Pharmacogenetics in pancreatic cancer. Highlights from the "45th ASCO Annual Meeting". Orlando, FL, USA. May 29 - June 2, 2009

Journal of the Pancreas

Volumn 10, Issue 4, 2009, Pages 357-360

  Strimpakos, Alexios S ^a   Syrigos, Kostas N ^a   Saif, Muhammad Wasif ^a  

^a YALE CANCER CENTER   (United States)

Author keywords

Adenocarcinoma; Pancreatic neoplasms; Pharmacogenetics

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; ATM PROTEIN; CAPECITABINE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEMCITABINE; HUR PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; RECQ HELICASE; S6 KINASE; TEMSIROLIMUS; THYMIDYLATE SYNTHASE;

ADJUVANT THERAPY; BIOLOGICAL ACTIVITY; CANCER GENETICS; CANCER SURVIVAL; CLINICAL TRIAL; CONFERENCE PAPER; DRUG PROTEIN BINDING; GENE ACTIVITY; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; GENOME ANALYSIS; HUMAN; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PHARMACOGENOMICS; PROGNOSIS; RNA STABILITY; RNA TRANSPORT; SINGLE NUCLEOTIDE POLYMORPHISM; SURVIVAL TIME; TREATMENT RESPONSE;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; ANTIMETABOLITES, ANTINEOPLASTIC; DEOXYCYTIDINE; HUMANS; PANCREATIC NEOPLASMS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 68649119589     PISSN: None     EISSN: 15908577     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008; 58:71-96.
2. Strimpakos A, Saif MW, Syrigos KN. Pancreatic cancer: from molecular pathogenesis to targeted therapy. Cancer Metastasis Rev 2008; 27:495-522.
3. Hinman MN, Lou H. Diverse molecular functions of Hu proteins. Cell Mol Life Sci 2008; 65:3168-81.
4. Costantino CL, Witkiewicz AK, Kuwano Y, Cozzitorto JA, Kennedy EP, Dasgupta A, et al. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res 2009; 69:4567-72.
5. Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, Zimmerman GA, et al. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest 2001; 108:1657-65.
6. Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol 2006; 24:1720-8.