phosphoglucomutase, an enzyme involved in lipooligosaccharide biosynthesis. Mol. Microbiol. 48(3), 737-751 (2003).
36. Weerapana E, Imperiali B: Asparagine-linked protein glycosylation: from eukaryotic to prokaryotic systems. Glycobiology 16(6), 91R-101R (2006).
37. Kus JV, Kelly J, Tessier L, Harvey H, Cvitkovitch DG, Burrows LL: Modification of Pseudomonas aeruginosa Pa5196 type IV pilins at multiple sites with d-Araf by a novel GT-C family Arabinosyltransferase, TfpW. J. Bacteriol. 190(22), 7464-7478 (2008).
38. Kus JV, Tullis E, Cvitkovitch DG, Burrows LL: Significant differences in type IV pilin allele distribution among Pseudomonas aeruginosa isolates from cystic fibrosis (CF) versus non-CF patients. Microbiology 150(Pt 5), 1315-1326 (2004).
39. Young NM, Brisson JR, Kelly J et al.: Structure of the N-linked glycan present on multiple glycoproteins in the Gram-negative bacterium, Campylobacter jejuni. J. Biol. Chem. 277(45), 42530-42539 (2002).
40. Kelly J, Jarrell H, Millar L et al.: Biosynthesis of the N-linked glycan in Campylobacter jejuni and addition onto protein through block transfer. J. Bacteriol. 188(7), 2427-2434 (2006).
41. Kowarik M, Young NM, Numao S et al.: Definition of the bacterial N-glycosylation site consensus sequence. EMBO J. 25(9), 1957-1966 (2006).
42. Wacker M, Linton D, Hitchen PG et al.: N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298(5599), 1790-1793 (2002).
43. Wacker M, Feldman MF, Callewaert N et al.: Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems. Proc. Natl Acad. Sci. USA 103(18), 7088-7093 (2006).
44. Hounsell EF, Davies MJ, Smith KD: O-linked oligosaccharide profiling by HPAEC-PAD. In: Protein Protocols Handbook. Walker J (Ed.). Humana Press, NY, USA, 651-652 (1996).
45. Harvey DJ: Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for 2003-2004. Mass Spectrom. Rev. 28(2), 273-361 (2009).
46. Harvey DJ, Dwek RA, Rudd PM: Determining the structure of glycan moieties by mass spectrometry. Curr. Protoc. Protein Sci. Chapter 12, Unit 12.7 (2006).
47. Harvey DJ: Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update covering the period 2001-2002. Mass Spectrom. Rev. 27(2), 125-201 (2008).
48. Harvey DJ: Proteomic analysis of glycosylation: structural determination of N- and O-linked glycans by mass spectrometry. Expert Rev. Proteomics 2(1), 87-101 (2005).
49. Ortner K, Sivanandam VN, Buchberger W, Muller N: Analysis of glycans in glycoproteins by diffusion-ordered nuclear magnetic resonance spectroscopy. Anal. Bioanal. Chem. 388(1), 173-177 (2007).
50. Wilson NL, Schulz BL, Karlsson NG, Packer NH: Sequential analysis of N- and O-linked glycosylation of 2D-PAGE separated glycoproteins. J. Proteome Res. 1(6), 521-529 (2002).
51. Guttman A: High-resolution carbohydrate profiling by capillary gel electrophoresis. Nature 380(6573), 461-462 (1996). (Pubitemid 26102727)
52. Koller A, Khandurina J, Li J, Kreps J, Schieltz D, Guttman A: Analysis of high-mannose-type oligosaccharides by microliquid chromatography-mass spectrometry and capillary electrophoresis. Electrophoresis 25(13), 2003-2009 (2004).
53. Olajos M, Hajos P, Bonn GK, Guttman A: Sample preparation for the analysis of complex carbohydrates by multicapillary gel electrophoresis with light-emitting diode induced fluorescence detection. Anal. Chem. 80(11), 4241-4246 (2008).
54. Hitchen PG, Dell A: Bacterial glycoproteomics. Microbiology 152(Pt 6), 1575-1580 (2006).
55. Twine SM, Tessier L, Kelly JF: Characterisation of glycoproteins. In: Functional Glycomics, Methods and Protocols. Li J (Ed.). Humana Press, NY, USA (2009).
56. Schirm M, Schoenhofen IC, Logan SM, Waldron KC, Thibault P: Identification of unusual bacterial glycosylation by tandem mass spectrometry analyses of intact proteins. Anal. Chem. 77(23), 7774-7782 (2005).
57. Carter AT, Paul CJ, Mason DR et al.: Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum. BMC Genomics 10, 115 (2009).
58. Balonova L, Hernychova L, Bilkova Z: Bioanalytical tools for the discovery of eukaryotic glycoproteins applied to the analysis of bacterial glycoproteins. Expert Rev. Proteomics 6(1), 75-85 (2009).
59. Ding W, Nothaft H, Szymanski CM, Kelly J: Identification and quantification of glycoproteins using ion-pairing normal-phase LC and MS. Mol. Cell. Proteomics 8, 2170-2185 (2009).
60. Ding W, Hill JJ, Kelly J: Selective enrichment of glycopeptides from glycoprotein digests using ion-pairing normal-phase liquid chromatography. Anal. Chem. 79(23), 8891-8899 (2007).
61. Liu X, McNally DJ, Nothaft H, Szymanski CM, Brisson JR, Li J: Mass spectrometry-based glycomics strategy for exploring N-linked glycosylation in eukaryotes and bacteria. Anal. Chem. 78(17), 6081-6087 (2006).
62. Howard SL, Jagannathan A, Soo EC et al.: Campylobacter jejuni glycosylation island important in cell charge, legionaminic acid biosynthesis, and colonization of chickens. Infect. Immun. 77(6), 2544-2556 (2009).
63. Hui JP, Yang J, Thorson JS, Soo EC: Selective detection of sugar phosphates by capillary electrophoresis/mass spectrometry and its application to an engineered E. coli host. Chembiochem 8(10), 1180-1188 (2007).
64. Logan SM, Hui JP, Vinogradov E et al.: Identification of novel carbohydrate modifications on Campylobacter jejuni 11168 flagellin using metabolomics-based approaches. FEBS J. 276(4), 1014-1023 (2009).
65. McNally DJ, Hui JP, Aubry AJ et al.: Functional characterization of the flagellar glycosylation locus in Campylobacter jejuni 81-176 using a focused metabolomics approach. J. Biol. Chem. 281(27), 18489-18498 (2006).
66. McNally DJ, Aubry AJ, Hui JP et al.: Targeted metabolomics analysis of Campylobacter coli VC167 reveals legionaminic acid derivatives as novel flagellar glycans. J. Biol. Chem. 282(19), 14463-14475 (2007).
67. Soo EC, Aubry AJ, Logan SM et al.: Selective detection and identification of sugar nucleotides by CE-electrospray-MS and its application to bacterial metabolomics. Anal. Chem. 76(3), 619-626 (2004).
68. Bino RJ, Hall RD, Fiehn O et al.: Potential of metabolomics as a functional genomics tool. Trends Plant Sci. 9(9), 418-425 (2004).
69. Mashego MR, Wu L, van Dam JC et al.: MIRACLE: mass isotopomer ratio analysis of U-13C-labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular metabolites. Biotechnol. Bioeng. 85(6), 620-628 (2004).
70. Mashego MR, Rumbold K, De MM, Vandamme E, Soetaert W, Heijnen JJ: Microbial metabolomics: past, present and future methodologies. Biotechnol. Lett. 29(1), 1-16 (2007).
71. Kussak A, Weintraub A: Quadrupole ion-trap mass spectrometry to locate fatty acids on lipid A from Gram-negative bacteria. Anal. Biochem. 307(1), 131-137 (2002).
72. Murphy RC, Raetz CRH, Reynolds CM, Barkley RM: Mass spectrometry advances in lipidomics: collision-induced decomposition of Kdo2-lipid A. Prostaglandins Other Lipid Mediat. 77, 131-140 (2005).
73. Gao N, Lehrman MA: Analyses of dolichol pyrophosphate-linked oligosaccharides in cell cultures and tissues by fluorophore-assisted carbohydrate electrophoresis. Glycobiology 12(5), 353-360 (2002).
74. Barreteau H, Magnet S, El GM et al.: Quantitative high-performance liquid chromatography analysis of the pool levels of undecaprenyl phosphate and its derivatives in bacterial membranes. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877(3), 213-220 (2009).
75. Guan Z, Breazeale SD, Raetz CR: Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli. Anal. Biochem. 345(2), 336-339 (2005).
76. Trent MS, Ribeiro AA, Doerrler WT, Lin S, Cotter RJ, Raetz CR: Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella Typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm. J. Biol. Chem. 276(46), 43132-43144 (2001).
77. Trent MS, Ribeiro AA, Lin S, Cotter RJ, Raetz CR: An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-l- arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. J. Biol. Chem. 276(46), 43122-43131 (2001).
78. Wang X, Ribeiro AA, Guan Z, Raetz CR: Identification of undecaprenyl phosphate-b-d-galactosamine in Francisella novicida and its function in lipid A modification. Biochemistry 48(6), 1162-1172 (2009).
79. Reid CW, Stupak J, Chen MM, Imperiali B, Li J, Szymanski CM: Affinity-capture tandem mass spectrometric characterization of polyprenyl-linked oligosaccharides: tool to study protein N-glycosylation pathways. Anal. Chem. 80(14), 5468-5475 (2008).
80. Karaoglu D, Kelleher DJ, Gilmore R: Allosteric regulation provides a molecular mechanism for preferential utilization of the fully assembled dolichol-linked oligosaccharide by the yeast oligosaccharyltransferase. Biochemistry 40(40), 12193-12206 (2001).
81. Lehrman MA: Teaching dolichol-linked oligosaccharides more tricks with alternatives to metabolic radiolabeling. Glycobiology 17(8), 75R-85R (2007).
82. Quigley WW, Dovichi NJ: Capillary electrophoresis for the analysis of biopolymers. Anal. Chem. 76(16), 4645-4658 (2004).
83. Li J, Purves RW, Richards JC: Coupling capillary electrophoresis and high-field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of complex lipopolysaccharides. Anal. Chem. 76(16), 4676-4683 (2004).
84. Li J, Cox AD, Hood DW, Schweda EK, Moxon ER, Richards JC: Electrophoretic and mass spectrometric strategies for profiling bacterial lipopolysaccharides. Mol. Biosyst. 1(1), 46-52 (2005).
85. Li J, Martin A, Cox AD, Moxon ER, Richards JC, Thibault P: Mapping bacterial glycolipid complexity using capillary electrophoresis and electrospray mass spectrometry. Methods Enzymol. 405, 369-397 (2005).
86. Thibault P, Richards JC: Applications of combined capillary electrophoresis- electrospray mass spectrometry in the characterization of short-chain lipopolysaccharides. Haemophilus influenzae. Methods Mol. Biol. 145, 327-344 (2000).
87. Thibault P, Martin A, Gilbert M, Wakarchuk WW, Richards JC: Analysis of bacterial glycolipids by capillary electrophoresis-electrospray mass spectrometry: Haemophilus influenzae and Neisseria meningitidis lipopolysaccharides. Methods Mol. Biol. 213, 241-259 (2003).
88. Li J, Cox AD, Hood D, Moxon ER, Richards JC: Application of capillary electrophoresis- electrospray-mass spectrometry to the separation and characterization of isomeric lipopolysaccharides of Neisseria meningitidis. Electrophoresis 25(13), 2017-2025 (2004).
89. St Michael F, Li J, Cox AD: Structural analysis of the core oligosaccharide from Pasteurella multocida strain X73. Carbohydr. Res. 340(6), 1253-1257 (2005).
90. St Michael F, Li J, Vinogradov E, Larocque S, Harper M, Cox AD: Structural analysis of the lipopolysaccharide of Pasteurella multocida strain VP161: identification of both Kdo-P and Kdo-Kdo species in the lipopolysaccharide. Carbohydr. Res. 340(1), 59-68 (2005). (Pubitemid 40023297)
91. St Michael F, Vinogradov E, Li J, Cox AD: Structural analysis of the lipopolysaccharide from Pasteurella multocida genome strain Pm70 and identification of the putative lipopolysaccharide glycosyltransferases. Glycobiology 15(4), 323-333 (2005). (Pubitemid 41214163)
92. Altman E, Smirnova N, Li J, Aubry A, Logan SM: Occurrence of a nontypable Helicobacter pylori strain lacking Lewis blood group O antigens and DD-heptoglycan: evidence for the role of the core a1,6-glucan chain in colonization. Glycobiology 13(11), 777-783 (2003).
93. Logan SM, Altman E, Mykytczuk O et al.: Novel biosynthetic functions of lipopolysaccharide rfaJ homologs from Helicobacter pylori. Glycobiology 15(7), 721-733 (2005).
94. Godschalk PC, Kuijf ML, Li J et al.: Structural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes. Infect. Immun. 75(3), 1245-1254 (2007).
95. Gilbert M, Godschalk PC, Karwaski MF et al.: Evidence for acquisition of the lipooligosaccharide biosynthesis locus in Campylobacter jejuni GB11, a strain isolated from a patient with Guillain-Barre syndrome, by horizontal exchange. Infect. Immun. 72(2), 1162-1165 (2004).
96. Szymanski CM, Michael FS, Jarrell HC et al.: Detection of conserved N-linked glycans and phase-variable lipooligosaccharides and capsules from Campylobacter cells by mass spectrometry and high resolution magic angle spinning NMR spectroscopy. J. Biol. Chem. 278(27), 24509-24520 (2003).
97. Wang Z, Vinogradov E, Li J, Lund V, Altman E: Structural characterization of the lipopolysaccharide O-antigen from atypical isolate of Vibrio anguillarum strain 1282. Carbohydr. Res. 344(11), 1371-1375 (2009).
98. Wang Z, Li J, Vinogradov E, Altman E: Structural studies of the core region of Aeromonas salmonicida subsp. salmonicida lipopolysaccharide. Carbohydr. Res. 341(1), 109-117 (2006). (Pubitemid 41796983)
99. Li J, Thibault P, Martin A, Richards JC, Wakarchuk WW, van der Wilp W: Development of an on-line preconcentration method for the analysis of pathogenic lipopolysaccharides using capillary electrophoresis-electrospray mass spectrometry. Application to small colony isolates. J. Chromatogr. A 817(1-2), 325-336 (1998).
100. Wang Z, Liu X, Garduno E, Garduno RA, Li J, Altman E: Application of an immunoaffinity-based preconcentration method for mass spectrometric analysis of the O-chain polysaccharide of Aeromonas salmonicida from in vitro- and in vivo-grown cells. FEMS Microbiol. Lett. 295(2), 148-155 (2009).
101. Wang Z, Vinogradov E, Larocque S, Harrison BA, Li J, Altman E: Structural and serological characterization of the O-chain polysaccharide of Aeromonas salmonicida strains A449, 80204 and 80204-80201. Carbohydr. Res. 340(4), 693-700 (2005).
102. Pichichero ME: Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis. Clin. Pediatr. (Phila.) 45(6), 493-502 (2006).
103. Cox AD, Masoud H, Thibault P et al.: Structural analysis of the lipopolysaccharide from the nontypable Haemophilus influenzae strain SB 33. Eur. J. Biochem. 268(20), 5278-5286 (2001).
104. Mansson M, Hood DW, Moxon ER, Schweda EK: Structural characterization of a novel branching pattern in the lipopolysaccharide from nontypeable Haemophilus influenzae. Eur. J. Biochem. 270(14), 2979-2991 (2003).
105. Mansson M, Hood DW, Moxon ER, Schweda EK: Structural diversity in lipopolysaccharide expression in nontypeable Haemophilus influenzae. Identification of l-glycerol-d-manno-heptose in the outer-core region in three clinical isolates. Eur. J. Biochem. 270(4), 610-624 (2003).
106. Mansson M, Hood DW, Li J, Richards JC, Moxon ER, Schweda EK: Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 1003. Eur. J. Biochem. 269(3), 808-818 (2002).
107. Mansson M, Bauer SH, Hood DW, Richards JC, Moxon ER, Schweda EK: A new structural type for Haemophilus influenzae lipopolysaccharide. Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain 486. Eur. J. Biochem. 268(7), 2148-2159 (2001).
108. Yildirim HH, Li J, Richards JC, Hood DW, Moxon ER, Schweda EK: Complex O-acetylation in non-typeable Haemophilus influenzae lipopolysaccharide: evidence for a novel site of O-acetylation. Carbohydr. Res. 340(17), 2598-2611 (2005).
109. Yildirim HH, Li J, Richards JC, Hood DW, Moxon ER, Schweda EK: An alternate pattern for globoside oligosaccharide expression in Haemophilus influenzae lipopolysaccharide: structural diversity in nontypeable strain 1124. Biochemistry 44(13), 5207-5224 (2005).
110. Bouchet V, Hood DW, Li J et al.: Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proc. Natl Acad. Sci. USA 100(15), 8898-8903 (2003).
111. Figueira MA, Ram S, Goldstein R, Hood DW, Moxon ER, Pelton SI: Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants. Infect. Immun. 75(1), 325-333 (2007).
112. Erwin AL, Smith AL: Nontypeable Haemophilus influenzae: understanding virulence and commensal behavior. Trends Microbiol. 15(8), 355-362 (2007).
113. Greiner LL, Watanabe H, Phillips NJ et al.: Nontypeable Haemophilus influenzae strain 2019 produces a biofilm containing N-acetylneuraminic acid that may mimic sialylated O-linked glycans. Infect. Immun. 72(7), 4249-4260 (2004).
114. Jurcisek J, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO: Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect. Immun. 73(6), 3210-3218 (2005).
115. Lundstrom SL, Li J, Mansson M et al.: Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimental otitis media. Infect. Immun. 76(7), 3255-3267 (2008).
116. Clowers BH, Hill HH Jr: Mass analysis of mobility-selected ion populations using dual gate, ion mobility, quadrupole ion trap mass spectrometry. Anal. Chem. 77(18), 5877-5885 (2005).
117. Clowers BH, Dwivedi P, Steiner WE, Hill HH Jr, Bendiak B: Separation of sodiated isobaric disaccharides and trisaccharides using electrospray ionization-atmospheric pressure ion mobility-time of flight mass spectrometry. J. Am. Soc. Mass Spectrom. 16(5), 660-669 (2005).
118. Tang K, Li F, Shvartsburg AA, Strittmatter EF, Smith RD: Two-dimensional gas-phase separations coupled to mass spectrometry for analysis of complex mixtures. Anal. Chem. 77(19), 6381-6388 (2005).
119. Venne K, Bonneil E, Eng K, Thibault P: Improvement in peptide detection for proteomics analyses using NanoLC-MS and high-field asymmetry waveform ion mobility mass spectrometry. Anal. Chem. 77(7), 2176-2186 (2005).
120. Goldberg D, Sutton-Smith M, Paulson J, Dell A: Automatic annotation of matrix-assisted laser desorption/ionization N-glycan spectra. Proteomics 5(4), 865-875 (2005).
121. Tang H, Mechref Y, Novotny MV: Automated interpretation of MS/MS spectra of oligosaccharides. Bioinformatics 21(Suppl. 1), i431-i439 (2005).
122. Irungu J, Go EP, Dalpathado DS, Desaire H: Simplification of mass spectral analysis of acidic glycopeptides using GlycoPep ID. Anal. Chem. 79(8), 3065-3074 (2007).
123. Cooper CA, Gasteiger E, Packer NH: GlycoMod - a software tool for determining glycosylation compositions from mass spectrometric data. Proteomics 1(2), 340-349 (2001).
124. Maass K, Ranzinger R, Geyer H, von der Lieth CW, Geyer R: 'Glyco-peakfinder' - de novo composition analysis of glycoconjugates. Proteomics 7(24), 4435-4444 (2007).
125. Hashimoto K, Goto S, Kawano S et al.: KEGG as a glycome informatics resource. Glycobiology 16(5), 63R-70R (2006).
126. von der Lieth CW, Lutteke T, Frank M: The role of informatics in glycobiology research with special emphasis on automatic interpretation of MS spectra. Biochim. Biophys. Acta 1760(4), 568-577 (2006).
127. Raman R, Venkataraman M, Ramakrishnan S, Lang W, Raguram S, Sasisekharan R: Advancing glycomics: implementation strategies at the consortium for functional glycomics. Glycobiology 16(5), 82R-90R (2006).
128. Aoki-Kinoshita KF: An introduction to bioinformatics for glycomics research. PLoS Comput. Biol. 4(5), e1000075 (2008).
129. Eakin RT, Morgan LO, Gregg CT, Matwyoff NA: Carbon-13 nuclear magnetic resonance spectroscopy of living cells and their metabolism of a specifically labeled 13C substrate. FEBS Lett. 28, 259-264 (1972).
130. Bergstrom N, Nair GB, Weintraub A, Jansson PE: Structure of the O-polysaccharide from the lipopolysaccharide from Vibrio cholerae O6. Carbohydr. Res. 337(9), 813-817 (2002).
131. Beynon LM, Richards JC, Perry MB: The structure of the lipopolysaccharide O antigen from Yersinia ruckeri serotype 01. Carbohydr. Res. 256(2), 303-317 (1994).
132. Beynon LM, Moreau M, Richards JC, Perry MB: Structure of the O-antigen of Actinobacillus pleuropneumoniae serotype 7 lipopolysaccharide. Carbohydr. Res. 209, 225-238 (1991).
133. Brooks BW, Perry MB, Lutze-Wallace CL, MacLean LL: Structural characterization and serological specificities of lipopolysaccharides from Salmonella enterica serovar Gallinarum biovar Pullorum standard, intermediate and variant antigenic type strains. Vet. Microbiol. 126(4), 334-344 (2008).
134. Bystrova OV, Knirel YA, Lindner B et al.: Structures of the core oligosaccharide and O-units in the R- and SR-type lipopolysaccharides of strains of Pseudomonas aeruginosa O-serogroups. FEMS Immunol. Med. Microbiol. 46(1), 85-99 (2006).
135. Vinogradov E, Perry MB: Characterisation of the core part of the lipopolysaccharide O-antigen of Francisella novicida (U112). Carbohydr. Res. 339(9), 1643-1648 (2004). (Pubitemid 38759290)
136. Vinogradov E, Frirdich E, MacLean LL et al.: Structures of lipopolysaccharides from Klebsiella pneumoniae. Eluicidation of the structure of the linkage region between core and polysaccharide O chain and identification of the residues at the non-reducing termini of the O chains. J. Biol. Chem. 277(28), 25070-25081 (2002).
137. Vinogradov E: The structure of the core-O-chain linkage region of the lipopolysaccharide from Bordetella hinzii. Carbohydr. Res. 342(3-4), 638-642 (2007).
138. Vinogradov E, Kubler-Kielb J, Korenevsky A: The structure of the carbohydrate backbone of the LPS from Shewanella spp. MR-4. Carbohydr. Res. 343(15), 2701-2705 (2008).
139. Griffin JL, Bollard M, Nicholson JK, Bhakoo K: Spectral profiles of cultured neuronal and glial cells derived from HRMAS 1H NMR spectroscopy. NMR Biomed. 15, 375-384 (2002).
140. Kurhanewicz J, Swanson MG, Nelson SJ, Vineron DB: Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer. J. Magn. Reson. Imaging 16, 451-463 (2002).
141. Cheng LL, Ma MJ, Becerra L et al.: Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc. Natl Acad. Sci. USA 94(12), 6408-6413 (1997).
142. Weybright P, Millis K, Campbell N, Cory DG, Singer S: Gradient, high-resolution, magic angle spinning 1H nuclear magnetic resonance spectroscopy of intact cells. Magn. Reson. Med. 39(3), 337-345 (1998).
143. Gudlavalleti SK, Szymanski CM, Jarrell HC, Stephens DS: In vivo determination of Neisseria meningitidis serogroup A capsular polysaccharide by whole cell high-resolution magic angle spinning NMR spectroscopy. Carbohydr. Res. 341(4), 557-562 (2006).
144. Lee REB, Li W, Chatterjee D, Lee RE: Rapid structural characterization of the arabinogalactan and lipoarabinomannan in live mycobacterial cells using 2D and 3D HR-MAS NMR: structural changes in the arabinan due to ethambutol treatment and gene mutation are observed. Glycobiology 15(2), 139-151 (2005).
145. Karlyshev AV, Champion OL, Churcher C et al.: Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses. Mol. Microbiol. 55(1), 90-103 (2005).
146. Bacon DJ, Szymanski CM, Burr DH, Silver RP, Alm RA, Guerry P: A phase-variable capsule is involved in virulence of Campylobacter jejuni 81-176. Mol. Microbiol. 40(3), 769-777 (2001).
147. Karlyshev AV, Linton D, Gregson NA, Lastovica AJ, Wren BW: Genetic and biochemical evidence of a Campylobacter jejuni capsular polysaccharide that accounts for Penner serotype specificity. Mol. Microbiol. 35(3), 529-541 (2000).
148. McNally DJ, Jarrell HC, Li J et al.: The HS:1 serostrain of Campylobacter jejuni has a complex teichoic acid-like capsular polysaccharide with nonstoichiometric fructofuranose branches and O-methyl phosphoramidate groups. FEBS J. 272(17), 4407-4422 (2005).
149. McNally DJ, Jarrell HC, Khieu NH et al.: The HS:19 serostrain of Campylobacter jejuni has a hyaluronic acid-type capsular polysaccharide with a nonstoichiometric sorbose branch and O-methyl phosphoramidate group. FEBS J. 273(17), 3975-3989 (2006).
150. McNally DJ, Lamoureux MP, Karlyshev AV et al.: Commonality and biosynthesis of the O-methyl phosphoramidate capsule modification in Campylobacter jejuni. J. Biol. Chem. 282(39), 28566-28576 (2007).
151. Li W, Lee REB, Lee RE, Li J: Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria. Anal. Chem. 77, 5785-5792 (2005).
152. Parsons LM, Salfinger M, Clobridge A et al.: Phenotypic and molecular characterization of Mycobacterium tuberculosis isolates resistant to both isoniazid and ethambutol. Antimicrob. Agents Chemother. 49(6), 2218-2225 (2005).
153. Reid CW, Brewer D, Clarke AJ: Substrate binding affinity of Pseudomonas aeruginosa membrane-bound lytic transglycosylase B by hydrogen-deuterium exchange MALDI MS. Biochemistry 43(35), 11275-11282 (2004).
154. Reid CW, Blackburn NT, Clarke AJ: Role of arginine residues in the active site of the membrane-bound lytic transglycosylase B from Pseudomonas aeruginosa. Biochemistry 45(7), 2129-2138 (2006).
155. Tong G, Pan Y, Dong H, Pryor R, Wilson GE, Schaefer J: Structure and dynamics of pentaglycyl bridges in the cell walls of Staphylococcus aureus by 13C-15N REDOR NMR. Biochemistry 36(32), 9859-9866 (1997).
156. Cegelski L, Steuber D, Mehta AK, Kulp DW, Axelsen PH, Schaefer J: Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling. J. Mol. Biol. 357, 1253-1262 (2006).
157. Kim SJ, Jones RC, Cha CJ, Kweon O, Edmondson RD, Cerniglia CE: Identification of proteins induced by polycyclic aromatic hydrocarbon in Mycobacterium vanbaalenii PYR-1 using two-dimensional polyacrylamide gel electrophoresis and de novo sequencing methods. Proteomics 4(12), 3899-3908 (2004).
158. Kim SJ, Cegelski L, Preobrazhenskaya M, Schaefer J: Structures of Staphylococcus aureus cell-wall complexes with vancomycin, eremomycin, and chloroeremomycin derivatives by 13C{19F} and 15N{19F} rotational-echo double resonance. Biochemistry 45(16), 5235-5250 (2006).
159. Patti GJ, Chen J, Schaefer J, Gross ML: Characterization of structural variations in the peptidoglycan of vancomycin-susceptible Enterococcus faecium: understanding glycopeptide-antibiotic binding sites using mass spectrometry. J. Am. Soc. Mass Spectrom. 19(10), 1467-1475 (2008).
160. Patti GJ, Kim SJ, Schaefer J: Characterization of the peptidoglycan of vancomycin-susceptible Enterococcus faecium. Biochemistry 47(32), 8378-8385 (2008).
161. Sharif S, Kim SJ, Labischinski H, Schaefer J: Characterization of peptidoglycan in Fem-deletion mutants of methicillin-resistant Staphylococcus aureus by solid-state NMR. Biochemistry 48, 3100-3108 (2009).
162. Boniface A, Parquet C, Arthur M, Mengin-Lecreulx D, Blanot D: The elucidation of the structure of Thermotoga maritima peptidoglycan reveals two novel types of cross-link. J. Biol. Chem. 284(33), 21856-21862 (2009).
163. Sharif S, Singh M, Kim SJ, Schaefer J: Staphylococcus aureus peptidoglycan tertiary structure from carbon-13 diffusion. J. Am. Chem. Soc. 131, 7023-7030 (2009).
164. Meroueh SO, Bencze KZ, Hesek D et al.: Three-dimensional structure of the bacterial cell wall peptidoglycan. Proc. Natl Acad. Sci. USA 103(12), 4404-4409 (2006).
165. Perez-Dorado I, Campillo NE, Monterroso B et al.: Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1. J. Biol. Chem. 282(34), 24990-24999 (2007).
166. Kim SJ, Matsuoka S, Patti GJ, Schaefer J: Vancomycin derivative with damaged d-Ala-d-Ala binding cleft binds to cross-linked peptidoglycan in the cell wall of Staphylococcus aureus. Biochemistry 47, 3822-3831 (2009).
167. Kim SJ, Cegelski L, Stueber D et al.: Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. J. Mol. Biol. 377(1), 281-293 (2008).
168. Kim SJ, Cegelski L, Studelska DR, O'Connor RD, Mehta AK, Schaefer J: Rotational-echo double resonance characterization of vancomycin binding sites in Staphylococcus aureus. Biochemistry 41(22), 6967-6977 (2002). (Pubitemid 34575668)
169. Agard NJ, Bertozzi CR: Chemical approaches to perturb, profile, and perceive glycans. Acc. Chem. Res. 42(6), 788-797 (2009).
170. Bertozzi CR, Kiessling LL: Chemical glycobiology. Science 291(5512), 2357-2364 (2001).
171. Chang PV, Chen X, Smyrniotis C et al.: Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew. Chem. Int. Ed. Engl. 48(22), 4030-4033 (2009).
172. Zeng Y, Ramya TN, Dirksen A, Dawson PE, Paulson JC: High-efficiency labeling of sialylated glycoproteins on living cells. Nat. Methods 6(3), 207-209 (2009).
173. Chang PV, Prescher JA, Hangauer MJ, Bertozzi CR: Imaging cell surface glycans with bioorthogonal chemical reporters. J. Am. Chem. Soc. 129(27), 8400-8401 (2007).
174. Gahmberg CG, Andersson LC: Selective radioactive labeling of cell surface sialoglycoproteins by periodate-tritiated borohydride. J. Biol. Chem. 252(16), 5888-5894 (1977).
175. Dirksen A, Dawson PE: Expanding the scope of chemoselective peptide ligations in chemical biology. Curr. Opin. Chem. Biol. 12(6), 760-766 (2008).
176. Guerry P: Campylobacter flagella: not just for motility. Trends Microbiol. 15(10), 456-461 (2007).
177. Liu F, Aubry AJ, Schoenhofen IC, Logan SM, Tanner ME: The engineering of bacteria bearing azido-pseudaminic acid-modified flagella. Chembiochem 10(8), 1317-1320 (2009).
178. Saxon E, Bertozzi CR: Chemical and biological strategies for engineering cell surface glycosylation. Annu. Rev. Cell Dev. Biol. 17, 1-23 (2001).
179. Saxon E, Luchansky SJ, Hang HC, Yu C, Lee SC, Bertozzi CR: Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J. Am. Chem. Soc. 124(50), 14893-14902 (2002).
180. Pilobello KT, Krishnamoorthy L, Slawek D, Mahal LK: Development of a lectin microarray for the rapid analysis of protein glycopatterns. Chembiochem 6(6), 985-989 (2005).
181. Kuno A, Uchiyama N, Koseki-Kuno S et al.: Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling. Nat. Methods 2(11), 851-856 (2005).
182. Ebe Y, Kuno A, Uchiyama N et al.: Application of lectin microarray to crude samples: differential glycan profiling of lec mutants. J. Biochem. 139(3), 323-327 (2006).
183. Rudiger H, Gabius HJ: Plant lectins: occurrence, biochemistry, functions and applications. Glycoconj. J. 18(8), 589-613 (2001).
184. Cummings RD: Use of lectins in analysis of glycoconjugates. Methods Enzymol. 230, 66-86 (1994).
185. Hsu KL, Mahal LK: A lectin microarray approach for the rapid analysis of bacterial glycans. Nat. Protoc. 1(2), 543-549 (2006).
186. Hsu KL, Pilobello KT, Mahal LK: Analyzing the dynamic bacterial glycome with a lectin microarray approach. Nat. Chem. Biol. 2(3), 153-157 (2006).
187. Coyne MJ, Reinap B, Lee MM, Comstock LE: Human symbionts use a host-like pathway for surface fucosylation. Science 307(5716), 1778-1781 (2005).
188. Karlsson KA: The human gastric colonizer Helicobacter pylori: a challenge for host- parasite glycobiology. Glycobiology 10(8), 761-771 (2000).
189. Friis LM, Pin C, Pearson BM, Wells JM: In vitro cell culture methods for investigating Campylobacter invasion mechanisms. J. Microbiol. Methods 61(2), 145-160 (2005).
190. Lis H, Sharon N: Lectins: carbohydrate-specific proteins that mediate cellular recognition. Chem. Rev. 98(2), 637-674 (1998).
191. Manimala JC, Li Z, Jain A, VedBrat S, Gildersleeve JC: Carbohydrate array analysis of anti-Tn antibodies and lectins reveals unexpected specificities: implications for diagnostic and vaccine development. Chembiochem 6(12), 2229-2241 (2005).
192. Morales BC, Gonzalez-Moa MJ, Boltz KW, Van der Werf BD, Johnston SA, Svarovsky SA: Bacterial glycoprofiling by using random sequence peptide microarrays. Chembiochem 10(5), 877-888 (2009).
193. Zhao C, Ge B, De Villena J et al.: Prevalence of Campylobacter spp., Escherichia coli, and Salmonella serovars in retail chicken, turkey, pork, and beef from the greater Washington, D.C., area. Appl. Environ. Microbiol. 67(12), 5431-5436 (2001).
194. Parkhill J, Wren BW, Mungall K et al.: The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403(6770), 665-668 (2000).
195. Whitfield C: Bacterial extracellular polysaccharides. Can. J. Microbiol. 34(4), 415-420 (1988).
196. Gilbert M, Mandrell RE, Parker CT, Li J, Vinogradov E: Structural analysis of the capsular polysaccharide from Campylobacter jejuni RM1221. Chembiochem 8(6), 625-631 (2007).
197. St Michael F, Szymanski CM, Li J et al.: The structures of the lipooligosaccharide and capsule polysaccharide of Campylobacter jejuni genome sequenced strain NCTC 11168. Eur. J. Biochem. 269(21), 5119-5136 (2002).
198. Ang CW, Noordzij PG, de Klerk MA, Endtz HP, van Doorn PA, Laman JD: Ganglioside mimicry of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity in rabbits. Infect. Immun. 70(9), 5081-5085 (2002).
199. Guerry P, Szymanski CM, Prendergast MM et al.: Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro. Infect. Immun. 70(2), 787-793 (2002).
200. Dzieciatkowska M, Brochu D, van BA et al.: Mass spectrometric analysis of intact lipooligosaccharide: direct evidence for O-acetylated sialic acids and discovery of O-linked glycine expressed by Campylobacter jejuni. Biochemistry 46(50), 14704-14714 (2007).
201. Houliston RS, Endtz HP, Yuki N et al.: Identification of a sialate O-acetyltransferase from Campylobacter jejuni: demonstration of direct transfer to the C-9 position of terminala-2, 8-linked sialic acid. J. Biol. Chem. 281(17), 11480-11486 (2006).
202. Champion OL, Gaunt MW, Gundogdu O et al.: Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proc. Natl Acad. Sci. USA 102(44), 16043-16048 (2005).
203. Thibault P, Logan SM, Kelly JF et al.: Identification of the carbohydrate moieties and glycosylation motifs in Campylobacter jejuni flagellin. J. Biol. Chem. 276(37), 34862-34870 (2001).
204. Logan SM, Kelly JF, Thibault P, Ewing CP, Guerry P: Structural heterogeneity of carbohydrate modifications affects serospecificity of Campylobacter flagellins. Mol. Microbiol. 46(2), 587-597 (2002).
205. Hendrixson DR, DiRita VJ: Identification of Campylobacter jejuni genes involved in commensal colonization of the chick gastrointestinal tract. Mol. Microbiol. 52(2), 471-484 (2004).
206. Joshua GW, Guthrie-Irons C, Karlyshev AV, Wren BW: Biofilm formation in Campylobacter jejuni. Microbiology 152(Pt 2), 387-396 (2006).
207. Linton D, Allan E, Karlyshev AV, Cronshaw AD, Wren BW: Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Mol. Microbiol. 43(2), 497-508 (2002).
208. Wyszynska A, Zycka J, Godlewska R, Jagusztyn-Krynicka EK: The Campylobacter jejuni/coli cjaA (cj0982c) gene encodes an N-glycosylated lipoprotein localized in the inner membrane. Curr. Microbiol. 57(3), 181-188 (2008).
209. Szymanski CM, Burr DH, Guerry P: Campylobacter protein glycosylation affects host cell interactions. Infect. Immun. 70(4), 2242-2244 (2002).
210. Karlyshev AV, Everest P, Linton D, Cawthraw S, Newell DG, Wren BW: The Campylobacter jejuni general glycosylation system is important for attachment to human epithelial cells and in the colonization of chicks. Microbiology 150(Pt 6), 1957-1964 (2004).
211. Jones MA, Marston KL, Woodall CA et al.: Adaptation of Campylobacter jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract. Infect. Immun. 72(7), 3769-3776 (2004).
212. Helenius A, Aebi M: Intracellular functions of N-linked glycans. Science 291(5512), 2364-2369 (2001).
213. Fouts DE, Mongodin EF, Mandrell RE et al.: Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species. PLoS Biol. 3(1), e15 (2005).
214. Guerry P, Szymanski CM: Campylobacter sugars sticking out. Trends Microbiol. 16(9), 428-435 (2008).
215. Stintzi A, van Vliet AH, Ketley JM. Iron metabolism, transport, and regulation. In: Campylobacter. Nachamkin I, Szymanski CM, Blaser MJ (Eds). ASM Press, Washington, DC, USA, 591-610 (2008).
216. Blixt O, Razi N: Chemoenzymatic synthesis of glycan libraries. Methods Enzymol. 415, 137-153 (2006).
217. Sinclair AM, Elliott S: Glycoengineering: the effect of glycosylation on the properties of therapeutic proteins. J. Pharm. Sci. 94(8), 1626-1635 (2005).
218. Langdon RH, Cuccui J, Wren BW: N-linked glycosylation in bacteria: an unexpected application. Future Microbiol. 4(4), 401-412 (2009).
219. Faridmoayer A, Fentabil MA, Haurat MF et al.: Extreme substrate promiscuity of the Neisseria oligosaccharyl transferase involved in protein O-glycosylation. J. Biol. Chem. 283(50), 34596-34604 (2008).