Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 2991-2995

  O'Neill, Paul M ^a   Verissimo, Edite ^a   Ward, Stephen A ^b   Davies, Jill ^b   Korshin, Edward E ^c   Araujo, Nuna ^d   Pugh, Matthew D ^a   Cristiano, M Lurdes S ^d   Stocks, Paul A ^a   Bachi, Mario D ^c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d UNIVERSITY OF ALGARVE   (Portugal)

Author keywords

Arteflene; Artemisinin; Endoperoxide; Malaria; Mechanism of action

Indexed keywords

ALKENE; ANTIMALARIAL AGENT; ARTEFLENE; BICYCLO COMPOUND; CARBON; ENDOPEROXIDE; RADICAL; SULFONE; THIOL DERIVATIVE; THIOPENTAL;

ARTICLE; CONTROLLED STUDY; DIELS ALDER REACTION; DRUG DEGRADATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; NONHUMAN; OXYGENATION; STRUCTURE ACTIVITY RELATION;

ALKANES; ALKENES; ANIMALS; ANTIMALARIALS; CYCLIZATION; CYCLOHEXENES; EPOXY COMPOUNDS; MOLECULAR STRUCTURE; OXYGEN; PEROXIDES; PLASMODIUM BERGHEI; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TERPENES;

BETULACEAE;

EID: 33646049650     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.059     Document Type: Article

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