Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumormarker of diagnostic significance

Clinical Cancer Research

Volumn 7, Issue 12, 2001, Pages 4033-4040

  Andrianifahanana, Mahefatiana ^a   Moniaux, Nicolas ^a   Ringel, Jorg ^a   Batra, Surinder K ^a,b   Hollingsworth, Michael A ^b   Aubert, Jean Pierre ^c   Schmied, Bruno M ^d   Friess, Helmut ^d   Büchler, Markus W ^d  

^a NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c INSERM   (France)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; MUCIN; RNA;

ARTICLE; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CHRONIC DISEASE; FEMALE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MUCINS; PANCREAS; PANCREATIC NEOPLASMS; PANCREATITIS; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, NEOPLASM; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0035678782     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Cancer statistics
2. Cancer statistics
3. Pancreatic carcinoma
4. Chronic pancreatitis and other risk factors for pancreatic cancer
5. Pancreatic cancer versus chronic pancreatitis: Diagnosis with CA 19-9 assessment, US, CT, and CT-guided fine-needle biopsy
6. DU-PAN-2 levels in serum and pancreatic ductal fluids of patients with benign and malignant pancreatic disease
7. Diagnosis and preoperative evaluation of pancreatic cancer, with implications for management
8. Tumor markers in pancreatic cancer - Current concepts
9. Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon
10. Detection of the anti-p53 antibody response in malignant and benign pancreatic disease
11. Pancreatic cancer: Development of a unifying etiologic concept
12. Epithelial mucin genes
13. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)
14. MUC genes: A superfamily of genes? Towards a functional classification of human apomucins
15. Multiple transcripts of MUC3: Evidence for two genes, MUC3A and MUC3B
16. Structure, function and gene expression of epithelial mucins
17. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxyl terminus
18. Two novel mucin genes down-regulated in colorectal cancer identified by differential display
19. MUC13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells
20. MUC-1 glycosylation in endometrium: Possible roles of the apical glycocalyx at implantation
21. Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor
22. Human MUC1 mucin: A multifaceted glycoprotein
23. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components
24. A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1
25. Mucins in the human gastrointestinal epithelium: A review
26. Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres
27. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
28. Serological pancreatic tumor markers and the MUC1 apomucin
29. Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule
30. Expression of mucin antigens in human cancers and its relationship with malignancy potential
31. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues
32. Retinoic acid-dependent transforming growth factor-β2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-aα signaling pathway
33. Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines
34. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
35. Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs
36. Human MUC4 mucin cDNA and its variants in pancreatic carcinoma
37. Cloning and sequencing of a human pancreatic tumor mucin cDNA
38. Assignment of human tracheobronchial mucin gene(s) to 11p15 and a tracheobronchial mucin-related sequence to chromosome 13
39. Pancreatic resection combined with intraoperative radiation therapy for pancreatic cancer
40. Palliative and adjuvant regional chemotherapy in pancreatic cancer
41. Single-chain antibodies in pancreatic cancer
42. The novel Trk receptor tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits antitumor efficacy against human pancreatic carcinoma (Panc1) xenograft growth and in vivo invasiveness
43. The matrix metalloproteinases and their inhibitors in the treatment of pancreatic cancer
44. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines
45. Developmental mucin gene expression in the gastroduodenal tract and accessory digestive glands. II. Duodenum and liver, gallbladder, and pancreas
46. Sialylated MUCI mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma
47. Differential MUC 1 expression in normal and neoplastic human pancreatic tissue. An immunohistochemical study of 60 samples
48. Developmental expression of mucin genes in the human gastrointestinal system
49. Expression of MUC apomucins in normal pancreas and pancreatic tumours
50. MUC4 mRNA in peripheral blood mononuclear cells (PBMC) as a potential tumor marker for pancreatic cancer
51. Prognosis of human pancreatic adenocarcinoma: Review of clinical and histopathological variables and possible uses of new molecular methods
52. Pancreatic cancer detection with magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography: A prospective controlled study
53. Combined imaging techniques for pancreatic cancer