메뉴 건너뛰기




Volumn 5, Issue 7, 2005, Pages 573-580

Killing time for cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTIMITOTIC AGENT; BCR ABL PROTEIN; BEVACIZUMAB; CANCER GROWTH FACTOR; CELL CYCLE INHIBITOR; CELL DNA; CISPLATIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; DASATINIB; ERLOTINIB; FLAVOPIRIDOL; GEFITINIB; GEMCITABINE; GROWTH FACTOR RECEPTOR; GUANOSINE TRIPHOSPHATASE; GX 15 070; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; OBLIMERSEN; ON 012380; PROTEIN INHIBITOR; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; SORAFENIB; SUNITINIB; TAXANE DERIVATIVE; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR;

EID: 21744449674     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1651     Document Type: Review
Times cited : (78)

References (67)
  • 1
    • 0035984912 scopus 로고    scopus 로고
    • ROS, stress-activated kinases and stress signalling in cancer
    • Benhar, M., Engelberg, D. & Levitzki, A. ROS, stress-activated kinases and stress signalling in cancer. EMBO Rep. 3, 420-425 (2002).
    • (2002) EMBO Rep. , vol.3 , pp. 420-425
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 2
    • 0024240990 scopus 로고
    • Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
    • Yaish, P. et al. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242, 933-935 (1988).
    • (1988) Science , vol.242 , pp. 933-935
    • Yaish, P.1
  • 3
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Leviteki, A. & Gazit, A. Tyrosine kinase inhibition: an approach to drug development. Science 267 1782-1788 (1995).
    • (1995) Science , vol.267 , pp. 1782-1788
    • Leviteki, A.1    Gazit, A.2
  • 4
    • 0028000069 scopus 로고
    • Signal-transduction therapy. A novel approach to disease management
    • Levitzki, A, Signal-transduction therapy. A novel approach to disease management Eur. J. Biochem. 226, 1-13 (1994).
    • (1994) Eur. J. Biochem. , vol.226 , pp. 1-13
    • Levitzki, A.1
  • 5
    • 0038793948 scopus 로고    scopus 로고
    • Apoptosis and melanoma chemoresistance
    • Soengas, M. S. & Lowe, S. W. Apoptosis and melanoma chemoresistance. Oncogene 22, 3138-3151 (2003).
    • (2003) Oncogene , vol.22 , pp. 3138-3151
    • Soengas, M.S.1    Lowe, S.W.2
  • 6
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumour activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumour progression and angiogenesis
    • Wilhelm, S. M. et al. BAY 43-9006 exhibits broad spectrum oral antitumour activity and targets the RAF/ MEK/ERK pathway and receptor tyrosine kinases involved in tumour progression and angiogenesis. Cancer Res, 64, 7099-7109 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1
  • 7
    • 4344584872 scopus 로고    scopus 로고
    • B-RAF is a therapeutic target in melanoma
    • Karasarides, M. et al. B-RAF is a therapeutic target in melanoma. Oncogene 23, 6292-6298 (2004).
    • (2004) Oncogene , vol.23 , pp. 6292-6298
    • Karasarides, M.1
  • 8
    • 0034644506 scopus 로고    scopus 로고
    • ARF
    • ARF. Cell 103, 321-330 (2000).
    • (2000) Cell , vol.103 , pp. 321-330
    • Ries, S.1
  • 9
    • 3042536038 scopus 로고    scopus 로고
    • Preclinical and clinical development of the cyclin-dependent kinase inhibitorflavopiridol
    • Shapiro, G. I. Preclinical and clinical development of the cyclin-dependent kinase inhibitorflavopiridol. Clin Cancer Res. 10, S4270-S4275 (2004).
    • (2004) Clin Cancer Res. , vol.10
    • Shapiro, G.I.1
  • 10
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown, J. M. & Attardi, L. D. The role of apoptosis in cancer development and treatment response. Nature Rev. Cancer 5, 231-237 (2005).
    • (2005) Nature Rev. Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 11
    • 9144234685 scopus 로고    scopus 로고
    • Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumour activity
    • Schimmer, A. D. et al. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumour activity. Cancer Cell 5, 25-35 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 25-35
    • Schimmer, A.D.1
  • 12
    • 0036565885 scopus 로고    scopus 로고
    • Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/ DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis
    • Quo, F. et al. Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/ DIABLO) or cotreatment with N-terminus of Smac/ DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood 99, 3419-3426 (2002).
    • (2002) Blood , vol.99 , pp. 3419-3426
    • Quo, F.1
  • 13
    • 0000449082 scopus 로고    scopus 로고
    • Reactivation of mutant p53: A new strategy for cancer therapy
    • Selivanova, G. et al. Reactivation of mutant p53: a new strategy for cancer therapy. Semin. Cancer Biol 8, 369-378 (1998).
    • (1998) Semin. Cancer Biol. , vol.8 , pp. 369-378
    • Selivanova, G.1
  • 14
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev, L. T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844-848 (2004).
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1
  • 15
    • 0036491256 scopus 로고    scopus 로고
    • A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity
    • Honda, T. et al. A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity. Cancer Biol. Ther. 1, 163-167 (2002).
    • (2002) Cancer Biol. Ther. , vol.1 , pp. 163-167
    • Honda, T.1
  • 16
    • 1642471831 scopus 로고    scopus 로고
    • PI3K/Akt and apoptosis: Size matters
    • Franke, T. F. et al. PI3K/Akt and apoptosis: size matters, Oncogene 22, 8983-8998 (2003).
    • (2003) Oncogene , vol.22 , pp. 8983-8998
    • Franke, T.F.1
  • 17
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo, J., Manning, B. D. & Cantley, L. C. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4, 257-262 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 18
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar, D. C. & Blenis, J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression, Oncogene 23, 3151-3171 (2004).
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 19
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo, M. & Rowinsky, E. K. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 19, 6680-6686 (2000).
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 20
    • 0042197413 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A new molecular target for breast cancer
    • Mita, M. M., Mita, A. & Rowinsky, E. K. Mammalian target of rapamycin: a new molecular target for breast cancer. Clin. Breast Cancer 4, 126-137 (2003).
    • (2003) Clin. Breast Cancer , vol.4 , pp. 126-137
    • Mita, M.M.1    Mita, A.2    Rowinsky, E.K.3
  • 21
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumours to inhibition of FRAP/mTOR
    • Neshat, M. S. et al. Enhanced sensitivity of PTEN-deficient tumours to inhibition of FRAP/mTOR. Proc. Natl Acad. Sci. USA 98, 10314-10319 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10314-10319
    • Neshat, M.S.1
  • 23
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colourectal cancer
    • Hurwitz, H, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colourectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2335-2342
    • Hurwitz, H.1
  • 24
    • 4444311880 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1α as a cancer drug target
    • Powis, G. & Kirkpatrick, L, Hypoxia inducible factor-1α as a cancer drug target. Mol. Cancer Ther. 3, 647-654 (2004).
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 647-654
    • Powis, G.1    Kirkpatrick, L.2
  • 25
    • 3142622930 scopus 로고    scopus 로고
    • Small molecule blockade of transcriptional co-activation of the hypoxia-inducible factor pathway
    • Kung, A. L. et al. Small molecule blockade of transcriptional co-activation of the hypoxia-inducible factor pathway. Cancer Cell 6, 33-43 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 33-43
    • Kung, A.L.1
  • 26
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukaemia
    • Kantarjian, H. et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukaemia. N. Engl. J. Med. 346, 645-652 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 645-652
    • Kantarjian, H.1
  • 27
    • 0036050013 scopus 로고    scopus 로고
    • Chronic myelogenous leukaemia: Mechanisms underlying disease progression
    • Shet, A. S., Jahagirdar, B. N. & Verfaillie, C. M. Chronic myelogenous leukaemia: mechanisms underlying disease progression. Leukaemia 16, 1402-1411 (2002).
    • (2002) Leukaemia , vol.16 , pp. 1402-1411
    • Shet, A.S.1    Jahagirdar, B.N.2    Verfaillie, C.M.3
  • 28
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre, M. E. et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880 (2001).
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1
  • 29
    • 0038700992 scopus 로고    scopus 로고
    • Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment
    • Roche-Lestienne, C. & Preudhomme, C, Mutations in the ABL kinase domain pre-exist the onset of imatinib treatment. Semin. Hematol. 40, 80-82 (2003).
    • (2003) Semin. Hematol. , vol.40 , pp. 80-82
    • Roche-Lestienne, C.1    Preudhomme, C.2
  • 30
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukaemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne, C. et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukaemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100, 1014-1018 (2002).
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1
  • 31
    • 10744231296 scopus 로고    scopus 로고
    • Results of a prospective phase 2 study combining Imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukaemia in chronic phase
    • Gardembas, M. et al. Results of a prospective phase 2 study combining Imatinib mesylate and cytarabine for the treatment of Philadelphia-positive patients with chronic myelogenous leukaemia in chronic phase. Stood 102, 4298-4305 (2003).
    • (2003) Stood , vol.102 , pp. 4298-4305
    • Gardembas, M.1
  • 32
    • 20844461336 scopus 로고    scopus 로고
    • Imatinib mesylate-sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukaemia: Report of two cases
    • Higashi, T. et al. Imatinib mesylate-sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukaemia: report of two cases. Am. J. Hematol. 76, 275-278 (2004).
    • (2004) Am. J. Hematol. , vol.76 , pp. 275-278
    • Higashi, T.1
  • 33
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a molecular response
    • Cortes, J., O'Brien, S. & Kantarjian, H. Discontinuation of imatinib therapy after achieving a molecular response. Blood 104, 2204-2205 (2004).
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 34
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
    • Jamieson, C. H, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML N. Engl. J. Med. 351, 657-667 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 657-667
    • Jamieson, C.H.1
  • 35
    • 6044229354 scopus 로고    scopus 로고
    • Concepts of human leukemic development
    • Warner, J. K. et al. Concepts of human leukemic development. Oncogene 23, 7164-7177 (2004).
    • (2004) Oncogene , vol.23 , pp. 7164-7177
    • Warner, J.K.1
  • 36
    • 0034691092 scopus 로고    scopus 로고
    • AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukaemia with 8;21 chromosomal translocation
    • Miyamoto, T., Weissman, I. L. & Akashi, K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukaemia with 8;21 chromosomal translocation. Proc. Natl Acad. Sci. USA 97, 7521-7526 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7521-7526
    • Miyamoto, T.1    Weissman, I.L.2    Akashi, K.3
  • 37
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukaemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope, K. J., Jin, L. & Dick, J. E. Acute myeloid leukaemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nature immunol. 5, 738-743 (2004).
    • (2004) Nature Immunol. , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 38
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj, M. et al. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983-3988 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1
  • 39
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004).
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1
  • 40
    • 0035795683 scopus 로고    scopus 로고
    • Five versus more than five years of tamoxifen for lymph node-negative breast cancer: Updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial
    • Fisher, B. et al. Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial. J. Natl Cancer Inst. 93, 684-690 (2001).
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 684-690
    • Fisher, B.1
  • 41
    • 3042820902 scopus 로고    scopus 로고
    • Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells
    • Georgantas, R. W. 3rd et al. Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells. Cancer Res. 64, 4434-4441 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 4434-4441
    • Georgantas III, R.W.1
  • 42
    • 0037059012 scopus 로고    scopus 로고
    • Preferential induction of apoptosis for primary human leukemic stem cells
    • Guzman, M. L. et al. Preferential induction of apoptosis for primary human leukemic stem cells. Proc. Natl Acad. Sci. USA 99, 16220-16225 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16220-16225
    • Guzman, M.L.1
  • 43
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher, B. et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J. Natl Cancer Inst. 90, 1371-1388 (1998).
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1371-1388
    • Fisher, B.1
  • 44
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch, T, J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 45
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 46
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella, R. et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 305, 1163-1167 (2004).
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1
  • 47
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Debiec-Rychter, M. et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer 40, 689-695 (2004).
    • (2004) Eur. J. Cancer , vol.40 , pp. 689-695
    • Debiec-Rychter, M.1
  • 48
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumour
    • Heinrich, M. C. et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumour. J. Clin. Oncol. 21, 4342-4349 (2003).
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4342-4349
    • Heinrich, M.C.1
  • 49
    • 0030044628 scopus 로고    scopus 로고
    • Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells
    • Tsai, C. M. et al. Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells. Cancer Res. 56, 1068-1074 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1068-1074
    • Tsai, C.M.1
  • 50
    • 13844261144 scopus 로고    scopus 로고
    • A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance
    • Gumireddy, K. et al. A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance. Proc. Natl Acad. Sci. USA 102, 1992-1997 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1992-1997
    • Gumireddy, K.1
  • 51
    • 19944433628 scopus 로고    scopus 로고
    • Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors
    • Barnett, S. F. et al. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385, 399-408 (2005).
    • (2005) Biochem. J. , vol.385 , pp. 399-408
    • Barnett, S.F.1
  • 52
    • 19944431003 scopus 로고    scopus 로고
    • Allosteric Akt (PKB) inhibitors: Discovery and SAR of isozyme selective inhibitors
    • Lindsley, C. W. et al. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg. Med. Chem. Lett. 15, 761-764 (2005).
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 761-764
    • Lindsley, C.W.1
  • 53
    • 0028968622 scopus 로고
    • Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenytaminopyrimidine class
    • Buchdunger, E. et al. Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenytaminopyrimidine class. Proc. Natl Acad. Sci. USA 92, 2558-2562 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2558-2562
    • Buchdunger, E.1
  • 54
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger, E. et al. Inhibition of the Abl protein-tyrosine kinase In vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res, 56, 100-104 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 100-104
    • Buchdunger, E.1
  • 55
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker, B. J. et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Med. 2, 561-566 (1996).
    • (1996) Nature Med. , vol.2 , pp. 561-566
    • Druker, B.J.1
  • 56
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger, E. et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J. Pharmacol. Exp. Ther. 295, 139-145 (2000).
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 139-145
    • Buchdunger, E.1
  • 57
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah, N. P. et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 305, 399-401 (2004).
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1
  • 58
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer
    • Abrams, T. J. et al. SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer. Mol. Cancer Ther. 2, 471-478 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 471-478
    • Abrams, T.J.1
  • 59
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumour activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel, D. B. et al. In vivo antitumour activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship, Clin. Cancer Res. 9, 327-337 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 327-337
    • Mendel, D.B.1
  • 60
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell, A, M. et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Stood 101, 3597-3605 (2003).
    • (2003) Stood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1
  • 61
    • 0031683109 scopus 로고    scopus 로고
    • Altered efficacy and selectivity of tyrosine kinase inhibitors of the activated states of protein tyrosine kinases
    • Levitzki, A. & Bohmer, F. D. Altered efficacy and selectivity of tyrosine kinase inhibitors of the activated states of protein tyrosine kinases. Anticancer Drug Des. 13. 731-734 (1998).
    • (1998) Anticancer Drug Des. , vol.13 , pp. 731-734
    • Levitzki, A.1    Bohmer, F.D.2
  • 62
    • 2542474181 scopus 로고    scopus 로고
    • Genomic profiling of viable and proliferate micrometastatic cells from early-stage breast cancer patients
    • Gangnus. R. et al. Genomic profiling of viable and proliferate micrometastatic cells from early-stage breast cancer patients. Clin. Cancer Res. 10, 3457-3464 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3457-3464
    • Gangnus, R.1
  • 63
    • 0037648348 scopus 로고    scopus 로고
    • The case for early detection
    • Etzioni, R. et al. The case for early detection. Nature Rev. Cancer 3, 243-252 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 243-252
    • Etzioni, R.1
  • 64
    • 4944242884 scopus 로고    scopus 로고
    • A vision for the National Cancer Program in the United States
    • von Eschenbach, A. C. A vision for the National Cancer Program in the United States. Nature Rev. Cancer 4, 820-828 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 820-828
    • Von Eschenbach, A.C.1
  • 66
    • 0038543824 scopus 로고    scopus 로고
    • Chemoprevention of colourectal cancer
    • Janne, P. A. & Mayer, R. J. Chemoprevention of colourectal cancer. N. Engl. J. Med. 342, 1960-1968 (2000).
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1960-1968
    • Janne, P.A.1    Mayer, R.J.2
  • 67
    • 3042668237 scopus 로고    scopus 로고
    • Molecularly targeted approaches to the Chemoprevention of lung cancer
    • Khuri, F. R. & Cohen, V. Molecularly targeted approaches to the Chemoprevention of lung cancer, Clin. Cancer Res 10, S4249-S4253 (2004).
    • (2004) Clin. Cancer Res , vol.10
    • Khuri, F.R.1    Cohen, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.