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Volumn 8, Issue 9, 2010, Pages 2068-2077

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols

(14) Amewu, Richard a Gibbons, Peter a Mukhtar, Amira a Stachulski, Andrew V a Ward, Stephen A b Hall, Charlotte b Rimmer, Karen b Davies, Jill b Vivas, Livia c Bacsa, John a Mercer, Amy E a Nixon, Gemma b Stocks, Paul A b O'Neill, Paul M a

a UNIVERSITY OF LIVERPOOL (United Kingdom)

b LIVERPOOL SCHOOL OF TROPICAL MEDICINE (United Kingdom)

c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYLIC ALCOHOL; ANTIMALARIAL ACTIVITY; COUPLING REACTION; IN-VITRO; MOUSE MODELS; SUBSTITUTION PATTERNS; TRIOXANE; WEAK BASE;

AMIDES; OXYGENATION; OXYGENATORS;

OLEFINS;

1,2,4 TRIOXANE; 1,2,4-TRIOXANE; ALKENE; ALLYL ALCOHOL; AMIDE; ANTIMALARIAL AGENT; HETEROCYCLIC COMPOUND; OXYGEN; PROPANOL; SULFIDE; SULFONE; THIOL DERIVATIVE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; DRUG SENSITIVITY; MALARIA; MOUSE; OXIDATION REDUCTION REACTION; PLASMODIUM BERGHEI; STEREOISOMERISM; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALKENES; AMIDES; ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; HETEROCYCLIC COMPOUNDS; MALARIA; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; OXYGEN; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PROPANOLS; STEREOISOMERISM; SULFHYDRYL COMPOUNDS; SULFIDES; SULFONES;

PLASMODIUM BERGHEI;

EID: 77951103171 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b924319d Document Type: Article

Times cited : (16)

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