메뉴 건너뛰기




Volumn 8, Issue 3, 2010, Pages

Spatial epigenetic control of mono- and bistable gene expression

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; DIFFUSION; DNA FLANKING REGION; EPIGENETICS; GENE ACTIVATION; GENE CLUSTER; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENE REGULATORY NETWORK; GENE SILENCING; GENE SWITCHING; GENETIC STABILITY; SIGNAL TRANSDUCTION; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; REGULATORY SEQUENCE; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION INITIATION;

EID: 77950590631     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000332     Document Type: Article
Times cited : (35)

References (60)
  • 1
    • 62549083590 scopus 로고    scopus 로고
    • Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
    • Nevozhay D, Adams RM, Murphy KF, Josic K, Balazsi G (2009) Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc Natl Acad Sci U S A 106: 5123-5128.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5123-5128
    • Nevozhay, D.1    Adams, R.M.2    Murphy, K.F.3    Josic, K.4    Balazsi, G.5
  • 2
    • 49649109812 scopus 로고    scopus 로고
    • Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade
    • Takahashi S, Pryciak PM (2008) Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade. Curr Biol 18: 1184-1191.
    • (2008) Curr Biol , vol.18 , pp. 1184-1191
    • Takahashi, S.1    Pryciak, P.M.2
  • 3
    • 0030746219 scopus 로고    scopus 로고
    • Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase
    • Ferrell JE, Jr., Bhatt RR (1997) Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J Biol Chem 272: 19008-19016.
    • (1997) J Biol Chem , vol.272 , pp. 19008-19016
    • Ferrell Jr., J.E.1    Bhatt, R.R.2
  • 4
    • 33845616177 scopus 로고    scopus 로고
    • Phenotypic consequences of promoter-mediated transcriptional noise
    • Blake WJ, Balazsi G, Kohanski MA, Isaacs FJ, Murphy KF, et al. (2006) Phenotypic consequences of promoter-mediated transcriptional noise. Mol Cell 24: 853-865.
    • (2006) Mol Cell , vol.24 , pp. 853-865
    • Blake, W.J.1    Balazsi, G.2    Kohanski, M.A.3    Isaacs, F.J.4    Murphy, K.F.5
  • 5
    • 33847394655 scopus 로고    scopus 로고
    • MAPKmediated bimodal gene expression and adaptive gradient sensing in yeast
    • Paliwal S, Iglesias PA, Campbell K, Hilioti Z, Groisman A, et al. (2007) MAPKmediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446: 46-51.
    • (2007) Nature , vol.446 , pp. 46-51
    • Paliwal, S.1    Iglesias, P.A.2    Campbell, K.3    Hilioti, Z.4    Groisman, A.5
  • 6
    • 33947304756 scopus 로고    scopus 로고
    • Substrate competition as a source of ultrasensitivity in the inactivation of Wee1
    • Kim SY, Ferrell JE, Jr. (2007) Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 128: 1133-1145.
    • (2007) Cell , vol.128 , pp. 1133-1145
    • Kim, S.Y.1    Ferrell Jr., J.E.2
  • 7
    • 59249086373 scopus 로고    scopus 로고
    • Control of stochastic gene expression by host factors at the HIV promoter
    • doi:10.1371/journal.ppat.1000260
    • Burnett JC, Miller-Jensen K, Shah PS, Arkin AP, Schaffer DV (2009) Control of stochastic gene expression by host factors at the HIV promoter. PLoS Pathog 5: e1000260. doi:10.1371/journal.ppat.1000260.
    • (2009) PLoS Pathog , vol.5
    • Burnett, J.C.1    Miller-Jensen, K.2    Shah, P.S.3    Arkin, A.P.4    Schaffer, D.V.5
  • 8
    • 43249103636 scopus 로고    scopus 로고
    • Cell-to-cell stochastic variation in gene expression is a complex genetic trait
    • doi:10.1371/journal.pgen.1000049
    • Ansel J, Bottin H, Rodriguez-Beltran C, Damon C, Nagarajan M, et al. (2008) Cell-to-cell stochastic variation in gene expression is a complex genetic trait. PLoS Genet 4: e1000049. doi:10.1371/journal.pgen.1000049.
    • (2008) PLoS Genet , vol.4
    • Ansel, J.1    Bottin, H.2    Rodriguez-Beltran, C.3    Damon, C.4    Nagarajan, M.5
  • 9
    • 68049139696 scopus 로고    scopus 로고
    • Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells
    • doi:10.1371/journal.pbio.1000149
    • Kalmar T, Lim C, Hayward P, Munoz-Descalzo S, Nichols J, et al. (2009) Regulated fluctuations in Nanog expression mediate cell fate decisions in embryonic stem cells. PLoS Biol 7: e1000149. doi:10.1371/journal.pbio.1000149.
    • (2009) PLoS Biol , vol.7
    • Kalmar, T.1    Lim, C.2    Hayward, P.3    Munoz-Descalzo, S.4    Nichols, J.5
  • 10
    • 33747189803 scopus 로고    scopus 로고
    • When it comes to decisions, myeloid progenitors crave positive feedback
    • Muzzey D, van Oudenaarden A (2006) When it comes to decisions, myeloid progenitors crave positive feedback. Cell 126: 650-652.
    • (2006) Cell , vol.126 , pp. 650-652
    • Muzzey, D.1    van Oudenaarden, A.2
  • 12
    • 35348868573 scopus 로고    scopus 로고
    • Epigenetic regulation of normal andmalignant hematopoiesis
    • Rice KL, Hormaeche I, Licht JD (2007) Epigenetic regulation of normal andmalignant hematopoiesis. Oncogene 26: 6697-6714.
    • (2007) Oncogene , vol.26 , pp. 6697-6714
    • Rice, K.L.1    Hormaeche, I.2    Licht, J.D.3
  • 13
    • 0036345455 scopus 로고    scopus 로고
    • Gene silencing quantitatively controls the function of a developmental trans-activator
    • Hutchins AS, Mullen AC, Lee HW, Sykes KJ, High FA, et al. (2002) Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell 10: 81-91.
    • (2002) Mol Cell , vol.10 , pp. 81-91
    • Hutchins, A.S.1    Mullen, A.C.2    Lee, H.W.3    Sykes, K.J.4    High, F.A.5
  • 14
    • 0036713367 scopus 로고    scopus 로고
    • Protosilencers as building blocks for heterochromatin
    • Fourel G, Lebrun E, Gilson E (2002) Protosilencers as building blocks for heterochromatin. Bioessays 24: 828-835.
    • (2002) Bioessays , vol.24 , pp. 828-835
    • Fourel, G.1    Lebrun, E.2    Gilson, E.3
  • 15
    • 84883798471 scopus 로고    scopus 로고
    • PcG proteins, DNA methylation, and gene repression by chromatin looping
    • doi:10.1371/journal.pbio.0060306
    • Tiwari VK, McGarvey KM, Licchesi JD, Ohm JE, Herman JG, et al. (2008) PcG proteins, DNA methylation, and gene repression by chromatin looping. PLoS Biol 6: e306. doi:10.1371/journal.pbio.0060306.
    • (2008) PLoS Biol , vol.6
    • Tiwari, V.K.1    McGarvey, K.M.2    Licchesi, J.D.3    Ohm, J.E.4    Herman, J.G.5
  • 16
    • 42149135457 scopus 로고    scopus 로고
    • Spreading of a corepressor linked to action of long-range repressor hairy
    • Martinez CA, Arnosti DN (2008) Spreading of a corepressor linked to action of long-range repressor hairy. Mol Cell Biol 28: 2792-2802.
    • (2008) Mol Cell Biol , vol.28 , pp. 2792-2802
    • Martinez, C.A.1    Arnosti, D.N.2
  • 17
    • 0035341208 scopus 로고    scopus 로고
    • Local action of long-range repressors in the Drosophila embryo
    • Nibu Y, Zhang H, Levine M (2001) Local action of long-range repressors in the Drosophila embryo. EMBO J 20: 2246-2253.
    • (2001) EMBO J , vol.20 , pp. 2246-2253
    • Nibu, Y.1    Zhang, H.2    Levine, M.3
  • 18
    • 33748805480 scopus 로고    scopus 로고
    • Spreading of silent chromatin: Inaction at a distance
    • Talbert PB, Henikoff S (2006) Spreading of silent chromatin: inaction at a distance. Nat Rev Genet 7: 793-803.
    • (2006) Nat Rev Genet , vol.7 , pp. 793-803
    • Talbert, P.B.1    Henikoff, S.2
  • 20
    • 1642276329 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast
    • Halme A, Bumgarner S, Styles C, Fink GR (2004) Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast. Cell 116: 405-415.
    • (2004) Cell , vol.116 , pp. 405-415
    • Halme, A.1    Bumgarner, S.2    Styles, C.3    Fink, G.R.4
  • 21
    • 17844385918 scopus 로고    scopus 로고
    • Nicotinic acid limitation regulates silencing of Candida adhesins during UTI
    • Domergue R, Castano I, De Las Penas A, Zupancic M, Lockatell V, et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science 308: 866-870.
    • (2005) Science , vol.308 , pp. 866-870
    • Domergue, R.1    Castano, I.2    De Las Penas, A.3    Zupancic, M.4    Lockatell, V.5
  • 22
    • 17144456808 scopus 로고    scopus 로고
    • Positive feedback in eukaryotic gene networks: Cell differentiation by graded to binary response conversion
    • Becskei A, Seraphin B, Serrano L (2001) Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J 20: 2528-2535.
    • (2001) EMBO J , vol.20 , pp. 2528-2535
    • Becskei, A.1    Seraphin, B.2    Serrano, L.3
  • 23
    • 34548088923 scopus 로고    scopus 로고
    • Synthetic biology: Lessons from the history of synthetic organic chemistry
    • Yeh BJ, Lim WA (2007) Synthetic biology: lessons from the history of synthetic organic chemistry. Nat Chem Biol 3: 521-525.
    • (2007) Nat Chem Biol , vol.3 , pp. 521-525
    • Yeh, B.J.1    Lim, W.A.2
  • 25
    • 34347389431 scopus 로고    scopus 로고
    • Mammalian synthetic biology: Engineering of sophisticated gene networks
    • Greber D, Fussenegger M (2007) Mammalian synthetic biology: engineering of sophisticated gene networks. J Biotechnol 130: 329-345.
    • (2007) J Biotechnol , vol.130 , pp. 329-345
    • Greber, D.1    Fussenegger, M.2
  • 26
    • 70350324632 scopus 로고    scopus 로고
    • Emergent bistability by a growth-modulating positive feedback circuit
    • Tan C, Marguet P, You L (2009) Emergent bistability by a growth-modulating positive feedback circuit. Nat Chem Biol 5: 842-848.
    • (2009) Nat Chem Biol , vol.5 , pp. 842-848
    • Tan, C.1    Marguet, P.2    You, L.3
  • 27
    • 59849108878 scopus 로고    scopus 로고
    • Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers
    • Adkins NL, McBryant SJ, Johnson CN, Leidy JM, Woodcock CL, et al. (2009) Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers. Biochemistry 48: 276-288.
    • (2009) Biochemistry , vol.48 , pp. 276-288
    • Adkins, N.L.1    McBryant, S.J.2    Johnson, C.N.3    Leidy, J.M.4    Woodcock, C.L.5
  • 28
    • 38049125593 scopus 로고    scopus 로고
    • Epigenetic chromatin silencing: Bistability and front propagation
    • Sedighi M, Sengupta AM (2007) Epigenetic chromatin silencing: bistability and front propagation. Phys Biol 4: 246-255.
    • (2007) Phys Biol , vol.4 , pp. 246-255
    • Sedighi, M.1    Sengupta, A.M.2
  • 29
    • 67649394764 scopus 로고    scopus 로고
    • Tracking of single quantum dot labeled EcoRV sliding along DNA manipulated by double optical tweezers
    • Biebricher A, Wende W, Escude C, Pingoud A, Desbiolles P (2009) Tracking of single quantum dot labeled EcoRV sliding along DNA manipulated by double optical tweezers. Biophys J 96: L50-52.
    • (2009) Biophys J , vol.96
    • Biebricher, A.1    Wende, W.2    Escude, C.3    Pingoud, A.4    Desbiolles, P.5
  • 30
    • 8644241631 scopus 로고    scopus 로고
    • p53 linear diffusion along DNA requires its C terminus
    • McKinney K, Mattia M, Gottifredi V, Prives C (2004) p53 linear diffusion along DNA requires its C terminus. Mol Cell 16: 413-424.
    • (2004) Mol Cell , vol.16 , pp. 413-424
    • McKinney, K.1    Mattia, M.2    Gottifredi, V.3    Prives, C.4
  • 31
    • 25444471803 scopus 로고    scopus 로고
    • Derivation of macroscopic equations for individual cell-based models: A formal approach
    • Bodnar M, Velazquez JJL (2005) Derivation of macroscopic equations for individual cell-based models: a formal approach. Math Methods Appl Sci 28: 1757-1779.
    • (2005) Math Methods Appl Sci , vol.28 , pp. 1757-1779
    • Bodnar, M.1    Velazquez, J.J.L.2
  • 32
    • 49349110342 scopus 로고    scopus 로고
    • An introduction. New York (New York): Springer
    • Murray JD (2007) Mathematical biology: I. An introduction. New York (New York): Springer. 555 p.
    • (2007) Mathematical Biology: I , pp. 555
    • Murray, J.D.1
  • 33
    • 68249153738 scopus 로고    scopus 로고
    • Silent chromatin at the middle and ends: Lessons from yeasts
    • Buhler M, Gasser SM (2009) Silent chromatin at the middle and ends: lessons from yeasts. EMBO J 28: 2149-2161.
    • (2009) EMBO J , vol.28 , pp. 2149-2161
    • Buhler, M.1    Gasser, S.M.2
  • 34
    • 50249084505 scopus 로고    scopus 로고
    • Bypassing Sir2 and O-acetyl-ADPribose in transcriptional silencing
    • Chou CC, Li YC, Gartenberg MR (2008) Bypassing Sir2 and O-acetyl-ADPribose in transcriptional silencing. Mol Cell 31: 650-659.
    • (2008) Mol Cell , vol.31 , pp. 650-659
    • Chou, C.C.1    Li, Y.C.2    Gartenberg, M.R.3
  • 35
    • 2542437656 scopus 로고    scopus 로고
    • Insulator dynamics and the setting of chromatin domains
    • Fourel G, Magdinier F, Gilson E (2004) Insulator dynamics and the setting of chromatin domains. Bioessays 26: 523-532.
    • (2004) Bioessays , vol.26 , pp. 523-532
    • Fourel, G.1    Magdinier, F.2    Gilson, E.3
  • 36
    • 33745977103 scopus 로고    scopus 로고
    • Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments
    • King DA, Hall BE, Iwamoto MA, Win KZ, Chang JF, et al. (2006) Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments. J Biol Chem 281: 20107-20119.
    • (2006) J Biol Chem , vol.281 , pp. 20107-20119
    • King, D.A.1    Hall, B.E.2    Iwamoto, M.A.3    Win, K.Z.4    Chang, J.F.5
  • 37
    • 0035093447 scopus 로고    scopus 로고
    • An activation-independent role of transcription factors in insulator function
    • Fourel G, Boscheron C, Revardel E, Lebrun E, Hu YF, et al. (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep 2: 124-132.
    • (2001) EMBO Rep , vol.2 , pp. 124-132
    • Fourel, G.1    Boscheron, C.2    Revardel, E.3    Lebrun, E.4    Hu, Y.F.5
  • 38
    • 62649129015 scopus 로고    scopus 로고
    • Synergy of repression and silencing gradients along the chromosome
    • Ratna P, Scherrer S, Fleischli C, Becskei A (2009) Synergy of repression and silencing gradients along the chromosome. J Mol Biol 387: 826-839.
    • (2009) J Mol Biol , vol.387 , pp. 826-839
    • Ratna, P.1    Scherrer, S.2    Fleischli, C.3    Becskei, A.4
  • 39
    • 38949210998 scopus 로고    scopus 로고
    • Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin
    • Vasiljeva L, Kim M, Terzi N, Soares LM, Buratowski S (2008) Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin. Mol Cell 29: 313-323.
    • (2008) Mol Cell , vol.29 , pp. 313-323
    • Vasiljeva, L.1    Kim, M.2    Terzi, N.3    Soares, L.M.4    Buratowski, S.5
  • 40
    • 23744505997 scopus 로고    scopus 로고
    • Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression
    • Irlbacher H, Franke J, Manke T, Vingron M, Ehrenhofer-Murray AE (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19: 1811-1822.
    • (2005) Genes Dev , vol.19 , pp. 1811-1822
    • Irlbacher, H.1    Franke, J.2    Manke, T.3    Vingron, M.4    Ehrenhofer-Murray, A.E.5
  • 41
    • 0033570901 scopus 로고    scopus 로고
    • Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae
    • Xie J, Pierce M, Gailus-Durner V, Wagner M, Winter E, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18: 6448-6454.
    • (1999) EMBO J , vol.18 , pp. 6448-6454
    • Xie, J.1    Pierce, M.2    Gailus-Durner, V.3    Wagner, M.4    Winter, E.5
  • 42
    • 0029879358 scopus 로고    scopus 로고
    • Cooperation at a distance between silencers and proto-silencers at the yeast HML locus
    • Boscheron C, Maillet L, Marcand S, Tsai-Pflugfelder M, Gasser SM, et al. (1996) Cooperation at a distance between silencers and proto-silencers at the yeast HML locus. EMBO J 15: 2184-2195.
    • (1996) EMBO J , vol.15 , pp. 2184-2195
    • Boscheron, C.1    Maillet, L.2    Marcand, S.3    Tsai-Pflugfelder, M.4    Gasser, S.M.5
  • 43
    • 0022344269 scopus 로고
    • SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae
    • Klar AJ, Kakar SN, Ivy JM, Hicks JB, Livi GP, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111: 745-758.
    • (1985) Genetics , vol.111 , pp. 745-758
    • Klar, A.J.1    Kakar, S.N.2    Ivy, J.M.3    Hicks, J.B.4    Livi, G.P.5
  • 44
    • 32044464761 scopus 로고    scopus 로고
    • Structural analyses of Sum1-1p-dependent transcriptionally silent chromatin in Saccharomyces cerevisiae
    • Yu Q, Elizondo S, Bi X (2006) Structural analyses of Sum1-1p-dependent transcriptionally silent chromatin in Saccharomyces cerevisiae. J Mol Biol 356: 1082-1092.
    • (2006) J Mol Biol , vol.356 , pp. 1082-1092
    • Yu, Q.1    Elizondo, S.2    Bi, X.3
  • 45
    • 42549110504 scopus 로고    scopus 로고
    • Embryonic pattern formation without morphogens
    • Bolouri H (2008) Embryonic pattern formation without morphogens. Bioessays 30: 412-417.
    • (2008) Bioessays , vol.30 , pp. 412-417
    • Bolouri, H.1
  • 46
    • 33749126328 scopus 로고    scopus 로고
    • (Re)modeling the transcriptional enhancer
    • Halfon MS (2006) (Re)modeling the transcriptional enhancer. Nat Genet 38: 1102-1103.
    • (2006) Nat Genet , vol.38 , pp. 1102-1103
    • Halfon, M.S.1
  • 47
    • 41649116238 scopus 로고    scopus 로고
    • Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos
    • Zhang Y, Lin N, Carroll PM, Chan G, Guan B, et al. (2008) Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. Dev Cell 14: 481-493.
    • (2008) Dev Cell , vol.14 , pp. 481-493
    • Zhang, Y.1    Lin, N.2    Carroll, P.M.3    Chan, G.4    Guan, B.5
  • 48
    • 44649200464 scopus 로고    scopus 로고
    • Polycomb complexes and epigenetic states
    • Schwartz YB, Pirrotta V (2008) Polycomb complexes and epigenetic states. Curr Opin Cell Biol 20: 266-273.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 266-273
    • Schwartz, Y.B.1    Pirrotta, V.2
  • 49
    • 51849119723 scopus 로고    scopus 로고
    • Stochastic and regulatory role of chromatin silencing in genomic response to environmental changes
    • doi:10.1371/journal.pone.0003002
    • Choi JK, Hwang S, Kim YJ (2008) Stochastic and regulatory role of chromatin silencing in genomic response to environmental changes. PLoS ONE 3: e3002. doi:10.1371/journal.pone.0003002.
    • (2008) PLoS ONE , vol.3
    • Choi, J.K.1    Hwang, S.2    Kim, Y.J.3
  • 50
    • 33745967090 scopus 로고    scopus 로고
    • Single-cell observations reveal intermediate transcriptional silencing states
    • Xu EY, Zawadzki KA, Broach JR (2006) Single-cell observations reveal intermediate transcriptional silencing states. Mol Cell 23: 219-229.
    • (2006) Mol Cell , vol.23 , pp. 219-229
    • Xu, E.Y.1    Zawadzki, K.A.2    Broach, J.R.3
  • 51
    • 33746579169 scopus 로고    scopus 로고
    • Noisy silencing of chromatin
    • Rando OJ, Paulsson J (2006) Noisy silencing of chromatin. Dev Cell 11: 134-136.
    • (2006) Dev Cell , vol.11 , pp. 134-136
    • Rando, O.J.1    Paulsson, J.2
  • 52
    • 0037464584 scopus 로고    scopus 로고
    • DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing
    • Saveliev A, Everett C, Sharpe T, Webster Z, Festenstein R (2003) DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing. Nature 422: 909-913.
    • (2003) Nature , vol.422 , pp. 909-913
    • Saveliev, A.1    Everett, C.2    Sharpe, T.3    Webster, Z.4    Festenstein, R.5
  • 53
    • 33748994704 scopus 로고    scopus 로고
    • Stochastic mRNA synthesis in mammalian cells
    • doi:10.1371/journal.pbio.0040309
    • Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S (2006) Stochastic mRNA synthesis in mammalian cells. PLoS Biol 4: e309. doi:10.1371/journal.pbio.0040309.
    • (2006) PLoS Biol , vol.4
    • Raj, A.1    Peskin, C.S.2    Tranchina, D.3    Vargas, D.Y.4    Tyagi, S.5
  • 54
    • 74049089249 scopus 로고    scopus 로고
    • Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals
    • Yin S, Wang P, Deng W, Zheng H, Hu L, et al. (2009) Dosage compensation on the active X chromosome minimizes transcriptional noise of X-linked genes in mammals. Genome Biol 10: R74.
    • (2009) Genome Biol , vol.10
    • Yin, S.1    Wang, P.2    Deng, W.3    Zheng, H.4    Hu, L.5
  • 55
    • 67649939154 scopus 로고    scopus 로고
    • Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres
    • Kagansky A, Folco HD, Almeida R, Pidoux AL, Boukaba A, et al. (2009) Synthetic heterochromatin bypasses RNAi and centromeric repeats to establish functional centromeres. Science 324: 1716-1719.
    • (2009) Science , vol.324 , pp. 1716-1719
    • Kagansky, A.1    Folco, H.D.2    Almeida, R.3    Pidoux, A.L.4    Boukaba, A.5
  • 56
    • 33646923128 scopus 로고    scopus 로고
    • Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing
    • Buhler M, Verdel A, Moazed D (2006) Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell 125: 873-886.
    • (2006) Cell , vol.125 , pp. 873-886
    • Buhler, M.1    Verdel, A.2    Moazed, D.3
  • 57
    • 43449125256 scopus 로고    scopus 로고
    • Exploring the behavior of small eukaryotic gene networks
    • Bruggeman FJ, Oancea I, van Driel R (2008) Exploring the behavior of small eukaryotic gene networks. J Theor Biol 252: 482-487.
    • (2008) J Theor Biol , vol.252 , pp. 482-487
    • Bruggeman, F.J.1    Oancea, I.2    van Driel, R.3
  • 58
    • 33645285263 scopus 로고    scopus 로고
    • Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs
    • Benecke A (2006) Chromatin code, local non-equilibrium dynamics, and the emergence of transcription regulatory programs. Eur Phys J E Soft Matter 19: 353-366.
    • (2006) Eur Phys J E Soft Matter , vol.19 , pp. 353-366
    • Benecke, A.1
  • 59
    • 70350036600 scopus 로고    scopus 로고
    • Transcriptional loops meet chromatin: A dual-layer network controls white-opaque switching in Candida albicans
    • Hnisz D, Schwarzmuller T, Kuchler K (2009) Transcriptional loops meet chromatin: a dual-layer network controls white-opaque switching in Candida albicans. Mol Microbiol 74: 1-15.
    • (2009) Mol Microbiol , vol.74 , pp. 1-15
    • Hnisz, D.1    Schwarzmuller, T.2    Kuchler, K.3
  • 60
    • 34249745727 scopus 로고    scopus 로고
    • A method for selecting the bin size of a time histogram
    • Shimazaki H, Shinomoto S (2007) A method for selecting the bin size of a time histogram. Neural Comput 19: 1503-1527.
    • (2007) Neural Comput , vol.19 , pp. 1503-1527
    • Shimazaki, H.1    Shinomoto, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.