메뉴 건너뛰기




Volumn 38, Issue 5, 2009, Pages 565-571

Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma

Author keywords

COX 2; Grade; MDM2; p53; Pancreatic cancer; Prognostic factor

Indexed keywords

CYCLOOXYGENASE 2; PROTEIN MDM2; PROTEIN P53;

EID: 67651093948     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31819fef8b     Document Type: Article
Times cited : (18)

References (48)
  • 3
    • 0033872039 scopus 로고    scopus 로고
    • Genetic progression in the pancreatic ducts
    • Hruban RH,Wilentz RE, Kern SE. Genetic progression in the pancreatic ducts. Am J Pathol. 2000;156:1821-1825.
    • (2000) Am J Pathol , vol.156 , pp. 1821-1825
    • Hruban, R.H.1    Wilentz, R.E.2    Kern, S.E.3
  • 5
    • 26044444704 scopus 로고    scopus 로고
    • Role of inflammation in pancreatic carcinogenesis and the implications for future therapy
    • DOI 10.1159/000087493
    • Garcea G, Dennison AR, Steward WP, et al. Role of the inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology. 2005;5:514-529. (Pubitemid 41407282)
    • (2005) Pancreatology , vol.5 , Issue.6 , pp. 514-529
    • Garcea, G.1    Dennison, A.R.2    Steward, W.P.3    Berry, D.P.4
  • 6
    • 0036093865 scopus 로고    scopus 로고
    • Inflammation and the development of pancreatic cancer
    • Farrow B, Evers BM. Inflammation and the development of pancreatic cancer. Surg Oncol. 2002;10:153-169.
    • (2002) Surg Oncol , vol.10 , pp. 153-169
    • Farrow, B.1    Evers, B.M.2
  • 7
    • 0036669611 scopus 로고    scopus 로고
    • Cyclooxygenase isoenzymes and their gene structures and expression
    • 95-114.
    • Tanabe T, Tohnai N. Cyclooxygenase isoenzymes and their gene structures and expression. Prostaglandins Other Lipid Mediat. 2002; 68-69:95-114.
    • (2002) Prostaglandins Other Lipid Mediat , pp. 68-69
    • Tanabe, T.1    Tohnai, N.2
  • 8
    • 0034471496 scopus 로고    scopus 로고
    • Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia
    • Fosslien E. Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. Crit Rev Clin Lab Sci. 2000;37:431-502. (Pubitemid 32173442)
    • (2000) Critical Reviews in Clinical Laboratory Sciences , vol.37 , Issue.5 , pp. 431-502
    • Fosslien, E.1
  • 9
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • Williams CS, Mann M, Dubios RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999;18: 7908-7916. (Pubitemid 30066236)
    • (1999) Oncogene , vol.18 , Issue.55 , pp. 7908-7916
    • Williams, C.S.1    Mann, M.2    Dubois, R.N.3
  • 11
    • 0035863223 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors
    • DOI 10.1002/1097-0142(20010115)91:2<333::AID-CNCR1006>3.0.CO;2-N
    • Kokawa A, Kondo H, Gotoda T, et al. Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential chemoprevention by cyclooxygenase inhibitors. Cancer. 2001;91: 333-338. (Pubitemid 32099234)
    • (2001) Cancer , vol.91 , Issue.2 , pp. 333-338
    • Kokawa, A.1    Kondo, H.2    Gotoda, T.3    Ono, H.4    Saito, D.5    Nakadaira, S.6    Kosuge, T.7    Yoshida, S.8
  • 12
    • 23844478990 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression associated with severity of PanIN lesions: A possible link between chronic pancreatitis and pancreatic cancer
    • DOI 10.1159/000086536
    • Albazaz R, Verbeke CS, Rahman SH, et al. Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer. Pancreatology. 2005;5:361-369. (Pubitemid 41160273)
    • (2005) Pancreatology , vol.5 , Issue.4-5 , pp. 361-369
    • Albazaz, R.1    Verbeke, C.S.2    Rahman, S.H.3    McMahon, M.J.4
  • 13
    • 0036672963 scopus 로고    scopus 로고
    • Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia
    • Maitra A, Ashfaq R, Gunn CR, et al. Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia. Am J Clin Pathol. 2002;118:194-201.
    • (2002) Am J Clin Pathol , vol.118 , pp. 194-201
    • Maitra, A.1    Ashfaq, R.2    Gunn, C.R.3
  • 14
    • 52749094806 scopus 로고    scopus 로고
    • Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: Analysis of COX-2 and p53 expression in premalignant and malignanat ductal pancreatic lesions
    • Hermanova M, Trna J, Nenutil R, et al. Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignanat ductal pancreatic lesions. Eur J Gastroenterol Hepatol. 2008;20: 732-739.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 732-739
    • Hermanova, M.1    Trna, J.2    Nenutil, R.3
  • 15
    • 0038489501 scopus 로고    scopus 로고
    • Potential involvement of cyclooxygenase-2 pathway in the regulation of tumor associated angiogenesis and growth in pancreatic cancer
    • Chu J, Lloyd FL, Trifan OC, et al. Potential involvement of cyclooxygenase-2 pathway in the regulation of tumor associated angiogenesis and growth in pancreatic cancer. Mol Cancer Ther. 2003;2:1-7.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1-7
    • Chu, J.1    Lloyd, F.L.2    Trifan, O.C.3
  • 16
    • 0036381118 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer
    • Kong G, Kim EK, Kim WS, et al. Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. J Gastroenterol Hepatol. 2002;17:914-921.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 914-921
    • Kong, G.1    Kim, E.K.2    Kim, W.S.3
  • 17
    • 0033859744 scopus 로고    scopus 로고
    • Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells
    • Ding XZ, Tong WG, Adrian TE. Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Anticancer Res. 2000;20:2625-2631.
    • (2000) Anticancer Res , vol.20 , pp. 2625-2631
    • Ding, X.Z.1    Tong, W.G.2    Adrian, T.E.3
  • 18
    • 0037757694 scopus 로고    scopus 로고
    • PGE (2) is generated by specific COX-2 activity and increases VEGF production in COX-2 expressing human pancreatic cancer cells
    • Eibl G, Bruemmer D, Okada Y, et al. PGE (2) is generated by specific COX-2 activity and increases VEGF production in COX-2 expressing human pancreatic cancer cells. Biochem Biophys Res Commun. 2003;306:887-897.
    • (2003) Biochem Biophys Res Commun , vol.306 , pp. 887-897
    • Eibl, G.1    Bruemmer, D.2    Okada, Y.3
  • 20
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA. The p53 pathway. J Pathol. 1999;187:112-126.
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 21
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 22
    • 0030612360 scopus 로고    scopus 로고
    • MDM2 - Arbiter of p53's destruction
    • Lane DP, Hall PA. MDM2 - arbiter of p53's destruction. Trends Biochem Sci. 1997;22:372-374.
    • (1997) Trends Biochem Sci , vol.22 , pp. 372-374
    • Lane, D.P.1    Hall, P.A.2
  • 23
    • 3843086271 scopus 로고    scopus 로고
    • Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2
    • DOI 10.1038/sj.onc.1207709
    • O'Hagan HM, Ljungman M. Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. Oncogene. 2004;23:5505-5512. (Pubitemid 39044061)
    • (2004) Oncogene , vol.23 , Issue.32 , pp. 5505-5512
    • O'Hagan, H.M.1    Ljungman, M.2
  • 24
    • 24144494193 scopus 로고    scopus 로고
    • Control of nuclear accumulation in stressed cells
    • Inoue T, Wu L, Stuart J, et al. Control of nuclear accumulation in stressed cells. FEBS Lett. 2005;22:4978-4984.
    • (2005) FEBS Lett , vol.22 , pp. 4978-4984
    • Inoue, T.1    Wu, L.2    Stuart, J.3
  • 26
    • 0026334753 scopus 로고
    • Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer
    • Barton CM, Staddon SL, Hughes CM, et al. Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer. Br J Cancer. 1991;64:1076-1082.
    • (1991) Br J Cancer , vol.64 , pp. 1076-1082
    • Barton, C.M.1    Staddon, S.L.2    Hughes, C.M.3
  • 27
    • 43049093873 scopus 로고    scopus 로고
    • The genetic basis of human cancer
    • Vogelstein B, Kinzler KW, eds. New York, NY: McGraw-Hill
    • Hruban RH, Yeo CJ, Kern SE. The genetic basis of human cancer. In: Vogelstein B, Kinzler KW, eds. Pancreatic Cancer. New York, NY: McGraw-Hill; 1996:603-613.
    • (1996) Pancreatic Cancer , pp. 603-613
    • Hruban, R.H.1    Yeo, C.J.2    Kern, S.E.3
  • 28
    • 0027434353 scopus 로고
    • Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies
    • DOI 10.1002/path.1711690106
    • Bartek J, Bartkova J, Lukas Z, et al. Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies. J Pathol. 1993;169:27-34. (Pubitemid 23034420)
    • (1993) Journal of Pathology , vol.169 , Issue.1 , pp. 27-34
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3    Staskova, Z.4    Vojtesek, B.5    Lane, D.P.6
  • 30
    • 14944379632 scopus 로고    scopus 로고
    • Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis
    • DOI 10.1038/sj.onc.1208353
    • Corcoran CA, He Q, Huang Y, et al. Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. Oncogene. 2005;24:1634-1640. (Pubitemid 40396093)
    • (2005) Oncogene , vol.24 , Issue.9 , pp. 1634-1640
    • Corcoran, C.A.1    He, Q.2    Huang, Y.3    Saeed Sheikh, M.4
  • 31
    • 0036845260 scopus 로고    scopus 로고
    • P53-mediated induction of Cox-2 counteracts p53- Or genotoxic stress-induced apoptosis
    • Han JA, Kim JI, Ongusaha PP, et al. P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J. 2002;21:5635-5644.
    • (2002) EMBO J , vol.21 , pp. 5635-5644
    • Han, J.A.1    Kim, J.I.2    Ongusaha, P.P.3
  • 34
    • 34547131815 scopus 로고    scopus 로고
    • Cross talk between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis
    • de Moraes E, Dar NA, de Moura Gallo CV, et al. Cross talk between cyclooxygenase-2 and tumor suppressor protein p53: balancing life and death during inflammatory stress and carcinogenesis. Int J Cancer. 2007;121:929-937.
    • (2007) Int J Cancer , vol.121 , pp. 929-937
    • De Moraes, E.1    Dar, N.A.2    De Moura Gallo, C.V.3
  • 35
    • 17444423293 scopus 로고    scopus 로고
    • Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer
    • Dong M, Ma G, TuW, et al. Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. World J Gastroenterol. 2005;11:2162-2165. (Pubitemid 40542663)
    • (2005) World Journal of Gastroenterology , vol.11 , Issue.14 , pp. 2162-2165
    • Dong, M.1    Ma, G.2    Tu, W.3    Guo, K.-J.4    Tian, Y.-L.5    Dong, Y.-T.6
  • 36
    • 0035751937 scopus 로고    scopus 로고
    • Assessing TP53 status in human tumours to evaluate clinical outcome
    • Soussi T, Beroud S. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer. 2001;1:233-240. (Pubitemid 33741898)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.3 , pp. 233-240
    • Soussi, T.1    Beroud, C.2
  • 37
    • 34047207337 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes
    • DOI 10.1038/sj.onc.1210302, PII 1210302
    • Petitjean A, Achatz MI, Borresen-Dale AL, et al. TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes. Oncogene. 2007;26:2157-2165. (Pubitemid 46536647)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2157-2165
    • Petitjean, A.1    Achatz, M.I.W.2    Borresen-Dale, A.L.3    Hainaut, P.4    Olivier, M.5
  • 38
    • 0032902994 scopus 로고    scopus 로고
    • Comparative significance of p53 and WAF/1-P21 expression on the efficacy of adjuvant chemotherapy for resectable invasive ductal carcinoma of the pancreas
    • Nio Y, Dong M, Uegaki K, et al. Comparative significance of p53 and WAF/1-p21 expression on the efficacy of adjuvant chemotherapy for resectable invasive ductal carcinoma of the pancreas. Pancreas. 1999;18:117-126. (Pubitemid 29180107)
    • (1999) Pancreas , vol.18 , Issue.2 , pp. 117-126
    • Nio, Y.1    Dong, M.2    Uegaki, K.3    Hirahara, N.4    Minari, Y.5    Sasaki, S.6    Takamura, M.7    Iguchi, C.8    Tamura, K.9
  • 39
    • 0035085625 scopus 로고    scopus 로고
    • Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: Effects on clinical outcome and efficacy of adjuvant chemotherapy
    • DOI 10.1002/jso.1033
    • Nio Y, Dong M, Iguchi C, et al. Expression of Bcl-2 and p53 protein in resectable invasive ductal carcinoma of the pancreas: effects on clinical outcome and efficacy of adjuvant chemotherapy. J Surg Oncol. 2001;76:188-196. (Pubitemid 32240229)
    • (2001) Journal of Surgical Oncology , vol.76 , Issue.3 , pp. 188-196
    • Nio, Y.1    Dong, M.2    Iguchi, C.3    Yamasawa, K.4    Toga, T.5    Itakura, M.6    Tamura, K.7
  • 41
    • 0028922149 scopus 로고
    • Association of p53 gene mutations with short survival in pancreatic adenocarcinoma
    • Nakamori S, Yashima K, Murakami Y, et al. Association of p53 gene mutations with short survival in pancreatic adenocarcinoma. Jpn J Cancer Res. 1995;86:174-181.
    • (1995) Jpn J Cancer Res , vol.86 , pp. 174-181
    • Nakamori, S.1    Yashima, K.2    Murakami, Y.3
  • 42
    • 0033199017 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs
    • Molina MA, Sitja-Arnau M, Lemoine MG, et al. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 1999;59:4356-4362. (Pubitemid 29418754)
    • (1999) Cancer Research , vol.59 , Issue.17 , pp. 4356-4362
    • Molina, M.A.1    Sitja-Arnau, M.2    Lemoine, M.G.3    Frazier, M.L.4    Sinicrope, F.A.5
  • 43
    • 0034883045 scopus 로고    scopus 로고
    • Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells
    • Yip-Schneider MT, Sweeney CJ, Jung SH, et al. Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001;298:976-985.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 976-985
    • Yip-Schneider, M.T.1    Sweeney, C.J.2    Jung, S.H.3
  • 44
    • 33645665983 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer
    • Juuti A, Louhimo J, Nordling S, et al. Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. J Clin Pathol. 2006;59:382-386.
    • (2006) J Clin Pathol , vol.59 , pp. 382-386
    • Juuti, A.1    Louhimo, J.2    Nordling, S.3
  • 46
    • 0032704323 scopus 로고    scopus 로고
    • Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors
    • Koshiba T, Hosotani R, Miyamoto Y, et al. Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. Int J Pancreatol. 1999;26:69-76.
    • (1999) Int J Pancreatol , vol.26 , pp. 69-76
    • Koshiba, T.1    Hosotani, R.2    Miyamoto, Y.3
  • 48
    • 34447641408 scopus 로고    scopus 로고
    • Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer
    • DOI 10.1159/000104241
    • Matsumoto G, Muta M, Tsuruta K, et al. Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer. Pancreatology. 2007;7:167-173. (Pubitemid 47094086)
    • (2007) Pancreatology , vol.7 , Issue.2-3 , pp. 167-173
    • Matsumoto, G.1    Muta, M.2    Tsuruta, K.3    Horiguchi, S.4    Karasawa, K.5    Okamoto, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.