-
1
-
-
45149117024
-
Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltagedependent anion channel-1: Mapping the site of binding
-
Abu-Hamad S, Zaid H, Israelson A, Nahon E, Shoshan-Barmatz V. 2008. Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltagedependent anion channel-1: Mapping the site of binding. J Biol Chem 283:13482-13490.
-
(2008)
J Biol Chem
, vol.283
, pp. 13482-13490
-
-
Abu-Hamad, S.1
Zaid, H.2
Israelson, A.3
Nahon, E.4
Shoshan-Barmatz, V.5
-
2
-
-
39149111234
-
2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress
-
Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, OberleyLW, DomannFE, Spitz DR. 2008. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free Radical Biology and Medicine 44:826-834.
-
(2008)
Free Radical Biology and Medicine
, vol.44
, pp. 826-834
-
-
Ahmad, I.M.1
Abdalla, M.Y.2
Aykin-Burns, N.3
Simons, A.L.4
Oberley, L.W.5
Domann, F.E.6
Spitz, D.R.7
-
3
-
-
20044361991
-
2 mediate glucose deprivation-induced stress in human cancer cells
-
2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem 280:4254-4263.
-
(2005)
J Biol Chem
, vol.280
, pp. 4254-4263
-
-
Imna-B, A.1
Sim, J.E.2
Walsh, S.A.3
Higashikubo, R.4
Buettner, G.R.5
Venkataraman, S.6
Mackey, M.A.7
Flanagan, S.W.8
Oberley, L.W.9
Spitz, D.R.10
-
4
-
-
63649100705
-
Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its antiapoptotic activity
-
Arzoine L, Zilberberg N, Ben-Romano R, Shoshan-Barmatz V. 2009. Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its antiapoptotic activity. J Biol Chem 284:3946-3955.
-
(2009)
J Biol Chem
, vol.284
, pp. 3946-3955
-
-
Arzoine, L.1
Zilberberg, N.2
Ben-Romano, R.3
Shoshan-Barmatz, V.4
-
5
-
-
0942290437
-
In selfdefence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death
-
Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V. 2004. In selfdefence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 377:347-355.
-
(2004)
Biochem J
, vol.377
, pp. 347-355
-
-
Azoulay-Zohar, H.1
Israelson, A.2
Abu-Hamad, S.3
Shoshan-Barmatz, V.4
-
6
-
-
62249162170
-
The mitochondrial permeability transition pore and ischemia-reperfusion injury
-
Baines C. 2009a. The mitochondrial permeability transition pore and ischemia-reperfusion injury. Basic Res Cardiol 104:181-188.
-
(2009)
Basic Res Cardiol
, vol.104
, pp. 181-188
-
-
Baines, C.1
-
7
-
-
34547865749
-
The mitochondrial permeability transition pore as a target of cardioprotective signaling
-
Baines CP. 2007. The mitochondrial permeability transition pore as a target of cardioprotective signaling. Am J Physiol Heart Circ Physiol 293:H903-904.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.293
-
-
Baines, C.P.1
-
8
-
-
67349285823
-
The molecular composition of the mitochondrial permeability transition pore
-
Baines CP. 2009b. The molecular composition of the mitochondrial permeability transition pore. J Mol Cell Cardiol 46:850-857.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 850-857
-
-
Baines, C.P.1
-
9
-
-
67349244350
-
Domestication of the cardiac mitochondrion for energy conversion
-
Balaban RS. 2009. Domestication of the cardiac mitochondrion for energy conversion. J Mol Cell Cardiol 46:832-841.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 832-841
-
-
Balaban, R.S.1
-
10
-
-
6344227760
-
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand
-
fje
-
Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB. 2004. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. FASEB J 18:03-1001fje.
-
(2004)
FASEB J
, vol.18
, pp. 03-1001
-
-
Bauer, D.E.1
Harris, M.H.2
Plas, D.R.3
Lum, J.J.4
Hammerman, P.S.5
Rathmell, J.C.6
Riley, J.L.7
Thompson, C.B.8
-
11
-
-
68949137001
-
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening
-
Baumgartner HK, Gerasimenko JV, Thorne C, Ferdek P, Pozzan T, Tepikin AV, Petersen OH, Sutton R,Watson AJM, Gerasimenko OV. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem 284:20796-20803.
-
(2009)
J Biol Chem
, vol.284
, pp. 20796-20803
-
-
Baumgartner, H.K.1
Gerasimenko, J.V.2
Thorne, C.3
Ferdek, P.4
Pozzan, T.5
Tepikin, A.V.6
Petersen, O.H.7
Sutton, R.8
Watson, A.J.M.9
Gerasimenko, O.V.10
-
12
-
-
70249146172
-
mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition
-
Bhaskar PT, Nogueira V, Patra KC, Jeon S-M, Park Y, Robey RB, Hay N. 2009. mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3β Inhibition. Mol Cell Biol 29:5136-5147.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5136-5147
-
-
Bhaskar, P.T.1
Nogueira, V.2
Patra, K.C.3
Jeon, S.-M.4
Park, Y.5
Robey, R.B.6
Hay, N.7
-
13
-
-
0030719486
-
Aerobic glycolysis by proliferating cells: Protection against oxidative stress at the expense of energy yield
-
Brand K. 1997. Aerobic glycolysis by proliferating cells: Protection against oxidative stress at the expense of energy yield. J Bioenerg Biomembr 29:355-364.
-
(1997)
J Bioenerg Biomembr
, vol.29
, pp. 355-364
-
-
Brand, K.1
-
14
-
-
68249126139
-
The published 3D structure of the VDAC channel:Native or not?
-
Colombini M. 2009. The published 3D structure of the VDAC channel: Native or not? Trends Biochem Sci 34:382-389.
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 382-389
-
-
Colombini, M.1
-
15
-
-
0032401567
-
Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore
-
Crompton M, Virji S, Ward JM. 1998. Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore. Eur J Biochem 258:729-735.
-
(1998)
Eur J Biochem
, vol.258
, pp. 729-735
-
-
Crompton, M.1
Virji, S.2
Ward, J.M.3
-
16
-
-
68649096360
-
Regulation of plasma membrane calcium fluxes by mitochondria
-
Demaurex N, Poburko D, Frieden M. 2009. Regulation of plasma membrane calcium fluxes by mitochondria. Biochim Biophys Acta 1787:1383-1394.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 1383-1394
-
-
Demaurex, N.1
Poburko, D.2
Frieden, M.3
-
17
-
-
38049155818
-
Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis
-
Deniaud A, Sharaf el dein O, Maillier E, Poncet D, Kroemer G, Lemaire C, Brenner C. 2007. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27: 285-299.
-
(2007)
Oncogene
, vol.27
, pp. 285-299
-
-
Deniaud, A.1
Sharaf El Dein, O.2
Maillier, E.3
Poncet, D.4
Kroemer, G.5
Lemaire, C.6
Brenner, C.7
-
18
-
-
0042860122
-
Cell biology: Metabolism meets death
-
Downward J. 2009. Cell biology: Metabolism meets death. Nature 424:896-897.
-
(2009)
Nature
, vol.424
, pp. 896-897
-
-
Downward, J.1
-
19
-
-
7744235672
-
Death by design: Apoptosis, necrosis and autophagy
-
Edinger A, Thompson CB. 2004. Death by design: Apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16:663-669.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 663-669
-
-
Edinger, A.1
Thompson, C.B.2
-
20
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, Thompson CB. 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64:3892-3899.
-
(2004)
Cancer Res
, vol.64
, pp. 3892-3899
-
-
Elstrom, R.L.1
Bauer, D.E.2
Buzzai, M.3
Karnauskas, R.4
Harris, M.H.5
Plas, D.R.6
Zhuang, H.7
Cinalli, R.M.8
Alavi, A.9
Rudin, C.M.10
Thompson, C.B.11
-
21
-
-
34447094919
-
Glycolysis in cancer: A potential target for therapy
-
Gatenby RA, Gillies RJ. 2004a. Glycolysis in cancer: A potential target for therapy. Int J Biochem Cell Biol 39:1358-1366.
-
(2004)
Int J Biochem Cell Biol
, vol.39
, pp. 1358-1366
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
22
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. 2004b. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
23
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
Gillies RJ, Robey I, Gatenby RA. 2008. Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 49:24S-42S.
-
(2008)
J Nucl Med
, vol.49
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
24
-
-
59149095449
-
Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3
-
Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J. 2009. Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J Biol Chem 284:3001-3011.
-
(2009)
J Biol Chem
, vol.284
, pp. 3001-3011
-
-
Gimenez-Cassina, A.1
Lim, F.2
Cerrato, T.3
Palomo, G.M.4
Diaz-Nido, J.5
-
25
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
-
Gingras AC, Kennedy SG, O'Leary MA, Sonenberg N, Hay N. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev 12:502-513.
-
(1998)
Genes Dev
, vol.12
, pp. 502-513
-
-
Gingras, A.C.1
Kennedy, S.G.2
O'Leary, M.A.3
Sonenberg, N.4
Hay, N.5
-
26
-
-
69049098806
-
Structural and functional link between the mitochondrial network and the endoplasmic reticulum
-
Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P. 2009. Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Bio Cell Bio 41:1817-1827.
-
(2009)
Int J Bio Cell Bio
, vol.41
, pp. 1817-1827
-
-
Giorgi, C.1
De Stefani, D.2
Bononi, A.3
Rizzuto, R.4
Pinton, P.5
-
27
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. 2001. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15:1406-1418.
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
Hay, N.6
-
28
-
-
1642473186
-
The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of adenine nucleotide transporter (ANT)-independent and ANTdependent events
-
Hadassah S, Nagamani SK, Mathew MK, Apurva S. 2004. The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of adenine nucleotide transporter (ANT)-independent and ANTdependent events. Eur J Immunol 34:119-125.
-
(2004)
Eur J Immunol
, vol.34
, pp. 119-125
-
-
Hadassah, S.1
Nagamani, S.K.2
Mathew, M.K.3
Apurva, S.4
-
29
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A, Nogueira V, Chen C-C, Skeen JE, Sonenberg N, Hay N. 2005. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 280:32081-32089.
-
(2005)
J Biol Chem
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.-C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
30
-
-
68649090703
-
The role of the mitochondrial permeability transition pore in heart disease
-
Halestrap AP, Pasdois P. 2009. The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta 1787:1402-1415.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 1402-1415
-
-
Halestrap, A.P.1
Pasdois, P.2
-
31
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. 2004. Upstream and downstream of mTOR. Genes Dev 18:1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
32
-
-
54949135707
-
The endoplasmic reticulum in apoptosis and autophagy: Role of the BCL-2 protein family
-
Heath-Engel HM, Chang NC, Shore GC. 2008. The endoplasmic reticulum in apoptosis and autophagy: Role of the BCL-2 protein family. Oncogene 27:6419-6433.
-
(2008)
Oncogene
, vol.27
, pp. 6419-6433
-
-
Heath-Engel, H.M.1
Chang, N.C.2
Shore, G.C.3
-
33
-
-
0017363944
-
The role of P(i) in glycolytic inhibition of calcium ion uptake by ELD ascites tumor cells
-
Hines R, Wenner CE. 1977. The role of P(i) in glycolytic inhibition of calcium ion uptake by ELD ascites tumor cells. Biochim Biophys Acta 465:391-399.
-
(1977)
Biochim Biophys Acta
, vol.465
, pp. 391-399
-
-
Hines, R.1
Wenner, C.E.2
-
34
-
-
0033604585
-
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
-
Kandel ES, Hay N. 1999. The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB. Exp Cell Res 253:210-229.
-
(1999)
Exp Cell Res
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
35
-
-
14744284637
-
Multifaceted roles of glycolytic enzymes
-
Kim J-W, Dang CV. 2005. Multifaceted roles of glycolytic enzymes. Trends Biochem Sci 30:142-150.
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 142-150
-
-
Kim, J.-W.1
Dang, C.V.2
-
37
-
-
44449147036
-
Tumor Cell Metabolism: Cancer's Achilles' Heel
-
DOI 10.1016/j.ccr.2008.05.005, PII S1535610808001608
-
Kroemer G, Pouyssegur J. 2008. Tumor Cell Metabolism: Cancer's Achilles' Heel. Cancer Cell 13:472-482. (Pubitemid 351766797)
-
(2008)
Cancer Cell
, vol.13
, Issue.6
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
38
-
-
67549134670
-
Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells
-
Kumar S, BryantC, Chamala S, Qazi A, Seward S, Pal J, SteffesC, Weaver D, Morris R, Malone J, Shammas M, Prasad M, Batchu R. 2009. Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells. Mol Cancer 8:26.
-
(2009)
Mol Cancer
, vol.8
, pp. 26
-
-
Kumar, S.1
Bryant, C.2
Chamala, S.3
Qazi, A.4
Seward, S.5
Pal, J.6
Steffes, C.7
Weaver, D.8
Morris, R.9
Malone, J.10
Shammas, M.11
Prasad, M.12
Batchu, R.13
-
39
-
-
0142039877
-
Glucose metabolism in cancer
-
Lee MG, Pedersen PL. 2003. Glucose metabolism in cancer. J Biol Chem 278:41047-41058.
-
(2003)
J Biol Chem
, vol.278
, pp. 41047-41058
-
-
Lee, M.G.1
Pedersen, P.L.2
-
40
-
-
33749611445
-
Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells
-
Lee AWM, States DJ. 2006. Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells. Cell Death Diff 13:1900-1914.
-
(2006)
Cell Death Diff
, vol.13
, pp. 1900-1914
-
-
Lee, A.W.M.1
States, D.J.2
-
41
-
-
29344468832
-
Voltage-dependent anion channel (VDAC) as mitochondrial governator - Thinking outside the box
-
DOI 10.1016/j.bbadis.2005.10.006, PII S0925443905001523, Mitochondria in Diseases and Therapeutics
-
Lemasters JJ, Holmuhamedov E. 2006. Voltage-dependent anion channel (VDAC) as mitochondrial governator - Thinking outside the box. Biochim Biophys Acta 1762:181-190. (Pubitemid 43006024)
-
(2006)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1762
, Issue.2
, pp. 181-190
-
-
Lemasters, J.J.1
Holmuhamedov, E.2
-
42
-
-
55549091082
-
The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition
-
Leung AWC, Varanyuwatana P, Halestrap AP. 2008. The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition. J Biol Chem 283:26312-26323.
-
(2008)
J Biol Chem
, vol.283
, pp. 26312-26323
-
-
Leung, A.W.C.1
Varanyuwatana, P.2
Halestrap, A.P.3
-
43
-
-
0025699745
-
Changes in Na+,K+- ATPase, Ca2+-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease
-
Liguri G, Taddei N, Nassi P, Latorraca S, Nediani C, Sorbi S. 1990. Changes in Na+,K+- ATPase, Ca2+-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease. Neurosci Lett 112:338-342.
-
(1990)
Neurosci Lett
, vol.112
, pp. 338-342
-
-
Liguri, G.1
Taddei, N.2
Nassi, P.3
Latorraca, S.4
Nediani, C.5
Sorbi, S.6
-
44
-
-
66149091940
-
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
-
Luo J, Emanuele MJ, LiD, Creighton CJ, Schlabach MR, Westbrook TF, Wong K-K, Elledge SJ. 2009. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene. Cell 137:835-848.
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
Creighton, C.J.4
Schlabach, M.R.5
Westbrook, T.F.6
Wong, K.-K.7
Elledge, S.J.8
-
45
-
-
0347986675
-
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases
-
Majewski N, Nogueira V, Robey RB, HayN. 2004. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol 24:730-740.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 730-740
-
-
Majewski, N.1
Nogueira, V.2
Robey, R.B.3
Hay, N.4
-
46
-
-
34250712408
-
18F] fluorodeoxyglucose and beyond
-
DOI 10.1158/1078-0432.CCR-07-0074
-
Mankoff DA, Eary JF, Link JM, Muzi M, Rajendran JG, Spence AM, Krohn KA. 2007. Tumor-specific positron emission tomography imaging in patients: [18F] Fluorodeoxyglucose and beyond. Clin Cancer Res 13:3460-3469. (Pubitemid 46955105)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3460-3469
-
-
Mankoff, D.A.1
Eary, J.F.2
Link, J.M.3
Muzi, M.4
Rajendran, J.G.5
Spence, A.M.6
Krohn, K.A.7
-
47
-
-
39449114808
-
Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II
-
DOI 10.1038/sj.cdd.4402285, PII 4402285
-
Miyamoto S, Murphy AN, Brown JH. 2007. Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. Cell Death Differ 15:521-529. (Pubitemid 351267303)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.3
, pp. 521-529
-
-
Miyamoto, S.1
Murphy, A.N.2
Brown, J.H.3
-
48
-
-
0842263745
-
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
-
DOI 10.1038/sj.emboj.7600045
-
Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. 2004. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21- dependent pathway. EMBO J 23:212-220. (Pubitemid 38165761)
-
(2004)
EMBO Journal
, vol.23
, Issue.1
, pp. 212-220
-
-
Miyauchi, H.1
Minamino, T.2
Tateno, K.3
Kunieda, T.4
Toko, H.5
Komuro, I.6
-
49
-
-
58149485586
-
Therapeutic modulation of apoptosis: Targeting the BCL-2 family at the interface of the mitochondrial membrane
-
Nemec KN, Khaled AR. 2008. Therapeutic modulation of apoptosis: Targeting the BCL-2 family at the interface of the mitochondrial membrane. Yonsei Med J 49:689-697.
-
(2008)
Yonsei Med J
, vol.49
, pp. 689-697
-
-
Nemec, K.N.1
Khaled, A.R.2
-
50
-
-
40849124038
-
Cardiac glycosides as novel cancer therapeutic agents
-
DOI 10.1124/mi.8.1.8
-
Newman RA, Yang P, Pawlus AD, Block KI. 2008. Cardiac glycosides as novel cancer therapeutic agents. Mol Interv 8:36-49. (Pubitemid 351398451)
-
(2008)
Molecular Interventions
, vol.8
, Issue.1
, pp. 36-49
-
-
Newman, R.A.1
Yang, P.2
Pawlus, A.D.3
Block, K.I.4
-
51
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N. 2009. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14:458-470.
-
(2009)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
Xu, P.Z.4
Chen, M.L.5
Tonic, I.6
Unterman, T.7
Hay, N.8
-
52
-
-
28544436922
-
Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
-
DOI 10.1158/0008-5472.CAN-05-1925
-
Pastorino JG, Hoek JB, Shulga N. 2005. Activation of Glycogen Synthase Kinase 3β Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity. Cancer Res 65:10545-10554. (Pubitemid 41743749)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10545-10554
-
-
Pastorino, J.G.1
Hoek, J.B.2
Shulga, N.3
-
53
-
-
0036510541
-
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
-
DOI 10.1074/jbc.M109950200
-
Pastorino JG, Shulga N, Hoek JB. 2002. Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis. J Biol Chem 277:7610-7618. (Pubitemid 34953160)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.9
, pp. 7610-7618
-
-
Pastorino, J.G.1
Shulga, N.2
Hoek, J.B.3
-
54
-
-
52449119836
-
Regulation of hexokinase binding to VDAC
-
Pastorino J, Hoek J. 2008. Regulation of hexokinase binding to VDAC. J Bioenerg Biomembr 40:171-182.
-
(2008)
J Bioenerg Biomembr
, vol.40
, pp. 171-182
-
-
Pastorino, J.1
Hoek, J.2
-
55
-
-
35448964610
-
Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen
-
Pedersen P. 2007. Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen. J Bioenerg Biomembr 39:211-222.
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 211-222
-
-
Pedersen, P.1
-
56
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
DOI 10.1038/nature04871, PII NATURE04871
-
Pouyssegur J, Dayan F, Mazure NM. 2006. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441:437-443. (Pubitemid 44050138)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
57
-
-
55349103358
-
Novel therapeutic applications of cardiac glycosides
-
Prassas I, Diamandis EP. 2008. Novel therapeutic applications of cardiac glycosides. Nat Rev Drug Discov 7:926-935.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 926-935
-
-
Prassas, I.1
Diamandis, E.P.2
-
59
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factorindependent survival
-
Rathmell JC, Fox CJ, Plas DR, Hammerman PS,Cinalli RM, Thompson CB. 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factorindependent survival. Mol Cell Biol 23:7315-7328.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
60
-
-
68649115556
-
Ca2+ transfer from the ER to mitochondria: When, how and why
-
Rizzuto R, Marchi S, BonoraM, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P. 2009. Ca2+ transfer from the ER to mitochondria: When, how and why. Biochim Biophys Acta 1787:1342-1351.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 1342-1351
-
-
Rizzuto, R.1
Marchi, S.2
Bonora, M.3
Aguiari, P.4
Bononi, A.5
De Stefani, D.6
Giorgi, C.7
Leo, S.8
Rimessi, A.9
Siviero, R.10
Zecchini, E.11
Pinton, P.12
-
61
-
-
33644847375
-
Microdomains of intracellular Ca2+: Molecular determinants and functional consequences
-
Rizzuto R, Pozzan T. 2006. Microdomains of intracellular Ca2+: Molecular determinants and functional consequences. Physiol Rev 86:369-408.
-
(2006)
Physiol Rev
, vol.86
, pp. 369-408
-
-
Rizzuto, R.1
Pozzan, T.2
-
62
-
-
33645069144
-
Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy
-
Robey RB, Hay N. 2005. Akt, hexokinase, mTOR: Targeting cellular energy metabolism for cancer therapy. Drug Discov Today 2:239-246.
-
(2005)
Drug Discov Today
, vol.2
, pp. 239-246
-
-
Robey, R.B.1
Hay, N.2
-
63
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
DOI 10.1038/sj.onc.1209595, PII 1209595
-
Robey RB, Hay N. 2006. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 25:4683-4696. (Pubitemid 44187618)
-
(2006)
Oncogene
, vol.25
, Issue.34
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
64
-
-
60549111398
-
Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis
-
Robey RB, Hay N. 2009. Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis. Semin Cancer Biol 19:25-31.
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 25-31
-
-
Robey, R.B.1
Hay, N.2
-
65
-
-
42549144606
-
Bcl-2 protein family members: Versatile regulators of calcium signaling in cell survival and apoptosis
-
DOI 10.1146/annurev.physiol.70.021507.105852
-
Rong Y, Distelhorst CW.2008. Bcl-2 protein family members: Versatile regulators of calcium signaling in cell survival and apoptosis. Ann Rev Physiol 70:73-91. (Pubitemid 351738172)
-
(2008)
Annual Review of Physiology
, vol.70
, pp. 73-91
-
-
Rong, Y.1
Distelhorst, C.W.2
-
66
-
-
65849111219
-
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
-
Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S,Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG. 2009. Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells. Cell 137:821-834.
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Fröhling, S.2
Dunn, I.F.3
Schinzel, A.C.4
Barbie, D.A.5
Kim, S.Y.6
Silver, S.J.7
Tamayo, P.8
Wadlow, R.C.9
Ramaswamy, S.10
Döhner, K.11
Bullinger, L.12
Sandy, P.13
Boehm, J.S.14
Root, D.E.15
Jacks, T.16
Hahn, W.C.17
Gilliland, D.G.18
-
67
-
-
0344181737
-
2+ signals, mitochondrial fission and sensitization to apoptosis
-
DOI 10.1038/sj.cdd.4401310
-
Scorrano L. 2003. Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis. Cell Death Differ 10:1287-1289. (Pubitemid 37536733)
-
(2003)
Cell Death and Differentiation
, vol.10
, Issue.12
, pp. 1287-1289
-
-
Scorrano, L.1
-
68
-
-
35448961940
-
HIF-1 mediates the Warburg effect in clear cell renal carcinoma
-
DOI 10.1007/s10863-007-9081-2, Special Topic: The Warburg Effect: Its Continued Impact on Cancer Research into the 21st Century
-
Semenza G. 2007. HIF-1 mediates theWarburg effect in clear cell renal carcinoma. J Bioenerg Biomembr 39:231-234. (Pubitemid 47619375)
-
(2007)
Journal of Bioenergetics and Biomembranes
, vol.39
, Issue.3
, pp. 231-234
-
-
Semenza, G.L.1
-
69
-
-
67349235529
-
Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase
-
Shoshan-Barmatz V, Zakar M, Rosenthal K, Abu-Hamad S. 2009. Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. Biochim Biophys Acta 1787:421-430.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 421-430
-
-
Shoshan-Barmatz, V.1
Zakar, M.2
Rosenthal, K.3
Abu-Hamad, S.4
-
70
-
-
70449099192
-
Mitochondria mediated cell death in diabetes
-
Szabadkai G, Duchen M. 2009. Mitochondria mediated cell death in diabetes. Apoptosis 14:1405-1423.
-
(2009)
Apoptosis
, vol.14
, pp. 1405-1423
-
-
Szabadkai, G.1
Duchen, M.2
-
72
-
-
71749121777
-
Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellular during stress-induced apoptosis
-
Tomasello F, Messina A, Lartigue L, Schembri L, Medina C, Reina S, Thoraval D, Crouzet M, Ichas F, De Pinto V, De Giorgi F. 2009. Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellular during stress-induced apoptosis. Cell Res 19:1363-1376.
-
(2009)
Cell Res
, vol.19
, pp. 1363-1376
-
-
Tomasello, F.1
Messina, A.2
Lartigue, L.3
Schembri, L.4
Medina, C.5
Reina, S.6
Thoraval, D.7
Crouzet, M.8
Ichas, F.9
De Pinto, V.10
De Giorgi, F.11
-
73
-
-
56649099192
-
The crystal structure of mouse VDAC1 at 2.3 Ã resolution reveals mechanistic insights into metabolite gating
-
Ujwal R, Cascio D, Colletier J-P, Faham S, Zhang J, Toro L, Ping P, Abramson J. 2008. The crystal structure of mouse VDAC1 at 2.3 Ã resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci 105:17742-17747.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 17742-17747
-
-
Ujwal, R.1
Cascio, D.2
Colletier, J.-P.3
Faham, S.4
Zhang, J.5
Toro, L.6
Ping, P.7
Abramson, J.8
-
74
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
75
-
-
52449115923
-
VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
-
Veenman L, Shandalov Y, Gavish M. 2008. VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis. J Bioenerg Biomembr 40:199-205.
-
(2008)
J Bioenerg Biomembr
, vol.40
, pp. 199-205
-
-
Veenman, L.1
Shandalov, Y.2
Gavish, M.3
-
76
-
-
68449092620
-
In situ modulation of oxidative stress: A novel and efficient strategy to kill cancer cells
-
Verrax J, Pedrosa RC, Beck R, Dejeans N, Taper H, Calderon PBuc. 2009. In situ modulation of oxidative stress: A novel and efficient strategy to kill cancer cells. Curr Med Chem 16:1821-1830.
-
(2009)
Curr Med Chem
, vol.16
, pp. 1821-1830
-
-
Verrax, J.1
Pedrosa, R.C.2
Beck, R.3
Dejeans, N.4
Taper, H.5
Calderon, P.B.6
-
77
-
-
35348909652
-
18F-FDG PET in non-Hodgkin's lymphoma: Qualitative or quantitative?
-
Weber WA. 2007. 18F-FDG PET in non-Hodgkin's lymphoma: Qualitative or quantitative? J Nucl Med 48:1580-1582.
-
(2007)
J Nucl Med
, vol.48
, pp. 1580-1582
-
-
Weber, W.A.1
-
78
-
-
0017173150
-
The Warburg hypothesis fifty years later
-
Weinhouse S. 1976. The Warburg hypothesis fifty years later. J Cancer Rec Clin Oncol 87:115-126.
-
(1976)
J Cancer Rec Clin Oncol
, vol.87
, pp. 115-126
-
-
Weinhouse, S.1
-
79
-
-
2342487353
-
Na+-K+-ATPase-mediated signal transduction: From protein interaction to cellular function
-
Xie Z,Cai T. 2003. Na+-K+-ATPase-mediated signal transduction: From protein interaction to cellular function. Mol Interv 3:157-168.
-
(2003)
Mol Interv
, vol.3
, pp. 157-168
-
-
Xie, Z.1
Cai, T.2
-
80
-
-
48749122530
-
Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis
-
Yuan S, Fu Y,Wang X, Shi H, Huang Y, Song X, Li L, Song N, Luo Y. 2008. Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis. FASEB J 22:2809-2820.
-
(2008)
FASEB J
, vol.22
, pp. 2809-2820
-
-
Yuan, S.1
Fu, Y.2
Wang, X.3
Shi, H.4
Huang, Y.5
Song, X.6
Li, L.7
Song, N.8
Luo, Y.9
-
81
-
-
70349331678
-
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
-
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JKV, Markowitz S, Zhou S, Diaz LA Jr, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. 2009. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells. Science 325:1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.V.8
Markowitz, S.9
Zhou, S.10
Diaz Jr., L.A.11
Velculescu, V.E.12
Lengauer, C.13
Kinzler, K.W.14
Vogelstein, B.15
Papadopoulos, N.16
-
82
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL. 2008. Digoxin and other cardiac glycosides inhibit HIF-1a synthesis and block tumor growth. Proc Natl Acad Sci 105:19579-19586.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
Ren, Y.R.6
Rey, S.7
Hammers, H.8
Chang, D.9
Pili, R.10
Dang, C.V.11
Liu, J.O.12
Semenza, G.L.13
-
83
-
-
42149156248
-
The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca2+ stores
-
Zhao X,Wang L, Sun Y, Ye L, Lu J, Yuan Y, Qian G, Ge S. 2008. The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca2+ stores. Mol Cell Biochem 312:33-38.
-
(2008)
Mol Cell Biochem
, vol.312
, pp. 33-38
-
-
Zhao, X.1
Wang, L.2
Sun, Y.3
Ye, L.4
Lu, J.5
Yuan, Y.6
Qian, G.7
Ge, S.8
-
84
-
-
1442327526
-
Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
-
DOI 10.1038/sj.onc.1207205
-
Zheng Y, Shi Y, Tian C, JiangC, Jin H, Chen J, Almasan A, Tang H, Chen Q. 2003. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 23:1239-1247. (Pubitemid 38297178)
-
(2004)
Oncogene
, vol.23
, Issue.6
, pp. 1239-1247
-
-
Zheng, Y.1
Shi, Y.2
Tian, C.3
Jiang, C.4
Jin, H.5
Chen, J.6
Almasan, A.7
Tang, H.8
Chen, Q.9
|