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Volumn 6, Issue 12, 2005, Pages 2229-2241

Carbohydrate array analysis of anti-Tn antibodies and lectins reveals unexpected specificities: Implications for diagnostic and vaccine development

Author keywords

Carbohydrates; Glycoconjugates; Glycosylation; Microarrays; Tn antigen

Indexed keywords

CARBOHYDRATE ANTIGEN; EPITOPE; GLYCOPROTEIN; LECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; TN ANTIGEN; VACCINE; ANTIBODY; CARBOHYDRATE; DIAGNOSTIC AGENT; TUMOR ANTIGEN;

EID: 33646458337     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200500165     Document Type: Article
Times cited : (103)

References (89)
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    • The Glycominds Ltd. carbohydrate data base was searched via the Consortium for Functional Genomics web site
    • The Glycominds Ltd. carbohydrate data base was searched via the Consortium for Functional Genomics web site.
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    • Poly(vinylpyrrolidone) and Tween 20 were also tested as blocking agents, but the best results were obtained with BSA.
    • Poly(vinylpyrrolidone) and Tween 20 were also tested as blocking agents, but the best results were obtained with BSA.
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    • VVL-B4 binds both mono- and clustered-Tn antigen; see E. Osinaga, S. Bay, D. Tello, A. Babino, O. Pritsch, K. Assemat, D. Cantacuzene, H. Nakada, P. Alzari, FEBS Lett. 2000, 469, 24-28.
    • VVL-B4 binds both mono- and clustered-Tn antigen; see E. Osinaga, S. Bay, D. Tello, A. Babino, O. Pritsch, K. Assemat, D. Cantacuzene, H. Nakada, P. Alzari, FEBS Lett. 2000, 469, 24-28.
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    • The lack of signal for blood group A indicates that the VVL-B4 sample used for the assays is not contaminated with VVL-A4 or VVL-A2B2.
    • The lack of signal for blood group A indicates that the VVL-B4 sample used for the assays is not contaminated with VVL-A4 or VVL-A2B2.
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    • The generation of antibody HBTn1 has not been published. Some minimal information on the specificity is supplied in the product specification sheet from Dako Cytomation.
    • The generation of antibody HBTn1 has not been published. Some minimal information on the specificity is supplied in the product specification sheet from Dako Cytomation.
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    • HBTn1 recognizes both monomeric and clustered Tn; see Y. Zhang, H. Iwasaki, H. Wang, T. Kudo, T. B. Kalka, T. Hennet, T. Kubota, L. Cheng, N. Inaba, M. Gotoh, A. Togayachi, J. Guo, H. Hisatomi, K. Nakajima, S. Nishihara, M. Nakamura, J. D. Marth, H. Narimatsu, J. Biol. Chem. 2003, 278, 573.
    • HBTn1 recognizes both monomeric and clustered Tn; see Y. Zhang, H. Iwasaki, H. Wang, T. Kudo, T. B. Kalka, T. Hennet, T. Kubota, L. Cheng, N. Inaba, M. Gotoh, A. Togayachi, J. Guo, H. Hisatomi, K. Nakajima, S. Nishihara, M. Nakamura, J. D. Marth, H. Narimatsu, J. Biol. Chem. 2003, 278, 573.
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    • In the context of a tissue sample or cell, other factors such as accessibility, spacing, and orientation can affect the affinity toward a particular epitope. Therefore, the Tn receptors might show enhanced binding for "off target" epitopes in some cellular environments.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.