Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence

Neuroscience Letters

Volumn 473, Issue 2, 2010, Pages 87-91

  Lohoff, Falk W ^a   Bloch, Paul J ^a   Hodge, Rachel ^a   Nall, Aleksandra H ^a   Ferraro, Thomas N ^a   Kampman, Kyle M ^a   Dackis, Charles A ^a   O'Brien, Charles P ^a   Pettinati, Helen M ^a   Oslin, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Addiction; Association study; Cocaine; Dopamine receptor; Dopamine transporter; Genetics; Substance abuse

Indexed keywords

COCAINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER;

ADULT; AFRICA; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; ETHNICITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VARIABLE NUMBER OF TANDEM REPEAT;

AFRICAN AMERICANS; COCAINE-RELATED DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D2; TANDEM REPEAT SEQUENCES;

EID: 77949917884     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.02.021     Document Type: Article

References (54)

1. Bacanu S.A., Devlin B., Roeder K. The power of genomic control. Am. J. Hum. Genet. 2000, 66:1933-1944.
2. Ballon N., Leroy S., Roy C., Bourdel M.C., Olie J.P., Charles-Nicolas A., Krebs M.O., Poirier M.F. Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3′ UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents?. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2007, 144:1034-1041.
3. Beitner-Johnson D, Nestler E. Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. J. Neurochem. 1991, 57:344-347.
4. Berggren U., Fahlke C., Aronsson E., Karanti A., Eriksson M., Blennow K., Thelle D., Zetterberg H., Balldin J. The taqi drd2 a1 allele is associated with alcohol-dependence although its effect size is small. Alcohol Alcohol. 2006, 41:479-485.
5. Berrettini W.H., Persico A.M. Dopamine D2 receptor gene polymorphisms and vulnerability to substance abuse in African Americans. Biol. Psychiatry 1996, 40:144-147.
6. Bloch P.J., Nall A.H., Weller A.E., Ferraro T.N., Berrettini W.H., Kampman K.M., Pettinati H.M., Dackis C.A., O'Brien C.P., Oslin D.W., Lohoff F.W. Association analysis between polymorphisms in the dopamine D3 receptor (DRD3) gene and cocaine dependence. Psychiatr. Genet. 2009, 19:275-276.
7. Comings D.E., Gonzalez N., Wu S., Saucier G., Johnson P., Verde R., MacMurray J.P. Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. Mol. Psychiatry 1999, 4:484-487.
8. Dackis C., O'Brien C. Neurobiology of addiction: treatment and public policy ramifications. Nat. Neurosci. 2005, 8:1431-1436.
9. Devlin B., Roeder K. Genomic control for association studies. Biometrics 1999, 55:997-1004.
10. Durston S., Fossella J.A., Casey B.J., Hulshoff Pol H.E., Galvan A., Schnack H.G., Steenhuis M.P., Minderaa R.B., Buitelaar J.K., Kahn R.S., Van Engeland H. Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls. Mol. Psychiatry 2005, 10:678-685.
11. Durston S, Fossella J.A., Mulder M.J., Casey B.J., Ziermans T.B., Vessaz M.N., Van Engeland H. Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation. J. Am. Acad. Child Adolesc. Psychiatry 2008, 47:61-67.
12. Forbes E.E., Brown S.M., Kimak M., Ferrell R.E., Manuck S.B., Hariri A.R. Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. Mol. Psychiatry 2009, 14:60-70.
13. Freimer M., Kranzler H., Satel S., Lacobelle J., Skipsey K., Charney D., Gelernter J. No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. Addict. Biol. 1996, 1:281-287.
14. Fuke S., Suo S., Takahashi N., Koike H., Sasagawa N., Ishiura S. The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J. 2001, 1:152-156.
15. Gauderman W.J. Sample size requirements for association studies of gene-gene interaction. Am. J. Epidemiol. 2002, 155:478-484.
16. Gelernter J., Kranzler H., Satel S.L. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Biol. Psychiatry 1999, 45:340-345.
17. Gelernter J., Kranzler H.R., Satel S.L., Rao P.A. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacology 1994, 11:195-200.
18. Gong W.H., Neill D., Justice J.B. 6-Hydroxydopamine lesion of ventral pallidum blocks acquisition of place preference conditioning to cocaine. Brain Res. 1997, 754:103-112.
19. Gong W.H., Neill D., Justice J.B. Conditioned place preference and locomotor activation produced by injection of psychostimulants into ventral pallidum. Brain Res. 1996, 707:64-74.
20. Guindalini C., Howard M., Haddley K., Laranjeira R., Collier D., Ammar N., Craig I., O'Gara C., Bubb V.J., Greenwood T., Kelsoe J., Asherson P., Murray R.M., Castelo A., Quinn J.P., Vallada H., Breen G. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:4552-4557.
21. Heath A.C., Madden P.A., Bucholz K.K., Dinwiddie S.H., Slutske W.S., Bierut L.J., Rohrbaugh J.W., Statham D.J., Dunne M.P., Whitfield J.B., Martin N.G. Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk. Psychol. Med. 1999, 29:1069-1081.
22. Hong C.J., Cheng C.-Y., Shu L.-R.R., Yang C.-Y., Tsai S.-J. Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males. J. Neural Transm. 2003, 110:345-351.
23. Hou Q.-F., Li S.-B. Potential association of DRD2 and DAT1 genetic variation with heroin dependence. Neurosci. Lett. 2009, 464:127-130.
24. Hubner C.B., Koob G.F. The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat. Brain Res. 1990, 508:20-29.
25. Hyman S.E., Malenka R.C., Nestler E.J. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu. Rev. Neurosci. 2006, 29:565-598.
26. Kendler K.S., Karkowski L.M., Neale M.C., Prescott C.A. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch. Gen. Psychiatry 2000, 57:261-269.
27. Kendler K.S, Prescott C.A. Cocaine use, abuse and dependence in a population-based sample of female twins. Br. J. Psychiatry 1998, 173:345-350.
28. Lachman H.M. An overview of the genetics of substance use disorders. Curr. Psychiatry Rep. 2006, 8:133-143.
29. Lafuente A., Bernardo M., Mas S., Crescenti A., Aparici M., Gassó P., Catalan R., Mateos J.J., Lomeña F., Parellada E. Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics. Schizophr. Res. 2007, 90:115-122.
30. Lee K.-W., Kim Y., Kim A.M., Helmin K., Nairn A.C., Greengard P. Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens. Proc. Natl. Acad. Sci. U.S.A. 2005, 103:3399-3404.
31. Lohoff F.W., Weller A.E., Bloch P.J., Nall A.H., Ferraro T.N., Kampman K.M., Pettinati H.M., Oslin D.W., Dackis C.A., O'Brien C.P., Berrettini W.H. Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. Neuropsychopharmacology 2008, 33:3078-3084.
32. Marchini J., Cardon L.R., Phillips M.S., Donnelly P. The effects of human population structure on large genetic association studies. Nat. Genet. 2004, 36:512-517.
33. McGeary J. The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review. Pharmacol. Biochem. Behav. 2009, 93:222-229.
34. Messas G., Meira-Lima I., Turchi M., Franco O., Guindalini C., Castelo A., Laranjeira R., Vallada H. Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence. Psychiatr. Genet. 2005, 15:171-174.
35. Michelhaugh S.K., Fiskerstrand C., Lovejoy E., Bannon M.J., Quinn J.P. The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons. J. Neurochem. 2001, 79:1033-1038.
36. Noble E.P., Blum K., Khalsa M.E., Ritchie T., Montgomery A., Wood R.C., Fitch R.J., Ozkaragoz T., Sheridan P.J., Anglin M.D. Allelic association of the D2 dopamine receptor gene with cocaine dependence. Drug Alcohol Depend. 1993, 33:271-285.
37. Opris I., Hampson R.E., Deadwyler S.A. The encoding of cocaine vs. natural rewards in the striatum of nonhuman primates: categories with different activations. Neuroscience 2009, 163:40-54.
38. Parra E.J., Kittles R.A., Argyropoulos G., Pfaff C.L., Hiester K., Bonilla C., Sylvester N., Parrish-Gause D., Garvey W.T., Jin L., McKeigue P.M., Kamboh M.I., Ferrell R.E., Pollitzer W.S., Shriver M.D. Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina. Am. J. Phys. Anthropol. 2001, 114:18-29.
39. Perez de los Cobos J., Baiget M., Trujols J., Sinol N., Volpini V., Banuls E., Calafell F., Luquero E., del Rio E., Alvarez E. Allelic and genotypic associations of DRD2 TaqI A polymorphism with heroin dependence in Spanish subjects: a case control study. Behav. Brain Funct. 2007, 1:25.
40. Persico A.M., Bird G., Gabbay F.H., Uhl G.R. D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusers. Biol. Psychiatry 1996, 40:776-784.
41. Persico A.M., Vandenbergh D.J., Smith S.S., Uhl G.R. Dopamine transporter gene polymorphisms are not associated with polysubstance abuse. Biol. Psychiatry 1993, 34:265-267.
42. Pfaff C.L., Parra E.J., Bonilla C., Hiester K., McKeigue P.M., Kamboh M.I., Hutchinson R.G., Ferrell R.E., Boerwinkle E., Shriver M.D. Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium. Am. J. Hum. Genet. 2001, 68:198-207.
43. Pritchard J.K., Donnelly P. Case-control studies of association in structured or admixed populations. Theor. Popul. Biol. 2001, 60:227-237.
44. Qian Q., Wang Y., Li J., Yang L., Wang B., Zhou R., Glatt S.J., Faraone S.V. Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 2007, 144B:200-206.
45. Robledo P., Koob G.F. Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat. Behav. Brain Res. 1993, 55:159-166.
46. Samochowiec J., Kucharska-Mazur J., Grzywacz A., Jablonski M., Rommelspacher H., Samochowiec A., Sznabowicz M., Horodnicki J., Sagan L., Pelka-Wysiecka J. Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence. Neurosci. Lett. 2006, 410:1-5.
47. Spielman R.S., Ewens W.J. The TDT and other family-based tests for linkage disequilibrium and association. Am. J. Hum. Genet. 1996, 59:983-989.
48. Thompson J., Thomas N., Singleton A., Piggott M., Lloyd S., Perry E.K., Morris C.M., Perry R.H., Ferrier I.N., Court J.A. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 1997, 7:479-484.
49. Tian C., Hinds D.A., Shigeta R., Kittles R., Ballinger D.G., Seldin M.F. A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping. Am. J. Hum. Genet. 2006, 79:640-649.
50. Volkow N., Wang G., Fischman M., Foltin R., Fowler J., Abumrad N., Vitkun S., Logan J., Gatley S., Pappas N., Hitzemann R., Shea C. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 1997, 386:827-830.
51. Wu J., Bell K., Najafi A., Widmark C., Keator D., Tang C., Klein E., Bunney B., Fallon J., Bunney W. Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal. Neuropsychopharmacology 1997, 17:402-409.
52. Xian H., Scherrer J., Grant J., Eisen S., True W., Jacob T., Bucholz K. Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. Addiction 2008, 103:1391-1398.
53. Zhu X., Cooper R.S., Elston R.C. Linkage analysis of a complex disease through use of admixed populations. Am. J. Hum. Genet. 2004, 74:1136-1153.
54. Zito K.A., Vickers G., Roberts D.C.S. Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens. Pharmacol. Biochem. Behav. 1985, 23:1029-1036.