Synthesis of lipid A type carboxymethyl derivatives with ether chains instead of ester chains and their LPS-antagonistic activities

Carbohydrate Research

Volumn 338, Issue 1, 2003, Pages 47-54

  Watanabe, Yukiko ^a   Miura, Kumiko ^a   Shiozaki, Masao ^a,c   Kanai, Saori ^a   Kurakata, Shin Ichi ^a   Nishijima, Masahiro ^b  

^a DAIICHI SANKYO CO   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c Chemtech Labo Inc   (Japan)

Author keywords

Endotoxin; Lipid A; LPS agonist; LPS antagonist; TNF production inhibitor

Indexed keywords

CELLS; ESTERS; ETHERS; SYNTHESIS (CHEMICAL);

ANTAGONISTIC ACTIVITIES;

LIPIDS;

BACTERIUM LIPOPOLYSACCHARIDE; CARBOHYDRATE DERIVATIVE; CARBOXYMETHYL 6 O [2 ACETAMIDO 2 DEOXY 3 O [3 (DODECYLOXY)TETRADECYL] 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOSYL] 2 DEOXY 2 (3 HYDROXYTETRADECANAMIDO) 3 O (3 HYDROXYTETRADECYL) ALPHA DEXTRO GLUCOPYRANOSIDE; CARBOXYMETHYL 6 O [2 ACETAMIDO 2 DEOXY 3 O [3 (DODECYLOXY)TETRADECYL] 6 O METHYL 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOSYL] 2 DEOXY 2 (3 HYDROXYTETRADECANAMIDO) 3 O (3 HYDROXYTETRADECYL) ALPHA DEXTRO GLUCOPYRANO; CARBOXYMETHYL 6 O [2 ACETAMIDO 2,6 DIDEOXY 3 O [3 (DODECYLOXY)TETRADECYL] 6 FLUORO 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOSYL] 2 DEOXY 2 (3 HYDROXYTETRADECANAMIDO) 3 O (3 HYDROXYTETRADECYL) ALPHA DEXTRO GLUCOPYRA; ETHER DERIVATIVE; LIPID A; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ETHER, ETHYL; HUMANS; INHIBITORY CONCENTRATION 50; LIPID A; LIPOPOLYSACCHARIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 0037413460     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6215(02)00357-9     Document Type: Article

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