메뉴 건너뛰기




Volumn 8, Issue 1, 2010, Pages 73-88

Pancreatic cancer and personalized medicine: Can genomics facilitate early diagnosis or improve therapeutic outcomes?

Author keywords

Early diagnosis; Genomics; Pancreatic cancer; Postgenomics medicine; Targeted oncopharmacology

Indexed keywords

6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; BEVACIZUMAB; CA 19-9 ANTIGEN; CAPECITABINE; CETUXIMAB; CISPLATIN; CURCUMIN; CYCLINE; CYCLOOXYGENASE 2; DEOXYCYTIDINE KINASE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IMC C2225; IRINOTECAN; MATRIX METALLOPROTEINASE; MATUZUMAB; MEMBRANE PROTEIN; OXALIPLATIN; PACLITAXEL; PROTEIN P53; SMAD4 PROTEIN; SORAFENIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 77950284740     PISSN: 18756921     EISSN: 18756913     Source Type: Journal    
DOI: 10.2174/1875692111008010073     Document Type: Review
Times cited : (2)

References (148)
  • 2
    • 0026628941 scopus 로고
    • Carcinoma of the body and tail of the pancreas: Is curative resection justified?
    • Dalton RR, Sarr MG, van Heerden JA, et al. Carcinoma of the body and tail of the pancreas: is curative resection justified? Surgery 1992; 111(5): 489-494
    • (1992) Surgery , vol.111 , Issue.5 , pp. 489-494
    • Dalton, R.R.1    Sarr, M.G.2    Van Heerden, J.A.3
  • 3
    • 47949117602 scopus 로고    scopus 로고
    • Pancreatic cancer: From molecular pathogenesis to targeted therapy
    • Strimpakos A, Saif MW, Syrigos KN. Pancreatic cancer: from molecular pathogenesis to targeted therapy. Cancer Metastasis Rev 2008; 27(3): 495-522.
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.3 , pp. 495-522
    • Strimpakos, A.1    Saif, M.W.2    Syrigos, K.N.3
  • 4
    • 0021345134 scopus 로고
    • Comparison of a new tumour marker, CA 19-9, with alpha-fetoprotein and carcinoembryonic antigen in patients with upper gastrointestinal diseases
    • Jalanko H, Kuusela P, Roberts P, et al. Comparison of a new tumour marker, CA 19-9, with alpha-fetoprotein and carcinoembryonic antigen in patients with upper gastrointestinal diseases. J Clin Pathol 1984; 37(2): 218-222
    • (1984) J Clin Pathol , vol.37 , Issue.2 , pp. 218-222
    • Jalanko, H.1    Kuusela, P.2    Roberts, P.3
  • 5
    • 0025307965 scopus 로고
    • The clinical utility of the CA 19-9 tumor-associated antigen
    • Steinberg W. The clinical utility of the CA 19-9 tumor-associated antigen. Am J Gastroenterol 1990; 85(4): 350-355
    • (1990) Am J Gastroenterol , vol.85 , Issue.4 , pp. 350-355
    • Steinberg, W.1
  • 6
    • 33846595479 scopus 로고    scopus 로고
    • ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer
    • Locker GY, Hamilton S, Harris J, et al. ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer. J Clin Oncol 2006; 24(33): 5313-5327
    • (2006) J Clin Oncol , vol.24 , Issue.33 , pp. 5313-5327
    • Locker, G.Y.1    Hamilton, S.2    Harris, J.3
  • 7
    • 48949095214 scopus 로고    scopus 로고
    • Translational research in pancreatic cancer
    • Saif MW. Translational research in pancreatic cancer. JOP 2008; 9(4): 398-402.
    • (2008) JOP , vol.9 , Issue.4 , pp. 398-402
    • Saif, M.W.1
  • 8
    • 34249878202 scopus 로고    scopus 로고
    • Mucin expression profile in pancreatic cancer and the precursor lesions
    • Nagata K, Horinouchi M, Saitou M, et al. Mucin expression profile in pancreatic cancer and the precursor lesions. J Hepatobiliary Pancreat Surg 2007; 14(3): 243-254
    • (2007) J Hepatobiliary Pancreat Surg , vol.14 , Issue.3 , pp. 243-254
    • Nagata, K.1    Horinouchi, M.2    Saitou, M.3
  • 9
    • 0036036341 scopus 로고    scopus 로고
    • The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms
    • Yonezawa S, Nakamura A, Horinouchi M, et al. The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms. J Hepatobiliary Pancreat Surg 2002; 9(3): 328-341
    • (2002) J Hepatobiliary Pancreat Surg , vol.9 , Issue.3 , pp. 328-341
    • Yonezawa, S.1    Nakamura, A.2    Horinouchi, M.3
  • 10
    • 16344373924 scopus 로고    scopus 로고
    • MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillarymucinous tumor (IPMT)
    • Ueda M, Miura Y, Kunihiro O, et al. MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillarymucinous tumor (IPMT). Hepatogastroenterology 2005; 52(62): 398-403.
    • (2005) Hepatogastroenterology , vol.52 , Issue.62 , pp. 398-403
    • Ueda, M.1    Miura, Y.2    Kunihiro, O.3
  • 11
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53(4): 549-554
    • (1988) Cell , vol.53 , Issue.4 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 12
    • 0023735997 scopus 로고
    • KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
    • Smit VT, Boot AJ, Smits AM, et al. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res 1988; 16(16): 7773-7782
    • (1988) Nucleic Acids Res , vol.16 , Issue.16 , pp. 7773-7782
    • Smit, V.T.1    Boot, A.J.2    Smits, A.M.3
  • 13
    • 0027733796 scopus 로고
    • K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
    • Hruban RH, van Mansfeld AD, Offerhaus GJ, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993; 143(2): 545-554
    • (1993) Am J Pathol , vol.143 , Issue.2 , pp. 545-554
    • Hruban, R.H.1    Van Mansfeld, A.D.2    Offerhaus, G.J.3
  • 14
    • 0034693635 scopus 로고    scopus 로고
    • K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
    • Kawesha A, Ghaneh P, Andren-Sandberg A, et al. K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. Int J Cancer 2000; 89(6): 469-474
    • (2000) Int J Cancer , vol.89 , Issue.6 , pp. 469-474
    • Kawesha, A.1    Ghaneh, P.2    Andren-Sandberg, A.3
  • 15
    • 16244418716 scopus 로고    scopus 로고
    • Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis
    • Talar-Wojnarowska R, Gasiorowska A, Smolarz B, et al. Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis. Int J Gastrointest Cancer 2005; 35(1): 33-41.
    • (2005) Int J Gastrointest Cancer , vol.35 , Issue.1 , pp. 33-41
    • Talar-Wojnarowska, R.1    Gasiorowska, A.2    Smolarz, B.3
  • 16
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997; 57(9): 1731-1734
    • (1997) Cancer Res , vol.57 , Issue.9 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 17
    • 0030999374 scopus 로고    scopus 로고
    • Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma
    • Dergham ST, Dugan MC, Kucway R, et al. Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma. Int J Pancreatol 1997; 21(2): 127-143
    • (1997) Int J Pancreatol , vol.21 , Issue.2 , pp. 127-143
    • Dergham, S.T.1    Dugan, M.C.2    Kucway, R.3
  • 18
    • 0037311096 scopus 로고    scopus 로고
    • p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer
    • Dong M, Nio Y, Yamasawa K, et al. p53 alteration is not an independent prognostic indicator, but affects the efficacy of adjuvant chemotherapy in human pancreatic cancer. J Surg Oncol 2003; 82(2): 111-120
    • (2003) J Surg Oncol , vol.82 , Issue.2 , pp. 111-120
    • Dong, M.1    Nio, Y.2    Yamasawa, K.3
  • 19
    • 0028884525 scopus 로고
    • Cancer therapy and p53
    • Lowe SW. Cancer therapy and p53. Curr Opin Oncol 1995; 7(6): 547-553
    • (1995) Curr Opin Oncol , vol.7 , Issue.6 , pp. 547-553
    • Lowe, S.W.1
  • 20
    • 0035883628 scopus 로고    scopus 로고
    • Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression
    • Zhan M, Yu D, Lang A, et al. Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression. Cancer 2001; 92(6): 1556-1566
    • (2001) Cancer , vol.92 , Issue.6 , pp. 1556-1566
    • Zhan, M.1    Yu, D.2    Lang, A.3
  • 21
    • 0032568329 scopus 로고    scopus 로고
    • Stable reintroduction of wild-type P53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells
    • Lang D, Miknyoczki SJ, Huang L, et al. Stable reintroduction of wild-type P53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells. Oncogene 1998; 16(12): 1593-1602
    • (1998) Oncogene , vol.16 , Issue.12 , pp. 1593-1602
    • Lang, D.1    Miknyoczki, S.J.2    Huang, L.3
  • 22
    • 17444423293 scopus 로고    scopus 로고
    • Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer
    • Dong M, Ma G, Tu W, et al. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. World J Gastroenterol 2005; 11(14): 2162-2165
    • (2005) World J Gastroenterol , vol.11 , Issue.14 , pp. 2162-2165
    • Dong, M.1    Ma, G.2    Tu, W.3
  • 23
    • 0028922149 scopus 로고
    • Association of p53 gene mutations with short survival in pancreatic adenocarcinoma
    • Nakamori S, Yashima K, Murakami Y, et al. Association of p53 gene mutations with short survival in pancreatic adenocarcinoma. Jpn J Cancer Res 1995; 86(2): 174-181
    • (1995) Jpn J Cancer Res , vol.86 , Issue.2 , pp. 174-181
    • Nakamori, S.1    Yashima, K.2    Murakami, Y.3
  • 24
    • 0036006684 scopus 로고    scopus 로고
    • p16INK4a is a prognostic marker in resected ductal pancreatic cancer: An analysis of p16INK4a, p53, MDM2, an Rb
    • Gerdes B, Ramaswamy A, Ziegler A, et al. p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. Ann Surg 2002; 235(1): 51-59
    • (2002) Ann Surg , Issue.2351 , pp. 51-59
    • Gerdes, B.1    Ramaswamy, A.2    Ziegler, A.3
  • 25
    • 0034032009 scopus 로고    scopus 로고
    • Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
    • Wilentz RE, Iacobuzio-Donahue CA, Argani P, et al. Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression. Cancer Res 2000; 60(7): 2002-2006
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 2002-2006
    • Wilentz, R.E.1    Iacobuzio-Donahue, C.A.2    Argani, P.3
  • 26
    • 9344223357 scopus 로고    scopus 로고
    • DPC4 gene in various tumor types
    • Schutte M, Hruban RH, Hedrick L, et al. DPC4 gene in various tumor types. Cancer Res 1996; 56(11): 2527-2530
    • (1996) Cancer Res , vol.56 , Issue.11 , pp. 2527-2530
    • Schutte, M.1    Hruban, R.H.2    Hedrick, L.3
  • 27
    • 0348227997 scopus 로고    scopus 로고
    • Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
    • Hua Z, Zhang YC, Hu XM, et al. Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. World J Gastroenterol 2003; 9(12): 2764-2767
    • (2003) World J Gastroenterol , vol.9 , Issue.12 , pp. 2764-2767
    • Hua, Z.1    Zhang, Y.C.2    Hu, X.M.3
  • 28
    • 0035671396 scopus 로고    scopus 로고
    • The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
    • Tascilar M, Skinner HG, Rosty C, et al. The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma. Clin Cancer Res 2001; 7(12): 4115-4121
    • (2001) Clin Cancer Res , vol.7 , Issue.12 , pp. 4115-4121
    • Tascilar, M.1    Skinner, H.G.2    Rosty, C.3
  • 29
    • 24044507297 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer
    • Khorana AA, Hu YC, Ryan CK, et al. Vascular endothelial growth factor and DPC4 predict adjuvant therapy outcomes in resected pancreatic cancer. J Gastrointest Surg 2005; 9(7): 903-911
    • (2005) J Gastrointest Surg , vol.9 , Issue.7 , pp. 903-911
    • Khorana, A.A.1    Hu, Y.C.2    Ryan, C.K.3
  • 30
    • 62249176551 scopus 로고    scopus 로고
    • DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer
    • Iacobuzio-Donahue CA, Fu B, Yachida S, et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009; 27(11): 1806-1813
    • (2009) J Clin Oncol , vol.27 , Issue.11 , pp. 1806-1813
    • Iacobuzio-Donahue, C.A.1    Fu, B.2    Yachida, S.3
  • 31
    • 33646574941 scopus 로고    scopus 로고
    • HER2/neu expression and gene alterations in pancreatic ductal adenocarcinoma: A comparative immunohistochemistry and chromogenic in situ hybridization study based on tissue microarrays and computerized image analysis
    • Tsiambas E, Karameris A, Dervenis C, et al. HER2/neu expression and gene alterations in pancreatic ductal adenocarcinoma: a comparative immunohistochemistry and chromogenic in situ hybridization study based on tissue microarrays and computerized image analysis. JOP 2006; 7(3): 283-294
    • (2006) JOP , vol.7 , Issue.3 , pp. 283-294
    • Tsiambas, E.1    Karameris, A.2    Dervenis, C.3
  • 32
    • 16544369548 scopus 로고    scopus 로고
    • Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma
    • Stoecklein NH, Luebke AM, Erbersdobler A, et al. Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma. J Clin Oncol 2004; 22(23): 4737-4745
    • (2004) J Clin Oncol , vol.22 , Issue.23 , pp. 4737-4745
    • Stoecklein, N.H.1    Luebke, A.M.2    Erbersdobler, A.3
  • 33
    • 0030936660 scopus 로고    scopus 로고
    • HER-2/neu expression in pancreatic adenocarcinoma: Relation to tumor differentiation and survival
    • Dugan MC, Dergham ST, Kucway R, et al. HER-2/neu expression in pancreatic adenocarcinoma: relation to tumor differentiation and survival. Pancreas 1997; 14(3): 229-236
    • (1997) Pancreas , vol.14 , Issue.3 , pp. 229-236
    • Dugan, M.C.1    Dergham, S.T.2    Kucway, R.3
  • 34
    • 4143128359 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis
    • Tobita K, Kijima H, Dowaki S, et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med 2003; 11(3): 305-309
    • (2003) Int J Mol Med , vol.11 , Issue.3 , pp. 305-309
    • Tobita, K.1    Kijima, H.2    Dowaki, S.3
  • 35
    • 33746820175 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique
    • Bloomston M, Bhardwaj A, Ellison EC, et al. Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique. Dig Surg 2006; 23(1-2): 74-79
    • (2006) Dig Surg , vol.23 , Issue.1-2 , pp. 74-79
    • Bloomston, M.1    Bhardwaj, A.2    Ellison, E.C.3
  • 36
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 2004; 29(1): e1-e8.
    • (2004) Pancreas , vol.29 , Issue.1
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3
  • 37
    • 0032556188 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors in tumorigenesis
    • Part I
    • (Part I). Taketo MM. Cyclooxygenase-2 inhibitors in tumorigenesis. J Natl Cancer Inst 1998; 90(20): 1529-1536
    • (1998) J Natl Cancer Inst , vol.90 , Issue.20 , pp. 1529-1536
    • Taketo, M.M.1
  • 38
    • 33645665983 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer
    • Juuti A, Louhimo J, Nordling S, et al. Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. J Clin Pathol 2006; 59(4): 382-386
    • (2006) J Clin Pathol , vol.59 , Issue.4 , pp. 382-386
    • Juuti, A.1    Louhimo, J.2    Nordling, S.3
  • 39
    • 6544295983 scopus 로고    scopus 로고
    • Overexpression of cyclooxygenase-2 in carcinoma of the pancreas
    • Okami J, Yamamoto H, Fujiwara Y, et al. Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res 1999; 5(8): 2018-2024
    • (1999) Clin Cancer Res , vol.5 , Issue.8 , pp. 2018-2024
    • Okami, J.1    Yamamoto, H.2    Fujiwara, Y.3
  • 40
    • 41649094069 scopus 로고    scopus 로고
    • Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer
    • Matsubayashi H, Infante JR, Winter J, et al. Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. Cancer Biol Ther 2007; 6(10): 1569-1575
    • (2007) Cancer Biol Ther , vol.6 , Issue.10 , pp. 1569-1575
    • Matsubayashi, H.1    Infante, J.R.2    Winter, J.3
  • 41
    • 67651093948 scopus 로고    scopus 로고
    • Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma
    • Hermanova M, Karasek P, Nenutil R, et al. Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma. Pancreas 2009; 38(5): 565-571
    • (2009) Pancreas , vol.38 , Issue.5 , pp. 565-571
    • Hermanova, M.1    Karasek, P.2    Nenutil, R.3
  • 42
    • 0031812131 scopus 로고    scopus 로고
    • Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival
    • Kornmann M, Ishiwata T, Itakura J, et al. Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Oncology 1998; 55(4): 363-369
    • (1998) Oncology , vol.55 , Issue.4 , pp. 363-369
    • Kornmann, M.1    Ishiwata, T.2    Itakura, J.3
  • 43
    • 3242718951 scopus 로고    scopus 로고
    • The importance of cyclin D1 and Ki67 expression on the biological behavior of pancreatic adenocarcinomas
    • Lebe B, Sagol O, Ulukus C, et al. The importance of cyclin D1 and Ki67 expression on the biological behavior of pancreatic adenocarcinomas. Pathol Res Pract 2004; 200(5): 389-396
    • (2004) Pathol Res Pract , vol.200 , Issue.5 , pp. 389-396
    • Lebe, B.1    Sagol, O.2    Ulukus, C.3
  • 44
    • 0035021841 scopus 로고    scopus 로고
    • Expression and possible role of cyclin D3 in human pancreatic adenocarcinoma
    • Ito Y, Takeda T, Wakasa K, et al. Expression and possible role of cyclin D3 in human pancreatic adenocarcinoma. Anticancer Res 2001; 21(2A): 1043-1048
    • (2001) Anticancer Res , vol.21 , Issue.2 A , pp. 1043-1048
    • Ito, Y.1    Takeda, T.2    Wakasa, K.3
  • 45
    • 0033999274 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer
    • Gong YL, Xu GM, Huang WD, et al. Expression of matrix metalloproteinases and the tissue inhibitors of metalloproteinases and their local invasiveness and metastasis in Chinese human pancreatic cancer. J Surg Oncol 2000; 73(2): 95-99
    • (2000) J Surg Oncol , vol.73 , Issue.2 , pp. 95-99
    • Gong, Y.L.1    Xu, G.M.2    Huang, W.D.3
  • 46
    • 34247111871 scopus 로고    scopus 로고
    • Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer
    • Juuti A, Lundin J, Nordling S, et al. Epithelial MMP-2 expression correlates with worse prognosis in pancreatic cancer. Oncology 2006; 71(1-2): 61-68
    • (2006) Oncology , vol.71 , Issue.1-2 , pp. 61-68
    • Juuti, A.1    Lundin, J.2    Nordling, S.3
  • 47
    • 33846405332 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
    • Oettle H, Post S, Neuhaus P, et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 2007; 297(3): 267-277
    • (2007) JAMA , vol.297 , Issue.3 , pp. 267-277
    • Oettle, H.1    Post, S.2    Neuhaus, P.3
  • 48
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998; 58(19): 4349-4357
    • (1998) Cancer Res , vol.58 , Issue.19 , pp. 4349-4357
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3
  • 49
    • 65349163336 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma
    • Marechal R, Mackey JR, Lai R, et al. Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma. Clin Cancer Res 2009; 15(8): 2913-2919
    • (2009) Clin Cancer Res , vol.15 , Issue.8 , pp. 2913-2919
    • Marechal, R.1    Mackey, J.R.2    Lai, R.3
  • 50
    • 34548580650 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
    • Mori R, Ishikawa T, Ichikawa Y, et al. Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep 2007; 17(5): 1201-1205
    • (2007) Oncol Rep , vol.17 , Issue.5 , pp. 1201-1205
    • Mori, R.1    Ishikawa, T.2    Ichikawa, Y.3
  • 51
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2′-difluorodeoxycytidine- Induced cytotoxicity
    • Garcia-Manteiga J, Molina-Arcas M, Casado FJ, et al. Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2′-difluorodeoxycytidine- induced cytotoxicity. Clin Cancer Res 2003; 9(13): 5000-5008
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 5000-5008
    • Garcia-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3
  • 52
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, et al. The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma. Clin Cancer Res 2004; 10(20): 6956-6961
    • (2004) Clin Cancer Res , vol.10 , Issue.20 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3
  • 53
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Del Tacca M, Mey V, et al. Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 2006; 66(7): 3928-3935
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3
  • 54
    • 0034327360 scopus 로고    scopus 로고
    • Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity
    • Rauchwerger DR, Firby PS, Hedley DW, et al. Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 2000; 60(21): 6075-6079
    • (2000) Cancer Res , vol.60 , Issue.21 , pp. 6075-6079
    • Rauchwerger, D.R.1    Firby, P.S.2    Hedley, D.W.3
  • 55
    • 2442451440 scopus 로고    scopus 로고
    • Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines
    • Giovannetti E, Mey V, Danesi R, et al. Synergistic cytotoxicity and pharmacogenetics of gemcitabine and pemetrexed combination in pancreatic cancer cell lines. Clin Cancer Res 2004; 10(9): 2936-2943
    • (2004) Clin Cancer Res , vol.10 , Issue.9 , pp. 2936-2943
    • Giovannetti, E.1    Mey, V.2    Danesi, R.3
  • 56
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells
    • Giovannetti E, Mey V, Nannizzi S, et al. Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Mol Pharmacol 2005; 68(1): 110-118
    • (2005) Mol Pharmacol , vol.68 , Issue.1 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3
  • 57
    • 49049100257 scopus 로고    scopus 로고
    • Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer
    • Ohhashi S, Ohuchida K, Mizumoto K, et al. Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer. Anticancer Res 2008; 28(4B): 2205-2212
    • (2008) Anticancer Res , vol.28 , Issue.4 B , pp. 2205-2212
    • Ohhashi, S.1    Ohuchida, K.2    Mizumoto, K.3
  • 58
    • 0002831066 scopus 로고    scopus 로고
    • Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    • Kroep JR, Loves WJ, van der Wilt CL, et al. Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 2002; 1(6): 371-376
    • (2002) Mol Cancer Ther , vol.1 , Issue.6 , pp. 371-376
    • Kroep, J.R.1    Loves, W.J.2    Van Der Wilt, C.L.3
  • 59
    • 0037103069 scopus 로고    scopus 로고
    • New applications of gemcitabine and future directions in the management of pancreatic cancer
    • Abbruzzese JL. New applications of gemcitabine and future directions in the management of pancreatic cancer. Cancer 2002; 95(4 Suppl): 941-945
    • (2002) Cancer , vol.95 , Issue.4 SUPPL. , pp. 941-945
    • Abbruzzese, J.L.1
  • 60
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J, et al. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009; 27(23): 3778-3785
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3
  • 61
    • 53849124668 scopus 로고    scopus 로고
    • Diverse molecular functions of Hu proteins
    • Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci 2008; 65(20): 3168-3181
    • (2008) Cell Mol Life Sci , vol.65 , Issue.20 , pp. 3168-3181
    • Hinman, M.N.1    Lou, H.2
  • 62
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase
    • Costantino CL, Witkiewicz AK, Kuwano Y, et al. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res 2009; 69(11): 4567-4572
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4567-4572
    • Costantino, C.L.1    Witkiewicz, A.K.2    Kuwano, Y.3
  • 63
    • 68649119589 scopus 로고    scopus 로고
    • Pharmacogenetics in pancreatic cancer
    • Strimpakos AS, Syrigos KN, Saif MW. Pharmacogenetics in pancreatic cancer. JOP 2009; 10(4): 357-360
    • (2009) JOP , vol.10 , Issue.4 , pp. 357-360
    • Strimpakos, A.S.1    Syrigos, K.N.2    Saif, M.W.3
  • 64
    • 62549146215 scopus 로고    scopus 로고
    • Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
    • Ueno H, Kaniwa N, Okusaka T, et al. Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients. Br J Cancer 2009; 100(6): 870-873
    • (2009) Br J Cancer , vol.100 , Issue.6 , pp. 870-873
    • Ueno, H.1    Kaniwa, N.2    Okusaka, T.3
  • 65
    • 34648847288 scopus 로고    scopus 로고
    • Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation
    • Mercier C, Raynal C, Dahan L, et al. Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation. Pharmacogenet Genomics 2007; 17(10): 841-844
    • (2007) Pharmacogenet Genomics , vol.17 , Issue.10 , pp. 841-844
    • Mercier, C.1    Raynal, C.2    Dahan, L.3
  • 66
    • 3042665933 scopus 로고    scopus 로고
    • Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery
    • Rosell R, Felip E, Taron M, et al. Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery. Clin Cancer Res 2004; 10(12 Pt 2): 4215S-9S.
    • (2004) Clin Cancer Res , vol.10 , Issue.12 PART 2
    • Rosell, R.1    Felip, E.2    Taron, M.3
  • 67
    • 33846958737 scopus 로고    scopus 로고
    • Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
    • Nakahira S, Nakamori S, Tsujie M, et al. Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer 2007; 120(6): 1355-1363
    • (2007) Int J Cancer , vol.120 , Issue.6 , pp. 1355-1363
    • Nakahira, S.1    Nakamori, S.2    Tsujie, M.3
  • 68
    • 68949154477 scopus 로고    scopus 로고
    • Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma
    • Akita H, Zheng Z, Takeda Y, et al. Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma. Oncogene 2009; 28(32): 2903-2909
    • (2009) Oncogene , vol.28 , Issue.32 , pp. 2903-2909
    • Akita, H.1    Zheng, Z.2    Takeda, Y.3
  • 69
    • 33745605221 scopus 로고    scopus 로고
    • Pharmacogenomics and gemcitabine
    • Rosell R, Cobo M, Isla D, et al. Pharmacogenomics and gemcitabine. Ann Oncol 2006; 17 (Suppl 5): v13-v16.
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 5
    • Rosell, R.1    Cobo, M.2    Isla, D.3
  • 70
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano Y, Tanno S, Koizumi K, et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007; 96(3): 457-463
    • (2007) Br J Cancer , vol.96 , Issue.3 , pp. 457-463
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 71
    • 0041338049 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    • Bondar VM, Sweeney-Gotsch B, Andreeff M, et al. Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther 2002; 1(12): 989-997
    • (2002) Mol Cancer Ther , vol.1 , Issue.12 , pp. 989-997
    • Bondar, V.M.1    Sweeney-Gotsch, B.2    Andreeff, M.3
  • 72
    • 34548845889 scopus 로고    scopus 로고
    • Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines
    • Lev-Ari S, Vexler A, Starr A, et al. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Invest 2007; 25(6): 411-418
    • (2007) Cancer Invest , vol.25 , Issue.6 , pp. 411-418
    • Lev-Ari, S.1    Vexler, A.2    Starr, A.3
  • 73
    • 17144390205 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
    • Akada M, Crnogorac-Jurcevic T, Lattimore S, et al. Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin Cancer Res 2005; 11(8): 3094-3101
    • (2005) Clin Cancer Res , vol.11 , Issue.8 , pp. 3094-3101
    • Akada, M.1    Crnogorac-Jurcevic, T.2    Lattimore, S.3
  • 74
    • 21744434389 scopus 로고    scopus 로고
    • Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    • Erkan M, Kleeff J, Esposito I, et al. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 2005; 24(27): 4421-4432
    • (2005) Oncogene , vol.24 , Issue.27 , pp. 4421-4432
    • Erkan, M.1    Kleeff, J.2    Esposito, I.3
  • 75
    • 34648823160 scopus 로고    scopus 로고
    • Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis
    • Ishida M, Sunamura M, Furukawa T, et al. Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis. World J Gastroenterol 2007; 13(34): 4593-4597
    • (2007) World J Gastroenterol , vol.13 , Issue.34 , pp. 4593-4597
    • Ishida, M.1    Sunamura, M.2    Furukawa, T.3
  • 76
    • 0035234651 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology
    • Williston Park
    • Diasio RB. Clinical implications of dihydropyrimidine dehydrogenase on 5-FU pharmacology. Oncology (Williston Park) 2001; 15(1 Suppl 2): 21-26
    • (2001) Oncology , vol.15 , Issue.1 SUPPL. 2 , pp. 21-26
    • Diasio, R.B.1
  • 77
    • 33846085042 scopus 로고    scopus 로고
    • Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Ciaparrone M, Quirino M, Schinzari G, et al. Predictive role of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer patients receiving adjuvant 5-fluorouracil. Oncology 2006; 70(5): 366-377
    • (2006) Oncology , vol.70 , Issue.5 , pp. 366-377
    • Ciaparrone, M.1    Quirino, M.2    Schinzari, G.3
  • 78
    • 0033930019 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues
    • Nagakawa T, Kayahara M, Ohta T, et al. Dihydropyrimidine dehydrogenase activity in human pancreatic tumor tissues. Cancer Invest 2000; 18(6): 516-520
    • (2000) Cancer Invest , vol.18 , Issue.6 , pp. 516-520
    • Nagakawa, T.1    Kayahara, M.2    Ohta, T.3
  • 79
    • 7044247819 scopus 로고    scopus 로고
    • Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer
    • Nakayama S, Takeda S, Kawase Y, et al. Clinical significance of dihydropyrimidine dehydrogenase in adjuvant 5-fluorouracil liver perfusion chemotherapy for pancreatic cancer. Ann Surg 2004; 240(5): 840-844
    • (2004) Ann Surg , vol.240 , Issue.5 , pp. 840-844
    • Nakayama, S.1    Takeda, S.2    Kawase, Y.3
  • 80
    • 0642319762 scopus 로고
    • Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′- deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase
    • Moran RG, Spears CP, Heidelberger C. Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase. Proc Natl Acad Sci USA 1979; 76(3): 1456-1460
    • (1979) Proc Natl Acad Sci USA , vol.76 , Issue.3 , pp. 1456-1460
    • Moran, R.G.1    Spears, C.P.2    Heidelberger, C.3
  • 81
    • 45749132692 scopus 로고    scopus 로고
    • Pharmacogenomics and pancreatic cancer treatment. Optimizing current therapy and individualizing future therapy
    • Kang SP, Saif MW. Pharmacogenomics and pancreatic cancer treatment. Optimizing current therapy and individualizing future therapy. JOP 2008; 9(3): 251-266
    • (2008) JOP , vol.9 , Issue.3 , pp. 251-266
    • Kang, S.P.1    Saif, M.W.2
  • 82
    • 0020660706 scopus 로고
    • Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil
    • Yin MB, Zakrzewski SF, Hakala MT. Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil. Mol Pharmacol 1983; 23(1): 190-197
    • (1983) Mol Pharmacol , vol.23 , Issue.1 , pp. 190-197
    • Yin, M.B.1    Zakrzewski, S.F.2    Hakala, M.T.3
  • 83
    • 67651089739 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers
    • Shimoda M, Sawada T, Kubota K. Thymidylate synthase and dihydropyrimidine dehydrogenase are upregulated in pancreatic and biliary tract cancers. Pathobiology 2009; 76(4): 193-198
    • (2009) Pathobiology , vol.76 , Issue.4 , pp. 193-198
    • Shimoda, M.1    Sawada, T.2    Kubota, K.3
  • 84
    • 60549103246 scopus 로고    scopus 로고
    • Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine
    • Uchida K, Danenberg PV, Danenberg KD, et al. Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine. BMC Cancer 2008; 8: 386.
    • (2008) BMC Cancer , vol.8 , pp. 386
    • Uchida, K.1    Danenberg, P.V.2    Danenberg, K.D.3
  • 85
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil
    • Beck A, Etienne MC, Cheradame S, et al. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 1994; 30A(10): 1517-1522
    • (1994) Eur J Cancer , vol.30 A , Issue.10 , pp. 1517-1522
    • Beck, A.1    Etienne, M.C.2    Cheradame, S.3
  • 86
    • 0012365921 scopus 로고    scopus 로고
    • Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues
    • Mori K, Hasegawa M, Nishida M, et al. Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. Int J Oncol 2000; 17(1): 33-38
    • (2000) Int J Oncol , vol.17 , Issue.1 , pp. 33-38
    • Mori, K.1    Hasegawa, M.2    Nishida, M.3
  • 87
    • 43049134491 scopus 로고    scopus 로고
    • Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
    • Soong R, Shah N, Salto-Tellez M, et al. Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. Ann Oncol 2008; 19(5): 915-919
    • (2008) Ann Oncol , vol.19 , Issue.5 , pp. 915-919
    • Soong, R.1    Shah, N.2    Salto-Tellez, M.3
  • 88
    • 70350482248 scopus 로고    scopus 로고
    • Prognostic value of thymidine phosphorylase expression for pancreatic cancer
    • Hong SP, Shin SK, Bang S, et al. Prognostic value of thymidine phosphorylase expression for pancreatic cancer. Hepatogastroenterology 2009; 56(93): 1178-1182
    • (2009) Hepatogastroenterology , vol.56 , Issue.93 , pp. 1178-1182
    • Hong, S.P.1    Shin, S.K.2    Bang, S.3
  • 89
    • 0034807893 scopus 로고    scopus 로고
    • A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: The mechanism for tumor-selective accumulation of 5-FU
    • Tsukamoto Y, Kato Y, Ura M, et al. A physiologically based pharmacokinetic analysis of capecitabine, a triple prodrug of 5-FU, in humans: the mechanism for tumor-selective accumulation of 5-FU. Pharm Res 2001; 18(8): 1190-1202
    • (2001) Pharm Res , vol.18 , Issue.8 , pp. 1190-1202
    • Tsukamoto, Y.1    Kato, Y.2    Ura, M.3
  • 90
    • 33947607213 scopus 로고    scopus 로고
    • Regulation of human dihydropyrimidine dehydrogenase: Implications in the pharmacogenetics of 5-FU-based chemotherapy
    • Zhang X, Diasio RB. Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy. Pharmacogenomics 2007; 8(3): 257-265
    • (2007) Pharmacogenomics , vol.8 , Issue.3 , pp. 257-265
    • Zhang, X.1    Diasio, R.B.2
  • 91
    • 56349087342 scopus 로고    scopus 로고
    • Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy
    • Amstutz U, Farese S, Aebi S, et al. Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy. J Exp Clin Cancer Res 2008; 27: 54.
    • (2008) J Exp Clin Cancer Res , vol.27 , pp. 54
    • Amstutz, U.1    Farese, S.2    Aebi, S.3
  • 92
    • 0032520168 scopus 로고    scopus 로고
    • Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts
    • Ishikawa T, Sekiguchi F, Fukase Y, et al. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 1998; 58(4): 685-690
    • (1998) Cancer Res , vol.58 , Issue.4 , pp. 685-690
    • Ishikawa, T.1    Sekiguchi, F.2    Fukase, Y.3
  • 93
    • 0036582566 scopus 로고    scopus 로고
    • Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5′-deoxy-5-fluorouridine as adjuvant chemotherapy
    • Nishimura G, Terada I, Kobayashi T, et al. Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5′-deoxy-5-fluorouridine as adjuvant chemotherapy. Oncol Rep 2002; 9(3): 479-482
    • (2002) Oncol Rep , vol.9 , Issue.3 , pp. 479-482
    • Nishimura, G.1    Terada, I.2    Kobayashi, T.3
  • 94
    • 34247356159 scopus 로고    scopus 로고
    • Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer
    • Miyake K, Imura S, Yoshizumi T, et al. Role of thymidine phosphorylase and orotate phosphoribosyltransferase mRNA expression and its ratio to dihydropyrimidine dehydrogenase in the prognosis and clinicopathological features of patients with pancreatic cancer. Int J Clin Oncol 2007; 12(2): 111-119
    • (2007) Int J Clin Oncol , vol.12 , Issue.2 , pp. 111-119
    • Miyake, K.1    Imura, S.2    Yoshizumi, T.3
  • 95
    • 69449096563 scopus 로고    scopus 로고
    • Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/dihydropyrimidine dehydrogenase ratio and its correlation with survival
    • Saif MW, Hashmi S, Bell D, et al. Prognostication of pancreatic adenocarcinoma by expression of thymidine phosphorylase/ dihydropyrimidine dehydrogenase ratio and its correlation with survival. Expert Opin Drug Saf 2009; 8(5): 507-514
    • (2009) Expert Opin Drug Saf , vol.8 , Issue.5 , pp. 507-514
    • Saif, M.W.1    Hashmi, S.2    Bell, D.3
  • 96
    • 4444339951 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    • Lecomte T, Ferraz JM, Zinzindohoue F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 2004; 10(17): 5880-5888
    • (2004) Clin Cancer Res , vol.10 , Issue.17 , pp. 5880-5888
    • Lecomte, T.1    Ferraz, J.M.2    Zinzindohoue, F.3
  • 97
    • 43749114271 scopus 로고    scopus 로고
    • Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: A prospective clinical trial by the German 5-FU Toxicity Study Group
    • Schwab M, Zanger UM, Marx C, et al. Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group. J Clin Oncol 2008; 26(13): 2131-2138
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2131-2138
    • Schwab, M.1    Zanger, U.M.2    Marx, C.3
  • 98
    • 38949175429 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients
    • Sharma R, Hoskins JM, Rivory LP, et al. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients. Clin Cancer Res 2008; 14(3): 817-825
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 817-825
    • Sharma, R.1    Hoskins, J.M.2    Rivory, L.P.3
  • 99
    • 23644452635 scopus 로고    scopus 로고
    • Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer
    • Wang L, Miao X, Tan W, et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer. Clin Gastroenterol Hepatol 2005; 3(8): 743-751
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.8 , pp. 743-751
    • Wang, L.1    Miao, X.2    Tan, W.3
  • 100
    • 33645727994 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms: Genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?
    • Marcuello E, Altes A, Menoyo A, et al. Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol 2006; 57(6): 835-840
    • (2006) Cancer Chemother Pharmacol , vol.57 , Issue.6 , pp. 835-840
    • Marcuello, E.1    Altes, A.2    Menoyo, A.3
  • 101
    • 0030728222 scopus 로고    scopus 로고
    • Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias
    • Clarke DJ, Moghrabi N, Monaghan G, et al. Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias. Clin Chim Acta 1997; 266(1): 63-74.
    • (1997) Clin Chim Acta , vol.266 , Issue.1 , pp. 63-74
    • Clarke, D.J.1    Moghrabi, N.2    Monaghan, G.3
  • 102
    • 34250629236 scopus 로고    scopus 로고
    • UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan
    • Cote JF, Kirzin S, Kramar A, et al. UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan. Clin Cancer Res 2007; 13(11): 3269-3275
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3269-3275
    • Cote, J.F.1    Kirzin, S.2    Kramar, A.3
  • 103
    • 0036025450 scopus 로고    scopus 로고
    • UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
    • Iyer L, Das S, Janisch L, et al. UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2002; 2(1): 43-47
    • (2002) Pharmacogenomics J , vol.2 , Issue.1 , pp. 43-47
    • Iyer, L.1    Das, S.2    Janisch, L.3
  • 104
    • 48249145381 scopus 로고    scopus 로고
    • UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: A Dutch Colorectal Cancer Group study
    • Kweekel DM, Gelderblom H, Van der ST, et al. UGT1A1*28 genotype and irinotecan dosage in patients with metastatic colorectal cancer: a Dutch Colorectal Cancer Group study. Br J Cancer 2008; 99(2): 275-282
    • (2008) Br J Cancer , vol.99 , Issue.2 , pp. 275-282
    • Kweekel, D.M.1    Gelderblom, H.2    Van Der, S.T.3
  • 105
    • 34347371390 scopus 로고    scopus 로고
    • Insights, challenges, and future directions in irinogenetics
    • Kim TW, Innocenti F. Insights, challenges, and future directions in irinogenetics. Ther Drug Monit 2007; 29(3): 265-270
    • (2007) Ther Drug Monit , vol.29 , Issue.3 , pp. 265-270
    • Kim, T.W.1    Innocenti, F.2
  • 106
    • 37249091253 scopus 로고    scopus 로고
    • Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene
    • Bellott R, Le MV, Charasson V, et al. Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene. Cancer Chemother Pharmacol 2008; 61(3): 481-488
    • (2008) Cancer Chemother Pharmacol , vol.61 , Issue.3 , pp. 481-488
    • Bellott, R.1    Le, M.V.2    Charasson, V.3
  • 107
    • 10044263002 scopus 로고    scopus 로고
    • Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38
    • Charasson V, Bellott R, Meynard D, et al. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. Clin Pharmacol Ther 2004; 76(6): 528-535
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.6 , pp. 528-535
    • Charasson, V.1    Bellott, R.2    Meynard, D.3
  • 108
    • 34248548838 scopus 로고    scopus 로고
    • Hypoxia-targeted overexpression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11)
    • Matzow T, Cowen RL, Williams KJ, et al. Hypoxia-targeted overexpression of carboxylesterase as a means of increasing tumour sensitivity to irinotecan (CPT-11). J Gene Med 2007; 9(4): 244-252
    • (2007) J Gene Med , vol.9 , Issue.4 , pp. 244-252
    • Matzow, T.1    Cowen, R.L.2    Williams, K.J.3
  • 109
    • 0042196122 scopus 로고    scopus 로고
    • Irinotecan pathway genotype analysis to predict pharmacokinetics
    • Mathijssen RH, Marsh S, Karlsson MO, et al. Irinotecan pathway genotype analysis to predict pharmacokinetics. Clin Cancer Res 2003; 9(9): 3246-3253
    • (2003) Clin Cancer Res , vol.9 , Issue.9 , pp. 3246-3253
    • Mathijssen, R.H.1    Marsh, S.2    Karlsson, M.O.3
  • 110
    • 12144286615 scopus 로고    scopus 로고
    • Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    • Sai K, Kaniwa N, Itoda M, et al. Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan. Pharmacogenetics 2003; 13(12): 741-757
    • (2003) Pharmacogenetics , vol.13 , Issue.12 , pp. 741-757
    • Sai, K.1    Kaniwa, N.2    Itoda, M.3
  • 111
    • 33846012498 scopus 로고    scopus 로고
    • Irinotecan-induced diarrhea: Functional significance of the polymorphic ABCC2 transporter protein
    • de Jong FA, Scott-Horton TJ, Kroetz DL, et al. Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein. Clin Pharmacol Ther 2007; 81(1): 42-49
    • (2007) Clin Pharmacol Ther , vol.81 , Issue.1 , pp. 42-49
    • De Jong, F.A.1    Scott-Horton, T.J.2    Kroetz, D.L.3
  • 112
    • 34249097816 scopus 로고    scopus 로고
    • Testing for excision repair cross-complementing 1 in patients with non-small-cell lung cancer for chemotherapy response
    • Felip E, Rosell R. Testing for excision repair cross-complementing 1 in patients with non-small-cell lung cancer for chemotherapy response. Expert Rev Mol Diagn 2007; 7(3): 261-268
    • (2007) Expert Rev Mol Diagn , vol.7 , Issue.3 , pp. 261-268
    • Felip, E.1    Rosell, R.2
  • 113
    • 0026648940 scopus 로고
    • ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients
    • Dabholkar M, Bostick-Bruton F, Weber C, et al. ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. J Natl Cancer Inst 1992; 84(19): 1512-1517
    • (1992) J Natl Cancer Inst , vol.84 , Issue.19 , pp. 1512-1517
    • Dabholkar, M.1    Bostick-Bruton, F.2    Weber, C.3
  • 114
    • 0035988959 scopus 로고    scopus 로고
    • Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
    • Lord RV, Brabender J, Gandara D, et al. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin Cancer Res 2002; 8(7): 2286-2291
    • (2002) Clin Cancer Res , vol.8 , Issue.7 , pp. 2286-2291
    • Lord, R.V.1    Brabender, J.2    Gandara, D.3
  • 115
    • 34848849833 scopus 로고    scopus 로고
    • ERCC1 mRNA expression is not associated with response and survival after platinum-based chemotherapy regimens in advanced non-small cell lung cancer
    • Booton R, Ward T, Ashcroft L, et al. ERCC1 mRNA expression is not associated with response and survival after platinum-based chemotherapy regimens in advanced non-small cell lung cancer. J Thorac Oncol 2007; 2(10): 902-906
    • (2007) J Thorac Oncol , vol.2 , Issue.10 , pp. 902-906
    • Booton, R.1    Ward, T.2    Ashcroft, L.3
  • 116
    • 74949133978 scopus 로고    scopus 로고
    • American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer
    • Azzoli CG, Baker S., Jr, Temin S, et al. American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol 2009; 27(36): 6251-6266
    • (2009) J Clin Oncol , vol.27 , Issue.36 , pp. 6251-6266
    • Azzoli, C.G.1    Baker Jr., S.2    Temin, S.3
  • 117
    • 4143051317 scopus 로고    scopus 로고
    • Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy
    • Zhou W, Gurubhagavatula S, Liu G, et al. Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy. Clin Cancer Res 2004; 10(15): 4939-4943
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 4939-4943
    • Zhou, W.1    Gurubhagavatula, S.2    Liu, G.3
  • 118
    • 65349117547 scopus 로고    scopus 로고
    • DNA repair gene polymorphisms predict favorable clinical outcome in advanced nonsmall-cell lung cancer
    • Kalikaki A, Kanaki M, Vassalou H, et al. DNA repair gene polymorphisms predict favorable clinical outcome in advanced nonsmall-cell lung cancer. Clin Lung Cancer 2009; 10(2): 118-123
    • (2009) Clin Lung Cancer , vol.10 , Issue.2 , pp. 118-123
    • Kalikaki, A.1    Kanaki, M.2    Vassalou, H.3
  • 119
    • 45849142592 scopus 로고    scopus 로고
    • ERCC1 codon 118 polymorphism is a useful prognostic marker in patients with pancreatic cancer treated with platinum-based chemotherapy
    • Kamikozuru H, Kuramochi H, Hayashi K, et al. ERCC1 codon 118 polymorphism is a useful prognostic marker in patients with pancreatic cancer treated with platinum-based chemotherapy. Int J Oncol 2008; 32(5): 1091-1096
    • (2008) Int J Oncol , vol.32 , Issue.5 , pp. 1091-1096
    • Kamikozuru, H.1    Kuramochi, H.2    Hayashi, K.3
  • 120
    • 0141954010 scopus 로고    scopus 로고
    • BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis
    • Quinn JE, Kennedy RD, Mullan PB, et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003; 63(19): 6221-6228
    • (2003) Cancer Res , vol.63 , Issue.19 , pp. 6221-6228
    • Quinn, J.E.1    Kennedy, R.D.2    Mullan, P.B.3
  • 121
    • 70249125405 scopus 로고    scopus 로고
    • Utility of gene promoter methylation in prediction of response to platinum-based chemotherapy in epithelial ovarian cancer (EOC)
    • Chaudhry P, Srinivasan R, Patel FD. Utility of gene promoter methylation in prediction of response to platinum-based chemotherapy in epithelial ovarian cancer (EOC). Cancer Invest 2009; 27(8): 877-884
    • (2009) Cancer Invest , vol.27 , Issue.8 , pp. 877-884
    • Chaudhry, P.1    Srinivasan, R.2    Patel, F.D.3
  • 122
    • 0037380801 scopus 로고    scopus 로고
    • Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines
    • Moufarij MA, Phillips DR, Cullinane C. Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines. Mol Pharmacol 2003; 63(4): 862-869
    • (2003) Mol Pharmacol , vol.63 , Issue.4 , pp. 862-869
    • Moufarij, M.A.1    Phillips, D.R.2    Cullinane, C.3
  • 123
    • 53049110722 scopus 로고    scopus 로고
    • Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy
    • Pare L, Marcuello E, Altes A, et al. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy. Br J Cancer 2008; 99(7): 1050-1055
    • (2008) Br J Cancer , vol.99 , Issue.7 , pp. 1050-1055
    • Pare, L.1    Marcuello, E.2    Altes, A.3
  • 124
    • 0035576102 scopus 로고    scopus 로고
    • ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
    • Shirota Y, Stoehlmacher J, Brabender J, et al. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J Clin Oncol 2001; 19(23): 4298-4304
    • (2001) J Clin Oncol , vol.19 , Issue.23 , pp. 4298-4304
    • Shirota, Y.1    Stoehlmacher, J.2    Brabender, J.3
  • 125
    • 0036047398 scopus 로고    scopus 로고
    • Clinical significance of prognostic and predictive markers in colorectal cancer
    • Longley DB, McDermott U, Johnston PG. Clinical significance of prognostic and predictive markers in colorectal cancer. Pharmacogenomics J 2002; 2(4): 209-216
    • (2002) Pharmacogenomics J , vol.2 , Issue.4 , pp. 209-216
    • Longley, D.B.1    McDermott, U.2    Johnston, P.G.3
  • 126
    • 0035174375 scopus 로고    scopus 로고
    • A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer
    • Stoehlmacher J, Ghaderi V, Iobal S, et al. A polymorphism of the XRCC1 gene predicts for response to platinum based treatment in advanced colorectal cancer. Anticancer Res 2001; 21(4B): 3075-3079
    • (2001) Anticancer Res , vol.21 , Issue.4 B , pp. 3075-3079
    • Stoehlmacher, J.1    Ghaderi, V.2    Iobal, S.3
  • 127
    • 3843130823 scopus 로고    scopus 로고
    • A multivariate analysis of genomic polymorphisms: Prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer
    • Stoehlmacher J, Park DJ, Zhang W, et al. A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer. Br J Cancer 2004; 91(2): 344-354
    • (2004) Br J Cancer , vol.91 , Issue.2 , pp. 344-354
    • Stoehlmacher, J.1    Park, D.J.2    Zhang, W.3
  • 128
    • 14844316287 scopus 로고    scopus 로고
    • Unfavourable expression of pharmacologic markers in mucinous colorectal cancer
    • Glasgow SC, Yu J, Carvalho LP, et al. Unfavourable expression of pharmacologic markers in mucinous colorectal cancer. Br J Cancer 2005; 92(2): 259-264
    • (2005) Br J Cancer , vol.92 , Issue.2 , pp. 259-264
    • Glasgow, S.C.1    Yu, J.2    Carvalho, L.P.3
  • 129
    • 0036911018 scopus 로고    scopus 로고
    • Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma
    • Trachte AL, Suthers SE, Lerner MR, et al. Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma. Am J Surg 2002; 184(6): 642-647
    • (2002) Am J Surg , vol.184 , Issue.6 , pp. 642-647
    • Trachte, A.L.1    Suthers, S.E.2    Lerner, M.R.3
  • 130
    • 33744787046 scopus 로고    scopus 로고
    • Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy
    • Lecomte T, Landi B, Beaune P, et al. Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy. Clin Cancer Res 2006; 12(10): 3050-3056
    • (2006) Clin Cancer Res , vol.12 , Issue.10 , pp. 3050-3056
    • Lecomte, T.1    Landi, B.2    Beaune, P.3
  • 131
    • 35948997380 scopus 로고    scopus 로고
    • Predictive factors of oxaliplatin neurotoxicity: The involvement of the oxalate outcome pathway
    • Gamelin L, Capitain O, Morel A, et al. Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway. Clin Cancer Res 2007; 13(21): 6359-6368
    • (2007) Clin Cancer Res , vol.13 , Issue.21 , pp. 6359-6368
    • Gamelin, L.1    Capitain, O.2    Morel, A.3
  • 132
    • 38849142020 scopus 로고    scopus 로고
    • Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract
    • Mahtani RL, Macdonald JS. Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract. Oncologist 2008; 13(1): 39-50.
    • (2008) Oncologist , vol.13 , Issue.1 , pp. 39-50
    • Mahtani, R.L.1    Macdonald, J.S.2
  • 133
    • 38049045220 scopus 로고    scopus 로고
    • Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation
    • Balin-Gauthier D, Delord JP, Pillaire MJ, et al. Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation. Br J Cancer 2008; 98(1): 120-128
    • (2008) Br J Cancer , vol.98 , Issue.1 , pp. 120-128
    • Balin-Gauthier, D.1    Delord, J.P.2    Pillaire, M.J.3
  • 134
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang KT, Ki CS, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007; 109(8): 1561-1569
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1561-1569
    • Lee, J.1    Jang, K.T.2    Ki, C.S.3
  • 135
    • 33748361817 scopus 로고    scopus 로고
    • Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity
    • Buck E, Eyzaguirre A, Haley JD, et al. Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. Mol Cancer Ther 2006; 5(8): 2051-2059
    • (2006) Mol Cancer Ther , vol.5 , Issue.8 , pp. 2051-2059
    • Buck, E.1    Eyzaguirre, A.2    Haley, J.D.3
  • 136
    • 34047216068 scopus 로고    scopus 로고
    • Molecular background of chemoresistance in pancreatic cancer
    • Zalatnai A, Molnar J. Molecular background of chemoresistance in pancreatic cancer. In Vivo 2007; 21(2): 339-347
    • (2007) In Vivo , vol.21 , Issue.2 , pp. 339-347
    • Zalatnai, A.1    Molnar, J.2
  • 137
    • 31544460436 scopus 로고    scopus 로고
    • Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A, Takimoto CH, et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 2006; 12(1): 144-151
    • (2006) Clin Cancer Res , vol.12 , Issue.1 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3
  • 138
    • 0035678782 scopus 로고    scopus 로고
    • Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumor marker of diagnostic significance
    • Andrianifahanana M, Moniaux N, Schmied BM, et al. Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. Clin Cancer Res 2001; 7(12): 4033-4040
    • (2001) Clin Cancer Res , vol.7 , Issue.12 , pp. 4033-4040
    • Andrianifahanana, M.1    Moniaux, N.2    Schmied, B.M.3
  • 139
    • 34248218177 scopus 로고    scopus 로고
    • MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins
    • Chaturvedi P, Singh AP, Moniaux N, et al. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol Cancer Res 2007; 5(4): 309-320
    • (2007) Mol Cancer Res , vol.5 , Issue.4 , pp. 309-320
    • Chaturvedi, P.1    Singh, A.P.2    Moniaux, N.3
  • 140
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis
    • Singh AP, Moniaux N, Chauhan SC, et al. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis. Cancer Res 2004; 64(2): 622-630
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 622-630
    • Singh, A.P.1    Moniaux, N.2    Chauhan, S.C.3
  • 141
    • 24644441892 scopus 로고    scopus 로고
    • Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer
    • Zhang Y, Dang C, Ma Q, et al. Expression of nerve growth factor receptors and their prognostic value in human pancreatic cancer. Oncol Rep 2005; 14(1): 161-171
    • (2005) Oncol Rep , vol.14 , Issue.1 , pp. 161-171
    • Zhang, Y.1    Dang, C.2    Ma, Q.3
  • 142
    • 0034827058 scopus 로고    scopus 로고
    • Expression of nerve growth factors in pancreatic neural tissue and pancreatic cancer
    • Schneider MB, Standop J, Ulrich A, et al. Expression of nerve growth factors in pancreatic neural tissue and pancreatic cancer. J Histochem Cytochem 2001; 49(10): 1205-1210
    • (2001) J Histochem Cytochem , vol.49 , Issue.10 , pp. 1205-1210
    • Schneider, M.B.1    Standop, J.2    Ulrich, A.3
  • 143
    • 57049086869 scopus 로고    scopus 로고
    • Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer
    • Ma J, Jiang Y, Jiang Y, et al. Expression of nerve growth factor and tyrosine kinase receptor A and correlation with perineural invasion in pancreatic cancer. J Gastroenterol Hepatol 2008; 23(12): 1852-1859
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.12 , pp. 1852-1859
    • Ma, J.1    Jiang, Y.2    Jiang, Y.3
  • 144
    • 0032792960 scopus 로고    scopus 로고
    • Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer
    • Zhu Z, Friess H, diMola FF, et al. Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol 1999; 17(8): 2419-2428
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2419-2428
    • Zhu, Z.1    Friess, H.2    DiMola, F.F.3
  • 145
    • 64949118648 scopus 로고    scopus 로고
    • Genetic variation in taste and its influence on food selection
    • Garcia-Bailo B, Toguri C, Eny KM, et al. Genetic variation in taste and its influence on food selection. OMICS 2009; 13(1): 69-80.
    • (2009) OMICS , vol.13 , Issue.1 , pp. 69-80
    • Garcia-Bailo, B.1    Toguri, C.2    Eny, K.M.3
  • 146
    • 56149105091 scopus 로고    scopus 로고
    • The pathway less traveled: Moving from candidate genes to candidate pathways in the analysis of genome-wide data from large scale pharmacogenetic association studies
    • Wilke RA, Mareedu RK, Moore JH. The pathway less traveled: moving from candidate genes to candidate pathways in the analysis of genome-wide data from large scale pharmacogenetic association studies. Curr Pharmacogenomics Person Med 2008; 6(3): 150-159
    • (2008) Curr Pharmacogenomics Person Med , vol.6 , Issue.3 , pp. 150-159
    • Wilke, R.A.1    Mareedu, R.K.2    Moore, J.H.3
  • 147
    • 70449685099 scopus 로고    scopus 로고
    • Paving the way to personalized genomic medicine: Steps to successful implementation
    • Fackler JL, McGuire AL. Paving the way to personalized genomic medicine: Steps to successful implementation. Curr Pharmacogenomics Person Med 2009; 7(2): 125-132
    • (2009) Curr Pharmacogenomics Person Med , vol.7 , Issue.2 , pp. 125-132
    • Fackler, J.L.1    McGuire, A.L.2
  • 148
    • 67650509132 scopus 로고    scopus 로고
    • Efficiency of CYP2C9 genetic test representation for automated pharmacogenetic decision support
    • Deshmukh VG, Hoffman MA, Arnoldi C, et al. Efficiency of CYP2C9 genetic test representation for automated pharmacogenetic decision support. Methods Inf Med 2009; 48: 282-290
    • (2009) Methods Inf Med , vol.48 , pp. 282-290
    • Deshmukh, V.G.1    Hoffman, M.A.2    Arnoldi, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.