Isolation, structure and biological activities of platencin A2-A4 from Streptomyces platensis

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2602-2610

  Zhang, Chaowei ^a   Ondeyka, John ^a   Dietrich, Lisa ^a   Gailliot, Francis P ^a   Hesse, Michelle ^a   Lester, Michael ^a   Dorso, Karen ^a   Motyl, Mary ^a   Ha, Sookhee N ^a   Wang, Jun ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibiotics; Fatty acid synthesis inhibitors; Platencins; Streptomyces platensis

Indexed keywords

ANTIINFECTIVE AGENT; DITERPENOID; FATTY ACID SYNTHASE INHIBITOR; NATURAL PRODUCT; PLATENCIN A2; PLATENCIN A3; PLATENCIN A4; PLATENSIMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STREPTOMYCES; STREPTOMYCES PLATENSIS;

ADAMANTANE; AMINOBENZOIC ACIDS; AMINOPHENOLS; ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERMENTATION; HAEMOPHILUS INFLUENZAE; HYDROXYLATION; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POLYCYCLIC COMPOUNDS; SPECTROPHOTOMETRY, ULTRAVIOLET; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); STREPTOMYCES PLATENSIS;

EID: 77950027640     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.030     Document Type: Article

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