A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53

Biochemical and Biophysical Research Communications

Volumn 370, Issue 4, 2008, Pages 594-598

  Wang, Hong ^a,b   Ozaki, Toshinori ^a,c   Shamim Hossain, M ^a,c   Nakamura, Yohko ^a   Kamijo, Takehiko ^a   Xue, Xindong ^b   Nakagawara, Akira ^a,c  

^a CHIBA CANCER CENTER   (Japan)

^b CHINA MEDICAL UNIVERSITY   (China)

^c CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adriamycin; Apoptosis; DNA damage; p53; Transcription; UNC5H4

Indexed keywords

DOXORUBICIN; NETRIN 1; NETRIN 1 RECEPTOR; PROTEIN P53; PROTEIN UNC5H4; RECEPTOR; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DAMAGE; DNA RESPONSIVE ELEMENT; ENZYME ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA DAMAGE; HUMANS; INTRONS; PROMOTER REGIONS (GENETICS); RECEPTORS, CELL SURFACE; RESPONSE ELEMENTS; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 43049094806     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.152     Document Type: Article

References (18)

1. Mehlen P., Rabizadeh S., Snipas S.J., Assa-Munt N., Salvesen G.S., and Bredesen D.E. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395 (1998) 801-804
2. Llambi F., Causeret F., Bloch-Gallego E., and Mehlen P. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J. 20 (2001) 2715-2722
3. Mehlen P., and Bredesen D.E. The dependence receptor hypothesis. Apoptosis 9 (2004) 37-49
4. Fearon E.R., Cho K.R., Nigro J.M., Kern S.E., Simons J.W., Ruppert J.M., Oliner J.D., Kinzler K.W., and Vogelstein B. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247 (1990) 49-56
5. Fearon E.R. DCC: is there a connection between tumorigenesis and cell guidance molecules?. Biochim. Biophys. Acta 1288 (1996) M17-M23
6. Tessier-Lavigne M., and Goodman C.S. The molecular biology of axon guidance. Science 274 (1996) 1123-1133
7. Leonardo E.D., Hinck I., Masu M., Keino-Masu K., Ackerman S.I., and Tessier-Lavigne M. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386 (1997) 833-838
8. Hong K., Hinck I., Nishiyama M., Poo M.M., Tessier-Lavigne M., and Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97 (1999) 927-941
9. Yokota N., Mainprize T.G., Taylor M.D., Kohata T., Loreto M., Ueda S., Dura W., Grajkowska W., Kuo J.S., and Rutka J.T. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 23 (2004) 3444-3453
10. Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.O., Scoazec J.Y., Saurin J.C., Romeo G., and Mehlen P. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc. Natl. Acad. Sci. USA 100 (2003) 4173-4178
11. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., and Chapmann K.T. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272 (1997) 17907-17911
12. Williams M.E., Strickland P., Watanabe K., and Hinck I. UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE. J. Biol. Chem. 278 (2003) 17483-17490
13. Tanikawa C., Matsuda K., Fukuda S., Nakamura Y., and Arakawa H. p53RDL1 regulates p53-dependent apoptosis. Nat. Cell Biol. 5 (2003) 216-223
14. Llambi F., Calheiros-Lourenco F., Gozuacik D., Guix C., Pays L., Del Rio G., Kimchi, and Mehlen P. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J. 24 (2005) 1192-1201
15. Reveh T., Droguertt G., Horwitz M.S., DePinho R.A., and Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat. Cell Biol. 3 (2001) 1-7
16. Ichikawa T., Suenaga Y., Koda T., Ozaki T., and Nakagawara A. TAp63-dependent induction of growth differentiation factor 15 (GDF15) plays a critical role in the regulation of keratinocyte differentiation. Oncogene 27 (2008) 409-420
17. Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2 (2002) 594-604
18. Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299