Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4756-4759

  Singh, Sheo B ^a   Ondeyka, John G ^a   Herath, Kithsiri B ^a   Zhang, Chaowei ^a   Jayasuriya, Hiranthi ^a   Zink, Deborah L ^a   Parthasarathy, Gopalakrishnan ^a   Becker, Joseph W ^a   Wang, Jun ^a   Soisson, Stephen M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibacterial; Enzyme bound ecFabF crystal structure; FabF; FabH; Fatty acid synthesis; Inhibitor; Natural products; Streptomyces platensis

Indexed keywords

ANTIBIOTIC AGENT; CITRATE SYNTHASE; PLATENCIN A1; PROTEIN; PROTEIN FABF; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; DRUG ISOLATION; DRUG STRUCTURE; ESCHERICHIA COLI; HYDROPHOBICITY; NONHUMAN; STREPTOMYCES; STREPTOMYCES PLATENSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADAMANTANE; AMINOBENZOIC ACIDS; AMINOPHENOLS; ANILIDES; ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; MOLECULAR CONFORMATION; POLYCYCLIC COMPOUNDS; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP;

STREPTOMYCES PLATENSIS;

EID: 67651095984     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.061     Document Type: Article

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