Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma

American Journal of Respiratory Cell and Molecular Biology

Volumn 42, Issue 4, 2010, Pages 491-497

  Duan, Yingli ^a   Learoyd, Jonathan ^a   Meliton, Angelo Y ^a   Clay, Bryan S ^a   Leff, Alan R ^a   Zhu, Xiangdong ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Eosinophils; Inflammation; Lung; Pyk2

Indexed keywords

FOCAL ADHESION KINASE 2; HYBRID PROTEIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; OVALBUMIN; TAT PYK2 C TERMINUS HYBRID PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; ANTIGEN; CYTOKINE; PTK2B PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; EOSINOPHIL; FEMALE; HISTOPATHOLOGY; INFLAMMATORY CELL; INHIBITION KINETICS; LUNG LAVAGE; LYMPHOCYTE; MOUSE; NONHUMAN; PROTEIN DOMAIN; ANIMAL; CELL MOTION; CHEMICALLY INDUCED DISORDER; HUMAN; INFLAMMATION; METABOLISM; PATHOLOGY; TH2 CELL;

MUS;

ANIMALS; ANTIGENS; ASTHMA; CELL MOVEMENT; CYTOKINES; EOSINOPHILS; FEMALE; FOCAL ADHESION KINASE 2; HUMANS; INFLAMMATION; MICE; RECOMBINANT FUSION PROTEINS; TH2 CELLS;

EID: 77950502133     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0469OC     Document Type: Article

References (38)

1. Shum BO, Rolph MS, Sewell WA. Mechanisms in allergic airway inflammation: lessons from studies in the mouse. Expert Rev Mol Med 2008;10:e15.
2. Lee NA, Gelfand EW, Lee JJ. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J Allergy Clin Immunol 2001;107:945-957.
3. Jacobsen EA, Ochkur SI, Lee NA, Lee JJ. Eosinophils and asthma. Curr Allergy Asthma Rep 2007;7:18-26.
4. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
5. Justice JP, Borchers MT, Crosby JR, Hines EM, Shen HH, Ochkur SI, McGarry MP, Lee NA, Lee JJ. Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathology. Am J Physiol Lung Cell Mol Physiol 2003;284:L169-L178.
6. Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004;305:1773-1776.
7. Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med 2002;195:1387-1395.
8. Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, et al. A critical role for eosinophils in allergic airways remodeling. Science 2004;305:1776-1779.
9. Tanaka H, Komai M, Nagao K, Ishizaki M, Kajiwara D, Takatsu K, Delespesse G, Nagai H. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol 2004;31:62-68.
10. Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, Martin TR, Gerard NP, Gerard C. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc Natl Acad Sci USA 2002;99:1479-1484.
11. Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 2002;109:621-628.
12. Wegmann M, Goggel R, Sel S, Sel S, Erb KJ, Kalkbrenner F, Renz H, Garn H. Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma. Am J Respir Cell Mol Biol 2007;36:61-67.
13. Barthel SR, Johansson MW, McNamee DM, Mosher DF. Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol 2008;83:1-12.
14. Broide D, Sriramarao P. Eosinophil trafficking to sites of allergic inflammation. Immunol Rev 2001;179:163-172.
15. Costa GG, Silva RM, Franco-Penteado CF, Antunes E, Ferreira HH. Interactions between eotaxin and interleukin-5 in the chemotaxis of primed and non-primed human eosinophils. Eur J Pharmacol 2007;566:200-205.
16. Rosas M, Dijkers PF, Lindemans CL, Lammers JW, Koenderman L, Coffer PJ. IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J Leukoc Biol 2006;80:186-195.
17. Simon HU. Molecules involved in the regulation of eosinophil apoptosis. Chem Immunol Allergy 2006;91:49-58.
18. Zhu X, Boetticher E, Wang L, Duan Y, Learoyd J, Leff AR. Proline-rich tyrosine kinase 2 regulates spreading and migration of eosinophils after beta2-integrin adhesion. Am J Respir Cell Mol Biol 2008;39:263-269.
19. Avraham S, Avraham H. Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells. Leuk Lymphoma 1997;27:247-256. (Pubitemid 27501186)
20. Okigaki M, Davis C, Falasca M, Harroch S, Felsenfeld DP, Sheetz MP, Schlessinger J. Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci USA 2003;100:10740-10745.
21. Guinamard R, Okigaki M, Schlessinger J, Ravetch JV. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol 2000;1:31-36.
22. Di Cioccio V, Strippoli R, Bizzarri C, Troiani G, Cervellera MN, Gloaguen I, Colagrande A, Cattozzo EM, Pagliei S, Santoni A, et al. Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis. Immunology 2004;111:407-415.
23. Myou S, Leff AR, Myo S, Boetticher E, Tong J, Meliton AY, Liu J, Munoz NM, Zhu X. Blockade of inflammation and airway hyper-responsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT. J Exp Med 2003;198:1573-1582.
24. Duan W, Chan JH, Wong CH, Leung BP, Wong WS. Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model. J Immunol 2004;172:7053-7059. (Pubitemid 38669147)
25. Han H, Fuortes M, Nathan C. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. J Exp Med 2003;197:63-75.
26. Dylla SJ, Deyle DR, Theunissen K, Padurean AM, Verfaillie CM. Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Exp Hematol 2004;32:365-374.
27. Zhu X, Boetticher E, Wang L, Duan Y, Learoyd J, Leff AR. Pyk2 regulates spreading and migration of eosinophils after fbetag2 integrin adhesion. Am J Respir Cell Mol Biol 2008;39:263-269.
28. Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 1999;285:1569-1572.
29. Cai SR, Xu G, Becker-Hapak M, Ma M, Dowdy SF, McLeod HL. The kinetics and tissue distribution of protein transduction in mice. Eur J Pharm Sci 2006;27:311-319.
30. Myou S, Zhu X, Myo S, Boetticher E, Meliton AY, Liu J, Munoz NM, Leff AR. Blockade of airway inflammation and hyperresponsiveness by HIV-TAT-dominant negative Ras. J Immunol 2003;171:4379-4384. (Pubitemid 37238716)
31. Ford JG, Rennick D, Donaldson DD, Venkayya R, McArthur C, Hansell E, Kurup VP, Warnock M, Grunig G. Il-13 and IFN-gamma: interactions in lung inflammation. J Immunol 2001;167:1769-1777. (Pubitemid 32703181)
32. Bandukwala HS, Clay BS, Tong J, Mody PD, Cannon JL, Shilling RA, Verbeek JS, Weinstock JV, Solway J, Sperling AI. Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med 2007;204:1875-1889.
33. Van Oosterhout AJ, Van Esch B, Hofman G, Hofstra CL, Van Ark I, Nijkamp FP, Kapsenberg ML, Savelkoul HF, Weller FR. Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma. Am J Respir Cell Mol Biol 1998;19:622-628. (Pubitemid 128354244)
34. Eum WS, Choung IS, Li MZ, Kang JH, Kim DW, Park J, Kwon HY, Choi SY. HIV-1 Tat-mediated protein transduction of Cu,Zn-superoxide dismutase into pancreatic beta cells in vitro and in vivo. Free Radic Biol Med 2004;37:339-349.
35. Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E. P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol 2008;295:C752-C760.
36. Simson L, Foster PS. Chemokine and cytokine cooperativity: eosinophil migration in the asthmatic response. Immunol Cell Biol 2000;78:415-422.
37. Jia GQ, Gonzalo JA, Hidalgo A, Wagner D, Cybulsky M, Gutierrez-Ramos JC. Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Int Immunol 1999;11:1-10.
38. Allingham MJ, van Buul JD, Burridge K. ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol 2007;179:4053-4064.