HIV-specific TGF-β-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4

AIDS Research and Human Retroviruses

Volumn 26, Issue 3, 2010, Pages 329-337

  Elrefaei, Mohamed ^a   Burke, Candace M ^a   Baker, Chris A R ^a   Jones, Norman G ^a   Bousheri, Stephanie ^a   Bangsberg, David R ^b   Cao, Huyen ^a  

^a CALIFORNIA DEPARTMENT OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOPHENOTYPING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ANTIGENS, CD; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; HIV INFECTIONS; HIV-1; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

EID: 77950277858     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2009.0149     Document Type: Article

References (50)

1. Groux H, Bigler M, de Vries JE, et al.: Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med 1996;184:19-29.
2. Tanchot C, Guillaume S, Delon J, et al.: Modifications of CD8+ T cell function during in vivo memory or tolerance induction. Immunity 1998;8:581-590.
3. Asseman C and von Herrath M: About CD4pos CD25pos regulatory cells. Autoimmun Rev 2002;1:190-197.
4. Baecher-Allan C, Brown JA, Freeman GJ, et al.: CD4+CD25 high regulatory cells in human peripheral blood. J Immunol 2001;167:1245-1253.
5. Fontenot JD, Gavin MA, and Rudensky AY: Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336.
6. Khattri R, Cox T, Yasayko SA, et al.: An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003;4:337-342.
7. Liu W, Putnam AL, Xu-Yu Z, et al.: CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006;203:1701-1711.
8. Seddiki N, Santner-Nanan B, Martinson J, et al.: Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-1700.
9. Scotto L, Naiyer AJ, Galluzzo S, et al.: Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells. Hum Immunol 2004; 65:1297-1306.
10. Elrefaei M, Ventura FL, Baker CA, et al.: HIV-specific IL-10- positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells. J Immunol 2007;178:3265-3271.
11. Cosmi L, Liotta F, Lazzeri E, et al.: Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 2003;102:4107-4114.
12. Levings MK, Sangregorio R, Sartirana C, et al.: Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med 2002;196:1335-1346.
13. Weiner HL: Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 2001;182:207-214.
14. Greenwald RJ, Freeman GJ, and Sharpe AH: The B7 family revisited. Annu Rev Immunol 2005;23:515-548.
15. Chen L: Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4: 336-347.
16. Andersson J, Boasso A, Nilsson J, et al.: The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. J Immunol 2005;174:3143-3147.
17. Kaufmann DE, Kavanagh DG, Pereyra F, et al.: Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction. Nat Immunol 2007;8:1246-1254.
18. Leng Q, Bentwich Z, Magen E, et al.: CTLA-4 upregulation during HIV infection: Association with anergy and possible target for therapeutic intervention. AIDS 2002;16:519-529.
19. Steiner K, Waase I, Rau T, et al.: Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. Clin Exp Immunol 1999;115:451-457.
20. Riley JL, Schlienger K, Blair PJ, et al.: Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule. J Exp Med 2000;191:1987-1997.
21. Letterio JJ and Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998;16:137-161.
22. Valdez H and Lederman MM: Cytokines and cytokine therapies in HIV infection. AIDS Clin Rev 1997;187-228.
23. Sousa AE, Chaves AF, Doroana M, et al.: Kinetics of the changes of lymphocyte subsets defined by cytokine pro- duction at single cell level during highly active antiretroviral therapy for HIV-1 infection. J Immunol 1999;162:3718-3726.
24. Garba ML, Pilcher CD, Bingham AL, et al.: HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells. J Immunol 2002;168:2247-2254.
25. Gorelik L and Flavell RA: Transforming growth factor-beta in T-cell biology. Nat Rev Immunol 2002;2:46-53.
26. Chen W, Jin W, Hardegen N, et al.: Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003;198:1875-1886.
27. Park HB, Paik DJ, Jang E, et al.: Acquisition of anergic and suppressive activities in transforming growth factor-betacostimulated CD4+CD25- T cells. Int Immunol 2004;16: 1203-1213.
28. Zheng SG, Gray JD, Ohtsuka K, et al.: Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol 2002;169:4183-4189.
29. Sung JL, Lin JT, and Gorham JD: CD28 co-stimulation regulates the effect of transforming growth factor-beta1 on the proliferation of naive CD4+ T cells. Int Immunopharmacol 2003;3:233-245.
30. Sharma V, Knobloch TJ, and Benjamin D: Differential expression of cytokine genes in HIV-1 tat transfected T and B cell lines. Biochem Biophys Res Commun 1995;208:704-713.
31. Reinhold D, Wrenger S, Kahne T, et al.: HIV-1 Tat: Immunosuppression via TGF-beta1 induction. Immunol Today 1999;20:384-385.
32. Wiercinska-Drapalo A, Flisiak R, Jaroszewicz J, et al.: Increased plasma transforming growth factor-beta1 is associated with disease progression in HIV-1-infected patients. Viral Immunol 2004;17:109-1013.
33. Moss AR, Hahn JA, Perry S, et al.: Adherence to highly active antiretroviral therapy in the homeless population in San Francisco: A prospective study. Clin Infect Dis 2004;39:1190-1198.
34. McEvers K, Elrefaei M, Norris P, et al.: Modified anthrax fusion proteins deliver HIV antigens through MHC Class I and II pathways. Vaccine 2005;23:4128-4135.
35. Elrefaei M, Baker CA, Jones NG, et al.: Presence of suppressor HIV-specific CD8+ T cells is associated with increased PD-1 expression on effector CD8+ T cells. J Immunol 2008;180:7757-7763.
36. Perfetto SP, Chattopadhyay PK, Lamoreaux L, et al.: Amine reactive dyes: An effective tool to discriminate live and dead cells in polychromatic flow cytometry. J Immunol Methods 2006;313:199-208.
37. Elrefaei M, Barugahare B, Ssali F, et al.: HIV-specific IL-10- positive CD8+ T cells are increased in advanced disease and are associated with decreased HIV-specific cytolysis. J Immunol 2006;176:1274-1280.
38. Zanussi S, Simonelli C, D'Andrea M, et al.: CD8+ lymphocyte phenotype and cytokine production in long-term nonprogressor and in progressor patients with HIV-1 infection. Clin Exp Immunol 1996;105:220-224.
39. Taylor A, Verhagen J, Blaser K, et al.: Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: The role of T regulatory cells. Immunology 2006;117:433-442.
40. Sansom DM and Walker LS: The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev 2006;212:131-148.
41. von Boehmer H: Mechanisms of suppression by suppressor T cells. Nat Immunol 2005;6:338-344.
42. Read S, Greenwald R, Izcue A, et al.: Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol 2006;177:4376-4383.
43. Zheng SG, Wang JH, Stohl W, et al.: TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol 2006;176:3321-3329.
44. Han Y, Guo Q, Zhang M, et al.: CD69+CD4+CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol 2009;182:111-120.
45. Li R, Perez N, Karumuthil-Melethil S, et al.: Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells. J Immunol 2007;179:5191-5203.
46. Kinter AL, Hennessey M, Bell A, et al.: CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 2004;200:331-343.
47. Weiss L, Donkova-Petrini V, Caccavelli L, et al.: Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients. Blood 2004;104:3249-3256.
48. Graziosi C, Pantaleo G, Gantt KR, et al.: Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIVinfected individuals. Science 1994;265:248-252.
49. Ostrowski MA, Gu JX, Kovacs C, et al.: Quantitative and qualitative assessment of human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cell immunity to gag in HIV- 1-infected individuals with differential disease progression: Reciprocal interferon-gamma and interleukin-10 responses. J Infect Dis 2001;184:1268-1278.
50. Wing K, et al.: CTLA-4 control over Foxp3+ regulatory T cell function. Science 2008;322:271-275.