Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis

International Journal of Oncology

Volumn 36, Issue 5, 2010, Pages 1253-1260

  Miyamoto, Yuji ^a,b   Futamura, Manabu ^a   Kitamura, Noriaki ^a   Nakamura, Yasuyuki ^a   Baba, Hideo ^b   Arakawa, Hiroufmi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Axon guidance; Dependence receptor; p53; UNC5A

Indexed keywords

CASPASE 3; MESSENGER RNA; PROTEIN P53; PROTEIN UNC5A; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CHROMATIN IMMUNOPRECIPITATION; COLON CANCER; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GAMMA IRRADIATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE TARGETING; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SPLEEN;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, REPORTER; HUMANS; MICE; MODELS, GENETIC; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77950442562     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000609     Document Type: Article

References (24)

1. Nakamura Y: Isolation of p53-target genes and their functional analysis. Cancer Sci 95: 7-11, 2004. (Pubitemid 38208400)
2. Kamino H, Futamura M, Nakamura Y, Kitamura N, Kabu K and Arakawa H: B-cell linker protein prevents aneuploidy by inhibiting cytokinesis. Cancer Sci 99: 2444-2454, 2008.
3. Vousden KH and Lu X: Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604, 2002.
4. Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG and Tessier-Lavigne M: Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 87: 175-185, 1996. (Pubitemid 26358997)
5. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL and Tessier-Lavigne M: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386: 833-838, 1997. (Pubitemid 27181257)
6. Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS and Bredesen DE: The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395: 801-804, 1998. (Pubitemid 28485447)
7. Bredesen DE, Mehlen P and Rabizadeh S: Receptors that mediate cellular dependence. Cell Death Differ 12: 1031-1043, 2005. (Pubitemid 41065421)
8. Arakawa H: p53, apoptosis and axon-guidance molecules. Cell Death Differ 12: 1057-1065, 2005.
9. Arakawa H: Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 4: 978-987, 2004.
10. Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G and Mehlen P: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc Natl Acad Sci USA 100: 4173-4178, 2003. (Pubitemid 36418176)
11. Bernet A, Mazelin L, Coissieux MM, Gadot N, Ackerman SL, Scoazec JY and Mehlen P: Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies. Gastroenterology 133: 1840-1848, 2007.
12. Llambi F, Causeret F, Bloch-Gallego E and Mehlen P: Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 20: 2715-2722, 2001. (Pubitemid 32938556)
13. Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE and Mehlen P: The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc Natl Acad Sci USA 98: 3416-3421, 2001. (Pubitemid 32220860)
14. Williams ME, Strickland P, Watanabe K and Hinck L: UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. J Biol Chem 278: 17483-17490, 2003. (Pubitemid 36799635)
15. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y and Arakawa H: p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 5: 216-223, 2003.
16. Wang H, Ozaki T, Shamim Hossain M, Nakamura Y, Kamijo T, Xue X and Nakagawara A: A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53. Biochem Biophys Res Commun 370: 594-598, 2008.
17. Masuda Y, Futamura M, Kamino H, Nakamura Y, Kitamura N, Ohnishi S, Miyamoto Y, Ichikawa H, Ohta T, Ohki M, Kiyono T, Egami H, Baba H and Arakawa H: The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage. J Hum Genet 51: 652-664, 2006. (Pubitemid 44354677)
18. Nakamura Y, Futamura M, Kamino H, Yoshida K, Nakamura Y and Arakawa H: Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. Cancer Sci 97: 633-641, 2006. (Pubitemid 44056612)
19. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T and Ikawa S: Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73. Cancer Res 62: 636-641, 2002. (Pubitemid 34126932)
20. Osada M, Ohba M, Kawahara C, Ishioka C, Kanamaru R, Katoh I, Ikawa Y, Nimura Y, Nakagawara A, Obinata M and Ikawa S: Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4: 839-843, 1998. (Pubitemid 28331028)
21. Futamura M, Kamino H, Miyamoto Y, Kitamura N, Nakamura Y, Ohnishi S, Masuda Y and Arakawa H: Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression. Cancer Res 67: 1451-1460, 2007. (Pubitemid 46383370)
22. Tsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, Matsuno I, Ikawa Y and Aizawa S: Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene 8: 3313-3322, 1993.
23. Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M and Hinck L: UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nat Neurosci 9: 996-998, 2006. (Pubitemid 44264908)
24. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT and Nicholson DW: A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272: 17907-17911, 1997. (Pubitemid 27306365)